BR0313732A - Compostos de pirimido tendo atividade antiproliferativa - Google Patents

Compostos de pirimido tendo atividade antiproliferativa

Info

Publication number
BR0313732A
BR0313732A BR0313732-5A BR0313732A BR0313732A BR 0313732 A BR0313732 A BR 0313732A BR 0313732 A BR0313732 A BR 0313732A BR 0313732 A BR0313732 A BR 0313732A
Authority
BR
Brazil
Prior art keywords
compounds
pyrimide
antiproliferative activity
selective
fgfr
Prior art date
Application number
BR0313732-5A
Other languages
English (en)
Inventor
Yi Chen
Andrzej Robert Daniewski
William Harris
Marek Michal Kabat
Emily Aijun Liu
Jin-Jun Liu
Kin-Chun Luk
Christophe Michoud
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0313732A publication Critical patent/BR0313732A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"COMPOSTOS DE PIRIMIDO TENDO ATIVIDADE ANTIPROLIFERATIVA". A presente invenção refere-se a compostos de pirimido da fórmula I que são inibidores seletivos de ambas cinases de FGFR e KDR e são seletivos contra LCK. Esses compostos e seus sais farmaceuticamente aceitáveis são agentes antiproliferativos úteis no tratamento ou controle de tumores sólidos, em tumores de mama, cólon, pulmão e próstata particulares. São também descritas composições farmacêuticas contendo esses compostos e um processo para sua preparação.
BR0313732-5A 2002-08-14 2003-08-07 Compostos de pirimido tendo atividade antiproliferativa BR0313732A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40351902P 2002-08-14 2002-08-14
PCT/EP2003/008744 WO2004018472A2 (en) 2002-08-14 2003-08-07 Pyrimido compounds having antiproliferative activity

Publications (1)

Publication Number Publication Date
BR0313732A true BR0313732A (pt) 2005-09-27

Family

ID=31946709

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0313732-5A BR0313732A (pt) 2002-08-14 2003-08-07 Compostos de pirimido tendo atividade antiproliferativa

Country Status (19)

Country Link
US (1) US7084270B2 (pt)
EP (1) EP1556384B1 (pt)
JP (1) JP2005538141A (pt)
KR (1) KR20070087687A (pt)
CN (1) CN1323080C (pt)
AR (1) AR040971A1 (pt)
AT (1) ATE386743T1 (pt)
AU (1) AU2003255389A1 (pt)
BR (1) BR0313732A (pt)
CA (1) CA2494127A1 (pt)
DE (1) DE60319255T2 (pt)
ES (1) ES2300644T3 (pt)
MX (1) MXPA05001629A (pt)
PA (1) PA8580001A1 (pt)
PL (1) PL375588A1 (pt)
RU (1) RU2336275C2 (pt)
TW (1) TW200407326A (pt)
UY (1) UY27937A1 (pt)
WO (1) WO2004018472A2 (pt)

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US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
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MX367878B (es) 2013-04-19 2019-09-10 Incyte Holdings Corp Heterociclos bicíclicos como inhibidores de los receptores del factor de crecimiento de fibroblastos (fgfr).
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AU2015292818B2 (en) 2014-07-21 2020-01-16 Dana-Farber Cancer Institute, Inc. Imidazolyl kinase inhibitors and uses thereof
EP3536323A1 (en) 2014-08-08 2019-09-11 Dana Farber Cancer Institute, Inc. Uses of salt-inducible kinase (sik) inhibitors
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
EP3259269B9 (en) 2015-02-20 2020-03-04 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
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US11241435B2 (en) 2016-09-16 2022-02-08 The General Hospital Corporation Uses of salt-inducible kinase (SIK) inhibitors for treating osteoporosis
CA3054809A1 (en) * 2017-02-28 2018-09-07 The General Hospital Corporation Uses of pyrimidopyrimidinones as sik inhibitors
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JP2021523118A (ja) 2018-05-04 2021-09-02 インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ Ｆｇｆｒ阻害剤の塩
BR112020022392A2 (pt) 2018-05-04 2021-02-02 Incyte Corporation formas sólidas de um inibidor de fgfr e processos para preparação das mesmas
WO2020139992A1 (en) * 2018-12-27 2020-07-02 Agios Pharmaceuticals, Inc. Aza-heterobicyclic inhibitors of mat2a and methods of use for treating cancer
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
BR112022007163A2 (pt) 2019-10-14 2022-08-23 Incyte Corp Heterociclos bicíclicos como inibidores de fgfr
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Also Published As

Publication number Publication date
ES2300644T3 (es) 2008-06-16
TW200407326A (en) 2004-05-16
AU2003255389A1 (en) 2004-03-11
US20040038995A1 (en) 2004-02-26
MXPA05001629A (es) 2005-04-25
UY27937A1 (es) 2004-02-27
DE60319255D1 (de) 2008-04-03
PL375588A1 (en) 2005-11-28
DE60319255T2 (de) 2009-03-05
PA8580001A1 (es) 2004-03-10
ATE386743T1 (de) 2008-03-15
EP1556384B1 (en) 2008-02-20
US7084270B2 (en) 2006-08-01
CN1323080C (zh) 2007-06-27
JP2005538141A (ja) 2005-12-15
CA2494127A1 (en) 2004-03-04
AR040971A1 (es) 2005-04-27
KR20070087687A (ko) 2007-08-28
WO2004018472A3 (en) 2004-04-29
CN1675214A (zh) 2005-09-28
RU2005107314A (ru) 2005-11-20
EP1556384A2 (en) 2005-07-27
RU2336275C2 (ru) 2008-10-20
WO2004018472A2 (en) 2004-03-04

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Legal Events

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B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]

Free format text: BASEADO NO ART. 216 1 DA LPI, APRESENTE COPIA AUTENTICADA DA PROCURACAO PARA QUE ESTA SEJA ACEITA.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012.