ATE321024T1 - Verfahren zur herstellung von oxazolidinonverbindungen - Google Patents
Verfahren zur herstellung von oxazolidinonverbindungenInfo
- Publication number
- ATE321024T1 ATE321024T1 AT01987740T AT01987740T ATE321024T1 AT E321024 T1 ATE321024 T1 AT E321024T1 AT 01987740 T AT01987740 T AT 01987740T AT 01987740 T AT01987740 T AT 01987740T AT E321024 T1 ATE321024 T1 AT E321024T1
- Authority
- AT
- Austria
- Prior art keywords
- oxazolidinone compounds
- butylcarbamoyl
- tert
- producing
- producing oxazolidinone
- Prior art date
Links
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- CWKOHZQHBLGJJL-UHFFFAOYSA-N 3-(aminomethyl)-n-tert-butyl-2-oxo-1,3-oxazolidine-5-carboxamide Chemical compound CC(C)(C)NC(=O)C1CN(CN)C(=O)O1 CWKOHZQHBLGJJL-UHFFFAOYSA-N 0.000 abstract 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- AFEQENGXSMURHA-UHFFFAOYSA-N oxiran-2-ylmethanamine Chemical class NCC1CO1 AFEQENGXSMURHA-UHFFFAOYSA-N 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- -1 tert-butylcarbamoyl Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24112200P | 2000-10-17 | 2000-10-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE321024T1 true ATE321024T1 (de) | 2006-04-15 |
Family
ID=22909351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01987740T ATE321024T1 (de) | 2000-10-17 | 2001-10-17 | Verfahren zur herstellung von oxazolidinonverbindungen |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6833453B2 (de) |
| EP (1) | EP1328509B1 (de) |
| JP (1) | JP4170753B2 (de) |
| AT (1) | ATE321024T1 (de) |
| AU (1) | AU2002224421A1 (de) |
| CA (1) | CA2423599A1 (de) |
| DE (1) | DE60118241T2 (de) |
| ES (1) | ES2256318T3 (de) |
| MX (1) | MXPA03003473A (de) |
| NZ (1) | NZ525923A (de) |
| WO (1) | WO2002032857A1 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| JPWO2004002973A1 (ja) * | 2002-06-28 | 2005-10-27 | 株式会社カネカ | 光学活性１−置換アミノ−２，３−エポキシプロパンの製造方法並びにその合成中間体およびそれらの製造方法 |
| US6875784B2 (en) * | 2002-10-09 | 2005-04-05 | Pharmacia & Upjohn Company | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives |
| WO2004045616A1 (en) * | 2002-11-21 | 2004-06-03 | Pharmacia & Upjohn Company Llc | N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinone-5-carboxamide derivates and related compounds as antibacterial agents |
| US20040204463A1 (en) * | 2003-04-01 | 2004-10-14 | Harris Christina Renee | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
| CA2521685A1 (en) * | 2003-04-09 | 2004-10-21 | Pharmacia & Upjohn Company Llc | Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues |
| EP2269610A3 (de) | 2004-09-20 | 2011-03-09 | Xenon Pharmaceuticals Inc. | Heterozyklische Derivate und ihre Verwendung als Stearoyl-Coa-Desaturase-Inhibitoren |
| EP1799667B1 (de) | 2004-09-20 | 2013-03-20 | Xenon Pharmaceuticals Inc. | Heterozyklische derivate und ihre verwendung als therapeutische wirkstoffe |
| JP4958786B2 (ja) | 2004-09-20 | 2012-06-20 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 複素環誘導体および治療薬としてのそれらの使用 |
| MX2007003332A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa. |
| MX2007003319A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como agentes terapeuticos. |
| EP2289510A1 (de) | 2004-09-20 | 2011-03-02 | Xenon Pharmaceuticals Inc. | Heterozyklische Derivate zur Behandlung von durch Stearoyl-Coa-Desaturase-Enzyme verursachten Krankheiten |
| MX2007003327A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa. |
| AU2006231919A1 (en) | 2005-04-06 | 2006-10-12 | Pharmacia & Upjohn Company Llc | 7-fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents |
| BRPI0611187A2 (pt) | 2005-06-03 | 2010-08-24 | Xenon Pharmaceuticals Inc | derivados aminotiazàis como inibidores da estearoil-coa desaturase humana |
| US8431714B2 (en) * | 2007-04-16 | 2013-04-30 | University Of Southern California | Synthesis of drug conjugates via reaction with epoxide-containing linkers |
| EP2033960A3 (de) * | 2007-09-04 | 2009-04-29 | Dipharma Francis S.r.l. | Kristalline Linezolidhydratform und Linezolidsalze |
| ITMI20072359A1 (it) * | 2007-12-18 | 2009-06-19 | Dipharma Francis Srl | Procedimento per la preparazione di derivati ossazolidinonici |
| EP2163547A1 (de) | 2008-09-16 | 2010-03-17 | Unión Químico Farmacéutica, S.A. (UQUIFA) | Verfahren für die Herstellung eines antibakteriellen Oxazolidinon-Wirkstoffs und Zwischenprodukte davon |
| EP2899185B1 (de) | 2010-04-30 | 2018-01-31 | Indiana University Research and Technology Corporation | Verfahren zur Herstellung von Linezolid |
| GEP20156397B (en) * | 2011-05-06 | 2015-11-10 | Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság | Process for the preparation of a rivaroxaban and intermediates formed in said process |
| AU2012277738A1 (en) | 2011-06-30 | 2014-01-16 | Dsm Ip Assets B.V. | Silicone-containing monomer |
| CN103254148B (zh) * | 2012-02-15 | 2016-04-13 | 浙江海正药业股份有限公司 | 利奈唑胺中间体的制备方法 |
| EP2834235A1 (de) | 2012-04-06 | 2015-02-11 | Indiana University Research and Technology Corporation | Verfahren zur herstellung von rivaroxaban |
| CN104327007B (zh) * | 2014-10-20 | 2016-07-27 | 安徽师范大学 | 3,4,5-三取代噁唑烷酮类化合物及其制备方法 |
| WO2017066964A1 (en) | 2015-10-22 | 2017-04-27 | Merck Sharp & Dohme Corp. | Oxazolidinone compounds and methods of use thereof as antibacterial agents |
| US11608320B2 (en) | 2020-02-02 | 2023-03-21 | Kuwait University | Oxazolidinone hydroxamic acid derivatives |
| WO2021184339A1 (en) * | 2020-03-20 | 2021-09-23 | Merck Sharp & Dohme Corp. | Oxazolidinone compound and methods of use thereof as an antibacterial agent |
| EP4568961A1 (de) * | 2022-08-10 | 2025-06-18 | Merck Sharp & Dohme LLC | Verfahren zur herstellung von oxazolidinonverbindungen |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1180089A (en) | 1967-10-20 | 1970-02-04 | Delalande Sa | Acetylenic Derivatives of 2-Oxazolidinones and processes of preparation |
| FR2356422A1 (fr) | 1976-03-01 | 1978-01-27 | Delalande Sa | Nouveaux hydroxymethyl-5 oxazolidinone-2, leur procede de preparation et leur application en therapeutique |
| LU80081A1 (fr) | 1977-08-26 | 1979-05-15 | Delalande Sa | Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique |
| US4340606A (en) | 1980-10-23 | 1982-07-20 | E. I. Du Pont De Nemours And Company | 3-(p-Alkylsulfonylphenyl)oxazolidinone derivatives as antibacterial agents |
| FR2500450A1 (fr) | 1981-02-25 | 1982-08-27 | Delalande Sa | Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique |
| US4705799A (en) | 1983-06-07 | 1987-11-10 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents |
| ES8506659A1 (es) * | 1983-06-07 | 1985-08-01 | Du Pont | Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno. |
| US4948801A (en) | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| US5225565A (en) | 1988-09-15 | 1993-07-06 | The Upjohn Company | Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones |
| US5164510A (en) | 1988-09-15 | 1992-11-17 | The Upjohn Company | 5'Indolinyl-5β-amidomethyloxazolidin-2-ones |
| US5182403A (en) | 1988-09-15 | 1993-01-26 | The Upjohn Company | Substituted 3(5'indazolyl) oxazolidin-2-ones |
| US5182296A (en) | 1989-10-26 | 1993-01-26 | Tanabe Seiyaky Co., Ltd. | Naphthyloxazolidone derivatives |
| US5231188A (en) | 1989-11-17 | 1993-07-27 | The Upjohn Company | Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents |
| WO1993001174A1 (en) | 1991-07-08 | 1993-01-21 | Glaxo Group Limited | Thiazolidine derivatives and their use as anti-viral compounds |
| AU667198B2 (en) | 1991-11-01 | 1996-03-14 | Pharmacia & Upjohn Company | Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents |
| SK283420B6 (sk) | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
| US5688792A (en) | 1994-08-16 | 1997-11-18 | Pharmacia & Upjohn Company | Substituted oxazine and thiazine oxazolidinone antimicrobials |
| MY115155A (en) * | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
| DK0788498T3 (da) | 1994-10-26 | 2001-11-05 | Upjohn Co | Phenyloxazolidinoner med antimikrobiel virkning |
| BR9509673A (pt) | 1994-11-15 | 1997-09-30 | Upjohn Co | Compostos e uso dos mesmos |
| US6262278B1 (en) | 1995-03-14 | 2001-07-17 | President And Fellows Of Harvard College | Stereoselective ring opening reactions |
| JP3796280B2 (ja) | 1995-04-17 | 2006-07-12 | バイエルクロップサイエンス株式会社 | １−（２−クロロフエニル）−５（４ｈ）−テトラゾリノンの製造方法 |
| HRP960159A2 (en) * | 1995-04-21 | 1997-08-31 | Bayer Ag | Benzocyclopentane oxazolidinones containing heteroatoms |
| PT1019385E (pt) * | 1995-09-15 | 2004-06-30 | Upjohn Co | N-oxidos de aminoaril-oxazolidinona |
| WO1999003764A1 (en) | 1997-07-16 | 1999-01-28 | Systemation Engineered Products, Inc. | Tray handling apparatus |
| DE19730847A1 (de) * | 1997-07-18 | 1999-01-28 | Bayer Ag | Tricyclisch substituierte Oxazolidinone |
| DE69823756T2 (de) | 1997-08-28 | 2005-04-14 | Alps Electric Co., Ltd. | Verfahren zum Sintern einer glasartige Eisenlegierungen |
| CA2304100A1 (en) | 1997-11-07 | 1999-05-20 | Pharmacia & Upjohn Company | Process to produce oxazolidinones |
| DE19802239A1 (de) | 1998-01-22 | 1999-07-29 | Bayer Ag | Neue mit Bicyclen substituierte Oxazolidinone |
| DE19805117A1 (de) | 1998-02-09 | 1999-08-12 | Bayer Ag | Neue Oxazolidinone mit azolhaltigen Tricyclen |
| EP1133493A1 (de) | 1998-11-27 | 2001-09-19 | PHARMACIA & UPJOHN COMPANY | Thiocarbonylgruppe enthaltende oxazolidinone als antibakterielle mittel |
| US6605732B1 (en) * | 1999-05-03 | 2003-08-12 | Aerojet Fine Chemicals Llc | Clean, high-yield preparation of S,S and R,S amino acid isosteres |
| US6441005B1 (en) | 1999-07-28 | 2002-08-27 | Pharmacia & Upjohn Company | Oxazolidinone compounds and compositions, and methods of using the same |
| US6413981B1 (en) * | 1999-08-12 | 2002-07-02 | Ortho-Mcneil Pharamceutical, Inc. | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods |
| PE20010851A1 (es) * | 1999-12-14 | 2001-08-17 | Upjohn Co | Esteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina |
| MXPA02007719A (es) * | 2000-02-10 | 2002-10-11 | Upjohn Co | Tioamidas de oxazolidinona con sustituyentes de piperazina y amida. |
-
2001
- 2001-10-17 DE DE60118241T patent/DE60118241T2/de not_active Expired - Fee Related
- 2001-10-17 JP JP2002536041A patent/JP4170753B2/ja not_active Expired - Fee Related
- 2001-10-17 WO PCT/US2001/032478 patent/WO2002032857A1/en not_active Ceased
- 2001-10-17 AT AT01987740T patent/ATE321024T1/de not_active IP Right Cessation
- 2001-10-17 ES ES01987740T patent/ES2256318T3/es not_active Expired - Lifetime
- 2001-10-17 MX MXPA03003473A patent/MXPA03003473A/es active IP Right Grant
- 2001-10-17 US US09/982,157 patent/US6833453B2/en not_active Expired - Fee Related
- 2001-10-17 CA CA002423599A patent/CA2423599A1/en not_active Abandoned
- 2001-10-17 NZ NZ525923A patent/NZ525923A/en unknown
- 2001-10-17 EP EP01987740A patent/EP1328509B1/de not_active Expired - Lifetime
- 2001-10-17 AU AU2002224421A patent/AU2002224421A1/en not_active Abandoned
-
2003
- 2003-12-23 US US10/744,655 patent/US6998420B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004511539A (ja) | 2004-04-15 |
| EP1328509B1 (de) | 2006-03-22 |
| US20040143131A1 (en) | 2004-07-22 |
| AU2002224421A1 (en) | 2002-04-29 |
| DE60118241D1 (de) | 2006-05-11 |
| EP1328509A1 (de) | 2003-07-23 |
| US20020086900A1 (en) | 2002-07-04 |
| NZ525923A (en) | 2005-11-25 |
| JP4170753B2 (ja) | 2008-10-22 |
| MXPA03003473A (es) | 2003-08-19 |
| US6833453B2 (en) | 2004-12-21 |
| US6998420B2 (en) | 2006-02-14 |
| ES2256318T3 (es) | 2006-07-16 |
| CA2423599A1 (en) | 2002-04-25 |
| WO2002032857A1 (en) | 2002-04-25 |
| DE60118241T2 (de) | 2006-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |