MD4557C1 - Procedeu de obţinere a rivaroxabanului şi un compus intermediar utilizat în acest procedeu - Google Patents

Procedeu de obţinere a rivaroxabanului şi un compus intermediar utilizat în acest procedeu

Info

Publication number
MD4557C1
MD4557C1 MDA20130094A MD20130094A MD4557C1 MD 4557 C1 MD4557 C1 MD 4557C1 MD A20130094 A MDA20130094 A MD A20130094A MD 20130094 A MD20130094 A MD 20130094A MD 4557 C1 MD4557 C1 MD 4557C1
Authority
MD
Moldova
Prior art keywords
rivaroxaban
preparation
oxo
intermediate used
relates
Prior art date
Application number
MDA20130094A
Other languages
English (en)
Russian (ru)
Other versions
MD20130094A2 (ro
MD4557B1 (ro
Inventor
Эва Шипош
ЛАКС Дьёрдьи КОВАНЬИНЭ
Балаж Хаваши
Балаж Волк
Дьёрдь Краснаи
Дьёрдь Ружич
Йожеф Баркоци
ЛАУРИЦ Мария ТОТНЭ
Дьула ЛУКАЧ
Андраш Боза
Ласло Хегедюш
ТОТ Мария Юлия ТАБОРИНЭ
Эва Печи
Original Assignee
Egis Gyogysszegyar Nyilvanosan Mukodo Reszvenytarsasag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU1100239A external-priority patent/HU230984B1/hu
Priority claimed from HU1100240A external-priority patent/HU230985B1/hu
Priority claimed from HU1100238A external-priority patent/HU230961B1/hu
Application filed by Egis Gyogysszegyar Nyilvanosan Mukodo Reszvenytarsasag filed Critical Egis Gyogysszegyar Nyilvanosan Mukodo Reszvenytarsasag
Publication of MD20130094A2 publication Critical patent/MD20130094A2/ro
Publication of MD4557B1 publication Critical patent/MD4557B1/ro
Publication of MD4557C1 publication Critical patent/MD4557C1/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Invenţia se referă la un procedeu de obţinere a compusului farmaceutic activ 5-clor-N-({(5S)-2-oxo-3-[4-(3-oxo-morfolin-4-il)-fenil]-l,3-oxazolidin-5-il}-metil)tiofen-2-carboxamidei cu formula:având denumirea comună internaţională (INN) rivaroxaban, care poate fi utilizat în tratamentul infarctului miocardic, în tromboza venelor profunde, în angina pectorală, în ocluzia arterială, restenoza arterială şi în embolismul pulmonar.Invenţia se referă, de asemenea, la un compus intermediar, utilizat în acest procedeu.
MDA20130094A 2011-05-06 2012-05-04 Procedeu de obţinere a rivaroxabanului şi un compus intermediar utilizat în acest procedeu MD4557C1 (ro)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HU1100239A HU230984B1 (hu) 2011-05-06 2011-05-06 Új eljárás gyógyszerhatóanyag előállítására és az eljárás során keletkező intermedierek
HU1100240A HU230985B1 (hu) 2011-05-06 2011-05-06 Új kapcsolási eljárás gyógyszerhatóanyag előállítására
HU1100238A HU230961B1 (hu) 2011-05-06 2011-05-06 Új eljárás gyógyszerhatóanyag előállítására és az eljárás során keletkező intermedierek
PCT/HU2012/000033 WO2012153155A1 (en) 2011-05-06 2012-05-04 Process for the preparation of a rivaroxaban and intermediates formed in said process

Publications (3)

Publication Number Publication Date
MD20130094A2 MD20130094A2 (ro) 2014-04-30
MD4557B1 MD4557B1 (ro) 2018-03-31
MD4557C1 true MD4557C1 (ro) 2018-10-31

Family

ID=89990276

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20130094A MD4557C1 (ro) 2011-05-06 2012-05-04 Procedeu de obţinere a rivaroxabanului şi un compus intermediar utilizat în acest procedeu

Country Status (8)

Country Link
US (1) US9556163B2 (ro)
EP (1) EP2705028B1 (ro)
JP (1) JP6325978B2 (ro)
EA (1) EA024685B1 (ro)
GE (1) GEP20156397B (ro)
MD (1) MD4557C1 (ro)
UA (1) UA114601C2 (ro)
WO (1) WO2012153155A1 (ro)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
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AU2011300365A1 (en) * 2010-09-07 2013-05-02 Symed Labs Limited Processes for the preparation of 4-{4-[5(S)-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl} morpholin-3-one
JP2015514114A (ja) 2012-04-06 2015-05-18 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ リバーロキサバンを調製するためのプロセス
HUE037188T2 (hu) 2012-12-21 2018-08-28 Farma Grs D O O Eljárás rivaroxaban elõállítására
US9394292B2 (en) 2012-12-26 2016-07-19 Wanbury Ltd. Rivaroxaban intermediate and preparation thereof
EP2897619A4 (en) 2012-12-26 2016-08-17 Wanbury Ltd ALDEHYDE DERIVATIVE FROM SUBSTITUTED OXAZOLIDINONES
CN103360380B (zh) * 2013-03-13 2016-01-20 浙江天宇药业股份有限公司 一种利伐沙班的合成方法和利伐沙班的中间体及其制备
IN2014MU00072A (ro) 2014-01-08 2015-08-21 Wockhardt Ltd
US20170267669A1 (en) * 2014-08-25 2017-09-21 Cipla Limited Process for the Preparation of Rivaroxaban
CN104311545B (zh) * 2014-09-29 2017-03-22 哈药集团制药总厂 一种利伐沙班关键中间体的制备方法
KR101811123B1 (ko) * 2016-02-19 2017-12-20 일동제약(주) 신규의 모르폴린 이인산염 및 이를 이용한 고순도 리바록사반의 제조방법
PL4073051T3 (pl) * 2019-12-10 2024-05-20 Eli Lilly And Company Sposób i związek pośredni do wytwarzania oksetan-2-ylometanoaminy

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AU764980B2 (en) * 1998-11-27 2003-09-04 Pharmacia & Upjohn Company Oxazolidinone antibacterial agents having a thiocarbonyl functionality
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Also Published As

Publication number Publication date
EP2705028A1 (en) 2014-03-12
MD20130094A2 (ro) 2014-04-30
JP6325978B2 (ja) 2018-05-16
EP2705028B1 (en) 2019-08-21
US20140142303A1 (en) 2014-05-22
GEP20156397B (en) 2015-11-10
UA114601C2 (uk) 2017-07-10
EA024685B1 (ru) 2016-10-31
JP2014513115A (ja) 2014-05-29
WO2012153155A1 (en) 2012-11-15
EA201391647A1 (ru) 2014-02-28
MD4557B1 (ro) 2018-03-31
US9556163B2 (en) 2017-01-31

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Legal Events

Date Code Title Description
HC9A Name of applicant changed (patent for invention)

Owner name: EGIS GYOGYSZERGYAR ZARTKOERUEN MUKOEDO RESZVENYTAR

Free format text: PREVIOUS NAME OF APPLICANT: EGIS GYOGYSZERGYAR NYILVANOSAN MUKOEDO RESZVENYTARSASAG, HU

TK4A Erratum in official gazette in regard to patent for invention

Free format text: RECTIFICATION IN INID 72

FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees