AR116394A2 - Mesilato de n-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil)fenil]acetamida monohidrato - Google Patents

Mesilato de n-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil)fenil]acetamida monohidrato

Info

Publication number
AR116394A2
AR116394A2 ARP190102595A ARP190102595A AR116394A2 AR 116394 A2 AR116394 A2 AR 116394A2 AR P190102595 A ARP190102595 A AR P190102595A AR P190102595 A ARP190102595 A AR P190102595A AR 116394 A2 AR116394 A2 AR 116394A2
Authority
AR
Argentina
Prior art keywords
methyl
aminosulfonyl
thiazol
pyridinyl
phenyl
Prior art date
Application number
ARP190102595A
Other languages
English (en)
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Publication of AR116394A2 publication Critical patent/AR116394A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Reivindicación 1: Un compuesto caracterizado porque es el mesilato de N-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-N-metil-2-[4-(2-piridinil)-fenil]acetamida monohidrato cristalino.
ARP190102595A 2011-09-26 2019-09-13 Mesilato de n-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil)fenil]acetamida monohidrato AR116394A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11007823A EP2573086A1 (en) 2011-09-26 2011-09-26 N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate

Publications (1)

Publication Number Publication Date
AR116394A2 true AR116394A2 (es) 2021-05-05

Family

ID=46889067

Family Applications (3)

Application Number Title Priority Date Filing Date
ARP120103551A AR088043A1 (es) 2011-09-26 2012-09-26 Mesilato de n-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil)fenil]acetamida monohidrato
ARP190102595A AR116394A2 (es) 2011-09-26 2019-09-13 Mesilato de n-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil)fenil]acetamida monohidrato
ARP200102938A AR120291A2 (es) 2011-09-26 2020-10-23 Mesilato de n-[5-(aminosulfonil)-4-metil-1,3-triazol-2-il]n-metil-2-[4-(2-piridinil)fenil]acetamida monohidrato

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP120103551A AR088043A1 (es) 2011-09-26 2012-09-26 Mesilato de n-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil)fenil]acetamida monohidrato

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP200102938A AR120291A2 (es) 2011-09-26 2020-10-23 Mesilato de n-[5-(aminosulfonil)-4-metil-1,3-triazol-2-il]n-metil-2-[4-(2-piridinil)fenil]acetamida monohidrato

Country Status (29)

Country Link
US (1) US9340535B2 (es)
EP (3) EP2573086A1 (es)
JP (2) JP6161614B2 (es)
KR (4) KR20180088530A (es)
CN (2) CN103842359B (es)
AR (3) AR088043A1 (es)
AU (2) AU2012314536B2 (es)
BR (1) BR112014003245B1 (es)
CA (1) CA2791142C (es)
CL (1) CL2014000149A1 (es)
DK (2) DK2598501T3 (es)
ES (2) ES2466221T3 (es)
HK (1) HK1220978A1 (es)
HR (1) HRP20140351T1 (es)
IL (2) IL230152A (es)
IN (1) IN2014DN01993A (es)
JO (2) JO3037B1 (es)
MX (2) MX371088B (es)
MY (2) MY190878A (es)
PE (1) PE20141148A1 (es)
PH (2) PH12014500567A1 (es)
PL (2) PL2598501T3 (es)
PT (1) PT2598501E (es)
RU (2) RU2620604C2 (es)
SG (1) SG10201407430TA (es)
TW (2) TWI567070B (es)
UA (2) UA119574C2 (es)
WO (1) WO2013045479A1 (es)
ZA (2) ZA201401773B (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2573085A1 (en) * 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(aminosulfonyl)-4methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl] acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range
EP2573086A1 (en) * 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate
AR108175A1 (es) * 2016-04-06 2018-07-25 Innovative Molecules Gmbh Compuestos antivíricos de tiazol acetamida
WO2018096170A1 (en) * 2016-11-28 2018-05-31 Aicuris Anti-Infective Cures Gmbh N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)-phenyl]-acetamide free base hemihydrate, methods of manufacture and uses thereof
UY37497A (es) * 2016-11-28 2018-06-29 Aicuris Anti Infective Cures Gmbh Formulación tópica que comprende n-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil)-fenil]-acetamida
TWI808591B (zh) 2016-11-28 2023-07-11 德商艾庫瑞斯公司 N-[5-(胺基磺醯基)-4-甲基-1,3-噻唑-2-基]-n-甲基-2-[4-(2-吡啶基)-苯基]-乙醯胺之游離鹼之硫酸鹽、其醫藥調配物及其用途
KR102335327B1 (ko) 2017-04-28 2021-12-03 현대자동차 주식회사 수냉식 이지알 쿨러
IL271725B2 (en) * 2017-06-28 2025-09-01 Aicuris Anti Infective Cures Ag Intravaginally applicable devices comprising antiviral compounds
EP4209491A1 (en) 2017-10-05 2023-07-12 Innovative Molecules GmbH Enantiomers of substituted thiazoles as antiviral compounds
KR102535452B1 (ko) * 2018-07-06 2023-05-26 파에노 테라퓨틱스 씨오., 엘티디. 티아졸 화합물의 결정형 및 이의 응용
EP4509118A3 (en) * 2018-09-19 2025-05-14 ModernaTX, Inc. High-purity peg lipids and uses thereof
TW202038947A (zh) 2018-11-28 2020-11-01 德商創新分子有限責任公司 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑
WO2021191320A1 (en) * 2020-03-26 2021-09-30 Aicuris Gmbh & Co. Kg Ophthalmic formulation comprising n-[5-(aminosulfonyl)-4-methyl-1,3- thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acetamide hemihydrate
US20260070900A1 (en) 2022-08-29 2026-03-12 Assembly Biosciences, Inc. A novel crystalline form of pritelivir
EP4581031A1 (en) 2022-08-29 2025-07-09 Assembly Biosciences, Inc. A novel crystalline form of pritelivir
AU2023332667A1 (en) 2022-08-29 2025-03-13 Assembly Biosciences, Inc. Pharmaceutical compositions for herpes virus

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DOP2000000109A (es) 1999-12-23 2002-08-30 Gerald Kleymann Derivados de tiazolilamida
DE10129714A1 (de) * 2001-06-22 2003-01-02 Bayer Ag Topische Anwendung von Thiazolylamiden
DE10129716A1 (de) * 2001-06-22 2003-01-02 Bayer Ag Kombinationspräparate zur Herpes-Behandlung
DE10129717A1 (de) * 2001-06-22 2003-01-02 Bayer Ag Kombinationspräparate zur Herpes-Behandlung
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GB0423653D0 (en) * 2004-10-25 2004-11-24 Piramed Ltd Pharmaceutical compounds
DE102005014248A1 (de) 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung von N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamid
JP2007314516A (ja) * 2006-04-25 2007-12-06 Daiichi Sankyo Co Ltd ２以上の置換基を有するベンゼン化合物を含有する医薬
EA200802417A1 (ru) * 2006-06-09 2009-06-30 Икос Корпорейшн Замещенные фенилуксусные кислоты как dp-2-антагонисты
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UA103918C2 (en) * 2009-03-02 2013-12-10 Айерем Элелси N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators
EP2573085A1 (en) * 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(aminosulfonyl)-4methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl] acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range
EP2573086A1 (en) * 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate

Also Published As

Publication number Publication date
PT2598501E (pt) 2014-06-25
EP2602258B8 (en) 2016-09-28
TWI532739B (zh) 2016-05-11
JP6161614B2 (ja) 2017-07-12
UA119574C2 (uk) 2019-07-10
ZA201408734B (en) 2016-08-31
UA115317C2 (uk) 2017-10-25
MX2014003389A (es) 2014-07-09
NZ718867A (en) 2016-05-27
MX338736B (es) 2016-04-29
EP2598501B1 (en) 2014-03-12
PE20141148A1 (es) 2014-09-15
ES2466221T8 (es) 2016-09-13
DK2598501T3 (da) 2014-04-22
AU2015260762B2 (en) 2016-06-09
JO3037B1 (ar) 2016-09-05
TW201625603A (zh) 2016-07-16
PL2602258T3 (pl) 2014-08-29
EP2602258A1 (en) 2013-06-12
PH12015502801A1 (en) 2016-10-03
MX371088B (es) 2020-01-16
IL230152A (en) 2015-04-30
CL2014000149A1 (es) 2014-09-05
JP2014528948A (ja) 2014-10-30
PL2598501T3 (pl) 2014-08-29
PH12014500567A1 (en) 2014-04-14
KR20180088530A (ko) 2018-08-03
US9340535B2 (en) 2016-05-17
IN2014DN01993A (es) 2015-05-15
TWI567070B (zh) 2017-01-21
AR088043A1 (es) 2014-05-07
KR20170055565A (ko) 2017-05-19
PH12015502801B1 (en) 2016-10-03
CN103842359B (zh) 2016-05-25
KR101768295B1 (ko) 2017-08-14
BR112014003245A2 (pt) 2017-03-01
HRP20140351T1 (hr) 2014-07-04
AU2012314536B2 (en) 2016-01-14
CN103842359A (zh) 2014-06-04
JP2017114859A (ja) 2017-06-29
JP6353022B2 (ja) 2018-07-04
HK1220978A1 (zh) 2017-05-19
RU2669388C1 (ru) 2018-10-11
TW201317234A (zh) 2013-05-01
ES2462492T3 (es) 2014-05-23
EP2598501A1 (en) 2013-06-05
US20140221433A1 (en) 2014-08-07
RU2620604C2 (ru) 2017-05-29
DK2602258T3 (da) 2014-04-22
KR20190104249A (ko) 2019-09-06
ES2466221T3 (es) 2014-06-09
SG10201407430TA (en) 2014-12-30
JO3734B1 (ar) 2021-01-31
ZA201401773B (en) 2015-12-23
AR120291A2 (es) 2022-02-09
AU2012314536A1 (en) 2014-02-06
CA2791142C (en) 2017-08-01
CA2791142A1 (en) 2013-03-26
MY185063A (en) 2021-04-30
RU2014107430A (ru) 2015-11-10
EP2602258B1 (en) 2014-03-19
KR20140066704A (ko) 2014-06-02
NZ621615A (en) 2016-04-29
BR112014003245B1 (pt) 2021-11-09
CN105541829A (zh) 2016-05-04
EP2573086A1 (en) 2013-03-27
MY190878A (en) 2022-05-13
AU2015260762A1 (en) 2016-02-04
IL234405A (en) 2015-04-30
WO2013045479A1 (en) 2013-04-04

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