EA201591300A1 - Формы меглуминовой соли 2-((1r,4r)-4-(4-(5-(бензоксазол-2-иламино)пиридин-2-ил)фенил)циклогексил)уксусной кислоты и их применение в качестве ингибиторов dgat1 - Google Patents

Формы меглуминовой соли 2-((1r,4r)-4-(4-(5-(бензоксазол-2-иламино)пиридин-2-ил)фенил)циклогексил)уксусной кислоты и их применение в качестве ингибиторов dgat1

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Publication number
EA201591300A1
EA201591300A1 EA201591300A EA201591300A EA201591300A1 EA 201591300 A1 EA201591300 A1 EA 201591300A1 EA 201591300 A EA201591300 A EA 201591300A EA 201591300 A EA201591300 A EA 201591300A EA 201591300 A1 EA201591300 A1 EA 201591300A1
Authority
EA
Eurasian Patent Office
Prior art keywords
acetic acid
cyclohexil
phenil
ilamino
benzoxazol
Prior art date
Application number
EA201591300A
Other languages
English (en)
Other versions
EA027688B1 (ru
Inventor
Кристина Капаччи-Даниель
Мэрилин Делакрус
Баоцин Гун
Акаш Джейн
Яньсун Лу
Лицзюнь Чжан
Original Assignee
Новартис Аг
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Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201591300A1 publication Critical patent/EA201591300A1/ru
Publication of EA027688B1 publication Critical patent/EA027688B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Изобретение относится к новым кристаллическим формам меглуминовой соли 2-((1R,4R)-4-(4-(5-(бензо[d]оксазол-2-иламино)пиридин-2-ил)фенил)циклогексил)уксусной кислоты формулы (I) и к их применению в лечении или предотвращении состояния или нарушения, ассоциированного с активностью DGAT1 у животных, в особенности у людей.
EA201591300A 2013-01-11 2014-01-10 Меглуминовая соль 2-((1r,4r)-4-(4-(5-(бензоксазол-2-иламино)пиридин-2-ил)фенил)циклогексил)уксусной кислоты и ее кристаллическая форма и их применение в качестве ингибиторов dgat1 EA027688B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361751443P 2013-01-11 2013-01-11
PCT/US2014/011005 WO2014110344A1 (en) 2013-01-11 2014-01-10 Meglumine salt forms of 2-((1 r,4r)-4-(4-(5-(benzoxazol-2-ylamino)pyridin-2-yl)phenyl)cyclohexyl) acetic acid and their use as dgat1 inhibitors

Publications (2)

Publication Number Publication Date
EA201591300A1 true EA201591300A1 (ru) 2015-11-30
EA027688B1 EA027688B1 (ru) 2017-08-31

Family

ID=50001335

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201591300A EA027688B1 (ru) 2013-01-11 2014-01-10 Меглуминовая соль 2-((1r,4r)-4-(4-(5-(бензоксазол-2-иламино)пиридин-2-ил)фенил)циклогексил)уксусной кислоты и ее кристаллическая форма и их применение в качестве ингибиторов dgat1

Country Status (16)

Country Link
US (2) US8987459B2 (ru)
EP (1) EP2943488B1 (ru)
JP (1) JP6302937B2 (ru)
KR (1) KR20150103747A (ru)
CN (1) CN104995188B (ru)
AR (1) AR101523A1 (ru)
AU (1) AU2014205276B2 (ru)
BR (1) BR112015016370A2 (ru)
CA (1) CA2896861A1 (ru)
EA (1) EA027688B1 (ru)
ES (1) ES2675398T3 (ru)
MX (1) MX2015008978A (ru)
PL (1) PL2943488T3 (ru)
PT (1) PT2943488T (ru)
TR (1) TR201808198T4 (ru)
WO (1) WO2014110344A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014110344A1 (en) * 2013-01-11 2014-07-17 Novartis Ag Meglumine salt forms of 2-((1 r,4r)-4-(4-(5-(benzoxazol-2-ylamino)pyridin-2-yl)phenyl)cyclohexyl) acetic acid and their use as dgat1 inhibitors
KR101684053B1 (ko) * 2015-01-20 2016-12-08 씨제이헬스케어 주식회사 벤즈이미다졸 유도체의 신규 결정형 및 이의 제조방법
EP3781155A4 (en) * 2018-04-17 2021-10-06 Cardurion Pharmaceuticals, LLC MEGLUMINAL SALT OF THIENOPYRIMIDINES

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200303742A (en) 2001-11-21 2003-09-16 Novartis Ag Organic compounds
ES2430115T3 (es) * 2006-03-31 2013-11-19 Novartis Ag Inhibidor de DGAT
WO2013169648A1 (en) * 2012-05-07 2013-11-14 Novartis Ag Pharmaceutical combinations comprising a dgat1 inhibtor and a triglyceride lowering drug
WO2014110344A1 (en) * 2013-01-11 2014-07-17 Novartis Ag Meglumine salt forms of 2-((1 r,4r)-4-(4-(5-(benzoxazol-2-ylamino)pyridin-2-yl)phenyl)cyclohexyl) acetic acid and their use as dgat1 inhibitors

Also Published As

Publication number Publication date
CA2896861A1 (en) 2014-07-17
PT2943488T (pt) 2018-06-12
EP2943488B1 (en) 2018-03-28
ES2675398T3 (es) 2018-07-11
CN104995188A (zh) 2015-10-21
AU2014205276B2 (en) 2016-10-20
TR201808198T4 (tr) 2018-07-23
CN104995188B (zh) 2018-09-14
AU2014205276A1 (en) 2015-07-16
KR20150103747A (ko) 2015-09-11
US20150166522A1 (en) 2015-06-18
AR101523A1 (es) 2016-12-28
MX2015008978A (es) 2015-09-29
EP2943488A1 (en) 2015-11-18
WO2014110344A1 (en) 2014-07-17
US20140200246A1 (en) 2014-07-17
US9242971B2 (en) 2016-01-26
JP6302937B2 (ja) 2018-03-28
BR112015016370A2 (pt) 2017-07-11
JP2016505017A (ja) 2016-02-18
PL2943488T3 (pl) 2018-09-28
US8987459B2 (en) 2015-03-24
EA027688B1 (ru) 2017-08-31

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU