MX371088B - Monohidrato de mesilato de n-[5-(aminosulfonil)-4-metil-1,3-tiazol -2-il]-2-[4-(2-piridinil)fenil]-n-metilacetamida. - Google Patents

Monohidrato de mesilato de n-[5-(aminosulfonil)-4-metil-1,3-tiazol -2-il]-2-[4-(2-piridinil)fenil]-n-metilacetamida.

Info

Publication number
MX371088B
MX371088B MX2015016192A MX2015016192A MX371088B MX 371088 B MX371088 B MX 371088B MX 2015016192 A MX2015016192 A MX 2015016192A MX 2015016192 A MX2015016192 A MX 2015016192A MX 371088 B MX371088 B MX 371088B
Authority
MX
Mexico
Prior art keywords
methyl
aminosulfonyl
thiazol
phenyl
pyridinyl
Prior art date
Application number
MX2015016192A
Other languages
English (en)
Inventor
Schwab Wilfred
Birkmann Alexander
Vögtli Kurt
Haag Dieter
Lender Andreas
Grunenberg Alfons
Rehse Joachim
Keil Birgit
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Publication of MX371088B publication Critical patent/MX371088B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Síntesis mejorada y reducida de N-[5-(aminosulfonil)-4-metil-1,3-t iazol-2-il]-2-[4-(2-piridiriil)fenil]-N-metilacetamida y la sal monohidrato mesilato de la misma usando reactivos derivados de ácido borónico o borolano y evitando compuestos orgánicos de estaño tóxicos. La sal monohidrato de mesilato de N-[5-(aminosulfonil)-4-metil-1, 3-tiazol-2-il]-2-[4-(2-piridinil)f enil]-N-metilacetamida ha demostrado tener una estabilidad a largo plazo y una cinética de liberación mejoradas en composiciones farmacéuticas.
MX2015016192A 2011-09-26 2012-09-26 Monohidrato de mesilato de n-[5-(aminosulfonil)-4-metil-1,3-tiazol -2-il]-2-[4-(2-piridinil)fenil]-n-metilacetamida. MX371088B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11007823A EP2573086A1 (en) 2011-09-26 2011-09-26 N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate
PCT/EP2012/068938 WO2013045479A1 (en) 2011-09-26 2012-09-26 N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate

Publications (1)

Publication Number Publication Date
MX371088B true MX371088B (es) 2020-01-16

Family

ID=46889067

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014003389A MX338736B (es) 2011-09-26 2012-09-26 Monohidrato de mesilato de n-[5- (aminosulfonil) - 4 -metil - 1,3 tiazol - 2 - il] - 2- [4 -(2- piridinil) fenil] -n - metilacetamida.
MX2015016192A MX371088B (es) 2011-09-26 2012-09-26 Monohidrato de mesilato de n-[5-(aminosulfonil)-4-metil-1,3-tiazol -2-il]-2-[4-(2-piridinil)fenil]-n-metilacetamida.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2014003389A MX338736B (es) 2011-09-26 2012-09-26 Monohidrato de mesilato de n-[5- (aminosulfonil) - 4 -metil - 1,3 tiazol - 2 - il] - 2- [4 -(2- piridinil) fenil] -n - metilacetamida.

Country Status (29)

Country Link
US (1) US9340535B2 (es)
EP (3) EP2573086A1 (es)
JP (2) JP6161614B2 (es)
KR (4) KR20180088530A (es)
CN (2) CN103842359B (es)
AR (3) AR088043A1 (es)
AU (2) AU2012314536B2 (es)
BR (1) BR112014003245B1 (es)
CA (1) CA2791142C (es)
CL (1) CL2014000149A1 (es)
DK (2) DK2602258T3 (es)
ES (2) ES2462492T3 (es)
HK (1) HK1220978A1 (es)
HR (1) HRP20140351T1 (es)
IL (2) IL230152A (es)
IN (1) IN2014DN01993A (es)
JO (2) JO3037B1 (es)
MX (2) MX338736B (es)
MY (2) MY185063A (es)
PE (1) PE20141148A1 (es)
PH (1) PH12015502801A1 (es)
PL (2) PL2602258T3 (es)
PT (1) PT2598501E (es)
RU (2) RU2669388C1 (es)
SG (1) SG10201407430TA (es)
TW (2) TWI532739B (es)
UA (2) UA119574C2 (es)
WO (1) WO2013045479A1 (es)
ZA (2) ZA201401773B (es)

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Publication number Priority date Publication date Assignee Title
EP2573085A1 (en) * 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(aminosulfonyl)-4methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl] acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range
EP2573086A1 (en) * 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate
AU2017245679B2 (en) * 2016-04-06 2021-07-01 Innovative Molecules Gmbh Aminothiazole derivatives useful as antiviral agents
TW201825095A (zh) * 2016-11-28 2018-07-16 德商艾庫里斯抗感染治療有限公司 包含n-[5-(胺基磺醯基)-4-甲基-1,3-噻唑-2-基]-n-甲基-2-[4-(2-吡啶基)-苯基]-乙醯胺之局部醫藥調配物
HUE054845T2 (hu) 2016-11-28 2021-10-28 Aicuris Gmbh & Co Kg Az N-[5-(amino-szulfonil)-4-metil-1,3-tiazol-2-il]-N-metil-2-[4-(2-piridinil)fenil]acetamid szabad bázis maleát sója, gyógyászati készítmények, elõállítási eljárások és Herpes vírusok kezelésére történõ alkalmazások
CN109996798B (zh) * 2016-11-28 2023-05-05 艾库里斯有限及两合公司 N-[5-(氨基磺酰基)-4-甲基-1,3-噻唑-2-基]-n-甲基-2-[4-(2-吡啶基)-苯基]-乙酰胺游离碱半水合物、其制造方法和用途
KR102335327B1 (ko) 2017-04-28 2021-12-03 현대자동차 주식회사 수냉식 이지알 쿨러
WO2019002486A1 (en) * 2017-06-28 2019-01-03 Aicuris Anti-Infective Cures Gmbh INTRAVAGINALLY APPLICABLE DEVICES COMPRISING ANTIVIRAL COMPOUNDS
EP4209491A1 (en) 2017-10-05 2023-07-12 Innovative Molecules GmbH Enantiomers of substituted thiazoles as antiviral compounds
CN112384512B (zh) 2018-07-06 2022-03-29 辉诺生物医药科技（杭州）有限公司 噻唑类化合物的晶型及其应用
MA53652A (fr) * 2018-09-19 2021-07-28 Modernatx Inc Lipides peg de haute pureté et leurs utilisations
TW202038947A (zh) 2018-11-28 2020-11-01 德商創新分子有限責任公司 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑
WO2024047508A1 (en) 2022-08-29 2024-03-07 Assembly Biosciences, Inc. Pharmaceutical compositions for herpes virus
WO2024047507A1 (en) 2022-08-29 2024-03-07 Assembly Biosciences, Inc. A novel crystalline form of pritelivir
WO2024047506A1 (en) 2022-08-29 2024-03-07 Assembly Biosciences, Inc. A novel crystalline form of pritelivir

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DE10129717A1 (de) * 2001-06-22 2003-01-02 Bayer Ag Kombinationspräparate zur Herpes-Behandlung
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DE102005014248A1 (de) 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung von N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamid
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UA103918C2 (en) * 2009-03-02 2013-12-10 Айерем Элелси N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators
EP2573085A1 (en) * 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(aminosulfonyl)-4methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl] acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range
EP2573086A1 (en) * 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate

Also Published As

Publication number Publication date
KR101768295B1 (ko) 2017-08-14
PH12015502801B1 (en) 2016-10-03
KR20180088530A (ko) 2018-08-03
ES2462492T3 (es) 2014-05-23
EP2573086A1 (en) 2013-03-27
CL2014000149A1 (es) 2014-09-05
CN103842359B (zh) 2016-05-25
EP2598501A1 (en) 2013-06-05
BR112014003245A2 (pt) 2017-03-01
SG10201407430TA (en) 2014-12-30
KR20190104249A (ko) 2019-09-06
KR20140066704A (ko) 2014-06-02
EP2602258B1 (en) 2014-03-19
AU2015260762B2 (en) 2016-06-09
TW201317234A (zh) 2013-05-01
AR116394A2 (es) 2021-05-05
RU2620604C2 (ru) 2017-05-29
JP2014528948A (ja) 2014-10-30
TWI532739B (zh) 2016-05-11
MX338736B (es) 2016-04-29
BR112014003245B1 (pt) 2021-11-09
RU2669388C1 (ru) 2018-10-11
MX2014003389A (es) 2014-07-09
HRP20140351T1 (hr) 2014-07-04
AR088043A1 (es) 2014-05-07
WO2013045479A1 (en) 2013-04-04
AU2012314536B2 (en) 2016-01-14
UA119574C2 (uk) 2019-07-10
ZA201408734B (en) 2016-08-31
HK1220978A1 (zh) 2017-05-19
EP2598501B1 (en) 2014-03-12
JP2017114859A (ja) 2017-06-29
UA115317C2 (uk) 2017-10-25
PT2598501E (pt) 2014-06-25
CN103842359A (zh) 2014-06-04
AU2015260762A1 (en) 2016-02-04
PH12015502801A1 (en) 2016-10-03
MY185063A (en) 2021-04-30
AR120291A2 (es) 2022-02-09
AU2012314536A1 (en) 2014-02-06
PL2602258T3 (pl) 2014-08-29
JP6353022B2 (ja) 2018-07-04
CA2791142C (en) 2017-08-01
IN2014DN01993A (es) 2015-05-15
RU2014107430A (ru) 2015-11-10
US20140221433A1 (en) 2014-08-07
DK2602258T3 (da) 2014-04-22
ES2466221T8 (es) 2016-09-13
TWI567070B (zh) 2017-01-21
JO3037B1 (ar) 2016-09-05
CN105541829A (zh) 2016-05-04
TW201625603A (zh) 2016-07-16
ZA201401773B (en) 2015-12-23
PL2598501T3 (pl) 2014-08-29
MY190878A (en) 2022-05-13
IL230152A (en) 2015-04-30
DK2598501T3 (da) 2014-04-22
NZ718867A (en) 2016-05-27
IL234405A (en) 2015-04-30
NZ621615A (en) 2016-04-29
JO3734B1 (ar) 2021-01-31
EP2602258A1 (en) 2013-06-12
PE20141148A1 (es) 2014-09-15
EP2602258B8 (en) 2016-09-28
CA2791142A1 (en) 2013-03-26
ES2466221T3 (es) 2014-06-09
JP6161614B2 (ja) 2017-07-12
KR20170055565A (ko) 2017-05-19
US9340535B2 (en) 2016-05-17

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