PE20010131A1 - Agentes inmunopotenciadores - Google Patents

Agentes inmunopotenciadores

Info

Publication number
PE20010131A1
PE20010131A1 PE2000000474A PE0004742000A PE20010131A1 PE 20010131 A1 PE20010131 A1 PE 20010131A1 PE 2000000474 A PE2000000474 A PE 2000000474A PE 0004742000 A PE0004742000 A PE 0004742000A PE 20010131 A1 PE20010131 A1 PE 20010131A1
Authority
PE
Peru
Prior art keywords
alkyl
phenyl
ch2cor8
coar1
fluorophenyl
Prior art date
Application number
PE2000000474A
Other languages
English (en)
Inventor
Lawrence Camillo Creemer
Janice Rhea Herring
Edward Deorsey Mcgruder
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20010131A1 publication Critical patent/PE20010131A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE REFIERE A UNA COMPOSICION QUE COMPRENDE UN DERIVADO DE PIPERIDINA I, DONDE: R1 ES H, ALQUILO C1-C4=O; R2 ES COR8, CH2COR8, CN, CH2OH, OH, OCOR9, OSO2R9; R3, R4, R5 SON H, ALQUILO C1-C4; R6 ES COOCH2Ar3, ENTRE OTROS; R7 ES H, CH2COR8; R8 ES H, ALQUILO C1-C4, OR10, NHR11, OH CUANDO R6 ES COAr1 O COCHR3Ar2; R9 ES ALQUILO C1-C4; R10 ES ALQUILO C2-C8, CH2CH2N(CH3)2, CH3 CUANDO R6 ES COAr1 Y Ar1 ES FENILO; R11 ES ALQUILO C2-C6, ALQUILO C7-C9 CUANDO R6 ES COAr1; Ar1 ES FENILO, 4-FLUOROFENILO, ENTRE OTROS; Ar2 ES FENILO, 2-TIENILO; Ar3 ES FENILO; Ar4 ES 2-TIENILO; Ar5 ES FENILO, 2-HALOFENILO; Ar6 ES FENILO, 4-FLUOROFENILO; CUANDO R7 ES CH2COR8, ENTONCES R2 Y R3 SON H, R4 Y R5 SON H, ALQUILO C1-C4; R6 ES COCHR3Ar4; R8 ES H, ALQUILO C1-C4OR9, NHR10; R9 ES ALQUILO C1-C8; R10 ES ALQUILO C2-C8, ENTRE OTRAS CONDICIONES; O UN COMPUESTO DE FORMULA II, DONDE R12 ES COR18, CH2COR18; R13, R14, 15 Y R16 SON H, ALQUILO C1-C4; R17 ES ALQUILO C1-C4; R18 ES H, ALQUILO C1-C4OR19, NHR20, N(CH3)2; R19 ES ALQUILO C1-C8; R20 ES ALQUILO C2-C8; Ar7 ES FENILO, 4-FLUOROFENILO, 1,3-TIAZOL-2-ILO; X ES I, Cl, Br, O(SO2)R21; R21 ES CH3, CF3, FENILO, p-METILFENILO. UN COMPUESTO PREFERIDO ES ETIL 1-BENZOIL-3-PIPERIDINACARBOXILATO, ENTRE OTROS. TAMBIEN SE REFIERE A COMPUESTO I, II Y UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS SON AGENTES INMUNOSUPRESORES
PE2000000474A 1999-05-21 2000-05-19 Agentes inmunopotenciadores PE20010131A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13533899P 1999-05-21 1999-05-21

Publications (1)

Publication Number Publication Date
PE20010131A1 true PE20010131A1 (es) 2001-02-09

Family

ID=22467653

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000474A PE20010131A1 (es) 1999-05-21 2000-05-19 Agentes inmunopotenciadores

Country Status (5)

Country Link
US (1) US6664271B1 (es)
AU (1) AU4971600A (es)
CO (1) CO5170515A1 (es)
PE (1) PE20010131A1 (es)
WO (1) WO2000071519A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002068391A1 (en) * 2000-11-20 2002-09-06 Eli Lilly And Company Process for resolving racemic mixtures of piperidine derivatives
JP2013522307A (ja) 2010-03-16 2013-06-13 アベンティス・ファーマスーティカルズ・インコーポレイテツド プロスタグランジンｄ２受容体アンタゴニストとしての置換ピリミジン

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2485014A1 (fr) 1980-06-20 1981-12-24 Pharmindustrie Nouveaux derives de (quinolyl-2, -3 ou -4)-1 (piperidyl ou pyrrolidinyl-2 ou -3)-2 ou -3 ethanone ou propanone, procedes pour leur preparation, et leur utilisation comme medicaments
FR2508445A1 (fr) 1981-06-29 1982-12-31 Sori Soc Rech Ind Nouveaux derives de benzoyl-phenyl-piperidine, leur procede de preparation et leur application, notamment en therapeutique
EP0641339B1 (en) * 1991-06-19 1999-09-15 Pfizer Inc. Azaspiro quinolone antibacterial agents
US5242783A (en) * 1991-07-31 1993-09-07 Eastman Kodak Company Photographic material and process
JPH06329627A (ja) 1993-05-03 1994-11-29 Bristol Myers Squibb Co グアニジニル−またはアミジニル−置換ヘテロ環トロンビンインヒビター
US5741800A (en) 1993-06-22 1998-04-21 Knoll Aktiengesellachaft Azolyl-cyclic amine derivates with immunomodulatory activity
US5561146A (en) 1994-06-10 1996-10-01 Bristol-Myers Squibb Company Modified guanidino and amidino thrombin inhibitors
WO1998046569A1 (fr) * 1997-04-11 1998-10-22 Sumitomo Pharmaceuticals Co., Ltd. Derives de benzene
WO2002068391A1 (en) * 2000-11-20 2002-09-06 Eli Lilly And Company Process for resolving racemic mixtures of piperidine derivatives

Also Published As

Publication number Publication date
WO2000071519A2 (en) 2000-11-30
WO2000071519A3 (en) 2001-04-26
AU4971600A (en) 2000-12-12
CO5170515A1 (es) 2002-06-27
US6664271B1 (en) 2003-12-16

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