KR880009910A - 리폭시게네이즈 억제 화합물 - Google Patents

리폭시게네이즈 억제 화합물 Download PDF

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Publication number
KR880009910A
KR880009910A KR1019880001202A KR880001202A KR880009910A KR 880009910 A KR880009910 A KR 880009910A KR 1019880001202 A KR1019880001202 A KR 1019880001202A KR 880001202 A KR880001202 A KR 880001202A KR 880009910 A KR880009910 A KR 880009910A
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South Korea
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hydrogen
compound
trihalomethyl
halogen
alkyl
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KR1019880001202A
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KR950011120B1 (ko
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쥬니어 제임스 비.서머스
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죠셉 엠. 버니크
애보트 래보러토리즈
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Publication of KR880009910A publication Critical patent/KR880009910A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음.

Description

리폭시게네이즈 억제 화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 다음 일반식(Ⅰ)의 화합물.
    상기식에서, R1은 아미노 또는 메틸이고; R2는 C1내지 C2알킬이며; R3는 수소, 할로겐, 및 트리할로메틸중에서 선택된 하나 이상의 치환체이고; R4는 수소, 할로겐, 트리할록메틸, C1내지 C4알콕시, 및 C1내지 C4알킬 중에서 선택된 하나 이상의 치환체이며; M은 수소, 약제학적으로 허용되는 양이온, 아로일, 또는 C1내지 C6알코일이다.
  2. 제1항에 있어서, R2가 메틸인 화합물.
  3. 제1항에 있어서, R3및 R4가 수소인 화합물.
  4. 제2항에 있어서, R1이 -NH2인 화합물.
  5. 제3항에 있어서, R1이 -NH2인 화합물.
  6. 치료학적으로 유효한량의 하기 일반식(Ⅰ)의 화합물을, 5- 및/또는 12-리폭시게네이즈 활성의 억제를 필요로 하는 포유류에 투여함을 특징으로 하여, 상기와 같은 치료를 필요로 하는 포유류에 있어서 5- 및/또는 12-리폭시게네이즈 활성을 억제하는 방법.
    상기식에서, R1은 아미노 또는 메틸이고; R2는 C1내지 C2알킬이며; R3는 수소, 할로겐, 및 트리할로메틸로부터 선택된 하나 이상의 치환체이고; R4는 수소, 할로겐, 트리할로메틸, C1내지 C4알콕시, 및 C1내지 C4알킬로부터 선택된 하나 이상의 치환체이며; M은 수소, 약제학적으로 허용되는 양이온, 아로일, 또는 C1내지 C6알코일이다.
  7. 제6항에 있어서, R2가 메틸인 방법.
  8. 제6항에 있어서, R3및 R4가 수소인 방법.
  9. 제7항에 있어서, R1이 -NH2인 방법.
  10. 제8항에 있어서, R1이 -NH2인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880001202A 1987-02-10 1988-02-09 리폭시게나제 억제 화합물 및 이를 함유하는 약제학적 조성물 KR950011120B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US012978 1987-02-10
US012,978 1987-02-10
US07/012,978 US4897422A (en) 1987-02-10 1987-02-10 Lipoxygenase inhibiting compounds

Publications (2)

Publication Number Publication Date
KR880009910A true KR880009910A (ko) 1988-10-05
KR950011120B1 KR950011120B1 (ko) 1995-09-28

Family

ID=21757673

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880001202A KR950011120B1 (ko) 1987-02-10 1988-02-09 리폭시게나제 억제 화합물 및 이를 함유하는 약제학적 조성물

Country Status (9)

Country Link
US (1) US4897422A (ko)
EP (1) EP0279281B1 (ko)
JP (1) JPS63225340A (ko)
KR (1) KR950011120B1 (ko)
AU (1) AU600336B2 (ko)
CA (1) CA1304391C (ko)
DE (1) DE3873936T2 (ko)
ES (1) ES2044982T3 (ko)
GR (1) GR3006232T3 (ko)

Families Citing this family (28)

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US5157053A (en) * 1985-02-04 1992-10-20 G. D. Searle & Co. Bicycloalky, tricycloalkyl, azabicycloalkyl, and azatricycloalkyl thio amides used to treat inflammation, allergy, asthma and skin disorders
DE3888574T2 (de) * 1987-04-24 1994-06-30 Abbott Lab Harnstoff-Derivate mit lipoxygenasehemmender Wirkung.
US5068251A (en) * 1988-12-16 1991-11-26 Abbott Laboratories Lipoxygenase inhibiting compounds
US5096919A (en) * 1989-01-05 1992-03-17 Ciba-Geigy Corporation Pyrrolylphenyl-substituted hydroxamic acid derivatives
US5175183A (en) * 1989-02-01 1992-12-29 Abbott Laboratories Lipoxygenase inhibiting compounds
DE69004119T2 (de) * 1989-02-03 1994-03-24 Wellcome Found Entzündungshemmende Arylderivate.
US4960787A (en) * 1989-02-06 1990-10-02 Ciba-Geigy Corporation Certain pyrrolyl-substituted hydroxamic acid derivatives
US4981865A (en) * 1989-05-26 1991-01-01 Warner-Lambert Co. N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents
US5075330A (en) * 1989-05-26 1991-12-24 Warner-Lambert Co. N-hydroxyamide, N-hydroxythioamide, N-hydroxyurea, and N-hydroxythiourea derivatives of selected NSAIDS as antiinflammatory agents
US5112846A (en) * 1989-05-26 1992-05-12 Warner-Lambert Company N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents
JP3065636B2 (ja) * 1989-06-29 2000-07-17 塩野義製薬株式会社 ［ジ―ｔｅｒｔ―ブチル（ヒドロキシ）フェニルチオ］置換ヒドロキサム酸誘導体
US5120752A (en) * 1989-12-28 1992-06-09 Abbott Laboratories Cyclopropyl derivative lipoxygenase inhibitors
US5220059A (en) * 1990-04-19 1993-06-15 Abbott Laboratories Lipoxygenase-inhibiting compounds derived from non-steroidal antiinflammatory carboxylic acids
KR900016822A (ko) * 1990-04-20 1990-11-14 하라 레이노스께 슬라이드 프로젝터
GB9012252D0 (en) * 1990-06-01 1990-07-18 Lilly Industries Ltd Pharmaceutical compounds
DE4023742A1 (de) * 1990-07-26 1992-01-30 Gruenenthal Gmbh Substituierte phenylacetylene, diese enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel
US5130485A (en) * 1991-04-23 1992-07-14 Eli Lilly And Company N-hydroxy-N-(3-(2-substituted phenyl)prop-2-enyl)ureas and thioureas useful as 5-lipoxygenase inhibiting agents
US5214204A (en) * 1991-07-19 1993-05-25 Abbott Laboratories Arylamidoalkyl-n-hydroxyurea compounds having lipoxygenase inhibitory activity
US5183818A (en) * 1991-08-27 1993-02-02 Abbott Laboratories Arylalkylether and arylalkylthioether inhibitors of lipoxygenase enzyme activity
US5234933A (en) * 1991-10-31 1993-08-10 Board Of Governors Of Wayne State University And Vanderbilt University Cyclic hydroxamic acids
DE4210332C1 (ko) * 1992-03-30 1993-07-15 Gruenenthal Gmbh, 5100 Aachen, De
DE4308535A1 (de) * 1992-03-30 1993-10-07 Volkswagen Ag Brennkraftmaschine mit einem desaktivierbaren Ladungswechselventil
WO1995002575A1 (en) * 1993-07-14 1995-01-26 Smithkline Beecham Corporation 5-lipoxygenase inhibitors
US5468760A (en) * 1993-11-08 1995-11-21 American Home Products Corporation Aralkyl-N-hydroxyureas as inhibitors of 5-lipoxygenase and oxidation of low density lipoprotein
US5459154A (en) * 1993-11-08 1995-10-17 American Home Products Corporation N-hydroxyureas as 5-lipoxygenase inhibitors and inhibitors of oxidative modification of low density lipoprotein
US5428048A (en) * 1993-11-08 1995-06-27 American Home Products Corporation Aryl-N-hydroxyureas as inhibitors of 5-lipoxygenase and anto-arteriosclerotic agents
US5612377A (en) * 1994-08-04 1997-03-18 Minnesota Mining And Manufacturing Company Method of inhibiting leukotriene biosynthesis
WO2015054662A1 (en) 2013-10-10 2015-04-16 Eastern Virginia Medical School 4-((2-hydroxy-3-methoxybenzyl)amino) benzenesulfonamide derivatives as 12-lipoxygenase inhibitors

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US3855242A (en) * 1967-12-15 1974-12-17 Aspro Nicholas Ltd Benzo{8 b{9 thienyl-alkyl-guanidines
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Also Published As

Publication number Publication date
JPS63225340A (ja) 1988-09-20
GR3006232T3 (ko) 1993-06-21
DE3873936D1 (de) 1992-10-01
AU600336B2 (en) 1990-08-09
ES2044982T3 (es) 1994-01-16
EP0279281A3 (en) 1989-05-03
EP0279281B1 (en) 1992-08-26
CA1304391C (en) 1992-06-30
KR950011120B1 (ko) 1995-09-28
DE3873936T2 (de) 1993-04-15
EP0279281A2 (en) 1988-08-24
US4897422A (en) 1990-01-30
AU1143288A (en) 1988-08-11

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