ATE80611T1 - Aryl-derivate. - Google Patents

Aryl-derivate.

Info

Publication number
ATE80611T1
ATE80611T1 AT86301895T AT86301895T ATE80611T1 AT E80611 T1 ATE80611 T1 AT E80611T1 AT 86301895 T AT86301895 T AT 86301895T AT 86301895 T AT86301895 T AT 86301895T AT E80611 T1 ATE80611 T1 AT E80611T1
Authority
AT
Austria
Prior art keywords
alkyl
hydrogen
optionally substituted
independently selected
groups
Prior art date
Application number
AT86301895T
Other languages
English (en)
Inventor
Geoffrey Kneen
William Paul Jackson
Peter John Islip
Peter John Wates
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858506871A external-priority patent/GB8506871D0/en
Priority claimed from GB858506870A external-priority patent/GB8506870D0/en
Priority claimed from GB858506873A external-priority patent/GB8506873D0/en
Priority claimed from GB858506872A external-priority patent/GB8506872D0/en
Priority claimed from GB858506874A external-priority patent/GB8506874D0/en
Priority claimed from GB858513863A external-priority patent/GB8513863D0/en
Priority claimed from GB858531839A external-priority patent/GB8531839D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Application granted granted Critical
Publication of ATE80611T1 publication Critical patent/ATE80611T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N3/00—Preservation of plants or parts thereof, e.g. inhibiting evaporation, improvement of the appearance of leaves or protection against physical influences such as UV radiation using chemical compositions; Grafting wax
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N3/00—Preservation of plants or parts thereof, e.g. inhibiting evaporation, improvement of the appearance of leaves or protection against physical influences such as UV radiation using chemical compositions; Grafting wax
    • A01N3/02—Keeping cut flowers fresh chemically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C07D213/643—2-Phenoxypyridines; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Pain & Pain Management (AREA)
  • Dentistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT86301895T 1985-03-16 1986-03-14 Aryl-derivate. ATE80611T1 (de)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB858506871A GB8506871D0 (en) 1985-03-16 1985-03-16 Aryl derivatives
GB858506870A GB8506870D0 (en) 1985-03-16 1985-03-16 Aryl derivatives
GB858506873A GB8506873D0 (en) 1985-03-16 1985-03-16 Aryl derivatives
GB858506872A GB8506872D0 (en) 1985-03-16 1985-03-16 Aryl derivatives
GB858506874A GB8506874D0 (en) 1985-03-16 1985-03-16 Aryl derivatives
GB858513863A GB8513863D0 (en) 1985-06-01 1985-06-01 Aryl derivatives
GB858531839A GB8531839D0 (en) 1985-12-30 1985-12-30 Aryl derivatives
EP86301895A EP0196184B1 (de) 1985-03-16 1986-03-14 Aryl-Derivate

Publications (1)

Publication Number Publication Date
ATE80611T1 true ATE80611T1 (de) 1992-10-15

Family

ID=27562725

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86301895T ATE80611T1 (de) 1985-03-16 1986-03-14 Aryl-derivate.

Country Status (14)

Country Link
EP (1) EP0196184B1 (de)
JP (1) JP2559699B2 (de)
AT (1) ATE80611T1 (de)
AU (1) AU602485B2 (de)
DE (1) DE3686733T2 (de)
DK (1) DK117986A (de)
FI (1) FI89709C (de)
HU (1) HU201300B (de)
IL (1) IL78157A (de)
MY (1) MY102236A (de)
NO (1) NO165341C (de)
NZ (1) NZ215487A (de)
PH (1) PH25218A (de)
PT (1) PT82200B (de)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8531839D0 (en) * 1985-12-30 1986-02-05 Wellcome Found Aryl derivatives
US4604407A (en) * 1985-04-04 1986-08-05 E. R. Squibb & Sons, Inc. Hydroxamates
US4608390A (en) * 1985-04-26 1986-08-26 Abbott Laboratories Lipoxygenase inhibiting compounds
GB2178031B (en) * 1985-06-10 1989-07-26 Procter & Gamble Phenylacetic acid amides having anti-inflammatory and analgesic activity
LU86258A1 (fr) * 1986-01-21 1987-09-03 Rech Dermatologiques C I R D S Composes benzamido aromatique,leur procede de preparation et leur utilisation en medecine humaine ou veterinaire et en cosmetique
US5185363A (en) * 1986-04-25 1993-02-09 Abbott Laboratories Urea based lipoxygenase inhibiting compounds
GB8619593D0 (en) * 1986-08-12 1986-09-24 Roussel Lab Ltd Chemical compounds
US4861798A (en) * 1986-12-29 1989-08-29 Bristol-Myers Company Lipoxygenase inhibitory compounds
US4873259A (en) * 1987-06-10 1989-10-10 Abbott Laboratories Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
US4897422A (en) * 1987-02-10 1990-01-30 Abbott Laboratories Lipoxygenase inhibiting compounds
US4820828A (en) * 1987-03-04 1989-04-11 Ortho Pharmaceutical Corporation Cinnamohydroxamic acids
US5227405A (en) * 1987-03-31 1993-07-13 Duke University Superoxide dismutase mimic
US5223538A (en) * 1987-03-31 1993-06-29 Duke University Superoxide dismutase mimic
ES2053609T3 (es) * 1987-04-24 1994-08-01 Abbott Lab Derivados de urea inhibidores de lipoxigenasa.
PL154186B1 (en) * 1987-07-15 1991-07-31 Wellcome Found Method for manufacturing arylic derivatives of the hydroxamic acid
US5155110A (en) * 1987-10-27 1992-10-13 Warner-Lambert Company Fenamic acid hydroxamate derivatives having cyclooxygenase and 5-lipoxygenase inhibition
US4822809A (en) * 1987-11-13 1989-04-18 Abbott Laboratories Benzazole lipoxygenase inhibiting compounds
CA1334975C (en) * 1987-11-13 1995-03-28 James H. Holms Furan and pyrrole containing lipoxygenase inhibiting compounds
GB2212153B (en) * 1987-11-16 1992-01-15 Squibb & Sons Inc Phenyl hydroxamic acids
US5112868A (en) * 1988-05-19 1992-05-12 Warner-Lambert Company Hydroxamate derivatives of selected nonsteroidal antiinflammatory acyl residues having cyclooxygenase and 5-lipoxygenase inhibition
US4943587A (en) * 1988-05-19 1990-07-24 Warner-Lambert Company Hydroxamate derivatives of selected nonsteroidal antiinflammatory acyl residues and their use for cyclooxygenase and 5-lipoxygenase inhibition
EP0351214A1 (de) * 1988-07-14 1990-01-17 The Wellcome Foundation Limited Entzündungshemmende Arylderivate
GB8820185D0 (en) * 1988-08-25 1988-09-28 Wellcome Found New medical use
AU4717889A (en) * 1988-12-29 1990-07-05 Ciba-Geigy Ag Amino-substituted hydroxamic acids
GB8830427D0 (en) * 1988-12-30 1989-03-01 Fujisawa Pharmaceutical Co New hydroxylamine derivatives,a process for the preparation thereof and pharmaceutical composition comprising the same
IL92915A0 (en) * 1989-01-05 1990-09-17 Ciba Geigy Ag Certain pyrrolylphenyl-substituted hydroxamic acid derivatives
US5096919A (en) * 1989-01-05 1992-03-17 Ciba-Geigy Corporation Pyrrolylphenyl-substituted hydroxamic acid derivatives
HU208523B (en) * 1989-02-03 1993-11-29 Wellcome Found Process for producing antiphlogistic aryl-compounds and pharmaceutical compositions containing them
US4960787A (en) * 1989-02-06 1990-10-02 Ciba-Geigy Corporation Certain pyrrolyl-substituted hydroxamic acid derivatives
US4981865A (en) * 1989-05-26 1991-01-01 Warner-Lambert Co. N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents
US5112846A (en) * 1989-05-26 1992-05-12 Warner-Lambert Company N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents
US5075330A (en) * 1989-05-26 1991-12-24 Warner-Lambert Co. N-hydroxyamide, N-hydroxythioamide, N-hydroxyurea, and N-hydroxythiourea derivatives of selected NSAIDS as antiinflammatory agents
JP3065636B2 (ja) * 1989-06-29 2000-07-17 塩野義製薬株式会社 ［ジ―ｔｅｒｔ―ブチル（ヒドロキシ）フェニルチオ］置換ヒドロキサム酸誘導体
US5028629A (en) * 1990-03-28 1991-07-02 Eli Lilly And Company 5-Lipoxygenase inhibitors
US5017604A (en) * 1990-04-11 1991-05-21 Warner-Lambert Company Novel fenamic acid methyl hydroxamate derivatives having cyclooxygenase and 5-lipoxygenase inhibition
KR900016822A (ko) * 1990-04-20 1990-11-14 하라 레이노스께 슬라이드 프로젝터
GB9009395D0 (en) * 1990-04-26 1990-06-20 Orion Yhtymae Oy Cyclic hydroxamic acids and their use
US5476873A (en) * 1990-07-25 1995-12-19 Abbott Laboratories Acetylene derivatives having lipoxygenase inhibitory activity
DE4023742A1 (de) * 1990-07-26 1992-01-30 Gruenenthal Gmbh Substituierte phenylacetylene, diese enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel
US5087634A (en) * 1990-10-31 1992-02-11 G. D. Searle & Co. N-substituted imidazol-2-one compounds for treatment of circulatory disorders
DE4035961A1 (de) * 1990-11-02 1992-05-07 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
JP3007138B2 (ja) 1990-11-27 2000-02-07 ファイザー製薬株式会社 新規なヒドロキサム酸とｎ―ヒドロキシ尿素誘導体およびそれらの組成物
JP2528741B2 (ja) * 1991-01-09 1996-08-28 ファイザー製薬株式会社 オキサゾ―ル、チアゾ―ルおよびイミダゾ―ル化合物
US5283361A (en) * 1991-04-23 1994-02-01 Eli Lilly And Company N-hydroxy-N-[3-[2-(halophenylthio)phenyl]prop-2-enyl]ureas as lipoxygenase inhibitors
US5130485A (en) * 1991-04-23 1992-07-14 Eli Lilly And Company N-hydroxy-N-(3-(2-substituted phenyl)prop-2-enyl)ureas and thioureas useful as 5-lipoxygenase inhibiting agents
US5140047A (en) * 1991-05-03 1992-08-18 Smithkline Beecham Corporation Lipoxygenase inhibitors
JPH07100687B2 (ja) * 1991-06-13 1995-11-01 ファイザー製薬株式会社 新規なｎ−ヒドロキシ尿素化合物および組成物
JPH0717612B2 (ja) * 1991-06-28 1995-03-01 ファイザー製薬株式会社 新規なテトラヒドロベンズアゼピン誘導体
DE4123613C1 (de) * 1991-07-17 1993-02-04 Gruenenthal Gmbh, 5100 Aachen, De
US5334600A (en) * 1991-07-30 1994-08-02 Ciba-Geigy Corporation Isoquinolyl substituted hydroxylamine derivatives
US5260316A (en) * 1991-07-30 1993-11-09 Ciba-Geigy Corporation Isoquinolyl substituted hydroxylamine derivatives
US5350761A (en) * 1991-07-30 1994-09-27 Ciba-Geigy Corporation Indolyl substituted hydroxylamine derivatives
ES2111059T3 (es) * 1991-07-30 1998-03-01 Ciba Geigy Ag Derivados de hidroxilamina substituidos con heteroarilo como inhibidores de lipoxigenasa.
US5234933A (en) * 1991-10-31 1993-08-10 Board Of Governors Of Wayne State University And Vanderbilt University Cyclic hydroxamic acids
DE4204686A1 (de) * 1992-02-17 1993-08-19 Gruenenthal Gmbh Imidazolylphenolderivate, diese enthaltende arzneimittel sowie ein verfahren zur herstellung dieser verbindungen und arzneimitteln
US5169854A (en) * 1992-02-26 1992-12-08 Abbott Laboratories N-substituted-furylalkenyl hydroxamic acid and N-hydroxyurea compounds having lipoxygenase inhibitory activity
DE4213919A1 (de) * 1992-04-28 1993-11-04 Thomae Gmbh Dr K Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4213931A1 (de) * 1992-04-28 1993-11-04 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
GB9215921D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Anti-inflammatory compounds
GB9308652D0 (en) * 1993-04-27 1993-06-09 Wellcome Found Anti-inflammatory compounds
WO1994025431A1 (en) * 1993-04-27 1994-11-10 The Wellcome Foundation Limited Cyclooxygenase and 5-lipoxygenase inhibiting n(3-biphenylyl-1(s)-methyl-2-propenyl) acetohydroxamic acid derivatives
WO1995013264A1 (fr) * 1993-11-08 1995-05-18 Terumo Kabushiki Kaisha Derive d'acide hydroxamique et preparation medicamenteuse contenant ledit derive
US5612377A (en) * 1994-08-04 1997-03-18 Minnesota Mining And Manufacturing Company Method of inhibiting leukotriene biosynthesis
US5527827A (en) * 1994-10-27 1996-06-18 Merck Frosst Canada, Inc. Bisarylcarbinol cinnamic acids as inhibitors of leukotriene biosynthesis
JP3662941B2 (ja) * 1997-07-31 2005-06-22 アボツト・ラボラトリーズ マトリックスメタロプロテイナーゼのリバースヒドロキサメート阻害剤
US6235786B1 (en) 1997-08-06 2001-05-22 Abbott Laboratories Reverse hydroxamate inhibitors of matrix metalloproteinases
US6294573B1 (en) 1997-08-06 2001-09-25 Abbott Laboratories Reverse hydroxamate inhibitors of matrix metalloproteinases
US6288261B1 (en) 1998-12-18 2001-09-11 Abbott Laboratories Inhibitors of matrix metalloproteinases
WO2000044712A1 (en) * 1999-01-27 2000-08-03 Abbott Laboratories N-hydroxyformamide derivatives as inhibitors of matrix metalloproteinases
AR029916A1 (es) 2000-05-05 2003-07-23 Smithkline Beecham Corp N-formil-n-hidroxi-ariloxi alquilaminas y metodos para tratar infecciones bacterianas
AR028075A1 (es) * 2000-05-05 2003-04-23 Smithkline Beecham Corp Inhibidores de la peptido-desformilasa
DE10130397A1 (de) 2001-06-23 2003-01-09 Bayer Cropscience Gmbh Herbizide substituierte Pyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbzide und Pflanzenwachstumsregulatoren
GB0810011D0 (en) * 2008-06-02 2008-07-09 Jackson William P 5-Lipoxygenase inhibitors
JP6372843B2 (ja) * 2013-11-06 2018-08-15 国立大学法人名古屋大学 亜鉛に配位する置換基を有する化合物を用いた植物成長調整剤

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3219428A (en) * 1961-04-17 1965-11-23 Hooker Chemical Corp O,n-diacylated-3,4-dihalophenylhydroxylamines as herbicides
DE1542822A1 (de) * 1966-03-10 1970-03-26 Basf Ag Selektive Herbizide
US3853905A (en) * 1968-08-15 1974-12-10 Lilly Co Eli Certain 5-(phenoxyphenalkyl) tetrazoles
FR2233039B1 (de) * 1973-06-14 1976-07-02 Roussel Uclaf
FR2242077B1 (de) * 1973-09-03 1977-01-28 Roussel Uclaf
CH650493A5 (en) * 1977-12-24 1985-07-31 Hoechst Ag D-(+)-alpha-phenoxypropionic acid derivatives
DE3045805A1 (de) * 1980-12-05 1982-07-08 Basf Ag, 6700 Ludwigshafen Diphenylether, verfahren zu ihrer herstellung und ihre verwendung als herbizide
DE3220526A1 (de) * 1982-06-01 1983-12-01 Bayer Ag, 5090 Leverkusen Trifluormethylphenoxy-phenyl-derivate, verfahren zu ihrer herstellung und ihre verwendung als herbizide
DD242802A1 (de) * 1983-02-28 1987-02-11 Univ Berlin Humboldt Verfahren zur herstellung neuer w(2'-naphthoxy)-hydroxamsaeuren enthaltende pharmazeutische zubereitungen und ihren salzen
US4607053A (en) * 1984-05-17 1986-08-19 E. R. Squibb & Sons, Inc. Arylhydroxamates useful as antiallergy agents

Also Published As

Publication number Publication date
FI861070A (fi) 1986-09-17
NZ215487A (en) 1990-01-29
IL78157A (en) 1989-08-15
DE3686733T2 (de) 1993-02-11
AU5475986A (en) 1986-10-16
EP0196184B1 (de) 1992-09-16
PH25218A (en) 1991-03-27
NO165341C (no) 1991-01-30
JPS61257951A (ja) 1986-11-15
MY102236A (en) 1992-05-15
DE3686733D1 (de) 1992-10-22
NO165341B (no) 1990-10-22
DK117986D0 (da) 1986-03-14
DK117986A (da) 1986-09-17
FI861070A0 (fi) 1986-03-14
NO860973L (no) 1986-09-17
JP2559699B2 (ja) 1996-12-04
EP0196184A3 (en) 1988-04-20
EP0196184A2 (de) 1986-10-01
PT82200B (pt) 1990-02-08
FI89709C (fi) 1993-11-10
IL78157A0 (en) 1986-07-31
AU602485B2 (en) 1990-10-18
FI89709B (fi) 1993-07-30
HU201300B (en) 1990-10-28
HUT40612A (en) 1987-01-28
PT82200A (en) 1986-04-01

Similar Documents

Publication Publication Date Title
DE3686733T2 (de) Aryl-derivate.
ATE141263T1 (de) Pharmazeutisch wirksame zns-verbindung
TW231258B (de)
FI930277A (fi) Omaettade 17b-substituerade 3-karboxisteroider
DK0382660T3 (da) Dioxaphosphorinanforbindelser og dermed stabiliserede polyolefinmaterialer
ES484616A1 (es) Un procedimiento para preparar nuevos derivados de pirrolil-piridazin-amina
DK117387D0 (da) Faste polymere stabilisatorforbindelser og fremgangsmaade til deres fremstilling
NZ214969A (en) Imidazole-5-carboximidates and fungicidal compositions
DE3472104D1 (en) N-substituted ûbis(hydroxymethyl)-methyl¨-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them
ES8702380A1 (es) Procedimiento para preparar un derivado de (imina ciclica)- difenil-eter
PL248779A1 (en) Method of obtaining novel amidino-derivatives of 2-substituted 4-phenylimidazolone
EP0253502A3 (de) Tertiär-Amin-Verbindungen
ES2076212T3 (es) Derivado de maleimida, procedimiento para la preparacion del mismo, y fungicida agricola y horticola que contiene dicho derivado de maleimida como un ingrediente activo.
ES8802413A1 (es) Procedimiento para preparar una composicion herbicida a base de carbamoiloxi-fenilcarbamato y aceite mineral de petroleo
HUT45988A (en) Process for production of derivatives of 1,4-dihydropiridine and medical preparatives containing such compositions as active substance
ATE98635T1 (de) Sterisch gehinderte aminoverbindungen und verfahren zu deren herstellung.
TH2282EX (th) สารเฟนนิลซัลโฟนิล กวานิดีน ที่มีกลุ่มแทนที่ชนิดใหม่สำหรับปราบวัชพืชและสารรายทาง
ES480872A1 (es) Procedimiento para la preparacion de composiciones de 1,2,3 triazolidin-3-onas y tionas como agentes fungicidas.
ES540288A0 (es) Un procedimiento de preparar un derivado de n-acil-amino- acido
TH2282A (th) สารเฟนนิลซัลโฟนิล กวานิดีน ที่มีกลุ่มแทนที่ชนิดใหม่สำหรับปราบวัชพืชและสารรายทาง

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee