ATE162525T1 - Heteroaryl substituierte hydroxylaminderivate als lipoxygenase-inhibitoren - Google Patents
Heteroaryl substituierte hydroxylaminderivate als lipoxygenase-inhibitorenInfo
- Publication number
- ATE162525T1 ATE162525T1 AT92810559T AT92810559T ATE162525T1 AT E162525 T1 ATE162525 T1 AT E162525T1 AT 92810559 T AT92810559 T AT 92810559T AT 92810559 T AT92810559 T AT 92810559T AT E162525 T1 ATE162525 T1 AT E162525T1
- Authority
- AT
- Austria
- Prior art keywords
- aryl
- lower alkyl
- cycloalkyl
- carbocyclic
- heterocyclic
- Prior art date
Links
- 239000000867 Lipoxygenase Inhibitor Substances 0.000 title abstract 2
- 150000002443 hydroxylamines Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 15
- 125000002837 carbocyclic group Chemical group 0.000 abstract 7
- 125000003282 alkyl amino group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 239000011593 sulfur Substances 0.000 abstract 2
- -1 C3-C7-cycloalkyl Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000006323 alkenyl amino group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000005089 alkenylaminocarbonyl group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000006319 alkynyl amino group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000005095 alkynylaminocarbonyl group Chemical group 0.000 abstract 1
- 125000005841 biaryl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Saccharide Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73807591A | 1991-07-30 | 1991-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE162525T1 true ATE162525T1 (de) | 1998-02-15 |
Family
ID=24966464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92810559T ATE162525T1 (de) | 1991-07-30 | 1992-07-21 | Heteroaryl substituierte hydroxylaminderivate als lipoxygenase-inhibitoren |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0526402B1 (de) |
| JP (1) | JPH0641104A (de) |
| KR (1) | KR930002329A (de) |
| AT (1) | ATE162525T1 (de) |
| AU (1) | AU662339B2 (de) |
| CA (1) | CA2074797A1 (de) |
| CZ (1) | CZ235192A3 (de) |
| DE (1) | DE69224115T2 (de) |
| DK (1) | DK0526402T3 (de) |
| ES (1) | ES2111059T3 (de) |
| FI (1) | FI923393A7 (de) |
| GR (1) | GR3026254T3 (de) |
| HU (1) | HUT66626A (de) |
| IE (1) | IE922471A1 (de) |
| IL (1) | IL102612A (de) |
| MX (1) | MX9204418A (de) |
| NO (1) | NO178925C (de) |
| NZ (1) | NZ243752A (de) |
| PH (1) | PH30092A (de) |
| TW (1) | TW281672B (de) |
| ZA (1) | ZA925688B (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
| US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
| US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US5516789A (en) * | 1995-04-12 | 1996-05-14 | Abbott Laboratories | Lipoxygenase and cyclooxygenase inhibiting compounds |
| BE1010487A6 (nl) | 1996-06-11 | 1998-10-06 | Unilin Beheer Bv | Vloerbekleding bestaande uit harde vloerpanelen en werkwijze voor het vervaardigen van dergelijke vloerpanelen. |
| AU2157400A (en) | 1998-12-23 | 2000-07-31 | G.D. Searle & Co. | Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications |
| PT1140190E (pt) | 1998-12-23 | 2003-02-28 | Searle Llc | Combinacoes de inibidores do transporte ileal dos acidos biliares e agentes sequestrantes dos acidos biliares usadas para problemas cardiovasculares |
| EP1342475A1 (de) | 1998-12-23 | 2003-09-10 | G.D. Searle LLC. | Kombinationen von Ileumgallensäuretransportinhibitoren und Cholesterylestertransferproteininhibitoren für kardiovaskuläre Indikationen |
| DK1140185T3 (da) | 1998-12-23 | 2003-09-29 | Searle Llc | Kombinationer af cholesterylestertransferhæmmere og galdesyre kompleksdannende forbindelser til hjertekar indikationer |
| MXPA01006472A (es) | 1998-12-23 | 2004-03-10 | Searle Llc | Combinaciones de inhibidores de transporte de acido biliar ileal y derivados de acido fibrico para indicaciones cardiovasculares. |
| EP1140186B1 (de) | 1998-12-23 | 2003-06-04 | G.D. Searle LLC. | Kombinationen von cholesteryl ester transfer protein inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationen |
| DK1140184T3 (da) | 1998-12-23 | 2003-09-29 | Searle Llc | Kombinationer af cholesterylestertransferproteinhæmmere og nikotinsyrederivater til hjertekar indikationer |
| EP1286984A2 (de) | 2000-03-10 | 2003-03-05 | Pharmacia Corporation | Verfahren zur herstellung von tetrahydrobenzothiepinen |
| DE10103506A1 (de) * | 2001-01-26 | 2002-08-14 | Ingo S Neu | Pharmazeutische Zusammensetzung zur Behandlung von Multiple Sklerose |
| US6740663B2 (en) | 2001-11-02 | 2004-05-25 | G.D. Searle, Llc | Mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake |
| AU2003207431A1 (en) | 2002-01-17 | 2003-09-02 | Pharmacia Corporation | Novel alkyl/aryl hydroxy or keto thiepines. |
| DE10229762A1 (de) * | 2002-07-03 | 2004-01-22 | Aventis Pharma Deutschland Gmbh | Pyrazoloisoquinolinenderivaten zur Inhibierung von NFkappaB-induzierende Kinase |
| EP1572660B1 (de) | 2002-12-20 | 2011-01-26 | X-Ceptor Therapeutics, Inc. | Isochinolinonderivate und deren verwendung als medikamente |
| EP3509588B1 (de) | 2016-09-12 | 2023-06-07 | Integral Health,Inc. | Bicyclische verbindungen verwendbar als gpr120-modulatoren |
| KR102537985B1 (ko) | 2016-09-12 | 2023-05-30 | 인테그랄 헬스 인코퍼레이티드 | Gpr120 조정제로서 유용한 단환형 화합물 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ215487A (en) * | 1985-03-16 | 1990-01-29 | Wellcome Found | Aryl derivatives, pharmaceutical compositions thereof and preservation of cut flowers |
| US4761403A (en) * | 1986-04-09 | 1988-08-02 | Abbott Laboratories | Lipoxygenase inhibiting compounds |
| EP0279263B1 (de) * | 1987-02-10 | 1993-08-04 | Abbott Laboratories | Indol, Benzofuran, Benzothiophen enthaltende, Lipoxygenase hemmende Verbindungen |
| US4981865A (en) * | 1989-05-26 | 1991-01-01 | Warner-Lambert Co. | N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents |
-
1992
- 1992-07-21 ES ES92810559T patent/ES2111059T3/es not_active Expired - Lifetime
- 1992-07-21 DE DE69224115T patent/DE69224115T2/de not_active Expired - Fee Related
- 1992-07-21 EP EP92810559A patent/EP0526402B1/de not_active Expired - Lifetime
- 1992-07-21 AT AT92810559T patent/ATE162525T1/de not_active IP Right Cessation
- 1992-07-21 DK DK92810559T patent/DK0526402T3/da active
- 1992-07-22 AU AU20482/92A patent/AU662339B2/en not_active Ceased
- 1992-07-23 IL IL10261292A patent/IL102612A/en not_active IP Right Cessation
- 1992-07-24 PH PH44703A patent/PH30092A/en unknown
- 1992-07-24 TW TW081105850A patent/TW281672B/zh active
- 1992-07-27 FI FI923393A patent/FI923393A7/fi not_active Application Discontinuation
- 1992-07-27 CZ CS922351A patent/CZ235192A3/cs unknown
- 1992-07-28 JP JP4201496A patent/JPH0641104A/ja active Pending
- 1992-07-28 CA CA002074797A patent/CA2074797A1/en not_active Abandoned
- 1992-07-28 NZ NZ243752A patent/NZ243752A/en unknown
- 1992-07-29 ZA ZA925688A patent/ZA925688B/xx unknown
- 1992-07-29 MX MX9204418A patent/MX9204418A/es unknown
- 1992-07-29 IE IE247192A patent/IE922471A1/en not_active Application Discontinuation
- 1992-07-29 KR KR1019920013541A patent/KR930002329A/ko not_active Abandoned
- 1992-07-29 NO NO922987A patent/NO178925C/no unknown
- 1992-07-29 HU HU9202479A patent/HUT66626A/hu unknown
-
1998
- 1998-02-27 GR GR980400432T patent/GR3026254T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUT66626A (en) | 1994-12-28 |
| EP0526402B1 (de) | 1998-01-21 |
| FI923393A7 (fi) | 1993-01-31 |
| MX9204418A (es) | 1993-02-01 |
| ZA925688B (en) | 1993-03-31 |
| IL102612A (en) | 1996-11-14 |
| AU662339B2 (en) | 1995-08-31 |
| HU9202479D0 (en) | 1992-10-28 |
| GR3026254T3 (en) | 1998-05-29 |
| IL102612A0 (en) | 1993-01-14 |
| JPH0641104A (ja) | 1994-02-15 |
| CA2074797A1 (en) | 1993-01-31 |
| DE69224115T2 (de) | 1998-08-20 |
| NO922987L (no) | 1993-02-01 |
| NO178925C (no) | 1996-07-03 |
| FI923393A0 (fi) | 1992-07-27 |
| DK0526402T3 (da) | 1998-09-14 |
| ES2111059T3 (es) | 1998-03-01 |
| EP0526402A1 (de) | 1993-02-03 |
| NO178925B (no) | 1996-03-25 |
| KR930002329A (ko) | 1993-02-23 |
| IE922471A1 (en) | 1993-02-10 |
| AU2048292A (en) | 1993-02-04 |
| NO922987D0 (no) | 1992-07-29 |
| NZ243752A (en) | 1994-09-27 |
| TW281672B (de) | 1996-07-21 |
| CZ235192A3 (en) | 1993-10-13 |
| DE69224115D1 (de) | 1998-02-26 |
| PH30092A (en) | 1996-12-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69224115D1 (de) | Heteroaryl substituierte Hydroxylaminderivate als Lipoxygenase-Inhibitoren | |
| ATE368655T1 (de) | Stickstoffhaltige heterocyclische verbindung und arzneimittel davon | |
| DK1022272T3 (da) | Substituerede, fusionerede, heterocykliske forbindelser | |
| WO2003016291A1 (en) | ACTIVATOR FOR PEROXISOME PROLIFERATOR-RESPONSIVE RECEPTOR δ | |
| IL147651A0 (en) | Isoxazoline derivative and herbicide containing the same as the active ingredient | |
| NO993706D0 (no) | Pyrrolidinderivater med fosfolipase A2 inhiberende aktivitet | |
| DE60223904D1 (de) | Benzylaminanalogen | |
| EP1422219A4 (de) | Cyclische aminverbindung | |
| DK1325923T3 (da) | Cephem-forbindelser og ESBL-detekterende reagenser indeholdende disse | |
| DK1205476T3 (da) | Fremgangsmåde til syntese af N-(mercaptoacyl)-aminosyrederivater ud fra alfa-substituerede acrylsyrer | |
| ATE119891T1 (de) | Benzothiazol-derivate als fungizide. | |
| HK1042288A1 (zh) | 6-[[(芳基和雜芳基)氧]甲基]-萘基-2-甲亞胺酸酰胺衍生物，其製備方法及其在治療方面的應用 | |
| ATE251632T1 (de) | Phosphonsäure-diester-derivate | |
| DE60113808D1 (de) | Therapeutikum oder Prophylaktikum für Lebererkrankungen, enthaltend ein Diaminotrifluorethylpyridin-Derivat | |
| NZ337142A (en) | Hydroxamic acid compounds | |
| DE69017627D1 (de) | Isochinolinderivate und ihre Salze als Proteasehemmer. | |
| DK1078916T3 (da) | Fremgangsmåde til fremstilling af N-acylaminosyreestere og N-acylaminoacetaler |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |