ES2111059T3 - Derivados de hidroxilamina substituidos con heteroarilo como inhibidores de lipoxigenasa. - Google Patents

Derivados de hidroxilamina substituidos con heteroarilo como inhibidores de lipoxigenasa.

Info

Publication number
ES2111059T3
ES2111059T3 ES92810559T ES92810559T ES2111059T3 ES 2111059 T3 ES2111059 T3 ES 2111059T3 ES 92810559 T ES92810559 T ES 92810559T ES 92810559 T ES92810559 T ES 92810559T ES 2111059 T3 ES2111059 T3 ES 2111059T3
Authority
ES
Spain
Prior art keywords
aryl
lower alkyl
cycloalkyl
carbocyclic
heterocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92810559T
Other languages
English (en)
Inventor
Duzer John H Van
Dennis M Roland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG, Novartis AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of ES2111059T3 publication Critical patent/ES2111059T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

SE DESCRIBE EL COMPUESTO DE FORMULA DONDE R REPRESENTA HIDROGENO, ALQUIL INFERIOR, ARIL, BIARIL, C3-C7CICLOALQUIL, ARIL-ALQUENIL INFERIOR, ARIL-ALQUINIL INFERIOR, ARILTIO-ALQUIL INFERIOR, C3-C7-CICLOALQUIL-ALQUIL INFERIOR, BIARIL-ALQUIL INFERIOR, ARIL-C3-C7-CICLOALQUIL, ARIL-C3-C7CICLOALQUIL-ALQUIL INFERIOR O ARILOXI-ARIL-ALQUIL INFERIOR, Y ARIL REPRESENTA ARIL CARBOCLICICO O HETEROCICLICO, Z REPRESENTA C1-C3-ALQUILENO O VINILENO, CADA UNO SUBSTITUIDO O NO POR ALQUIL INFERIOR; Y REPRESENTA SO2 (SULFONIL) O CO (CARBONIL); A REPRESENTA O (OXIGENO), S (AZUFRE) O UN ENLACE DIRECTO; B REPRESENTA ALQUILENO INFERIOR; O B REPRESENTA ALQUILENO INFERIOR SUPUESTO QUE A REPRESENTA UN ENLACE DIRECTO; X REPRESENTA OXIGENO O AZUFRE; R1 REPRESENTA HIDROGENO, ACIL, ALCOXICARBONIL INFERIOR, AMINOCARBONIL, ALQUILAMINOCARBONIL MONO ERIOR, ALQUINILAMINOCARBONIL INFERIOR, ARIL CARBOCICLICO O HETEROCICLICO-ALQUILAMINOCARBONIL INFERIOR, ARILAMINOCARBONIL CARBOCICLICO O HETEROCICLICO, C3-C7CICLOALQUILAMINOCARBONILO C3-C7-CICLOALQUIL QUI INFERIOR, ALCOXICARBONIL INFERIOR-ALQUIL INFERIOR, C3-C7-CICLOALQUIL, ARIL CARBOCICLICO O HETEROCICLICO, AMINO, ALQUILAMINO MONO INFERIOR, ARIL CARBOCICLICO O HETEROCICLICOALQUILAMINO INFERIOR, ARILAMINO CARBOCICLICO O HETEROCICLICO, C3C7-CICLOALQUILAMINO, C3-C7-CICLOALQUIL-ALQUILAMINO INFERIOR O ALCOXICARBONIL INFERIOR-ALQUILAMINO INFERIOR; R3 Y R4 INDEPENDIENTEMENTE REPRESENTAN HIDROGENO O ALQUIL INFERIOR; RA REPRESENTA HIDROGENO, ALQUIL INFERIOR, HALO, TRIFLUOROMETIL O ALCOXI INFERIOR; Y SUS SALES FARMACEUTICAMENTE ACEPTABLES; QUE SON UTILIES COMO INHIBIDORES DE LIPOXIGENASA.
ES92810559T 1991-07-30 1992-07-21 Derivados de hidroxilamina substituidos con heteroarilo como inhibidores de lipoxigenasa. Expired - Lifetime ES2111059T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73807591A 1991-07-30 1991-07-30

Publications (1)

Publication Number Publication Date
ES2111059T3 true ES2111059T3 (es) 1998-03-01

Family

ID=24966464

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92810559T Expired - Lifetime ES2111059T3 (es) 1991-07-30 1992-07-21 Derivados de hidroxilamina substituidos con heteroarilo como inhibidores de lipoxigenasa.

Country Status (21)

Country Link
EP (1) EP0526402B1 (es)
JP (1) JPH0641104A (es)
KR (1) KR930002329A (es)
AT (1) ATE162525T1 (es)
AU (1) AU662339B2 (es)
CA (1) CA2074797A1 (es)
CZ (1) CZ235192A3 (es)
DE (1) DE69224115T2 (es)
DK (1) DK0526402T3 (es)
ES (1) ES2111059T3 (es)
FI (1) FI923393A (es)
GR (1) GR3026254T3 (es)
HU (1) HUT66626A (es)
IE (1) IE922471A1 (es)
IL (1) IL102612A (es)
MX (1) MX9204418A (es)
NO (1) NO178925C (es)
NZ (1) NZ243752A (es)
PH (1) PH30092A (es)
TW (1) TW281672B (es)
ZA (1) ZA925688B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US5516789A (en) * 1995-04-12 1996-05-14 Abbott Laboratories Lipoxygenase and cyclooxygenase inhibiting compounds
BE1010487A6 (nl) 1996-06-11 1998-10-06 Unilin Beheer Bv Vloerbekleding bestaande uit harde vloerpanelen en werkwijze voor het vervaardigen van dergelijke vloerpanelen.
EP1340510A1 (en) 1998-12-23 2003-09-03 G.D. Searle LLC. Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications
WO2000038722A1 (en) 1998-12-23 2000-07-06 G.D. Searle & Co. COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG CoA REDUCTASE INHIBITORS FOR CARDIOVASCULAR INDICATIONS
EA004231B1 (ru) 1998-12-23 2004-02-26 Джи.Ди.Сирл Ллс Сочетание ингибиторов белка, переносящего эфир холестерила, и производных фибриновой кислоты для сердечно-сосудистых показаний
ES2189529T3 (es) 1998-12-23 2003-07-01 Searle Llc Combinaciones de inhiidores para el transporte de acidos biliares en el ileon y agentes complejantes para indicaciones cardiovasculares.
HUP0201972A3 (en) 1998-12-23 2005-06-28 G D Searle Llc Chicago Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
BR9916565A (pt) 1998-12-23 2002-01-29 Searle Llc Combinações de inibidores do transporte ácido da bile ileal e derivados do ácido fìbrico para indicações cardiovasculares
PT1140184E (pt) 1998-12-23 2003-10-31 Searle Llc Combinacoes de inibidores de proteina de transferencia de ester de colesterilo com derivados de acido nicotinico para indicacoes cardiovasculares
AU2001240115A1 (en) 2000-03-10 2001-09-24 Pharmacia Corporation Method for the preparation of tetrahydrobenzothiepines
DE10103506A1 (de) * 2001-01-26 2002-08-14 Ingo S Neu Pharmazeutische Zusammensetzung zur Behandlung von Multiple Sklerose
WO2003040127A1 (en) 2001-11-02 2003-05-15 G.D. Searle Llc Novel mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (asbt) and taurocholate uptake
CA2471639A1 (en) 2002-01-17 2003-07-31 Pharmacia Corporation Novel alkyl/aryl hydroxy or keto thiepines.
DE10229762A1 (de) * 2002-07-03 2004-01-22 Aventis Pharma Deutschland Gmbh Pyrazoloisoquinolinenderivaten zur Inhibierung von NFkappaB-induzierende Kinase
EP1572660B1 (en) 2002-12-20 2011-01-26 X-Ceptor Therapeutics, Inc. Isoquinolinone derivatives and their use as therapeutic agents
CA3041033A1 (en) 2016-09-12 2018-03-15 Numerate, Inc. Monocyclic compounds useful as gpr120 modulators
CA3041038A1 (en) 2016-09-12 2018-03-15 Numerate, Inc. Bicyclic compounds useful as gpr120 modulators

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK117986A (da) * 1985-03-16 1986-09-17 Wellcome Found Arylderivater, fremgangsmaader til deres fremstilling og deres anvendelse
US4761403A (en) * 1986-04-09 1988-08-02 Abbott Laboratories Lipoxygenase inhibiting compounds
DE3882732T2 (de) * 1987-02-10 1993-12-02 Abbott Lab Indol, Benzofuran, Benzothiophen enthaltende, Lipoxygenase hemmende Verbindungen.
US4981865A (en) * 1989-05-26 1991-01-01 Warner-Lambert Co. N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents

Also Published As

Publication number Publication date
CZ235192A3 (en) 1993-10-13
DE69224115T2 (de) 1998-08-20
TW281672B (es) 1996-07-21
ATE162525T1 (de) 1998-02-15
MX9204418A (es) 1993-02-01
GR3026254T3 (en) 1998-05-29
HUT66626A (en) 1994-12-28
DK0526402T3 (da) 1998-09-14
AU2048292A (en) 1993-02-04
NO922987L (no) 1993-02-01
IL102612A (en) 1996-11-14
NZ243752A (en) 1994-09-27
JPH0641104A (ja) 1994-02-15
PH30092A (en) 1996-12-27
FI923393A0 (fi) 1992-07-27
EP0526402A1 (en) 1993-02-03
CA2074797A1 (en) 1993-01-31
DE69224115D1 (de) 1998-02-26
NO178925C (no) 1996-07-03
AU662339B2 (en) 1995-08-31
IL102612A0 (en) 1993-01-14
IE922471A1 (en) 1993-02-10
KR930002329A (ko) 1993-02-23
FI923393A (fi) 1993-01-31
NO922987D0 (no) 1992-07-29
EP0526402B1 (en) 1998-01-21
NO178925B (no) 1996-03-25
ZA925688B (en) 1993-03-31
HU9202479D0 (en) 1992-10-28

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