DE69224115D1 - Heteroaryl substituierte Hydroxylaminderivate als Lipoxygenase-Inhibitoren - Google Patents

Heteroaryl substituierte Hydroxylaminderivate als Lipoxygenase-Inhibitoren

Info

Publication number
DE69224115D1
DE69224115D1 DE1992624115 DE69224115A DE69224115D1 DE 69224115 D1 DE69224115 D1 DE 69224115D1 DE 1992624115 DE1992624115 DE 1992624115 DE 69224115 A DE69224115 A DE 69224115A DE 69224115 D1 DE69224115 D1 DE 69224115D1
Authority
DE
Germany
Prior art keywords
heteroaryl substituted
lipoxygenase inhibitors
hydroxylamine derivatives
substituted hydroxylamine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE1992624115
Other languages
English (en)
Other versions
DE69224115T2 (de
Inventor
Duzer John H Van
Dennis M Roland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ciba Geigy AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US73807591A priority Critical
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of DE69224115D1 publication Critical patent/DE69224115D1/de
Anticipated expiration legal-status Critical
Application status is Expired - Fee Related legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D279/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/021,2-Thiazines; Hydrogenated 1,2-thiazines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
DE1992624115 1991-07-30 1992-07-21 Heteroaryl substituierte Hydroxylaminderivate als Lipoxygenase-Inhibitoren Expired - Fee Related DE69224115D1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US73807591A true 1991-07-30 1991-07-30

Publications (1)

Publication Number Publication Date
DE69224115D1 true DE69224115D1 (de) 1998-02-26

Family

ID=24966464

Family Applications (2)

Application Number Title Priority Date Filing Date
DE1992624115 Expired - Fee Related DE69224115D1 (de) 1991-07-30 1992-07-21 Heteroaryl substituierte Hydroxylaminderivate als Lipoxygenase-Inhibitoren
DE1992624115 Expired - Lifetime DE69224115T2 (de) 1991-07-30 1992-07-21 Heteroaryl substituierte Hydroxylaminderivate als Lipoxygenase-Inhibitoren

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE1992624115 Expired - Lifetime DE69224115T2 (de) 1991-07-30 1992-07-21 Heteroaryl substituierte Hydroxylaminderivate als Lipoxygenase-Inhibitoren

Country Status (21)

Country Link
EP (1) EP0526402B1 (de)
JP (1) JPH0641104A (de)
KR (1) KR930002329A (de)
AT (1) AT162525T (de)
AU (1) AU662339B2 (de)
CA (1) CA2074797A1 (de)
CZ (1) CZ235192A3 (de)
DE (2) DE69224115D1 (de)
DK (1) DK526402T3 (de)
ES (1) ES2111059T3 (de)
FI (1) FI923393A (de)
GR (1) GR3026254T3 (de)
HU (1) HUT66626A (de)
IE (1) IE922471A1 (de)
IL (1) IL102612A (de)
MX (1) MX9204418A (de)
NO (1) NO178925C (de)
NZ (1) NZ243752A (de)
PH (1) PH30092A (de)
TW (1) TW281672B (de)
ZA (1) ZA9205688B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US5516789A (en) * 1995-04-12 1996-05-14 Abbott Laboratories Lipoxygenase and cyclooxygenase inhibiting compounds
BE1010487A6 (nl) 1996-06-11 1998-10-06 Unilin Beheer Bv Vloerbekleding bestaande uit harde vloerpanelen en werkwijze voor het vervaardigen van dergelijke vloerpanelen.
EA004877B1 (ru) 1998-12-23 2004-08-26 Джи.Ди.Сирл Ллс Сочетания ингибиторов транспорта желчных кислот в подвздошной кишке и агентов, секвестрирующих желчные кислоты, для сердечно-сосудистых показаний
AT242009T (de) 1998-12-23 2003-06-15 Searle Llc Kombinationen von cholesteryl ester transfer protein inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationen
US6462091B1 (en) 1998-12-23 2002-10-08 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications
AU2157500A (en) 1998-12-23 2000-07-31 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications
AU776620B2 (en) 1998-12-23 2004-09-16 G.D. Searle Llc Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
JP2002533408A (ja) 1998-12-23 2002-10-08 ジー.ディー.サール エルエルシー 心臓血管に適用するためのコレステリルエステル転送タンパク質阻害剤およびニコチン酸誘導体の組み合わせ
AU776658B2 (en) 1998-12-23 2004-09-16 G.D. Searle Llc Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications
EP1286984A2 (de) 2000-03-10 2003-03-05 Pharmacia Corporation Verfahren zur herstellung von tetrahydrobenzothiepinen
US6740663B2 (en) 2001-11-02 2004-05-25 G.D. Searle, Llc Mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake
US6852753B2 (en) 2002-01-17 2005-02-08 Pharmacia Corporation Alkyl/aryl hydroxy or keto thiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake
DE10229762A1 (de) * 2002-07-03 2004-01-22 Aventis Pharma Deutschland Gmbh Pyrazoloisoquinolinenderivaten zur Inhibierung von NFkappaB-induzierende Kinase
WO2004058717A1 (en) 2002-12-20 2004-07-15 X-Ceptor Therapeutics, Inc. Isoquinolinone derivatives and their use as therapeutic agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2559699B2 (ja) * 1985-03-16 1996-12-04 ザ ウエルカム フアウンデ−シヨン リミテツド 新規なアリ−ル誘導体
US4761403A (en) * 1986-04-09 1988-08-02 Abbott Laboratories Lipoxygenase inhibiting compounds
EP0279263B1 (de) * 1987-02-10 1993-08-04 Abbott Laboratories Indol, Benzofuran, Benzothiophen enthaltende, Lipoxygenase hemmende Verbindungen
US4981865A (en) * 1989-05-26 1991-01-01 Warner-Lambert Co. N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents

Also Published As

Publication number Publication date
DK526402T3 (da) 1998-09-14
EP0526402A1 (de) 1993-02-03
NO922987D0 (no) 1992-07-29
EP0526402B1 (de) 1998-01-21
NO178925C (no) 1996-07-03
IE922471A1 (en) 1993-02-10
KR930002329A (ko) 1993-02-23
FI923393A0 (fi) 1992-07-27
HU9202479D0 (en) 1992-10-28
ES2111059T3 (es) 1998-03-01
AT162525T (de) 1998-02-15
GR3026254T3 (en) 1998-05-29
FI923393D0 (de)
IL102612A (en) 1996-11-14
DE69224115T2 (de) 1998-08-20
IL102612D0 (en) 1993-01-14
NO922987L (no) 1993-02-01
AU2048292A (en) 1993-02-04
NZ243752A (en) 1994-09-27
PH30092A (en) 1996-12-27
ZA9205688B (en) 1993-03-31
CA2074797A1 (en) 1993-01-31
FI923393A (fi) 1993-01-31
CZ235192A3 (en) 1993-10-13
JPH0641104A (ja) 1994-02-15
NO178925B (no) 1996-03-25
DK0526402T3 (da) 1998-09-14
MX9204418A (es) 1993-02-01
AU662339B2 (en) 1995-08-31
HUT66626A (en) 1994-12-28
TW281672B (de) 1996-07-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee