DE69224115D1 - Heteroaryl substituierte Hydroxylaminderivate als Lipoxygenase-Inhibitoren - Google Patents
Heteroaryl substituierte Hydroxylaminderivate als Lipoxygenase-InhibitorenInfo
- Publication number
- DE69224115D1 DE69224115D1 DE69224115T DE69224115T DE69224115D1 DE 69224115 D1 DE69224115 D1 DE 69224115D1 DE 69224115 T DE69224115 T DE 69224115T DE 69224115 T DE69224115 T DE 69224115T DE 69224115 D1 DE69224115 D1 DE 69224115D1
- Authority
- DE
- Germany
- Prior art keywords
- aryl
- lower alkyl
- cycloalkyl
- carbocyclic
- heterocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Saccharide Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73807591A | 1991-07-30 | 1991-07-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69224115D1 true DE69224115D1 (de) | 1998-02-26 |
| DE69224115T2 DE69224115T2 (de) | 1998-08-20 |
Family
ID=24966464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69224115T Expired - Fee Related DE69224115T2 (de) | 1991-07-30 | 1992-07-21 | Heteroaryl substituierte Hydroxylaminderivate als Lipoxygenase-Inhibitoren |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0526402B1 (de) |
| JP (1) | JPH0641104A (de) |
| KR (1) | KR930002329A (de) |
| AT (1) | ATE162525T1 (de) |
| AU (1) | AU662339B2 (de) |
| CA (1) | CA2074797A1 (de) |
| CZ (1) | CZ235192A3 (de) |
| DE (1) | DE69224115T2 (de) |
| DK (1) | DK0526402T3 (de) |
| ES (1) | ES2111059T3 (de) |
| FI (1) | FI923393A7 (de) |
| GR (1) | GR3026254T3 (de) |
| HU (1) | HUT66626A (de) |
| IE (1) | IE922471A1 (de) |
| IL (1) | IL102612A (de) |
| MX (1) | MX9204418A (de) |
| NO (1) | NO178925C (de) |
| NZ (1) | NZ243752A (de) |
| PH (1) | PH30092A (de) |
| TW (1) | TW281672B (de) |
| ZA (1) | ZA925688B (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
| US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
| US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US5516789A (en) * | 1995-04-12 | 1996-05-14 | Abbott Laboratories | Lipoxygenase and cyclooxygenase inhibiting compounds |
| BE1010487A6 (nl) | 1996-06-11 | 1998-10-06 | Unilin Beheer Bv | Vloerbekleding bestaande uit harde vloerpanelen en werkwijze voor het vervaardigen van dergelijke vloerpanelen. |
| AU2157400A (en) | 1998-12-23 | 2000-07-31 | G.D. Searle & Co. | Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications |
| PT1140190E (pt) | 1998-12-23 | 2003-02-28 | Searle Llc | Combinacoes de inibidores do transporte ileal dos acidos biliares e agentes sequestrantes dos acidos biliares usadas para problemas cardiovasculares |
| EP1342475A1 (de) | 1998-12-23 | 2003-09-10 | G.D. Searle LLC. | Kombinationen von Ileumgallensäuretransportinhibitoren und Cholesterylestertransferproteininhibitoren für kardiovaskuläre Indikationen |
| DK1140185T3 (da) | 1998-12-23 | 2003-09-29 | Searle Llc | Kombinationer af cholesterylestertransferhæmmere og galdesyre kompleksdannende forbindelser til hjertekar indikationer |
| MXPA01006472A (es) | 1998-12-23 | 2004-03-10 | Searle Llc | Combinaciones de inhibidores de transporte de acido biliar ileal y derivados de acido fibrico para indicaciones cardiovasculares. |
| EP1140186B1 (de) | 1998-12-23 | 2003-06-04 | G.D. Searle LLC. | Kombinationen von cholesteryl ester transfer protein inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationen |
| DK1140184T3 (da) | 1998-12-23 | 2003-09-29 | Searle Llc | Kombinationer af cholesterylestertransferproteinhæmmere og nikotinsyrederivater til hjertekar indikationer |
| EP1286984A2 (de) | 2000-03-10 | 2003-03-05 | Pharmacia Corporation | Verfahren zur herstellung von tetrahydrobenzothiepinen |
| DE10103506A1 (de) * | 2001-01-26 | 2002-08-14 | Ingo S Neu | Pharmazeutische Zusammensetzung zur Behandlung von Multiple Sklerose |
| US6740663B2 (en) | 2001-11-02 | 2004-05-25 | G.D. Searle, Llc | Mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake |
| AU2003207431A1 (en) | 2002-01-17 | 2003-09-02 | Pharmacia Corporation | Novel alkyl/aryl hydroxy or keto thiepines. |
| DE10229762A1 (de) * | 2002-07-03 | 2004-01-22 | Aventis Pharma Deutschland Gmbh | Pyrazoloisoquinolinenderivaten zur Inhibierung von NFkappaB-induzierende Kinase |
| EP1572660B1 (de) | 2002-12-20 | 2011-01-26 | X-Ceptor Therapeutics, Inc. | Isochinolinonderivate und deren verwendung als medikamente |
| EP3509588B1 (de) | 2016-09-12 | 2023-06-07 | Integral Health,Inc. | Bicyclische verbindungen verwendbar als gpr120-modulatoren |
| KR102537985B1 (ko) | 2016-09-12 | 2023-05-30 | 인테그랄 헬스 인코퍼레이티드 | Gpr120 조정제로서 유용한 단환형 화합물 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ215487A (en) * | 1985-03-16 | 1990-01-29 | Wellcome Found | Aryl derivatives, pharmaceutical compositions thereof and preservation of cut flowers |
| US4761403A (en) * | 1986-04-09 | 1988-08-02 | Abbott Laboratories | Lipoxygenase inhibiting compounds |
| EP0279263B1 (de) * | 1987-02-10 | 1993-08-04 | Abbott Laboratories | Indol, Benzofuran, Benzothiophen enthaltende, Lipoxygenase hemmende Verbindungen |
| US4981865A (en) * | 1989-05-26 | 1991-01-01 | Warner-Lambert Co. | N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents |
-
1992
- 1992-07-21 ES ES92810559T patent/ES2111059T3/es not_active Expired - Lifetime
- 1992-07-21 DE DE69224115T patent/DE69224115T2/de not_active Expired - Fee Related
- 1992-07-21 EP EP92810559A patent/EP0526402B1/de not_active Expired - Lifetime
- 1992-07-21 AT AT92810559T patent/ATE162525T1/de not_active IP Right Cessation
- 1992-07-21 DK DK92810559T patent/DK0526402T3/da active
- 1992-07-22 AU AU20482/92A patent/AU662339B2/en not_active Ceased
- 1992-07-23 IL IL10261292A patent/IL102612A/en not_active IP Right Cessation
- 1992-07-24 PH PH44703A patent/PH30092A/en unknown
- 1992-07-24 TW TW081105850A patent/TW281672B/zh active
- 1992-07-27 FI FI923393A patent/FI923393A7/fi not_active Application Discontinuation
- 1992-07-27 CZ CS922351A patent/CZ235192A3/cs unknown
- 1992-07-28 JP JP4201496A patent/JPH0641104A/ja active Pending
- 1992-07-28 CA CA002074797A patent/CA2074797A1/en not_active Abandoned
- 1992-07-28 NZ NZ243752A patent/NZ243752A/en unknown
- 1992-07-29 ZA ZA925688A patent/ZA925688B/xx unknown
- 1992-07-29 MX MX9204418A patent/MX9204418A/es unknown
- 1992-07-29 IE IE247192A patent/IE922471A1/en not_active Application Discontinuation
- 1992-07-29 KR KR1019920013541A patent/KR930002329A/ko not_active Abandoned
- 1992-07-29 NO NO922987A patent/NO178925C/no unknown
- 1992-07-29 HU HU9202479A patent/HUT66626A/hu unknown
-
1998
- 1998-02-27 GR GR980400432T patent/GR3026254T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUT66626A (en) | 1994-12-28 |
| EP0526402B1 (de) | 1998-01-21 |
| FI923393A7 (fi) | 1993-01-31 |
| MX9204418A (es) | 1993-02-01 |
| ZA925688B (en) | 1993-03-31 |
| IL102612A (en) | 1996-11-14 |
| AU662339B2 (en) | 1995-08-31 |
| HU9202479D0 (en) | 1992-10-28 |
| ATE162525T1 (de) | 1998-02-15 |
| GR3026254T3 (en) | 1998-05-29 |
| IL102612A0 (en) | 1993-01-14 |
| JPH0641104A (ja) | 1994-02-15 |
| CA2074797A1 (en) | 1993-01-31 |
| DE69224115T2 (de) | 1998-08-20 |
| NO922987L (no) | 1993-02-01 |
| NO178925C (no) | 1996-07-03 |
| FI923393A0 (fi) | 1992-07-27 |
| DK0526402T3 (da) | 1998-09-14 |
| ES2111059T3 (es) | 1998-03-01 |
| EP0526402A1 (de) | 1993-02-03 |
| NO178925B (no) | 1996-03-25 |
| KR930002329A (ko) | 1993-02-23 |
| IE922471A1 (en) | 1993-02-10 |
| AU2048292A (en) | 1993-02-04 |
| NO922987D0 (no) | 1992-07-29 |
| NZ243752A (en) | 1994-09-27 |
| TW281672B (de) | 1996-07-21 |
| CZ235192A3 (en) | 1993-10-13 |
| PH30092A (en) | 1996-12-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |