GR3026254T3 - Heteroaryl substituted hydroxylamine derivatives as lipoxygenase inhibitors - Google Patents
Heteroaryl substituted hydroxylamine derivatives as lipoxygenase inhibitorsInfo
- Publication number
- GR3026254T3 GR3026254T3 GR980400432T GR980400432T GR3026254T3 GR 3026254 T3 GR3026254 T3 GR 3026254T3 GR 980400432 T GR980400432 T GR 980400432T GR 980400432 T GR980400432 T GR 980400432T GR 3026254 T3 GR3026254 T3 GR 3026254T3
- Authority
- GR
- Greece
- Prior art keywords
- aryl
- lower alkyl
- cycloalkyl
- carbocyclic
- heterocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73807591A | 1991-07-30 | 1991-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3026254T3 true GR3026254T3 (en) | 1998-05-29 |
Family
ID=24966464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR980400432T GR3026254T3 (en) | 1991-07-30 | 1998-02-27 | Heteroaryl substituted hydroxylamine derivatives as lipoxygenase inhibitors |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0526402B1 (el) |
| JP (1) | JPH0641104A (el) |
| KR (1) | KR930002329A (el) |
| AT (1) | ATE162525T1 (el) |
| AU (1) | AU662339B2 (el) |
| CA (1) | CA2074797A1 (el) |
| CZ (1) | CZ235192A3 (el) |
| DE (1) | DE69224115T2 (el) |
| DK (1) | DK0526402T3 (el) |
| ES (1) | ES2111059T3 (el) |
| FI (1) | FI923393A (el) |
| GR (1) | GR3026254T3 (el) |
| HU (1) | HUT66626A (el) |
| IE (1) | IE922471A1 (el) |
| IL (1) | IL102612A (el) |
| MX (1) | MX9204418A (el) |
| NO (1) | NO178925C (el) |
| NZ (1) | NZ243752A (el) |
| PH (1) | PH30092A (el) |
| TW (1) | TW281672B (el) |
| ZA (1) | ZA925688B (el) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
| US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
| US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US5516789A (en) * | 1995-04-12 | 1996-05-14 | Abbott Laboratories | Lipoxygenase and cyclooxygenase inhibiting compounds |
| BE1010487A6 (nl) | 1996-06-11 | 1998-10-06 | Unilin Beheer Bv | Vloerbekleding bestaande uit harde vloerpanelen en werkwijze voor het vervaardigen van dergelijke vloerpanelen. |
| JP2002533409A (ja) | 1998-12-23 | 2002-10-08 | ジー．ディー．サール エルエルシー | 心臓血管に適用するためのコレステリルエステル転送タンパク質阻害剤および胆汁酸隔離剤の組み合わせ |
| BR9916484A (pt) | 1998-12-23 | 2002-01-22 | Searle Llc | Combinações de inibidores do transporte de ácido biliar ileal e de agentes sequestrantes de ácido biliar em indicações cardiovasculares |
| CN1338944A (zh) | 1998-12-23 | 2002-03-06 | G.D.瑟尔有限公司 | 用于心血管适应症的胆固醇酯转移蛋白抑制剂和苯氧异丁酸类衍生物的联合形式 |
| NZ512537A (en) | 1998-12-23 | 2003-11-28 | G | Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications |
| ATE241386T1 (de) | 1998-12-23 | 2003-06-15 | Searle Llc | Kombinationen von ileumgallensäuretransports inhibitoren und cholesteryl ester transfer protein inhibitoren |
| AU2157400A (en) | 1998-12-23 | 2000-07-31 | G.D. Searle & Co. | Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications |
| ES2201822T3 (es) | 1998-12-23 | 2004-03-16 | G.D. Searle Llc | Combinaciones de inhibididores de la proteina de transferencia de ester de colesterilo y de derivados de acido nicotinico para indicaciones cardiovasculares. |
| JP2003528830A (ja) | 2000-03-10 | 2003-09-30 | ファルマシア・コーポレーション | テトラヒドロベンゾチエピン類の製造方法 |
| DE10103506A1 (de) * | 2001-01-26 | 2002-08-14 | Ingo S Neu | Pharmazeutische Zusammensetzung zur Behandlung von Multiple Sklerose |
| BR0213501A (pt) | 2001-11-02 | 2004-08-24 | Searle Llc | Compostos de benzotiepina mono- e di-fluorada como inibidores de transporte de ácido biliar co-dependente de sódio apical (asbt) e captação de taurocolato |
| JP2005521653A (ja) | 2002-01-17 | 2005-07-21 | ファルマシア コーポレイション | 先端ナトリウム同時依存性胆汁酸輸送（ａｓｂｔ）およびタウロコール酸塩取込みの阻害剤としての新規アルキル／アリールヒドロキシまたはケトチエピン化合物 |
| DE10229762A1 (de) * | 2002-07-03 | 2004-01-22 | Aventis Pharma Deutschland Gmbh | Pyrazoloisoquinolinenderivaten zur Inhibierung von NFkappaB-induzierende Kinase |
| DE60335911D1 (de) | 2002-12-20 | 2011-03-10 | Daiichi Sankyo Co Ltd | Isochinolinonderivate und deren verwendung als medikamente |
| CN110121343B (zh) | 2016-09-12 | 2023-11-03 | 整体健康 | 用作gpr120调节剂的双环化合物 |
| US10800773B2 (en) | 2016-09-12 | 2020-10-13 | Integral Health, Inc. | Monocyclic compounds useful as GPR120 modulators |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL78157A (en) * | 1985-03-16 | 1989-08-15 | Wellcome Found | Aryl derivatives,their preparation and pharmaceutical compositions containing them |
| US4761403A (en) * | 1986-04-09 | 1988-08-02 | Abbott Laboratories | Lipoxygenase inhibiting compounds |
| EP0279263B1 (en) * | 1987-02-10 | 1993-08-04 | Abbott Laboratories | Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds |
| US4981865A (en) * | 1989-05-26 | 1991-01-01 | Warner-Lambert Co. | N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents |
-
1992
- 1992-07-21 DE DE69224115T patent/DE69224115T2/de not_active Expired - Fee Related
- 1992-07-21 DK DK92810559T patent/DK0526402T3/da active
- 1992-07-21 EP EP92810559A patent/EP0526402B1/en not_active Expired - Lifetime
- 1992-07-21 AT AT92810559T patent/ATE162525T1/de not_active IP Right Cessation
- 1992-07-21 ES ES92810559T patent/ES2111059T3/es not_active Expired - Lifetime
- 1992-07-22 AU AU20482/92A patent/AU662339B2/en not_active Ceased
- 1992-07-23 IL IL10261292A patent/IL102612A/en not_active IP Right Cessation
- 1992-07-24 PH PH44703A patent/PH30092A/en unknown
- 1992-07-24 TW TW081105850A patent/TW281672B/zh active
- 1992-07-27 FI FI923393A patent/FI923393A/fi not_active Application Discontinuation
- 1992-07-27 CZ CS922351A patent/CZ235192A3/cs unknown
- 1992-07-28 CA CA002074797A patent/CA2074797A1/en not_active Abandoned
- 1992-07-28 JP JP4201496A patent/JPH0641104A/ja active Pending
- 1992-07-28 NZ NZ243752A patent/NZ243752A/en unknown
- 1992-07-29 NO NO922987A patent/NO178925C/no unknown
- 1992-07-29 KR KR1019920013541A patent/KR930002329A/ko active IP Right Grant
- 1992-07-29 ZA ZA925688A patent/ZA925688B/xx unknown
- 1992-07-29 HU HU9202479A patent/HUT66626A/hu unknown
- 1992-07-29 IE IE247192A patent/IE922471A1/en not_active Application Discontinuation
- 1992-07-29 MX MX9204418A patent/MX9204418A/es unknown
-
1998
- 1998-02-27 GR GR980400432T patent/GR3026254T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ235192A3 (en) | 1993-10-13 |
| IE922471A1 (en) | 1993-02-10 |
| IL102612A0 (en) | 1993-01-14 |
| NZ243752A (en) | 1994-09-27 |
| PH30092A (en) | 1996-12-27 |
| IL102612A (en) | 1996-11-14 |
| AU2048292A (en) | 1993-02-04 |
| ATE162525T1 (de) | 1998-02-15 |
| FI923393A (fi) | 1993-01-31 |
| NO922987L (no) | 1993-02-01 |
| DK0526402T3 (da) | 1998-09-14 |
| KR930002329A (ko) | 1993-02-23 |
| FI923393A0 (fi) | 1992-07-27 |
| AU662339B2 (en) | 1995-08-31 |
| NO178925C (no) | 1996-07-03 |
| MX9204418A (es) | 1993-02-01 |
| JPH0641104A (ja) | 1994-02-15 |
| NO922987D0 (no) | 1992-07-29 |
| EP0526402B1 (en) | 1998-01-21 |
| EP0526402A1 (en) | 1993-02-03 |
| HUT66626A (en) | 1994-12-28 |
| DE69224115T2 (de) | 1998-08-20 |
| CA2074797A1 (en) | 1993-01-31 |
| DE69224115D1 (de) | 1998-02-26 |
| ES2111059T3 (es) | 1998-03-01 |
| HU9202479D0 (en) | 1992-10-28 |
| ZA925688B (en) | 1993-03-31 |
| TW281672B (el) | 1996-07-21 |
| NO178925B (no) | 1996-03-25 |
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