CO4900056A1 - Analogos de indazol sustituidos - Google Patents
Analogos de indazol sustituidosInfo
- Publication number
- CO4900056A1 CO4900056A1 CO97035540A CO97035540A CO4900056A1 CO 4900056 A1 CO4900056 A1 CO 4900056A1 CO 97035540 A CO97035540 A CO 97035540A CO 97035540 A CO97035540 A CO 97035540A CO 4900056 A1 CO4900056 A1 CO 4900056A1
- Authority
- CO
- Colombia
- Prior art keywords
- oxo
- pyrimidyl
- alkyl
- cycloalkyl
- alkenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de fórmula I o una sal farmacéuticamenteaceptable del mismo, en la que R es H, un alquilo C1 -C6 , -(CH2 )m (cicloalquilo C3 -C7 ), -(CH2 )m (heterociclil C3 -C9 ), donde m es de 0 a 2, (alcoxi C1 -C6 ) alquilo (C1 -C6 ), alquenilo C2 -C6 o -(Z1 )b (Z2 )c (arilo C6 -C10 ), donde b y c son de forma independiente 0 ó 1; Z1 es un alquileno C1 -C6 o un alquenileno C2 -C6 , y Z2 es O, S, SO2 o NR10 , y en la que los grupos R citados están opcionalmente sustituidos por uno o más sustituyentes seleccionados de forma independiente de entre el grupo formado por halógenos, hidroxilo, alquilos C1 -C5 , alquenilos C2 -C5 , alcoxilos C1 -C5 , cicloalcoxilos C3 -C6 , trifluorometilo, nitro, -CO2 R10 , -C(O)NR10 R11 y -SO2 NR10 R11 ; R1 es H, un alquilo C1 -C7 , un alquenilo C2 -C3 , fenilo, cicloalquilo C3 -C7 o (cicloalquil C3 -C7 )alquilo C1 -C2 , donde dichos grupos R1 alquilo, alquenilo y fenilo están opcionalmente sustituidos por 1 a 3 sustituyentes seleccionados de forma independiente de entre el grupo formado por metilo, etilo, trifluorometilo y halógenos; R2 es 2-oxo-4-pirrolilo, pirazolilo, 2-oxo-3,4- dihidro-5-pirimidilo, 2-oxo-3,4-dihidro-4-pirimidilo, 2-oxo-tetrahidro-4-pirimidilo, 2-oxo-tetrahidro- 5-pirimidilo, 2-oxo-4-pirimidilo o 2-oxo-5- pirimidilo, donde cada uno de los grupos R2 citados está opcionalmente sustituido por 1 a 4 grupos R6 ; o R2 es
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2038596P | 1996-06-25 | 1996-06-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4900056A1 true CO4900056A1 (es) | 2000-03-27 |
Family
ID=21798354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO97035540A CO4900056A1 (es) | 1996-06-25 | 1997-06-25 | Analogos de indazol sustituidos |
Country Status (43)
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2223920A3 (en) * | 1996-06-19 | 2011-09-28 | Aventis Pharma Limited | Substituted azabicyclic compounds |
| CA2264798A1 (en) * | 1996-09-04 | 1998-03-12 | Pfizer Inc. | Indazole derivatives and their use as inhibitors of phosphodiesterase (pde) type iv and the production of tumor necrosis factor (tnf) |
| US6248746B1 (en) | 1998-01-07 | 2001-06-19 | Euro-Celtique S.A. | 3-(arylalkyl) xanthines |
| SK6262000A3 (en) * | 1997-11-04 | 2002-03-05 | Pfizer Prod Inc | Therapeutically active compounds based on indazole bioisostere replacement of catechol in pde4 inhibitors |
| US6362213B1 (en) | 1999-12-23 | 2002-03-26 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
| JP2003519139A (ja) * | 1999-12-23 | 2003-06-17 | アイコス コーポレイション | 環状ａｍｐ−特異的ホスホジエステラーゼ阻害剤 |
| US6953774B2 (en) | 2000-08-11 | 2005-10-11 | Applied Research Systems Ars Holding N.V. | Methods of inducing ovulation |
| US7205320B2 (en) | 2001-01-22 | 2007-04-17 | Memory Pharmaceuticals Corp. | Phosphodiesterase 4 inhibitors |
| US7153871B2 (en) | 2001-01-22 | 2006-12-26 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs |
| ATE449763T1 (de) * | 2001-04-16 | 2009-12-15 | Eisai R&D Man Co Ltd | 1h-indazolverbindungen die jnk hemmen |
| IL162506A0 (en) | 2001-12-14 | 2005-11-20 | Applied Research Systems | Ovulation induction |
| WO2004009552A1 (en) | 2002-07-19 | 2004-01-29 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors, including n-substituted aniline and diphenylamine analogs |
| CN101423497A (zh) * | 2002-07-19 | 2009-05-06 | 记忆药物公司 | 作为磷酸二酯酶4抑制剂的6-氨基-1h-吲唑和4-氨基苯并呋喃化合物 |
| US7087625B2 (en) * | 2002-11-19 | 2006-08-08 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors |
| RU2379292C2 (ru) * | 2003-04-18 | 2010-01-20 | Мемори Фармасьютиклз Корпорейшн | Производные пиразола в качестве ингибиторов фосфодиэстеразы 4 |
| US20090048255A1 (en) * | 2003-07-21 | 2009-02-19 | Schumacher Richard A | Phosphodiesterase 4 inhibitors, including n-substituted aniline and diphenylamine analogs |
| MY141255A (en) * | 2003-12-11 | 2010-03-31 | Memory Pharm Corp | Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs |
| EP1799673A1 (en) | 2004-10-15 | 2007-06-27 | Memory Pharmaceuticals Corporation | Pyrazole derivatives as phosphodiesterase 4 inhibitors |
| US7601847B2 (en) | 2004-10-26 | 2009-10-13 | Wyeth | Preparation and purification of 4-(indazol-3-yl)phenols |
| WO2006129158A2 (en) * | 2005-05-30 | 2006-12-07 | Ranbaxy Laboratories Limited | 3 - indazolyl - isoxazoline derivatives as inhibitors of phosphodiesterase type - i |
| US7678363B2 (en) | 2005-08-26 | 2010-03-16 | Braincells Inc | Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| US7781460B2 (en) | 2005-09-05 | 2010-08-24 | Ranbaxy Laboratories Limited | Substituted indazoles as inhibitors of phosphodiesterase type-IV |
| EP1934219A1 (en) | 2005-09-16 | 2008-06-25 | Ranbaxy Laboratories Limited | Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors |
| EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| EP2021000A2 (en) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| NZ579645A (en) | 2007-03-14 | 2012-01-12 | Ranbaxy Lab Ltd | Pyrazolo (3, 4-b) pyridine derivatives as phosphodiesterase inhibitors |
| US20100029689A1 (en) * | 2008-07-02 | 2010-02-04 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| NZ599597A (en) * | 2009-10-30 | 2013-05-31 | Janssen Pharmaceutica Nv | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS |
| EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| US20150125438A1 (en) * | 2012-07-20 | 2015-05-07 | Sang Jae Kim | Anti-Inflammatory Peptides and Composition Comprising the Same |
| WO2015166370A1 (en) | 2014-04-28 | 2015-11-05 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine d1 ligands |
| KR20220167804A (ko) * | 2021-06-11 | 2022-12-22 | 주식회사 메타센테라퓨틱스 | 인돌 유도체를 포함하는 최종당화산물 관련 질환의 치료용 조성물 |
| KR20220167441A (ko) * | 2021-06-11 | 2022-12-21 | 주식회사 메타센테라퓨틱스 | 신규한 인돌 유도체 및 이의 최종당화산물 관련 질환의 치료 용도 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB753573A (en) * | 1953-06-17 | 1956-07-25 | Ici Ltd | New dyestuffs intermediates |
| GB8707051D0 (en) * | 1986-04-15 | 1987-04-29 | Ici America Inc | Heterocyclic carboxamides |
| PT100441A (pt) * | 1991-05-02 | 1993-09-30 | Smithkline Beecham Corp | Pirrolidinonas, seu processo de preparacao, composicoes farmaceuticas que as contem e uso |
| TW223004B (es) * | 1991-11-25 | 1994-05-01 | Sumitomo Chemical Co | |
| US5444038A (en) * | 1992-03-09 | 1995-08-22 | Zeneca Limited | Arylindazoles and their use as herbicides |
| AU677776B2 (en) * | 1992-04-02 | 1997-05-08 | Smithkline Beecham Corporation | Compounds useful for treating allergic and inflammatory diseases |
| US5612360A (en) * | 1992-06-03 | 1997-03-18 | Eli Lilly And Company | Angiotensin II antagonists |
| US5554620A (en) * | 1993-09-14 | 1996-09-10 | Sterling Winthrop Inc. | Substituted 6,11-ethano-6,11-dihydrobenzo[b] quinolizinium salts and compositions and methods of use thereof |
| JPH07215952A (ja) * | 1993-12-06 | 1995-08-15 | Otsuka Pharmaceut Factory Inc | カテコール誘導体 |
| PL319758A1 (en) * | 1994-10-20 | 1997-08-18 | Pfizer | Bicyclic tetrahydropyrasole pyridines and their application as medicines |
-
1997
- 1997-06-02 AU AU27857/97A patent/AU716376B2/en not_active Ceased
- 1997-06-02 WO PCT/IB1997/000630 patent/WO1997049702A1/en not_active Application Discontinuation
- 1997-06-02 JP JP50258998A patent/JP3152940B2/ja not_active Expired - Fee Related
- 1997-06-02 EP EP97921992A patent/EP0912558B1/en not_active Expired - Lifetime
- 1997-06-02 PT PT97921992T patent/PT912558E/pt unknown
- 1997-06-02 AT AT97921992T patent/ATE244713T1/de not_active IP Right Cessation
- 1997-06-02 BR BR9712782-5A patent/BR9712782A/pt not_active Application Discontinuation
- 1997-06-02 SI SI9730553T patent/SI0912558T1/xx unknown
- 1997-06-02 ES ES97921992T patent/ES2201299T3/es not_active Expired - Lifetime
- 1997-06-02 EA EA199801047A patent/EA002274B1/ru not_active IP Right Cessation
- 1997-06-02 TR TR1998/02685T patent/TR199802685T2/xx unknown
- 1997-06-02 CN CN97195846A patent/CN1080260C/zh not_active Expired - Fee Related
- 1997-06-02 SK SK1765-98A patent/SK176598A3/sk unknown
- 1997-06-02 PL PL97330974A patent/PL330974A1/xx unknown
- 1997-06-02 CZ CZ984233A patent/CZ423398A3/cs unknown
- 1997-06-02 DK DK97921992T patent/DK0912558T3/da active
- 1997-06-02 HU HU9903009A patent/HUP9903009A3/hu unknown
- 1997-06-02 CA CA002258285A patent/CA2258285C/en not_active Expired - Fee Related
- 1997-06-02 KR KR1019980710961A patent/KR20000022516A/ko active IP Right Grant
- 1997-06-02 DE DE69723447T patent/DE69723447T2/de not_active Expired - Fee Related
- 1997-06-02 IL IL12703697A patent/IL127036A/en not_active IP Right Cessation
- 1997-06-05 US US08/869,358 patent/US6040329A/en not_active Expired - Fee Related
- 1997-06-05 HN HN1997000079A patent/HN1997000079A/es unknown
- 1997-06-10 PA PA19978432301A patent/PA8432301A1/es unknown
- 1997-06-12 GT GT199700075A patent/GT199700075A/es unknown
- 1997-06-19 AP APAP/P/1997/001020A patent/AP1025A/en active
- 1997-06-20 TW TW086108723A patent/TW434237B/zh not_active IP Right Cessation
- 1997-06-23 AR ARP970102755A patent/AR007456A1/es unknown
- 1997-06-23 MY MYPI97002820A patent/MY116915A/en unknown
- 1997-06-24 ID IDP972170A patent/ID18579A/id unknown
- 1997-06-24 DZ DZ970104A patent/DZ2254A1/fr active
- 1997-06-24 TN TNTNSN97108A patent/TNSN97108A1/fr unknown
- 1997-06-24 ZA ZA975581A patent/ZA975581B/xx unknown
- 1997-06-25 HR HR970350A patent/HRP970350B1/xx not_active Application Discontinuation
- 1997-06-25 CO CO97035540A patent/CO4900056A1/es unknown
- 1997-06-25 MA MA24679A patent/MA24225A1/fr unknown
-
1998
- 1998-11-27 IS IS4910A patent/IS4910A/is unknown
- 1998-12-11 OA OA9800235A patent/OA10934A/en unknown
- 1998-12-23 NZ NZ332752A patent/NZ332752A/en unknown
- 1998-12-23 NO NO986103A patent/NO986103L/no not_active Application Discontinuation
- 1998-12-24 YU YU60198A patent/YU60198A/sh unknown
-
1999
- 1999-01-07 BG BG103056A patent/BG64052B1/bg unknown
- 1999-08-31 HK HK99103733A patent/HK1018700A1/xx not_active IP Right Cessation
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