AR011189A1 - 1,4-benzotiazepin-1,1-dioxidos hipolipemiantes, composiciones farmaceuticas, uso de dichos compuestos para fabricar medicamentos y metodos para preparar dichos compuestos y compuestos intermediarios para su preparacion - Google Patents

1,4-benzotiazepin-1,1-dioxidos hipolipemiantes, composiciones farmaceuticas, uso de dichos compuestos para fabricar medicamentos y metodos para preparar dichos compuestos y compuestos intermediarios para su preparacion

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Publication number
AR011189A1
AR011189A1 ARP980101096A ARP980101096A AR011189A1 AR 011189 A1 AR011189 A1 AR 011189A1 AR P980101096 A ARP980101096 A AR P980101096A AR P980101096 A ARP980101096 A AR P980101096A AR 011189 A1 AR011189 A1 AR 011189A1
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Argentina
Prior art keywords
compounds
hydrogen
6alkyl
preparation
alkyl
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ARP980101096A
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English (en)
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Hoechst Ag
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Publication of AR011189A1 publication Critical patent/AR011189A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C12N2830/00—Vector systems having a special element relevant for transcription
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    • C12N2830/00—Vector systems having a special element relevant for transcription
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
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  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Diabetes (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
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  • Cardiology (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1,4-benzotiazepin-1,1-dioxidos que comprende la formula (I), en la que R1 es un grupo alquilo de C1-6 de cadena lineal; R2 es un grupo alquilo deC1-6 de cadena lineal; R3 es hidrogeno o un grupo OR11 en el que R11 es hidrogeno, un grupoalquilo de C1-6 o alquilcarbonilo de C1-6 opcionalmentesustituidos; R4 es piridilo o fenilo opcionalmente sustituido; R5, R6 y R8 son iguales o diferentes y cada uno se selecciona de hidrogeno, halogeno, ciano,R15-acetiluro, OR15, alquilo de C1-6op cionalmente sustituido, COR15, CH(OH)R15, S(O)nR15, P(O)(OR15)2, OCOR15, OCF3, OCN, SCN, NHCN, CH2OR15, CHO,(CH2)pCN, CONR12R13, (CH2)pCO2R15, (CH2)pNR12R13, CO2R15, NHCOCF3, NHSO2R15, OCH2OR15, OCH=CHR15, O(CH2CH2O)nR15,O(CH2)pSO3R15, O(CH2)pNR12R13 yO(CH2)pN+R12R14 en los que p es un numero entero de 1-4; n es un numero entero de 0-3 y R12, R13, R14 y R15 se seleccionan independientemente de hidrogeno yalquilo de C1-6 opcionalmente sustituido; R7 es un grupo dela formula (II) en la que los grupos hidroxilo pueden estar sustituidos con acetilo o bencilo,o formula:-alquil(C1-C6)-R17 en el que el grupo alquilo puede estar sustituido con uno o más grupos hidroxilo; R16 es -COOH o -CH2-OH; R17 es H, -OH,-NH2,-COOH o COOR1 8; R18 es alquilo (C1-C4) o -NH-alquilo (C1-C4); X es -NH- u -O-; y R9 y R10 son iguales o diferentes y cada uno es hidrogeno o alquilo de C1-6;y sus sales, solvatos y derivados fisiologicamente funcionales; a composicionesfarmacéuticas que los con tienen y a su uso en medicina, particularmente en laprofilaxis y tratamiento de estados hiperlipemiantes, tal como la ateroesclorosis, a sus procedimientos para su preparacion y nuevos compuestosintermediariospara su preparacion.
ARP980101096A 1997-03-14 1998-03-11 1,4-benzotiazepin-1,1-dioxidos hipolipemiantes, composiciones farmaceuticas, uso de dichos compuestos para fabricar medicamentos y metodos para preparar dichos compuestos y compuestos intermediarios para su preparacion AR011189A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97104348 1997-03-14

Publications (1)

Publication Number Publication Date
AR011189A1 true AR011189A1 (es) 2000-08-02

Family

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ARP980101096A AR011189A1 (es) 1997-03-14 1998-03-11 1,4-benzotiazepin-1,1-dioxidos hipolipemiantes, composiciones farmaceuticas, uso de dichos compuestos para fabricar medicamentos y metodos para preparar dichos compuestos y compuestos intermediarios para su preparacion

Country Status (23)

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US (2) US6020330A (es)
EP (1) EP0864582B1 (es)
JP (1) JP3282998B2 (es)
KR (1) KR19980080223A (es)
CN (1) CN1070484C (es)
AR (1) AR011189A1 (es)
AT (1) ATE242258T1 (es)
AU (1) AU731575B2 (es)
BR (1) BR9801126A (es)
CA (1) CA2231971C (es)
CZ (1) CZ75998A3 (es)
DE (1) DE69815180T2 (es)
DK (1) DK0864582T3 (es)
ES (1) ES2198613T3 (es)
HU (1) HUP9800541A3 (es)
ID (1) ID20053A (es)
IL (1) IL123648A (es)
NZ (1) NZ329932A (es)
PL (1) PL325363A1 (es)
PT (1) PT864582E (es)
RU (1) RU2179977C2 (es)
TR (1) TR199800444A3 (es)
ZA (1) ZA982140B (es)

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JP2023504643A (ja) 2019-12-04 2023-02-06 アルビレオ・アクチボラグ ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
JP2023504644A (ja) 2019-12-04 2023-02-06 アルビレオ・アクチボラグ ベンゾチアジアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
WO2022029101A1 (en) 2020-08-03 2022-02-10 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
CN116157389A (zh) 2020-08-03 2023-05-23 阿尔比里奥公司 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
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TW202313579A (zh) 2021-06-03 2023-04-01 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
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TR199800444A2 (xx) 1998-10-21
US6020330A (en) 2000-02-01
CA2231971C (en) 2008-05-20
PL325363A1 (en) 1998-09-28
JP3282998B2 (ja) 2002-05-20
AU5834998A (en) 1998-09-17
EP0864582B1 (en) 2003-06-04
NZ329932A (en) 1999-01-28
IL123648A (en) 2000-11-21
RU2179977C2 (ru) 2002-02-27
HUP9800541A3 (en) 2000-08-28
KR19980080223A (ko) 1998-11-25
CN1070484C (zh) 2001-09-05
ATE242258T1 (de) 2003-06-15
DE69815180T2 (de) 2004-04-29
DE69815180D1 (de) 2003-07-10
ZA982140B (en) 1998-09-14
AU731575B2 (en) 2001-04-05
JPH10279568A (ja) 1998-10-20
US6114322A (en) 2000-09-05
HUP9800541A1 (hu) 1999-06-28
CN1194979A (zh) 1998-10-07
EP0864582A3 (en) 1998-10-21
DK0864582T3 (da) 2003-09-29
PT864582E (pt) 2003-10-31
HU9800541D0 (en) 1998-05-28
ID20053A (id) 1998-09-17
EP0864582A2 (en) 1998-09-16
IL123648A0 (en) 1998-10-30
CZ75998A3 (cs) 1998-09-16
BR9801126A (pt) 2000-03-21
ES2198613T3 (es) 2004-02-01
TR199800444A3 (tr) 1998-10-21

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