BR9801126A - 1,4-benzotiazepina-1,1-dióxidos hipolipidêmicos. - Google Patents

1,4-benzotiazepina-1,1-dióxidos hipolipidêmicos.

Info

Publication number
BR9801126A
BR9801126A BR9801126A BR9801126A BR9801126A BR 9801126 A BR9801126 A BR 9801126A BR 9801126 A BR9801126 A BR 9801126A BR 9801126 A BR9801126 A BR 9801126A BR 9801126 A BR9801126 A BR 9801126A
Authority
BR
Brazil
Prior art keywords
hypolipidemic
benzothiazepine
dioxides
atheroscopy
ages
Prior art date
Application number
BR9801126A
Other languages
English (en)
Inventor
Eugen Falk
Alfons Enhsen
Siegfried Stengelin
Heiner Glombik
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of BR9801126A publication Critical patent/BR9801126A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/007—Vector systems having a special element relevant for transcription cell cycle specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

IDOS HIPOLIPIDêMICOS"<D>. A presente invenção refere-se a compostos hipolipdêmicos, com processos e intermediários para suas preparações, com composições farmacêuticas contendo-as e com seus usos na medicina, particularmente na profilaxia e tratamento de condições hiperlipidêmicas, tais como aterosc R^ 10^ e X são como definidos.
BR9801126A 1997-03-14 1998-03-13 1,4-benzotiazepina-1,1-dióxidos hipolipidêmicos. BR9801126A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97104348 1997-03-14

Publications (1)

Publication Number Publication Date
BR9801126A true BR9801126A (pt) 2000-03-21

Family

ID=8226598

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9801126A BR9801126A (pt) 1997-03-14 1998-03-13 1,4-benzotiazepina-1,1-dióxidos hipolipidêmicos.

Country Status (23)

Country Link
US (2) US6020330A (pt)
EP (1) EP0864582B1 (pt)
JP (1) JP3282998B2 (pt)
KR (1) KR19980080223A (pt)
CN (1) CN1070484C (pt)
AR (1) AR011189A1 (pt)
AT (1) ATE242258T1 (pt)
AU (1) AU731575B2 (pt)
BR (1) BR9801126A (pt)
CA (1) CA2231971C (pt)
CZ (1) CZ75998A3 (pt)
DE (1) DE69815180T2 (pt)
DK (1) DK0864582T3 (pt)
ES (1) ES2198613T3 (pt)
HU (1) HUP9800541A3 (pt)
ID (1) ID20053A (pt)
IL (1) IL123648A (pt)
NZ (1) NZ329932A (pt)
PL (1) PL325363A1 (pt)
PT (1) PT864582E (pt)
RU (1) RU2179977C2 (pt)
TR (1) TR199800444A3 (pt)
ZA (1) ZA982140B (pt)

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IL108633A (en) * 1993-02-15 1998-07-15 Wellcome Found History of Benzothiazepine Hypolipidemic Preparation and Pharmaceutical Preparations Containing Them
ZA956647B (en) * 1994-08-10 1997-02-10 Wellcome Found Hypolipidaemic compounds.
EP0864582B1 (en) * 1997-03-14 2003-06-04 Aventis Pharma Deutschland GmbH Hypolipidemic 1,4-benzothiazepine-1,-dioxides

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EP0864582A3 (en) 1998-10-21
HUP9800541A1 (hu) 1999-06-28
AU731575B2 (en) 2001-04-05
HU9800541D0 (en) 1998-05-28
RU2179977C2 (ru) 2002-02-27
ID20053A (id) 1998-09-17
CN1070484C (zh) 2001-09-05
PT864582E (pt) 2003-10-31
CN1194979A (zh) 1998-10-07
ATE242258T1 (de) 2003-06-15
US6020330A (en) 2000-02-01
AU5834998A (en) 1998-09-17
CA2231971C (en) 2008-05-20
DE69815180D1 (de) 2003-07-10
ES2198613T3 (es) 2004-02-01
IL123648A (en) 2000-11-21
AR011189A1 (es) 2000-08-02
CZ75998A3 (cs) 1998-09-16
KR19980080223A (ko) 1998-11-25
CA2231971A1 (en) 1998-09-14
DK0864582T3 (da) 2003-09-29
JP3282998B2 (ja) 2002-05-20
IL123648A0 (en) 1998-10-30
ZA982140B (en) 1998-09-14
JPH10279568A (ja) 1998-10-20
TR199800444A2 (xx) 1998-10-21
US6114322A (en) 2000-09-05
NZ329932A (en) 1999-01-28
DE69815180T2 (de) 2004-04-29
EP0864582A2 (en) 1998-09-16
EP0864582B1 (en) 2003-06-04
PL325363A1 (en) 1998-09-28
HUP9800541A3 (en) 2000-08-28
TR199800444A3 (tr) 1998-10-21

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