ES2102475T3 - Nuevas alquil-amidas heterociclicas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen. - Google Patents

Nuevas alquil-amidas heterociclicas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen.

Info

Publication number
ES2102475T3
ES2102475T3 ES92400782T ES92400782T ES2102475T3 ES 2102475 T3 ES2102475 T3 ES 2102475T3 ES 92400782 T ES92400782 T ES 92400782T ES 92400782 T ES92400782 T ES 92400782T ES 2102475 T3 ES2102475 T3 ES 2102475T3
Authority
ES
Spain
Prior art keywords
amides
pharmaceutical compositions
compositions containing
cyclic alkyl
preparation procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92400782T
Other languages
English (en)
Inventor
Said Yous
Isabelle Lesieur
Patrick Depreux
Daniel-Henri Caignard
Beatrice Guardiola
Gerard Adam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2102475T3 publication Critical patent/ES2102475T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

NUEVAS AMIDAS ALQUILHETEROCICLICAS, SU PROCESO DE PREPARACION Y LAS COMPOSICIONES FARMACEUTICAS QUE LAS CONTIENEN. COMPUESTOS DE FORMULA GENERAL: EN LA QUE: A REPRESENTA UN ATOMO DE OXIGENO O DE AZUFRE, X REPRESENTA UN GRUPO CH2 O UN ENLACE SENCILLO, F REPRESENTA: O UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO INFERIOR Y EN ESTE CASO P = 1 Y B REPRESENTA UN ESLABON -CH2 HIDROGENO O UN GRUPO ALQUILO INFERIOR LINEAL O RAMIFICADO. Y R2 REPRESENTA: . UN ATOMO DE HIDROGENO, . UN GRUPO CICLOALQUILO O ALQUILO INFERIOR LINEAL O RAMIFICADO, EVENTUALMENTE SUSTITUIDO POR UN ATOMO DE HALOGENO, . UN GRUPO CICLOALQUILO SUSTITUIDO POR UN GRUPO ALQUILO INFERIOR LINEAL O RAMIFICADO, . UN GRUPO ARILO O HETEROARILO O ARILALQUILO O ARILO SUSTITUIDO O HETEROARILO SUSTITUIDO O ARILALQUILO SUSTITUIDO, ENTENDIENDOSE QUE POR GRUPO HETEROARILO SE ENTIENDE UN GRUPO INSATURADO MONO O BICICLICO QUE COMPRENDE DE 1 A 3 HETEROATOMOS ELEGIDOS ENTRE EL NITROGENO, EL OXIGENO, O EL AZUFRE COMPRENDIENDO CADA CICLO 4 O 5 VERTICES,. UN GRUPO DE FORMULA: G REPRESENTA UN GRUPO ALQUILO INFERIOR LINEAL O RAMIFICADO, R3 Y R4 IDENTICOS O DIFERENTES REPRESENTAN CADA UNO UN GRUPO ALQUILO INFERIOR O UN ATOMO DE HIDROGENO O UN GRUPO FENILO O FENILALQUILO INFERIOR, O R3 Y R4 FORMAN CON EL ATOMO DE NITROGENO AL QUE ESTAN UNIDOS UN SISTEMA HETEROCICLICO, AROMATICO O NO, MONO O BICICLICO QUE COMPRENDE EVENTUALMENTE OTRO HETEROATOMO ELEGIDO ENTRE EL NITROGENO, EL OXIGENO O EL AZUFRE Y EVENTUALMENTE SUSTITUIDO POR UNO O VARIOS GRUPOS ALQUILO INFERIOR U OXO, ARILO O ARILALQUILO INFERIOR, O ARILO SUSTITUIDO O ARIALQUILO INFERIOR SUSTITUIDO, ENTENDIENDO QUE EN LAS DEFINICIONES DE R2, R3 Y R4 EL TERMINO SUSTITUIDO QUE AFECTA A LOS GRUPOS ARILO Y ARILAKILO Y HETEROARILO SIGNIFICA QUE ESTOS GRUPOS ESTAN SUSTITUIDOS POR UNO O VARIOS RADICALES ELEGIDOS ENTRE ALQUILO INFERIOR, ALCOXI INFERIOR, TRIFLUOROMETILO O ATOMO DE HALOGENO, O BIEN R1 FORMA CON R2 Y EL GRUPO N - CO UN SISTEMA HETEROCICLICO DE FORMULA: SIENDO J UN RADICAL ALQUILO LINEALO RAMIFICADO QUE COMPRENDE DE 2 A 8 ATOMOS DE CARBONO, O BIEN UN ESLABON (CH2)2 TENIENDO LA MISMA DEFINICION QUE ANTERIORMENTE Y EN ESTE CASO P VALE 0 O 1 Y B REPRESENTA UN GRUPO ALCOXI INFERIOR, MEDICAMENTOS
ES92400782T 1991-03-25 1992-03-24 Nuevas alquil-amidas heterociclicas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen. Expired - Lifetime ES2102475T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9103538A FR2674524B1 (fr) 1991-03-25 1991-03-25 Nouveaux amides alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
ES2102475T3 true ES2102475T3 (es) 1997-08-01

Family

ID=9411046

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92400782T Expired - Lifetime ES2102475T3 (es) 1991-03-25 1992-03-24 Nuevas alquil-amidas heterociclicas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen.

Country Status (13)

Country Link
US (7) US5240919A (es)
EP (1) EP0506539B1 (es)
JP (1) JPH0794448B2 (es)
AT (1) ATE152448T1 (es)
AU (1) AU649115B2 (es)
CA (1) CA2063885A1 (es)
DE (1) DE69219394T2 (es)
DK (1) DK0506539T3 (es)
ES (1) ES2102475T3 (es)
FR (1) FR2674524B1 (es)
GR (1) GR3023936T3 (es)
IE (1) IE920943A1 (es)
NZ (1) NZ242104A (es)

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WO2001007654A1 (en) * 1999-07-22 2001-02-01 The General Hospital Corporation Method for identifying compounds which modulate circadian rhythm
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US20040209877A1 (en) * 2000-04-13 2004-10-21 Shelby Nancy J. Methods for augmenting immune defenses contemplating the administration of phenolic and indoleamine-like compounds for use in animals ans humans
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US20040192669A1 (en) * 2000-04-13 2004-09-30 Rosenfeld Mark J. Novel compounds for use in weight loss and appetite suppression in humans
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BR102016024814A2 (pt) 2016-10-24 2018-05-08 Aché Laboratórios Farmacêuticos S.A. composto, processo de obtenção do composto, composição farmacêutica, uso do composto e método de tratamento de desordens psiquiátricas e/ou distúrbios do sono
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Also Published As

Publication number Publication date
US5322849A (en) 1994-06-21
FR2674524A1 (fr) 1992-10-02
DE69219394T2 (de) 1997-12-11
JPH0597828A (ja) 1993-04-20
EP0506539B1 (fr) 1997-05-02
GR3023936T3 (en) 1997-09-30
US5326775A (en) 1994-07-05
IE920943A1 (en) 1992-10-07
US5300507A (en) 1994-04-05
EP0506539A1 (fr) 1992-09-30
CA2063885A1 (fr) 1992-09-26
US5436348A (en) 1995-07-25
AU1311292A (en) 1992-10-01
NZ242104A (en) 1994-09-27
DK0506539T3 (da) 1997-12-01
US5322843A (en) 1994-06-21
FR2674524B1 (fr) 1993-05-21
US5240919A (en) 1993-08-31
AU649115B2 (en) 1994-05-12
US5386034A (en) 1995-01-31
DE69219394D1 (de) 1997-06-05
JPH0794448B2 (ja) 1995-10-11
ATE152448T1 (de) 1997-05-15

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