MX2021008981A - Compuestos de benzotiadiazepina y su uso como moduladores del acido biliar. - Google Patents
Compuestos de benzotiadiazepina y su uso como moduladores del acido biliar.Info
- Publication number
- MX2021008981A MX2021008981A MX2021008981A MX2021008981A MX2021008981A MX 2021008981 A MX2021008981 A MX 2021008981A MX 2021008981 A MX2021008981 A MX 2021008981A MX 2021008981 A MX2021008981 A MX 2021008981A MX 2021008981 A MX2021008981 A MX 2021008981A
- Authority
- MX
- Mexico
- Prior art keywords
- bile acid
- compounds
- acid modulators
- diseases
- benzothiadiazepine
- Prior art date
Links
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 title abstract 3
- 239000003613 bile acid Substances 0.000 title abstract 3
- KAOYLRLQZXRRBD-UHFFFAOYSA-N 1,2,3-benzothiadiazepine Chemical class S1N=NC=CC2=CC=CC=C12 KAOYLRLQZXRRBD-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102100021711 Ileal sodium/bile acid cotransporter Human genes 0.000 abstract 2
- 108091006614 SLC10A2 Proteins 0.000 abstract 2
- CICPSCXBPAGDJY-UHFFFAOYSA-N 1,2,5-benzothiadiazepine Chemical class S1N=CC=NC2=CC=CC=C12 CICPSCXBPAGDJY-UHFFFAOYSA-N 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000004129 fatty acid metabolism Effects 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 208000019423 liver disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/36—Seven-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
La invención se refiere a los derivados 1,2,5 de benzotiadiazepina de la fórmula (I). Estos compuestos son moduladores del ácido biliar que tienen el transportador apical del ácido biliar dependiente del sodio (ASBT) y/o actividad inhibidora del transporte del ácido biliar del hígado (LBAT). La invención también se refiere a las composiciones farmacéuticas que comprenden estos compuestos y con el uso de estos compuestos en el tratamiento de enfermedades cardiovasculares, metabolismo del ácido graso y trastornos debido al uso de la glucosa, enfermedades gastrointestinales y enfermedades hepáticas.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201911004690 | 2019-02-06 | ||
| SE1950464 | 2019-04-12 | ||
| IN201911049981 | 2019-12-04 | ||
| PCT/EP2020/052942 WO2020161217A1 (en) | 2019-02-06 | 2020-02-06 | Benzothiadiazepine compounds and their use as bile acid modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2021008981A true MX2021008981A (es) | 2021-09-08 |
Family
ID=69591608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021008981A MX2021008981A (es) | 2019-02-06 | 2020-02-06 | Compuestos de benzotiadiazepina y su uso como moduladores del acido biliar. |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US20230406832A1 (es) |
| EP (1) | EP3921028B1 (es) |
| JP (1) | JP2022519370A (es) |
| KR (1) | KR20210126053A (es) |
| CN (1) | CN113677398A (es) |
| AU (1) | AU2020218908A1 (es) |
| BR (1) | BR112021015060A2 (es) |
| CA (1) | CA3127568A1 (es) |
| CL (1) | CL2021001934A1 (es) |
| CO (1) | CO2021010400A2 (es) |
| CR (1) | CR20210458A (es) |
| DK (1) | DK3921028T3 (es) |
| EC (1) | ECSP21056710A (es) |
| ES (1) | ES2937153T3 (es) |
| FI (1) | FI3921028T3 (es) |
| HR (1) | HRP20230039T1 (es) |
| HU (1) | HUE060905T2 (es) |
| IL (1) | IL284983B1 (es) |
| LT (1) | LT3921028T (es) |
| MX (1) | MX2021008981A (es) |
| PE (1) | PE20212251A1 (es) |
| PL (1) | PL3921028T3 (es) |
| PT (1) | PT3921028T (es) |
| RS (1) | RS63899B1 (es) |
| SG (1) | SG11202108566VA (es) |
| SI (1) | SI3921028T1 (es) |
| TW (1) | TW202045483A (es) |
| UA (1) | UA127911C2 (es) |
| WO (1) | WO2020161217A1 (es) |
| ZA (1) | ZA202106472B (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG190029A1 (en) | 2010-11-08 | 2013-06-28 | Albireo Ab | Ibat inhibitors for the treatment of liver diseases |
| KR102560954B1 (ko) | 2014-06-25 | 2023-07-31 | 이에이 파마 가부시키가이샤 | 고형 제제 및 그의 착색 방지 또는 착색 감소 방법 |
| EP3802504B1 (en) | 2018-06-05 | 2023-01-18 | Albireo AB | Benzothia(di)azepine compounds and their use as bile acid modulators |
| CA3100691A1 (en) | 2018-06-20 | 2019-12-26 | Albireo Ab | Crystal modifications of odevixibat |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
| US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| EP4069247A1 (en) | 2019-12-04 | 2022-10-12 | Albireo AB | Benzothiadiazepine compounds and their use as bile acid modulators |
| JP2023504647A (ja) | 2019-12-04 | 2023-02-06 | アルビレオ・アクチボラグ | ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| WO2021110885A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| PT4069360T (pt) | 2019-12-04 | 2024-03-06 | Albireo Ab | Compostos de benzotia(di)azepina e a sua utilização como moduladores de ácido biliar |
| AR120683A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como ácido biliar |
| TW202134220A (zh) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
| CN114761080A (zh) | 2019-12-04 | 2022-07-15 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| AR120674A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzotiazepina y su uso como ácido biliar |
| JP2023504645A (ja) | 2019-12-04 | 2023-02-06 | アルビレオ・アクチボラグ | ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| JP2023537285A (ja) | 2020-08-03 | 2023-08-31 | アルビレオ・アクチボラグ | ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| AU2021379076A1 (en) | 2020-11-12 | 2023-06-08 | Albireo Ab | Odevixibat for treating progressive familial intrahepatic cholestasis (pfic) |
| AU2021390172A1 (en) | 2020-12-04 | 2023-06-22 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| WO2023164186A1 (en) | 2022-02-25 | 2023-08-31 | Assembly Biosciences, Inc. | Benzothia(dia)zepine compounds for treatment of hbv and hdv |
| WO2023164179A1 (en) | 2022-02-25 | 2023-08-31 | Assembly Biosciences, Inc. | Benzothia(dia)zepine compounds for treatment of hbv and hdv |
| WO2023164181A1 (en) | 2022-02-25 | 2023-08-31 | Assembly Biosciences, Inc. | Benzothia(dia)zepine compounds for treatment of hbv and hdv |
| WO2023164183A1 (en) | 2022-02-25 | 2023-08-31 | Assembly Biosciences, Inc. | Benzothia(dia)zepine compounds for treatment of hbv and hdv |
| US20230338392A1 (en) | 2022-04-22 | 2023-10-26 | Albireo Ab | Subcutaneous administration of an asbt inhibitor |
| WO2023237728A1 (en) | 2022-06-09 | 2023-12-14 | Albireo Ab | Treating hepatitis |
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| FI106800B (fi) | 1990-12-06 | 2001-04-12 | Hoechst Ag | Menetelmä uusien terapeuttisesti käyttökelpoisten dimeeristen sappihappojohdannaisten valmistamiseksi |
| AU653658B2 (en) | 1991-12-20 | 1994-10-06 | Hoechst Aktiengesellschaft | Polymers and oligomers of bile acid derivatives, process for their preparation and their use as pharmaceuticals |
| GB9203347D0 (en) | 1992-02-17 | 1992-04-01 | Wellcome Found | Hypolipidaemic compounds |
| EP0573848B1 (de) | 1992-06-12 | 1997-12-03 | Hoechst Aktiengesellschaft | Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel |
| ZA941003B (en) | 1993-02-15 | 1995-08-14 | Wellcome Found | Hypolipidaemic compounds |
| IL108634A0 (en) | 1993-02-15 | 1994-05-30 | Wellcome Found | Hypolipidaemic heterocyclic compounds, their prepatation and pharmaceutical compositions containing them |
| TW289020B (es) | 1993-05-08 | 1996-10-21 | Hoechst Sktiengesellschaft | |
| TW289757B (es) | 1993-05-08 | 1996-11-01 | Hoechst Ag | |
| TW289021B (es) | 1993-05-08 | 1996-10-21 | Hoechst Ag | |
| EP0624593A3 (de) | 1993-05-08 | 1995-06-07 | Hoechst Ag | Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel. |
| ZA956647B (en) | 1994-08-10 | 1997-02-10 | Wellcome Found | Hypolipidaemic compounds. |
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| GB9423172D0 (en) | 1994-11-17 | 1995-01-04 | Wellcom Foundation The Limited | Hypolipidemic benzothiazepines |
| CN1110494C (zh) | 1996-03-11 | 2003-06-04 | G·D·瑟尔公司 | 具有作为回肠胆汁酸转运和牛磺胆酸盐吸收抑制剂活性的新的苯并噻庚因 |
| WO1998003818A1 (de) | 1996-07-24 | 1998-01-29 | Zumtobel Staff Gmbh | Adapter für ein haltemittel, welches zum befestigen einer einbauleuchte in einer einbauöffnung bestimmt ist, oder haltemittel oder einbauleuchte mit einem solchen adapter |
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| WO1998040375A2 (en) | 1997-03-11 | 1998-09-17 | G.D. Searle & Co. | COMBINATION OF ILEAL BILE ACID TRANSPORT INHIBITING BENZOTHIEPINES AND HMG Co-A REDUCTASE INHIBITORS |
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| SE9901387D0 (sv) | 1999-04-19 | 1999-04-19 | Astra Ab | New pharmaceutical foromaulations |
| SE0000772D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | Chemical compounds |
| AU2001247331A1 (en) | 2000-03-10 | 2001-09-24 | Pharmacia Corporation | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders |
| SE0003766D0 (sv) | 2000-10-18 | 2000-10-18 | Astrazeneca Ab | Novel formulation |
| EG26979A (en) | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
| GB0121337D0 (en) | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
| GB0121622D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
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| GB0201850D0 (en) | 2002-01-26 | 2002-03-13 | Astrazeneca Ab | Therapeutic treatment |
| GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| GB0213669D0 (en) | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
| GB0216321D0 (en) | 2002-07-13 | 2002-08-21 | Astrazeneca Ab | Therapeutic treatment |
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| GB0304194D0 (en) | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
| US20050215882A1 (en) | 2004-03-23 | 2005-09-29 | The Regents Of The University Of Michigan | Noninvasive method to determine fat content of tissues using MRI |
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| JO3131B1 (ar) | 2010-04-27 | 2017-09-20 | Glaxosmithkline Llc | مركبات كيميائية |
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| KR20160061492A (ko) | 2014-11-21 | 2016-06-01 | 삼성디스플레이 주식회사 | 휴대용 먼지 센서 및 이를 이용한 휴대전화 |
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| EP3413878B1 (en) | 2016-02-09 | 2021-04-14 | Albireo AB | Oral cholestyramine formulation and use thereof |
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| CN110996915B (zh) | 2017-08-09 | 2023-10-03 | 阿尔比里奥公司 | 考来烯胺丸粒、口服考来烯胺制剂及其用途 |
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2020
- 2020-02-06 RS RS20230040A patent/RS63899B1/sr unknown
- 2020-02-06 IL IL284983A patent/IL284983B1/en unknown
- 2020-02-06 BR BR112021015060-9A patent/BR112021015060A2/pt unknown
- 2020-02-06 CA CA3127568A patent/CA3127568A1/en active Pending
- 2020-02-06 PT PT207053059T patent/PT3921028T/pt unknown
- 2020-02-06 PL PL20705305.9T patent/PL3921028T3/pl unknown
- 2020-02-06 PE PE2021001268A patent/PE20212251A1/es unknown
- 2020-02-06 DK DK20705305.9T patent/DK3921028T3/da active
- 2020-02-06 CN CN202080012140.4A patent/CN113677398A/zh active Pending
- 2020-02-06 SI SI202030140T patent/SI3921028T1/sl unknown
- 2020-02-06 UA UAA202104946A patent/UA127911C2/uk unknown
- 2020-02-06 ES ES20705305T patent/ES2937153T3/es active Active
- 2020-02-06 HU HUE20705305A patent/HUE060905T2/hu unknown
- 2020-02-06 TW TW109103758A patent/TW202045483A/zh unknown
- 2020-02-06 CR CR20210458A patent/CR20210458A/es unknown
- 2020-02-06 AU AU2020218908A patent/AU2020218908A1/en active Pending
- 2020-02-06 KR KR1020217028378A patent/KR20210126053A/ko active Search and Examination
- 2020-02-06 JP JP2021545897A patent/JP2022519370A/ja active Pending
- 2020-02-06 EP EP20705305.9A patent/EP3921028B1/en active Active
- 2020-02-06 MX MX2021008981A patent/MX2021008981A/es unknown
- 2020-02-06 FI FIEP20705305.9T patent/FI3921028T3/fi active
- 2020-02-06 HR HRP20230039TT patent/HRP20230039T1/hr unknown
- 2020-02-06 LT LTEPPCT/EP2020/052942T patent/LT3921028T/lt unknown
- 2020-02-06 SG SG11202108566VA patent/SG11202108566VA/en unknown
- 2020-02-06 WO PCT/EP2020/052942 patent/WO2020161217A1/en unknown
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2021
- 2021-07-22 CL CL2021001934A patent/CL2021001934A1/es unknown
- 2021-07-30 EC ECSENADI202156710A patent/ECSP21056710A/es unknown
- 2021-08-06 CO CONC2021/0010400A patent/CO2021010400A2/es unknown
- 2021-09-03 ZA ZA2021/06472A patent/ZA202106472B/en unknown
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2023
- 2023-02-03 US US18/164,185 patent/US20230406832A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| LT3921028T (lt) | 2023-02-10 |
| PE20212251A1 (es) | 2021-11-24 |
| PL3921028T3 (pl) | 2023-02-13 |
| JP2022519370A (ja) | 2022-03-23 |
| IL284983B1 (en) | 2024-03-01 |
| HUE060905T2 (hu) | 2023-04-28 |
| ECSP21056710A (es) | 2021-08-31 |
| DK3921028T3 (da) | 2023-01-23 |
| SI3921028T1 (sl) | 2023-02-28 |
| UA127911C2 (uk) | 2024-02-07 |
| US20230406832A1 (en) | 2023-12-21 |
| CN113677398A (zh) | 2021-11-19 |
| PT3921028T (pt) | 2023-02-15 |
| AU2020218908A1 (en) | 2021-08-26 |
| EP3921028B1 (en) | 2022-11-09 |
| BR112021015060A2 (pt) | 2021-10-05 |
| FI3921028T3 (fi) | 2023-01-31 |
| EP3921028A1 (en) | 2021-12-15 |
| HRP20230039T1 (hr) | 2023-06-09 |
| CL2021001934A1 (es) | 2022-04-01 |
| CO2021010400A2 (es) | 2021-08-19 |
| ES2937153T3 (es) | 2023-03-24 |
| SG11202108566VA (en) | 2021-09-29 |
| RS63899B1 (sr) | 2023-02-28 |
| ZA202106472B (en) | 2023-04-26 |
| CR20210458A (es) | 2021-11-04 |
| TW202045483A (zh) | 2020-12-16 |
| CA3127568A1 (en) | 2020-08-13 |
| WO2020161217A1 (en) | 2020-08-13 |
| IL284983A (en) | 2021-09-30 |
| KR20210126053A (ko) | 2021-10-19 |
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