ECSP22040834A - Compuestos de benzoti(di)azepina y su uso como moduladores del ácido biliar - Google Patents

Compuestos de benzoti(di)azepina y su uso como moduladores del ácido biliar

Info

Publication number
ECSP22040834A
ECSP22040834A ECSENADI202240834A ECDI202240834A ECSP22040834A EC SP22040834 A ECSP22040834 A EC SP22040834A EC SENADI202240834 A ECSENADI202240834 A EC SENADI202240834A EC DI202240834 A ECDI202240834 A EC DI202240834A EC SP22040834 A ECSP22040834 A EC SP22040834A
Authority
EC
Ecuador
Prior art keywords
bile acid
compounds
benzothi
acid modulators
diseases
Prior art date
Application number
ECSENADI202240834A
Other languages
English (en)
Inventor
Santosh S Kulkarni
Per-Göran Gillberg
Ingemar Starke
Original Assignee
Albireo Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albireo Ab filed Critical Albireo Ab
Publication of ECSP22040834A publication Critical patent/ECSP22040834A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención se refiere a los derivados 1,5-benzotiazepina y 1,2,5-benzotiadiazepina de la fórmula (I). Estos compuestos son moduladores del ácido biliar que tienen el transportador apical del ácido biliar dependiente del sodio (ASBT) y/o actividad inhibidora del transporte del ácido biliar del hígado (LBAT). La invención también se refiere a composiciones farmacéuticas que comprenden estos compuestos y al uso de estos compuestos en el tratamiento de enfermedades cardiovasculares, metabolismo de ácidos grasos y trastornos debidos al uso de la glucosa, enfermedades gastrointestinales y enfermedades hepáticas.
ECSENADI202240834A 2019-12-04 2022-05-19 Compuestos de benzoti(di)azepina y su uso como moduladores del ácido biliar ECSP22040834A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN201911049982 2019-12-04

Publications (1)

Publication Number Publication Date
ECSP22040834A true ECSP22040834A (es) 2022-06-30

Family

ID=73790062

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202240834A ECSP22040834A (es) 2019-12-04 2022-05-19 Compuestos de benzoti(di)azepina y su uso como moduladores del ácido biliar

Country Status (6)

Country Link
AR (1) AR120679A1 (es)
CL (1) CL2022001453A1 (es)
EC (1) ECSP22040834A (es)
PT (1) PT4069360T (es)
TW (1) TW202134223A (es)
WO (1) WO2021110883A1 (es)

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* Cited by examiner, † Cited by third party
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TW202313579A (zh) 2021-06-03 2023-04-01 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
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WO2023164183A1 (en) * 2022-02-25 2023-08-31 Assembly Biosciences, Inc. Benzothia(dia)zepine compounds for treatment of hbv and hdv
WO2023164179A1 (en) * 2022-02-25 2023-08-31 Assembly Biosciences, Inc. Benzothia(dia)zepine compounds for treatment of hbv and hdv
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Also Published As

Publication number Publication date
WO2021110883A1 (en) 2021-06-10
PT4069360T (pt) 2024-03-06
CL2022001453A1 (es) 2023-06-02
AR120679A1 (es) 2022-03-09
TW202134223A (zh) 2021-09-16

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