ES2093440T3 - Derivados en la serie de la vitamina d con modificaciones en la posicion 20, procedimiento para su preparacion, productos intermedios para este procedimiento, preparados farmaceuticos que contienen estos derivados asi como su utilizacion para la preparacion de medicamentos. - Google Patents

Derivados en la serie de la vitamina d con modificaciones en la posicion 20, procedimiento para su preparacion, productos intermedios para este procedimiento, preparados farmaceuticos que contienen estos derivados asi como su utilizacion para la preparacion de medicamentos.

Info

Publication number
ES2093440T3
ES2093440T3 ES93914720T ES93914720T ES2093440T3 ES 2093440 T3 ES2093440 T3 ES 2093440T3 ES 93914720 T ES93914720 T ES 93914720T ES 93914720 T ES93914720 T ES 93914720T ES 2093440 T3 ES2093440 T3 ES 2093440T3
Authority
ES
Spain
Prior art keywords
derivatives
procedure
preparation
vitamin
well
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93914720T
Other languages
English (en)
Inventor
Andreas Dr Steinmeyer
Gunter Dr Neef
Gerald Dr Kirsch
Katica Schwarz
Ruth Dr Thieroff-Ekerdt
Herbert Dr Wiesinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2093440T3 publication Critical patent/ES2093440T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/517—Saturated compounds containing a keto group being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA INVENCION SE REFIERE A DERIVADOS DE VITAMINA D MODIFICADA EN LA POSICION 20 DE LA FORMULA GENERAL (I), DONDE L, X, Y, Z, R1, R2 ASI COMO R3 TIENEN EL SIGNIFICADO DADO EN LA DESCRIPCION, PROCESO PARA SU ELABORACION Y SU UTILIZACION COMO AGENTES PARA EL TRATAMIENTO DE ENFERMEDADES HIPERPROLIFERATIVAS DE LA PIEL.
ES93914720T 1992-06-24 1993-06-24 Derivados en la serie de la vitamina d con modificaciones en la posicion 20, procedimiento para su preparacion, productos intermedios para este procedimiento, preparados farmaceuticos que contienen estos derivados asi como su utilizacion para la preparacion de medicamentos. Expired - Lifetime ES2093440T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4220757A DE4220757A1 (de) 1992-06-24 1992-06-24 Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln

Publications (1)

Publication Number Publication Date
ES2093440T3 true ES2093440T3 (es) 1996-12-16

Family

ID=6461752

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93914720T Expired - Lifetime ES2093440T3 (es) 1992-06-24 1993-06-24 Derivados en la serie de la vitamina d con modificaciones en la posicion 20, procedimiento para su preparacion, productos intermedios para este procedimiento, preparados farmaceuticos que contienen estos derivados asi como su utilizacion para la preparacion de medicamentos.

Country Status (24)

Country Link
US (2) US5585368A (es)
EP (1) EP0647219B1 (es)
JP (1) JPH08501531A (es)
KR (1) KR100300274B1 (es)
CN (2) CN1055921C (es)
AT (1) ATE140918T1 (es)
AU (1) AU679685B2 (es)
CA (1) CA2138989A1 (es)
CZ (1) CZ282151B6 (es)
DE (2) DE4220757A1 (es)
DK (1) DK0647219T3 (es)
ES (1) ES2093440T3 (es)
FI (1) FI111720B (es)
GR (1) GR3020974T3 (es)
HU (1) HUT70563A (es)
IL (1) IL106128A0 (es)
MX (1) MX9303799A (es)
NO (1) NO306614B1 (es)
NZ (1) NZ253698A (es)
PL (1) PL174024B1 (es)
SK (1) SK281244B6 (es)
TW (1) TW255883B (es)
WO (1) WO1994000428A1 (es)
ZA (1) ZA934550B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830885A (en) * 1992-03-12 1998-11-03 The Johns Hopkins University Antiproliferative vitamin D3 hybrids
AU666563B2 (en) * 1992-08-07 1996-02-15 Wisconsin Alumni Research Foundation Preparation of 19-nor-vitamin D compounds
US5449668A (en) * 1993-06-04 1995-09-12 Duphar International Research B.V. Vitamin D compounds and method of preparing these compounds
IL112759A0 (en) * 1994-02-25 1995-05-26 Khepri Pharmaceuticals Inc Novel cysteine protease inhibitors
ATE195513T1 (de) * 1994-04-11 2000-09-15 Chugai Pharmaceutical Co Ltd 22-thiavitamin-d3-derivate
EP0717034B1 (en) * 1994-12-14 1999-04-07 Duphar International Research B.V Vitamin D compounds and method of preparing these compounds
US6242434B1 (en) 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
IL118156A (en) * 1995-05-09 2001-08-26 Duphar Int Res Vitamin d compounds, their preparation and pharmaceutical compositions containing them
DE19619036A1 (de) 1996-04-30 1997-11-13 Schering Ag Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
SG70010A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Fluorinated vitamin d3 analogs
CN1090180C (zh) * 1997-06-25 2002-09-04 帝人株式会社 维生素d3衍生物及其用于炎性呼吸道疾病的治疗剂
AU1022999A (en) 1997-09-08 1999-03-29 F. Hoffmann-La Roche Ag 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs
DE19744127B4 (de) * 1997-10-01 2006-10-05 Schering Ag Neue Vitamin D-Derivate mit Cyclopropylringen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung sowie ihre Verwendung zur Herstellung von Arzneimitteln
US5972917A (en) * 1998-05-29 1999-10-26 Bone Care Int Inc 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
DE19935771A1 (de) * 1999-07-23 2001-02-01 Schering Ag Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
AU2001278744A1 (en) * 2000-08-17 2002-02-25 Chugai Seiyaku Kabushiki Kaisha Remedial agent for osteoporosis
US7491711B2 (en) * 2001-09-21 2009-02-17 Roche Palo Alto Llc Methods of treatment using 3-desoxy vitamin D3 analogs
US7351869B2 (en) * 2002-11-18 2008-04-01 Teva Pharmaceutical Industries Ltd Crystallization method for purification of calcipotriene
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
US20090298800A1 (en) * 2005-09-23 2009-12-03 Bioxell S.P.A. 1,25-dihydroxy, 20-cyclopropyl,26-27-deuteroalkyl vitamin d3 compounds and methods of use thereof
KR101696727B1 (ko) 2006-07-17 2017-01-16 글락소스미스클라인 바이오로지칼즈 에스.에이. 인플루엔자 백신
US7888339B2 (en) 2008-07-10 2011-02-15 Wisconsin Alumni Research Foundation 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs
EP2393494A1 (en) 2009-01-27 2011-12-14 Berg Biosystems, LLC Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
CA2770683C (en) 2009-08-14 2018-09-04 Berg Biosystems, Llc Vitamin d3 and analogs thereof for treating alopecia
CN103073608B (zh) * 2013-02-26 2014-09-03 昆明理工大学 雄甾-4,6,8（9）,13（14）-四烯-3,11,16-三酮及其应用
CN103073607B (zh) * 2013-02-26 2014-09-03 昆明理工大学 12β-羟基雄甾-4,6,8（9）,13（14）-四烯-3,11,16-三酮及其应用
SG10201709894RA (en) 2013-05-29 2018-01-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
US10548908B2 (en) * 2016-09-15 2020-02-04 Nostopharma, LLC Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4617297A (en) * 1982-02-12 1986-10-14 Hoffmann-La Roche Inc. Method of treating disease states by the administration of 1α,25,26-trihydroxycholecalciferol
US4594432A (en) * 1983-01-28 1986-06-10 Hoffman-La Roche Inc. Process for the synthesis of 1α,23(S),25-trihydroxycholecalciferol and 1α,23(R),25-trihydroxycholecalciferol
US4719205A (en) * 1984-01-30 1988-01-12 Wisconsin Alumini Research Foundation Side-chain unsaturated 1-hydroxyvitamin D compounds
JPS6144860A (ja) * 1984-08-10 1986-03-04 Taisho Pharmaceut Co Ltd １α．２５−ジヒドロキシ−２６．２７−ジメチルビタミンＤ↓３
CA1332841C (en) * 1984-11-27 1994-11-01 Noboru Kubodera Vitamin d derivatives and process for producing the same
US4612308A (en) * 1984-11-29 1986-09-16 Hoffmann-La Roche Inc. 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
EP0205285B1 (en) * 1985-05-30 1989-08-09 Taisho Pharmaceutical Co. Ltd Vitamin d3 derivatives
EP0245524B1 (en) * 1985-11-21 1991-04-17 Taisho Pharmaceutical Co. Ltd Vitamin d 3 derivative
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US4851401A (en) * 1988-07-14 1989-07-25 Wisconsin Alumni Research Foundation Novel cyclopentano-vitamin D analogs
US4970203A (en) * 1988-12-09 1990-11-13 Deluca Hector F Method for improving reproductive functions in mammals
NZ232734A (en) * 1989-03-09 1991-11-26 Wisconsin Alumni Res Found 19-nor vitamin d derivatives and pharmaceutical compositions
CA1333616C (en) * 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
GB8915770D0 (en) * 1989-07-10 1989-08-31 Leo Pharm Prod Ltd Chemical compounds
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
DE4011682A1 (de) * 1990-04-06 1991-10-10 Schering Ag 24-oxa-derivate in der vitamin d-reihe
ATE143007T1 (de) * 1991-07-05 1996-10-15 Duphar Int Res Vitamin-d derivat, verfahren zu dessen herstellung sowie zwischenprodukte dafür
DE4141746A1 (de) * 1991-12-13 1993-06-17 Schering Ag 20-methyl-substituierte vitamin d-derivate
US5200536A (en) * 1992-02-10 1993-04-06 Daikin Industries Ltd. Fluorine-containing vitamin D3 analogues
US5194431A (en) * 1992-07-08 1993-03-16 Wisconsin Alumni Research Foundation 24-cyclopropane vitamin D derivatives
IL107185A (en) * 1992-10-06 1998-02-22 Schering Ag History of 52-carboxylic acid, processes for their preparation and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
GR3020974T3 (en) 1996-12-31
NO945034D0 (no) 1994-12-23
JPH08501531A (ja) 1996-02-20
CN1173909C (zh) 2004-11-03
CN1089599A (zh) 1994-07-20
WO1994000428A1 (de) 1994-01-06
US5585368A (en) 1996-12-17
DE4220757A1 (de) 1994-01-05
TW255883B (es) 1995-09-01
MX9303799A (es) 1994-07-29
SK281244B6 (sk) 2001-01-18
HUT70563A (en) 1995-10-30
PL174024B1 (pl) 1998-06-30
NO945034L (no) 1995-02-24
FI946073A (fi) 1994-12-23
NO306614B1 (no) 1999-11-29
HU9403771D0 (en) 1995-02-28
EP0647219A1 (de) 1995-04-12
KR950702181A (ko) 1995-06-19
FI111720B (fi) 2003-09-15
IL106128A0 (en) 1993-10-20
ATE140918T1 (de) 1996-08-15
AU679685B2 (en) 1997-07-10
KR100300274B1 (ko) 2001-11-22
DK0647219T3 (da) 1996-12-09
DE59303365D1 (de) 1996-09-05
ZA934550B (en) 1994-01-27
US5700791A (en) 1997-12-23
NZ253698A (en) 1996-11-26
CZ327694A3 (en) 1995-06-14
FI946073A0 (fi) 1994-12-23
EP0647219B1 (de) 1996-07-31
CN1262267A (zh) 2000-08-09
AU4500793A (en) 1994-01-24
CA2138989A1 (en) 1994-01-06
CN1055921C (zh) 2000-08-30
SK158494A3 (en) 1995-07-11
CZ282151B6 (cs) 1997-05-14

Similar Documents

Publication Publication Date Title
ES2093440T3 (es) Derivados en la serie de la vitamina d con modificaciones en la posicion 20, procedimiento para su preparacion, productos intermedios para este procedimiento, preparados farmaceuticos que contienen estos derivados asi como su utilizacion para la preparacion de medicamentos.
ES2186677T3 (es) Derivados de deuteroporfirina sustituidos en las posiciones 3 y 8, agentes farmaceuticos que contienen estos derivados y procedimientos para su preparacion.
ES2144239T3 (es) Derivados de vitamina d con sustituyentes en c-25, procedimiento para su preparacion, productos intermedios y la utilizacion para la preparacion de medicamentos.
IT1265101B1 (it) Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico
HUP9802121A2 (hu) Imidazolinszármazékok, eljárás előállításukra és e vegyületeket tartalmazó gyógyszerkészítmények
ES2191449T3 (es) Derivados de ciclopentabenzofurano y su uso.
HUT35958A (en) Process for the production of pharmaceutical preparation suitable for therapic treatment of rheumatic diseases
DE3261625D1 (en) Tricyclic thiazolyl oxamic acids and derivatives, process for their production, and therapeutic agents containing them
DE3371515D1 (en) Cycloalkyl derivatives of benzisoselenazolones, process for their preparation and pharmaceutical compositions containing them
ES2072332T3 (es) Derivados de la dibenzo(1,5)dioxocin-5-ona, su uso en medicamentos y procedimiento para su fabricacion.
ES2118248T3 (es) Esteres y amidas de 9-cloro-prostaglandina y su empleo para preparar medicamentos.
ES2006121A6 (es) Procedimiento para la preparacion de una composicion farmaceutica destinada al tratamiento de enfermedades cutaneas.
EP0443957A3 (en) New 17-spiro substituted steroid compounds, process for their preparation and intermediates of this process, their use as medicines and pharmaceutical preparations containing them
MY103593A (en) Bicyclic compounds, their use as pharmaceuticals, their preparation, and intermediates useful in their preparation
ES2060440T3 (es) Derivados de acidos 1,4-dihidropiridin-dicarboxilicos aril-quinolil substituidos, procedimiento para su fabricacion y su uso en medicamentos.
ES2043736T3 (es) Acidos 3,5-dihidroxi-heptanoicos sustituidos con (1h-pirrol-3-ilo) en posicion 7, sus correspondientes delta-lactonas y sales, procedimientos para su preparacion, su utilizacion como medicamentos, preparados farmaceuticos y productos intermedios.
MX9303392A (es) Derivados de imidazo benzoxazin-1-ona substituidos y proceso para su preparacion.
ES2137665T3 (es) Nuevos derivados de piridina o piridazina, procedimientos para su preparacion, y medicamentos que contienen estos compuestos.
ES2123796T3 (es) Derivados de acidos fosfono-succinicos y su utilizacion como medicamentos.
MX9300244A (es) Derivados de difluorometilenandrostenona y proceso para su preparacion.
ECSP044968A (es) DERIVADOS DEL ÁCIDO 5,6,6a,11b-TETRAHIDRO- 7-OXA-5-AZA-BENZO [C] FLUORENO-6-CARBOXÍLICO SUSTITUIDOS COMO ANTAGONISTAS DE NMDA
ES2094734T3 (es) Derivados de cefalosporinas y procedimiento para su preparacion.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 647219

Country of ref document: ES