ATE45347T1 - Vitamin d3-derivate. - Google Patents

Vitamin d3-derivate.

Info

Publication number
ATE45347T1
ATE45347T1 AT86304103T AT86304103T ATE45347T1 AT E45347 T1 ATE45347 T1 AT E45347T1 AT 86304103 T AT86304103 T AT 86304103T AT 86304103 T AT86304103 T AT 86304103T AT E45347 T1 ATE45347 T1 AT E45347T1
Authority
AT
Austria
Prior art keywords
difluoro
sub
derivatives
vitamin
ortreat
Prior art date
Application number
AT86304103T
Other languages
English (en)
Inventor
Nobuo Ikekawa
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE45347T1 publication Critical patent/ATE45347T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
AT86304103T 1985-05-30 1986-05-29 Vitamin d3-derivate. ATE45347T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP11748785 1985-05-30
EP86304103A EP0205285B1 (de) 1985-05-30 1986-05-29 Vitamin D3-Derivate

Publications (1)

Publication Number Publication Date
ATE45347T1 true ATE45347T1 (de) 1989-08-15

Family

ID=14712930

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86304103T ATE45347T1 (de) 1985-05-30 1986-05-29 Vitamin d3-derivate.

Country Status (5)

Country Link
US (1) US4868165A (de)
EP (1) EP0205285B1 (de)
JP (1) JPS6253960A (de)
AT (1) ATE45347T1 (de)
DE (1) DE3664909D1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5084323A (en) * 1989-04-07 1992-01-28 Nippondenso Co., Ltd. Ceramic multi-layer wiring substrate and process for preparation thereof
GB9017890D0 (en) * 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i
US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
IL99368A (en) * 1991-09-02 1996-01-19 Teva Pharma Preparations for the treatment of psoriasis and atopic dermatitis, which contain the result of xanthine
DE4220757A1 (de) * 1992-06-24 1994-01-05 Schering Ag Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
DE4221961A1 (de) * 1992-06-30 1994-01-05 Schering Ag 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel
GB9223061D0 (en) * 1992-11-04 1992-12-16 Leo Pharm Prod Ltd Chemical compounds
JPH06329622A (ja) * 1993-05-11 1994-11-29 Wisconsin Alumni Res Found ヨードビタミンｄ３ 化合物類及びその調製方法
US5401733A (en) * 1993-10-01 1995-03-28 Hoffmann-La Roche Inc. Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol
US5661140A (en) * 1994-11-21 1997-08-26 Wisconsin Alumni Research Foundation 18-nor-vitamin D compounds
US6043386A (en) * 1998-06-03 2000-03-28 John Hopkins University Non-calcemic, antiproliferative, transcriptionally active 24-fluorinated hybrid analogs of 1α,-25-dihydroxy vitamin D3
CN107936076B (zh) 2011-09-08 2021-10-15 萨奇治疗股份有限公司 神经活性类固醇、组合物、及其用途
AU2014243773B2 (en) 2013-03-13 2018-12-13 Sage Therapeutics, Inc. Neuroactive steroids and methods of use thereof
US11117924B2 (en) 2015-07-06 2021-09-14 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
CA2991214C (en) 2015-07-06 2024-04-30 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
JP6882996B2 (ja) * 2015-07-06 2021-06-02 セージ セラピューティクス， インコーポレイテッド オキシステロールおよびそれらの使用の方法
WO2017193046A1 (en) 2016-05-06 2017-11-09 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
MA45598B1 (fr) 2016-07-07 2021-09-30 Sage Therapeutics Inc Stéroles 24-hydroxylés substitués en position 11 pour le traitement des maladies liées au récepteur nmda
MA46351A (fr) 2016-09-30 2021-06-02 Sage Therapeutics Inc Oxystérols substitués en c7 et procédés en tant que modulateurs nmda

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4225596A (en) * 1978-10-13 1980-09-30 Wisconsin Alumni Research Foundation Method for treating calcium imbalance and improving calcium absorption in mammals
JPS5576857A (en) * 1978-12-04 1980-06-10 Teijin Ltd 24, 24-difluoro-25-hydroxyvitamin d3, its oh-protected derivative, and their preparation
JPS55111460A (en) * 1979-02-16 1980-08-28 Sachiko Yamada Novel vitamin d3 derivative and its preparation
US4196133A (en) * 1979-03-05 1980-04-01 Wisconsin Alumni Research Foundation 24,24-Difluoro-25-hydroxycholecalciferol
US4201881A (en) * 1979-03-28 1980-05-06 Wisconsin Alumni Research Foundation 24,24-Difluoro-1α,25-dihydroxycholecalciferol
US4521410A (en) * 1984-05-03 1985-06-04 The General Hospital Corporation Vitamin D glycosyl orthoesters
JPS6144860A (ja) * 1984-08-10 1986-03-04 Taisho Pharmaceut Co Ltd １α．２５−ジヒドロキシ−２６．２７−ジメチルビタミンＤ↓３

Also Published As

Publication number Publication date
EP0205285B1 (de) 1989-08-09
DE3664909D1 (en) 1989-09-14
US4868165A (en) 1989-09-19
JPS6253960A (ja) 1987-03-09
EP0205285A1 (de) 1986-12-17

Similar Documents

Publication Publication Date Title
ATE45347T1 (de) Vitamin d3-derivate.
ATE30583T1 (de) Vitamin-d3-derivate.
DK654689D0 (da) Phosphonsyresubstituerede aromatiske steroider som inhibitorer af steroid-5alfa-reduktase
KR890011837A (ko) 디데하이드로 비타민 d₃유도체
MY103850A (en) Phenol substituted gem-diphosphonate derivatives, process for their preparation and pharmaceutical compositions containing them.
ES2104090T3 (es) Nuevas 3',5'-di-t-butil-4'-hidroxi-flavonas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen.
CO4950531A1 (es) Analogos de la vitamina d3 composciiones farmaceuticas que los contienen
EP0390114A3 (de) Unterdrückung der Synthese und der Sekretion des Nebenschilddrüsenhormons mit Vitamin D3-Derivaten
IT1264563B1 (it) Composti fotocromatici e metodo per la loro preparazione
AU548396B2 (en) 2-aryl-3,4-diazabicyclo(4.n.0)alk-2-en-5-ones
IE851205L (en) Beta-carbolines
ES8707731A1 (es) Un procedimiento para la preparacion de derivados de oxindol
ES8504977A1 (es) Procedimiento para preparar -monohidrato de (+)-catequina.
KR970074763A (ko) 불소화된 비타민 d₃ 유사체
DE3575715D1 (de) Adamantanamin-derivate, verfahren zur herstellung und diese enthaltende heilmittel.
DK288686A (da) Farmaceutiske praeparater
ES8706148A1 (es) Un procedimiento para preparar nuevos derivados de carbapenem.
ES2148240T3 (es) Sintesis de derivados del acido n-acetil neuraminico.
ES553412A0 (es) Un procedimiento para la produccion de derivados de benzoilurea
DE69023939D1 (de) Förderung der Osteogenese durch Verwendung von Vitamin D-Derivaten.
ES2155948T3 (es) 20-oxopregna-derivados 17-cadena lateral alquinilica de la vitamina d, metodos para su produccion y composiciones farmaceuticas de los mismos.
ATE215934T1 (de) Neue histidinderivate, verfahren zu ihrer herstellung und ihre verwendung als mittel gegen freie radikale
ATE140693T1 (de) Phenylalkylaminoalkyl-verbindungen sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
NO870423L (no) 5-substituerte oktahydroindolizin-analgetiske forbindelser og 7-keto mellomprodukter.
FI860098A0 (fi) Nya piperazinderivat, foerfarande foer deras framstaellning och farmaceutiska kompositioner som innehaoller dessa foereningar som aktiv ingrediens.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee