ATE178596T1 - Vitamin-d-derivate und verfahren zur herstellung dieser verbindungen - Google Patents

Vitamin-d-derivate und verfahren zur herstellung dieser verbindungen

Info

Publication number
ATE178596T1
ATE178596T1 AT95203412T AT95203412T ATE178596T1 AT E178596 T1 ATE178596 T1 AT E178596T1 AT 95203412 T AT95203412 T AT 95203412T AT 95203412 T AT95203412 T AT 95203412T AT E178596 T1 ATE178596 T1 AT E178596T1
Authority
AT
Austria
Prior art keywords
group
branched
alkyl group
compounds
vitamin
Prior art date
Application number
AT95203412T
Other languages
English (en)
Inventor
Antonio Mourino
Jose Antonio Martinez
Los Angeles Rey Maria De
Juan Granja
Sebastianus J Halkes
Original Assignee
Duphar Int Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar Int Res filed Critical Duphar Int Res
Application granted granted Critical
Publication of ATE178596T1 publication Critical patent/ATE178596T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
AT95203412T 1994-12-14 1995-12-08 Vitamin-d-derivate und verfahren zur herstellung dieser verbindungen ATE178596T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP94203616 1994-12-14

Publications (1)

Publication Number Publication Date
ATE178596T1 true ATE178596T1 (de) 1999-04-15

Family

ID=8217451

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95203412T ATE178596T1 (de) 1994-12-14 1995-12-08 Vitamin-d-derivate und verfahren zur herstellung dieser verbindungen

Country Status (9)

Country Link
US (1) US5929056A (de)
EP (1) EP0717034B1 (de)
JP (1) JP4036490B2 (de)
AT (1) ATE178596T1 (de)
CA (1) CA2164916A1 (de)
DE (1) DE69508895T2 (de)
DK (1) DK0717034T3 (de)
ES (1) ES2130522T3 (de)
IL (1) IL116326A (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0884308T3 (da) * 1997-05-02 2003-07-21 Duphar Int Res Fremgangsmåde til at fremstille 16-dehydro vitamin D forbindelser
GB9721156D0 (en) 1997-10-06 1997-12-03 Leo Pharm Prod Ltd Novel vitamin d analogues
DE19935771A1 (de) * 1999-07-23 2001-02-01 Schering Ag Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
US6358939B1 (en) 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
US6989377B2 (en) 1999-12-21 2006-01-24 Wisconsin Alumni Research Foundation Treating vitamin D responsive diseases
US20040258801A1 (en) * 2001-09-27 2004-12-23 Alvin Ling Vitamin fortification of foodstuffs
ES2344989T3 (es) * 2004-11-22 2010-09-13 Wisconsin Alumni Research Foundation Analogos de 17,20(e)-deshidro vitamina d y sus usos.
US8193169B2 (en) * 2006-04-06 2012-06-05 Wisconsin Alumni Research Foundation (20R)-2α-methyl-19,26,2-trinor-vitamin D analogs
US8222236B2 (en) * 2008-07-10 2012-07-17 Wisconsin Alumni Research Foundation 2-methylene-(20E)-20(22)-dehydro-19-nor-vitamin D analogs
US8399439B2 (en) 2008-07-10 2013-03-19 Wisconsin Alumni Research Foundation 2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs
US7713953B2 (en) * 2008-07-10 2010-05-11 Wisconsin Alumni Research Foundation 2-methylene-(22E)-25-(1-methylene-hexyl)-26,27-cyclo-22-dehydro-19-nor-vitamin D analogs
US8193170B2 (en) 2008-07-10 2012-06-05 Wisconsin Alumni Research Foundation 2-methylene-19,26-dinor-(20R,22E,25R)-vitamin D analogs
US7893043B2 (en) * 2008-07-10 2011-02-22 Wisconsin Alumni Research Foundation 2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-vitamin D analogs
US7879829B2 (en) * 2008-07-10 2011-02-01 Wisconsin Alumni Research Foundation 19-nor-vitamin D analogs with 1,2-dihydrofuran ring
US7888339B2 (en) 2008-07-10 2011-02-15 Wisconsin Alumni Research Foundation 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs
US7648974B1 (en) * 2008-07-10 2010-01-19 Wisconsin Alumni Research Foundation 19-nor-vitamin D analogs with 3,2-dihydrofuran ring
CN102341110B (zh) 2009-01-27 2017-04-12 博格有限责任公司 用于减轻与化疗有关的副作用的维生素d3及其类似物
IN2012DN02137A (de) 2009-08-14 2015-08-07 Berg Biosystems Llc
WO2011041596A2 (en) 2009-10-02 2011-04-07 Wisconsin Alumni Research Foundation 19-nor-vitamin d analogs with 1,2-or 3,2-cyclopentene ring
US8445468B2 (en) 2009-10-02 2013-05-21 Wisconsin Alumni Research Foundation (20S,22E)-2-methylene-19-nor-22-ene-1α,25-dihydroxyvitamin D3
CA2837882C (en) 2011-06-03 2019-03-26 Wisconsin Alumni Research Foundation (22e)-2-methylene-26,27-cyclo-22-dehydro-1.alpha.-hydroxy-19-norvitamin d3 derivatives
US10479764B2 (en) 2011-06-28 2019-11-19 Wisconsin Alumni Research Foundation 2-methylene-(22E)-25-hexanoyl-24-oxo-26,27-cyclo-22-dehydro-19-nor-vitamin D analogs
WO2013012644A1 (en) 2011-07-18 2013-01-24 Wisconsin Alumni I Research Foundation 2-methylene-20(21)-dehydro-19,24,25,26,27,-pentanor-vitamin d analogs
US9416102B2 (en) 2013-01-23 2016-08-16 Wisconsin Alumni Research Foundation (22E)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3 analogs
SG11201509715UA (en) 2013-05-29 2015-12-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
CN106279239B (zh) * 2015-05-29 2019-06-28 上海彩迩文生化科技有限公司 多烯化合物、制备方法及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0374219A1 (de) * 1988-04-29 1990-06-27 Wisconsin Alumni Research Foundation In den seitenketten ungesättigte 1-alpha-hydroxy-vitamin-d-homologe
NZ232734A (en) * 1989-03-09 1991-11-26 Wisconsin Alumni Res Found 19-nor vitamin d derivatives and pharmaceutical compositions
FR2677022B1 (fr) * 1991-05-29 1995-03-10 Medgenix Group Sa Derives de la vitamine d comportant un groupe epoxyde sur la chaine laterale.
DE69213844T2 (de) * 1991-07-05 1997-04-10 Duphar Int Res Vitamin-D Derivat, Verfahren zu dessen Herstellung sowie Zwischenprodukte dafür
DE4220757A1 (de) * 1992-06-24 1994-01-05 Schering Ag Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
GB9214202D0 (en) * 1992-07-03 1992-08-12 Leo Pharm Prod Ltd Chemical compounds

Also Published As

Publication number Publication date
JP4036490B2 (ja) 2008-01-23
CA2164916A1 (en) 1996-06-15
EP0717034A1 (de) 1996-06-19
DE69508895T2 (de) 1999-10-21
IL116326A (en) 2000-08-13
JPH08319268A (ja) 1996-12-03
ES2130522T3 (es) 1999-07-01
US5929056A (en) 1999-07-27
DK0717034T3 (da) 1999-10-18
IL116326A0 (en) 1996-03-31
EP0717034B1 (de) 1999-04-07
DE69508895D1 (de) 1999-05-12

Similar Documents

Publication Publication Date Title
ATE178596T1 (de) Vitamin-d-derivate und verfahren zur herstellung dieser verbindungen
ATE142198T1 (de) Vitamin-d-derivate und verfahren zur herstellung dieser verbindungen
ATE132370T1 (de) Verwendung von alpha-tocopherolphosphat oder eines derivates davon zur herstellung kosmetischer dermatologischer oder pharmazeutischer präparate
ES2018832B3 (es) Derivados de amida.
MX9606136A (es) Inhibidores de enzimas.
HUP9802323A2 (hu) Pirimidinszármazékok, eljárás előállításukra és az ezeket tartalmazó gyógyászati készítmények
HUP0303108A2 (hu) Szubsztituált pirazolok és ezeket tartalmazó gyógyszerkészítmények
AR004672A1 (es) Derivados de la banzo(g)quinolina, proceso para prepararlos,su utilizacion como productos farmaceuticos, las composiciones farmaceuticas que los contieneny los metodos de tratamiento de la depresion, ansiedad y desordenes bipolares que utilizan dichos compuestos.
HUT60258A (en) Aminokumaran derivatives and process for producing aminokumaran derivatives and pharmaceutical compositions comprising such compounds
HUP9902576A1 (hu) Új eritromicinszármazékok, eljárás előállításukra és alkalmazásuk gyógyászati készítményekben
HU9202215D0 (en) Hydrazine derivatives having medical effect and method for producing them
ATE161723T1 (de) Arzneimittel zur verwendung bei der behandlung von parkinsonismus
HUP0402076A2 (hu) Szubsztituált indolok, eljárás az előállításukra és fájdalomcsillapítókénti alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
ES2014482B3 (es) Nuevas 2-tiazolil imidazo/1,2-a/pirimidinas y sus sales, su procedimiento de preparacion, su aplicacion a titulo de medicamentos y las composiciones que las encierran.
ATE206926T1 (de) Verwendung eines phosphorsäurediesters zur herstellung eines arzneimittels zur behandlung von akne
PT1022276E (pt) Derivados de epoxissuccinamida
PT96164A (pt) Processo de preparacao de uma composicao farmaceutica a base de derivados de fluoroquinolona
HUP9801751A2 (hu) Benzopiránszármazékok, azok előállítása és alkalmazása, valamint ilyen származékokat tartalmazó gyógyszerkészítmények
ATE417831T1 (de) Ceramid ähnliche verbindungen, verfahren zu deren herstellung und deren verwendung als antitumormittel
ATE116647T1 (de) Thiophenderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen.
ATE162195T1 (de) 4-hydroxy-phenyl-beta-d-glukose-monoester, verfahren zur ihrer herstellung und ihre verwendung in der kosmetik, der pharmazie, als zahnpflegemitteln und lebensmitteln
ES466795A1 (es) Un procedimiento para la produccion de imidazo(1,5-b)pirida-zinas
ATE79866T1 (de) 1-arylsulfonyl 1,5-dihydro 2h-pyrrol-2-onderivate, verfahren und zwischenprodukte zur herstellung, anwendung als heilmittel und zusammenstellungen, die sie enthalten.
ATE132867T1 (de) 20,21-dinoreburnaminderivate, substituiert in position 15, verfahren zu deren herstellung und die auf diese weise erhaltenen zwischenverbindungen, deren anwendung als arzneimittel und diese enthaltende zusammensetzungen
DE3860117D1 (de) 2,3-dihydro-3-phenyl-benzofuran-2-on-acetamidderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee