AR004672A1 - Derivados de la banzo(g)quinolina, proceso para prepararlos,su utilizacion como productos farmaceuticos, las composiciones farmaceuticas que los contieneny los metodos de tratamiento de la depresion, ansiedad y desordenes bipolares que utilizan dichos compuestos. - Google Patents
Derivados de la banzo(g)quinolina, proceso para prepararlos,su utilizacion como productos farmaceuticos, las composiciones farmaceuticas que los contieneny los metodos de tratamiento de la depresion, ansiedad y desordenes bipolares que utilizan dichos compuestos.Info
- Publication number
- AR004672A1 AR004672A1 ARP960103468A AR10346896A AR004672A1 AR 004672 A1 AR004672 A1 AR 004672A1 AR P960103468 A ARP960103468 A AR P960103468A AR 10346896 A AR10346896 A AR 10346896A AR 004672 A1 AR004672 A1 AR 004672A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- anxiety
- alkyl
- carbon atoms
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/08—Aza-anthracenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La invención proporciona compuestos de la fórmula (I), X es 0O ó H,H; Y es -CH2-, -O-,-NH- ó -S-, R1 es H o alquilo de 1 a 4 átomos de carbono, R2 es H,bencilo, pirimidilo, bis (4-fluorofenil)metilo o un grupo de las fórmulas (a), (b), (c),(d ), en donde R5 es H, o alquilo de 1 a 4 átomos de carbono, yR6, R7, R8 y R9 son independientemente H, OH, NO2, CF3, alquilo de 1 a 4 átomos de carbono, acetilo, CONR10R11, COOR12, [R11 y R12 que son independientementeH o alquilo de 1 a 4 átomosde ca rbono], CN ó (C1-4)alquilsulfonilo, R3 es H, alquilo de 1 a 4 átomos de carbono, (C1-4)alquilsulfonilo, trifluorometilsulfonilo o un grupo de la fórmula (II), en donde n es de 1 a 5 y m es de 1 a 3, en la forma de sal de adición de ácido ode bas e libre. Los compuestos de lafórmula (I) son útiles como productos farmacéuticos.Se describen además las composiciones farmacéuticas que contienen dichos compuestos (I) y los métodosde tratamiento de la depresión, ansiedad y desórdenesbipolares que utilizan dichcos compuestos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9513880.6A GB9513880D0 (en) | 1995-07-07 | 1995-07-07 | Organic compounds |
| GBGB9603988.8A GB9603988D0 (en) | 1996-02-26 | 1996-02-26 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR004672A1 true AR004672A1 (es) | 1999-03-10 |
Family
ID=26307342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960103468A AR004672A1 (es) | 1995-07-07 | 1996-07-05 | Derivados de la banzo(g)quinolina, proceso para prepararlos,su utilizacion como productos farmaceuticos, las composiciones farmaceuticas que los contieneny los metodos de tratamiento de la depresion, ansiedad y desordenes bipolares que utilizan dichos compuestos. |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5885988A (es) |
| EP (1) | EP0839136B1 (es) |
| JP (1) | JPH11509197A (es) |
| KR (1) | KR19990028757A (es) |
| CN (1) | CN1193964A (es) |
| AR (1) | AR004672A1 (es) |
| AT (1) | ATE201199T1 (es) |
| AU (1) | AU703325B2 (es) |
| BR (1) | BR9609326A (es) |
| CA (1) | CA2224436A1 (es) |
| CO (1) | CO4750662A1 (es) |
| CZ (1) | CZ1698A3 (es) |
| DE (1) | DE69612852T2 (es) |
| DK (1) | DK0839136T3 (es) |
| ES (1) | ES2158327T3 (es) |
| GR (1) | GR3036346T3 (es) |
| HU (1) | HUP9802937A3 (es) |
| IL (1) | IL122854A (es) |
| NO (1) | NO310070B1 (es) |
| NZ (1) | NZ313606A (es) |
| PE (1) | PE1998A1 (es) |
| PL (1) | PL324106A1 (es) |
| PT (1) | PT839136E (es) |
| RU (1) | RU2158738C2 (es) |
| SK (1) | SK1798A3 (es) |
| TR (1) | TR199800011T1 (es) |
| TW (1) | TW357143B (es) |
| WO (1) | WO1997003054A1 (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9711043D0 (en) | 1997-05-29 | 1997-07-23 | Ciba Geigy Ag | Organic compounds |
| AU5265599A (en) | 1998-04-08 | 1999-11-01 | Takeda Chemical Industries Ltd. | Amine compounds, their production and their use as somatostatin receptor antagonists or agonists |
| CA2246791A1 (en) * | 1998-09-01 | 2000-03-01 | Alison Buchan | Treatment of endothelium with somatostatin analogues |
| EP1122242B1 (en) * | 1998-09-22 | 2008-01-16 | Astellas Pharma Inc. | Cyanophenyl derivatives |
| GB9902938D0 (en) * | 1999-02-10 | 1999-03-31 | Novartis Ag | Organic compounds |
| PE20030240A1 (es) | 2001-07-09 | 2003-04-16 | Novartis Ag | DERIVADOS DE BENZO [g] QUINOLINA |
| FI20031454A0 (fi) | 2003-10-06 | 2003-10-06 | Juvantia Pharma Ltd Oy | Selektiivisiä somatostatiinireseptori 1 ja/tai 4 -agonisteja ja -antagonisteja |
| KR100594234B1 (ko) | 2003-12-05 | 2006-06-30 | 삼성전자주식회사 | 편광 현상을 이용하여 해상도를 향상시킬 수 있는 포토마스크 및 그 제조방법 |
| BRPI0515489A (pt) | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e sua utilização como inibidores de estearoil-coa desaturase |
| BRPI0515488A (pt) | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados de heterocìclicos e seu uso como agentes terapêuticos |
| TW200626139A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
| BRPI0515505A (pt) | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e sua utilização como inibidores da estearoil-coa desaturase |
| AU2005286731A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase |
| CA2580844A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase |
| BRPI0515483A (pt) | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos para o tratamento de doenças mediadas por enzimas estearoil-coa desaturase |
| WO2007130075A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| TWI404702B (zh) * | 2007-08-31 | 2013-08-11 | Lundbeck & Co As H | 兒茶酚胺衍生物和其前藥 |
| US8067410B2 (en) | 2008-06-27 | 2011-11-29 | H. Lundbeck A/S | Phenolic and catecholic amines and prodrugs thereof |
| JP7343170B2 (ja) | 2017-05-12 | 2023-09-12 | ボード オブ トラスティーズ オブ ザ サザン イリノイ ユニバーシティ オン ビハーフ オブ サザン イリノイ ユニバーシティ エドワーズビル | ３，４，５－三置換－１，２，４－トリアゾールおよび３，４，５－三置換－３－チオ－１，２，４－トリアゾール、ならびにそれらの使用 |
| US11912687B2 (en) | 2017-05-12 | 2024-02-27 | Board of Trustees of the Southern Illinois University | 3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof |
| JOP20200114A1 (ar) | 2017-11-24 | 2020-05-17 | H Lundbeck As | عقاقير أولية جديدة من الكاتيكولامين للاستخدام في علاج مرض باركنسون |
| US11104697B2 (en) | 2019-05-20 | 2021-08-31 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| US11111263B2 (en) | 2019-05-20 | 2021-09-07 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| US11168056B2 (en) | 2019-05-20 | 2021-11-09 | H. Lundbeck A/S | Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol |
| US11130775B2 (en) | 2019-05-20 | 2021-09-28 | H. Lundbeck A/S | Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| JP7099717B2 (ja) | 2019-09-30 | 2022-07-12 | 株式会社理研バイオ | ソマトスタチン受容体 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU88619I2 (fr) * | 1981-10-16 | 1995-07-10 | Sandoz Ag | QUINAGOLIDE, éventuellement sous forme de sel, par exemple du chlorhydrate |
| NL194166C (nl) * | 1984-06-12 | 2001-08-03 | Novartis Ag | Naftoxazinen en bereiding en toepassing daarvan. Hexahydronaft[2,3-b]-1,4-oxazinen en farmaceutische preparaten die ze bevatten. |
| NL8702680A (nl) * | 1986-11-21 | 1988-06-16 | Sandoz Ag | Nieuwe benzogchinolinen en werkwijzen voor het bereiden en toepassen van deze verbindingen. |
| DE4329776A1 (de) * | 1993-09-03 | 1995-03-09 | Sandoz Ag | Naphthoxazine, ihre Herstellung und Verwendung |
-
1996
- 1996-06-12 TW TW085107047A patent/TW357143B/zh active
- 1996-07-05 HU HU9802937A patent/HUP9802937A3/hu unknown
- 1996-07-05 KR KR1019980700056A patent/KR19990028757A/ko not_active Application Discontinuation
- 1996-07-05 AU AU66120/96A patent/AU703325B2/en not_active Ceased
- 1996-07-05 CA CA002224436A patent/CA2224436A1/en not_active Abandoned
- 1996-07-05 TR TR1998/00011T patent/TR199800011T1/xx unknown
- 1996-07-05 ES ES96925672T patent/ES2158327T3/es not_active Expired - Lifetime
- 1996-07-05 CZ CZ9816A patent/CZ1698A3/cs unknown
- 1996-07-05 PT PT96925672T patent/PT839136E/pt unknown
- 1996-07-05 DE DE69612852T patent/DE69612852T2/de not_active Expired - Fee Related
- 1996-07-05 JP JP9505489A patent/JPH11509197A/ja active Pending
- 1996-07-05 RU RU98102128/04A patent/RU2158738C2/ru active
- 1996-07-05 EP EP96925672A patent/EP0839136B1/en not_active Expired - Lifetime
- 1996-07-05 US US08/983,535 patent/US5885988A/en not_active Expired - Fee Related
- 1996-07-05 DK DK96925672T patent/DK0839136T3/da active
- 1996-07-05 PL PL96324106A patent/PL324106A1/xx unknown
- 1996-07-05 IL IL12285496A patent/IL122854A/xx not_active IP Right Cessation
- 1996-07-05 CN CN96196551A patent/CN1193964A/zh active Pending
- 1996-07-05 CO CO96035363A patent/CO4750662A1/es unknown
- 1996-07-05 WO PCT/EP1996/002969 patent/WO1997003054A1/en not_active Application Discontinuation
- 1996-07-05 NZ NZ313606A patent/NZ313606A/xx unknown
- 1996-07-05 SK SK17-98A patent/SK1798A3/sk unknown
- 1996-07-05 AR ARP960103468A patent/AR004672A1/es unknown
- 1996-07-05 BR BR9609326A patent/BR9609326A/pt active Search and Examination
- 1996-07-05 AT AT96925672T patent/ATE201199T1/de not_active IP Right Cessation
- 1996-07-05 PE PE1996000517A patent/PE1998A1/es not_active Application Discontinuation
-
1998
- 1998-01-05 NO NO980043A patent/NO310070B1/no not_active IP Right Cessation
-
2001
- 2001-08-07 GR GR20010401198T patent/GR3036346T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR19990028757A (ko) | 1999-04-15 |
| PL324106A1 (en) | 1998-05-11 |
| AU6612096A (en) | 1997-02-10 |
| PE1998A1 (es) | 1998-02-14 |
| TR199800011T1 (xx) | 1998-04-21 |
| DK0839136T3 (da) | 2001-08-06 |
| CO4750662A1 (es) | 1999-03-31 |
| ATE201199T1 (de) | 2001-06-15 |
| ES2158327T3 (es) | 2001-09-01 |
| NO980043L (no) | 1998-01-05 |
| GR3036346T3 (en) | 2001-11-30 |
| CZ1698A3 (cs) | 1998-04-15 |
| AU703325B2 (en) | 1999-03-25 |
| EP0839136B1 (en) | 2001-05-16 |
| CA2224436A1 (en) | 1997-01-30 |
| TW357143B (en) | 1999-05-01 |
| RU2158738C2 (ru) | 2000-11-10 |
| DE69612852D1 (de) | 2001-06-21 |
| EP0839136A1 (en) | 1998-05-06 |
| JPH11509197A (ja) | 1999-08-17 |
| WO1997003054A1 (en) | 1997-01-30 |
| BR9609326A (pt) | 1999-05-25 |
| PT839136E (pt) | 2001-09-28 |
| NZ313606A (en) | 1999-07-29 |
| NO310070B1 (no) | 2001-05-14 |
| NO980043D0 (no) | 1998-01-05 |
| US5885988A (en) | 1999-03-23 |
| CN1193964A (zh) | 1998-09-23 |
| MX9710530A (es) | 1998-03-31 |
| DE69612852T2 (de) | 2001-10-04 |
| IL122854A (en) | 2000-12-06 |
| SK1798A3 (en) | 1998-06-03 |
| HUP9802937A2 (hu) | 1999-10-28 |
| IL122854A0 (en) | 1998-08-16 |
| HUP9802937A3 (en) | 2002-10-28 |
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