BRPI0515489A - derivados heterocìclicos e sua utilização como inibidores de estearoil-coa desaturase - Google Patents

derivados heterocìclicos e sua utilização como inibidores de estearoil-coa desaturase

Info

Publication number
BRPI0515489A
BRPI0515489A BRPI0515489-8A BRPI0515489A BRPI0515489A BR PI0515489 A BRPI0515489 A BR PI0515489A BR PI0515489 A BRPI0515489 A BR PI0515489A BR PI0515489 A BRPI0515489 A BR PI0515489A
Authority
BR
Brazil
Prior art keywords
stearoyl
coat
heterocyclic derivatives
desaturase inhibitors
mammal
Prior art date
Application number
BRPI0515489-8A
Other languages
English (en)
Inventor
Rajender Kamboj
Zaihui Zhang
Serguei Sviridov
Vandna Raina
Duanjie Hou
Vishnumurthy Kodumuru
Mehran Seid Bagherzadeh
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of BRPI0515489A publication Critical patent/BRPI0515489A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS HETEROCìCLICOS E SUA UTILIZAçãO COMO INIBIDORES DE ESTEAROIL-COA DESATURASE" São apresentados métodos para o tratamento de uma doença ou condição mediada por SCD em um mamífero, de preferência um ser humano, onde os métodos são compostos da administração a um mamífero necessitando do mesmo de um composto da fórmula (1) e onde X, Y, J, K, W, V, R¬ 3¬, R¬ 4¬, R¬ 5¬, R¬ 5a¬, R¬ 6¬, R¬ 6a¬, R¬ 7¬, R¬ 7a¬, R¬ 8¬ e R¬ 8a¬ são definidos aqui. Também são apresentadas composições farmacêuticas compostas dos compostos da fórmula (1).
BRPI0515489-8A 2004-09-20 2005-09-20 derivados heterocìclicos e sua utilização como inibidores de estearoil-coa desaturase BRPI0515489A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61164804P 2004-09-20 2004-09-20
PCT/US2005/034130 WO2006034441A1 (en) 2004-09-20 2005-09-20 Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors

Publications (1)

Publication Number Publication Date
BRPI0515489A true BRPI0515489A (pt) 2008-07-29

Family

ID=35768112

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515489-8A BRPI0515489A (pt) 2004-09-20 2005-09-20 derivados heterocìclicos e sua utilização como inibidores de estearoil-coa desaturase

Country Status (11)

Country Link
US (1) US8071603B2 (pt)
EP (1) EP1799664A1 (pt)
JP (2) JP2008513515A (pt)
CN (1) CN101084207A (pt)
AR (1) AR051202A1 (pt)
AU (1) AU2005286648A1 (pt)
BR (1) BRPI0515489A (pt)
CA (1) CA2580856A1 (pt)
MX (1) MX2007003332A (pt)
TW (1) TW200624427A (pt)
WO (1) WO2006034441A1 (pt)

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AR051202A1 (es) 2006-12-27
TW200624427A (en) 2006-07-16
MX2007003332A (es) 2007-06-05
EP1799664A1 (en) 2007-06-27
CA2580856A1 (en) 2006-03-30
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CN101084207A (zh) 2007-12-05
JP2008513515A (ja) 2008-05-01

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