BRPI0515499A - derivados de piridina para a inibição de estearoil-coa-desaturase humana - Google Patents
derivados de piridina para a inibição de estearoil-coa-desaturase humanaInfo
- Publication number
- BRPI0515499A BRPI0515499A BRPI0515499-5A BRPI0515499A BRPI0515499A BR PI0515499 A BRPI0515499 A BR PI0515499A BR PI0515499 A BRPI0515499 A BR PI0515499A BR PI0515499 A BRPI0515499 A BR PI0515499A
- Authority
- BR
- Brazil
- Prior art keywords
- inhibition
- pyridine derivatives
- coa desaturase
- human
- stearoyl coa
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
Abstract
"DERIVADOS DE PIRIDINA A INIBIçãO DE ESTEAROIL-COA-DESATURASE HUMANA". Métodos de tratamento de uma doença ou condição mórbida mediada a SCD em um mamífero, de forma preferida um ser humano, são descritos, onde os métodos compreendem a administração a um mamífero em necessidade do mesmo de um composto de fórmula (I), onde x, y, G, J, K, L, M, W, V, R , R , R¬ 4¬, R¬ 5a¬, R¬ 7¬, R¬ 7a¬, R¬ 8¬, R¬ 8a¬ são aqui definidos. As composições farmacêuticas que compreende os compostos de fórmula (I) são também descritas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61164704P | 2004-09-20 | 2004-09-20 | |
PCT/US2005/034136 WO2006034446A2 (en) | 2004-09-20 | 2005-09-20 | Pyridine derivatives for inhibiting human stearoyl-coa-desaturase |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0515499A true BRPI0515499A (pt) | 2008-07-29 |
Family
ID=36035771
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0515499-5A BRPI0515499A (pt) | 2004-09-20 | 2005-09-20 | derivados de piridina para a inibição de estearoil-coa-desaturase humana |
Country Status (14)
Country | Link |
---|---|
US (1) | US20080167321A1 (pt) |
EP (2) | EP2316457A1 (pt) |
JP (1) | JP4958787B2 (pt) |
CN (1) | CN101090724A (pt) |
AR (1) | AR051095A1 (pt) |
AT (1) | ATE494895T1 (pt) |
AU (1) | AU2005286653A1 (pt) |
BR (1) | BRPI0515499A (pt) |
CA (1) | CA2580860A1 (pt) |
DE (1) | DE602005025924D1 (pt) |
ES (1) | ES2359840T5 (pt) |
MX (1) | MX2007003330A (pt) |
TW (1) | TW200626153A (pt) |
WO (1) | WO2006034446A2 (pt) |
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WO2004065380A1 (en) | 2003-01-14 | 2004-08-05 | Arena Pharmaceuticals Inc. | 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prpphylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia |
AR045047A1 (es) | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
JP4920410B2 (ja) | 2003-07-14 | 2012-04-18 | アリーナ ファーマシューティカルズ, インコーポレイテッド | 代謝モジュレーターとしての縮合アリールおよびヘテロアリール誘導体ならびに代謝に関連する障害の予防および治療 |
JP5080256B2 (ja) | 2004-09-20 | 2012-11-21 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 二環式複素環誘導体およびステアロイル−CoAデサチュラーゼ(SCD)のインヒビターとしてのそれらの使用 |
EP2269610A3 (en) * | 2004-09-20 | 2011-03-09 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
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AU2005286647A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
BRPI0515488A (pt) * | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados de heterocìclicos e seu uso como agentes terapêuticos |
HUE039584T2 (hu) | 2004-10-29 | 2019-01-28 | Kalypsys Inc | PPAR-modulátor szulfonil-szubsztituált biciklusos vegyületek |
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JP5322650B2 (ja) | 2005-10-25 | 2013-10-23 | カリプシス・インコーポレーテッド | Ppar調節剤の塩および代謝障害の治療方法 |
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RU2009110254A (ru) | 2006-08-24 | 2010-09-27 | Новартис АГ (CH) | Производные 2-(пиразин-2-ил)тиазола и 2-(1н-пиразол-3-ил)тиразола и связанные с ним соединения в качестве ингибиторов стеароил-соа десатуразы для лечения метаболических, сердечно-сосудистых и других нарушений |
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2005
- 2005-09-20 BR BRPI0515499-5A patent/BRPI0515499A/pt not_active IP Right Cessation
- 2005-09-20 CN CNA2005800397373A patent/CN101090724A/zh active Pending
- 2005-09-20 JP JP2007532685A patent/JP4958787B2/ja not_active Expired - Fee Related
- 2005-09-20 TW TW094132565A patent/TW200626153A/zh unknown
- 2005-09-20 MX MX2007003330A patent/MX2007003330A/es unknown
- 2005-09-20 ES ES05810510.7T patent/ES2359840T5/es active Active
- 2005-09-20 DE DE602005025924T patent/DE602005025924D1/de active Active
- 2005-09-20 EP EP10012999A patent/EP2316457A1/en not_active Withdrawn
- 2005-09-20 EP EP05810510.7A patent/EP1827438B2/en not_active Not-in-force
- 2005-09-20 US US11/575,645 patent/US20080167321A1/en not_active Abandoned
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- 2005-09-20 AR ARP050103910A patent/AR051095A1/es unknown
- 2005-09-20 AU AU2005286653A patent/AU2005286653A1/en not_active Abandoned
- 2005-09-20 WO PCT/US2005/034136 patent/WO2006034446A2/en active Application Filing
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AR051095A1 (es) | 2006-12-20 |
EP1827438B2 (en) | 2014-12-10 |
WO2006034446A3 (en) | 2006-05-26 |
DE602005025924D1 (en) | 2011-02-24 |
ES2359840T5 (es) | 2015-03-25 |
JP2008513516A (ja) | 2008-05-01 |
JP4958787B2 (ja) | 2012-06-20 |
ATE494895T1 (de) | 2011-01-15 |
CA2580860A1 (en) | 2006-03-30 |
EP2316457A1 (en) | 2011-05-04 |
MX2007003330A (es) | 2007-06-05 |
US20080167321A1 (en) | 2008-07-10 |
TW200626153A (en) | 2006-08-01 |
EP1827438A2 (en) | 2007-09-05 |
ES2359840T3 (es) | 2011-05-27 |
CN101090724A (zh) | 2007-12-19 |
WO2006034446A2 (en) | 2006-03-30 |
EP1827438B1 (en) | 2011-01-12 |
AU2005286653A1 (en) | 2006-03-30 |
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