EA200802213A1 - Способы лечения заболеваний крови - Google Patents
Способы лечения заболеваний кровиInfo
- Publication number
- EA200802213A1 EA200802213A1 EA200802213A EA200802213A EA200802213A1 EA 200802213 A1 EA200802213 A1 EA 200802213A1 EA 200802213 A EA200802213 A EA 200802213A EA 200802213 A EA200802213 A EA 200802213A EA 200802213 A1 EA200802213 A1 EA 200802213A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methods
- treating blood
- blood diseases
- diseases
- treating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/12—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 3 and unsubstituted in position 7
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/39—Heterocyclic compounds having sulfur as a ring hetero atom having oxygen in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
Abstract
Описаны способы лечения заболеваний крови с использованием соединений формул (II), (I), (III) или (II'):
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79905406P | 2006-05-09 | 2006-05-09 | |
PCT/US2007/011335 WO2007133653A2 (en) | 2006-05-09 | 2007-05-09 | Methods for treating blood disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200802213A1 true EA200802213A1 (ru) | 2009-10-30 |
Family
ID=38626483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200802213A EA200802213A1 (ru) | 2006-05-09 | 2007-05-09 | Способы лечения заболеваний крови |
Country Status (9)
Country | Link |
---|---|
US (2) | US20080075692A1 (ru) |
EP (1) | EP2023913A2 (ru) |
JP (1) | JP2009536659A (ru) |
CN (1) | CN101489544A (ru) |
AU (1) | AU2007249827A1 (ru) |
BR (1) | BRPI0713096A2 (ru) |
CA (1) | CA2652235A1 (ru) |
EA (1) | EA200802213A1 (ru) |
WO (1) | WO2007133653A2 (ru) |
Families Citing this family (54)
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CA2324426A1 (en) | 1998-02-11 | 1999-08-19 | Douglas V. Faller | Compositions and methods for the treatment of cystic fibrosis |
ES2561048T3 (es) | 2004-07-23 | 2016-02-24 | Acceleron Pharma Inc. | Polipéptidos del receptor ActRII |
US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
KR20160137665A (ko) | 2005-11-23 | 2016-11-30 | 악셀레론 파마 인코포레이티드 | 액티빈-actrⅱa 길항제 및 골 성장을 촉진하기 위한 이들의 용도 |
US20100028332A1 (en) * | 2006-12-18 | 2010-02-04 | Acceleron Pharma Inc. | Antagonists of actriib and uses for increasing red blood cell levels |
US8895016B2 (en) * | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
NZ707292A (en) * | 2006-12-18 | 2017-06-30 | Acceleron Pharma Inc | Activin-actrii antagonists and uses for increasing red blood cell levels |
AU2008211007B2 (en) * | 2007-02-01 | 2013-09-19 | Acceleron Pharma Inc. | Activin-ActRIIa antagonists and uses for treating or preventing breast cancer |
TW202021980A (zh) | 2007-02-02 | 2020-06-16 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
CA3039330C (en) * | 2007-02-09 | 2021-11-09 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for promoting bone growth in cancer patients |
CN107412734A (zh) * | 2007-09-18 | 2017-12-01 | 阿塞勒隆制药公司 | 活化素‑actriia拮抗剂和减少或抑制fsh分泌的用途 |
US8741966B2 (en) | 2007-11-09 | 2014-06-03 | Pronova Biopharma Norge As | Lipid compounds for use in cosmetic products, as food supplement or as a medicament |
KR20230085944A (ko) | 2008-03-18 | 2023-06-14 | 아레나 파마슈티칼스, 인크. | 프로스타시클린 (pgi2) 수용체와 관련된 장애의 치료에 유용한 상기 수용체의 조절제 |
EP3363453A1 (en) * | 2008-06-26 | 2018-08-22 | Acceleron Pharma Inc. | Soluble actriia as activin-actriia antagonist for use in treating anemia or bone-related disorders |
EP3620795A1 (en) * | 2008-06-26 | 2020-03-11 | Acceleron Pharma Inc. | Antagonists of soluble activin-actriia and uses for increasing red blood cell levels |
EP2147910A1 (en) * | 2008-07-15 | 2010-01-27 | Pronova BioPharma Norge AS | Novel lipid compounds |
JP5922928B2 (ja) | 2008-08-14 | 2016-05-24 | アクセルロン ファーマ, インコーポレイテッド | 赤血球レベルを高めるためのgdfトラップの使用 |
US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
BRPI0921369B8 (pt) | 2008-11-26 | 2021-05-25 | Arena Pharm Inc | composto modulador do receptor de prostaciclina (pgi2), sua composição, sua composição farmacêutica, seus usos, bem como processos para a preparação das referidas composições |
DK2370413T3 (en) | 2008-12-08 | 2015-11-02 | Arena Pharm Inc | Modulators of prostacyclin (PG12) receptor, which can be used for the treatment of disorders related to this |
EP2387412A4 (en) | 2009-01-13 | 2013-04-03 | Acceleron Pharma Inc | METHODS FOR INCREASING ADIPONECTIN |
JP5843755B2 (ja) | 2009-05-08 | 2016-01-13 | プロノヴァ・バイオファーマ・ノルゲ・アーエスPronova BioPharma Norge AS | 心血管性、代謝性および炎症性疾患領域に関する疾患の処置のための多価不飽和脂肪酸 |
EP2440576A4 (en) | 2009-06-08 | 2013-11-20 | Acceleron Pharma Inc | PROCESS FOR INCREASING THE NUMBER OF THERMOUS ADIPOCYTES |
AU2010263182B2 (en) | 2009-06-12 | 2016-05-12 | Acceleron Pharma Inc. | Truncated ActRIIB-Fc fusion proteins |
AU2010292203A1 (en) * | 2009-09-09 | 2012-04-12 | Acceleron Pharma Inc. | ActRIIb antagonists and dosing and uses thereof |
CN101653449B (zh) * | 2009-09-11 | 2012-05-23 | 南京大学 | ADDA和/或DMTA在制备提高γ-珠蛋白表达量的药物中的应用 |
US20110086869A1 (en) | 2009-09-24 | 2011-04-14 | The Trustees Of Boston University | Methods for treating viral disorders |
US20110129469A1 (en) * | 2009-11-03 | 2011-06-02 | Acceleron Pharma Inc. | Methods for treating fatty liver disease |
CA2781152A1 (en) * | 2009-11-17 | 2011-05-26 | Acceleron Pharma Inc. | Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
CN102802412A (zh) * | 2009-12-08 | 2012-11-28 | 海玛奎斯特医药公司 | 用于治疗红细胞病症的方法及低剂量方案 |
US20110177033A1 (en) * | 2010-01-20 | 2011-07-21 | Academia Sinica | Ras responsive element binding protein 1 (rreb1) as a therapeutic target for thalassemias and sickle cell anemia |
US20110245154A1 (en) | 2010-03-11 | 2011-10-06 | Hemaquest Pharmaceuticals, Inc. | Methods and Compositions for Treating Viral or Virally-Induced Conditions |
SG190114A1 (en) | 2010-11-05 | 2013-07-31 | Pronova Biopharma Norge As | Methods of treatment using lipid compounds |
CA2817008A1 (en) | 2010-11-08 | 2012-05-18 | Acceleron Pharma Inc. | Actriia binding agents and uses thereof |
US9018176B2 (en) | 2010-12-02 | 2015-04-28 | Susan Perrine | Inducers of hematopoiesis and fetal globin production for treatment of cytopenias and hemoglobin disorders |
ES2884095T3 (es) | 2012-11-02 | 2021-12-10 | Celgene Corp | Antagonistas de activina-actrii y usos para el tratamiento de trastornos óseos y otros trastornos |
MX2015011074A (es) | 2013-02-28 | 2016-03-09 | Pronova Biopharma Norge As | Composicion que comprende un compuesto lipido, un triglicerido y un tensioactivo, y metodos de uso de la misma. |
PE20160874A1 (es) | 2013-05-28 | 2016-09-04 | Astrazeneca Ab | Compuestos quimicos |
CA3120111A1 (en) * | 2013-08-20 | 2015-02-26 | Phoenicia Biosciences, Inc. | Chemical inducers of fetal hemoglobin |
BR122023023170A2 (pt) | 2014-06-13 | 2024-02-20 | Acceleron Pharma Inc. | Uso de um antagonista de actrii no tratamento ou prevenção de úlcera cutânea associada com beta-talassemia |
MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
WO2016065103A1 (en) | 2014-10-23 | 2016-04-28 | Arena Pharmaceuticals, Inc. | Method of treating conditions related to the pgi2 receptor |
MD4801C1 (ru) | 2014-12-03 | 2022-10-31 | Celgene Corporation | Антагонисты активина-ActRII и их применение для лечения миелодиспластических синдромов |
JP6784696B2 (ja) | 2015-04-28 | 2020-11-11 | プロノヴァ バイオファーマ ノルゲ エーエス | 硫黄を含有する構造的に強化された脂肪酸の非アルコール性脂肪性肝炎の予防及び/又は治療のための使用 |
ES2897024T3 (es) | 2017-03-01 | 2022-02-28 | Arena Pharm Inc | Composiciones que comprenden agonistas del receptor de PGI2 y procesos para la preparación de las mismas |
EP3681885B1 (en) | 2017-09-15 | 2024-02-28 | Forma Therapeutics, Inc. | Tetrahydro-imidazo quinoline compositions as cbp/p300 inhibitors |
WO2019084402A1 (en) * | 2017-10-27 | 2019-05-02 | St. Jude Children's Research Hospital | METHOD OF TREATMENT OF THALASSEMIA |
KR20200096791A (ko) | 2017-12-06 | 2020-08-13 | 바스프 에이에스 | 비알콜성 지방간염 치료용 지방산 유도체 |
WO2020006483A1 (en) | 2018-06-29 | 2020-01-02 | Forma Therapeutics, Inc. | Inhibiting creb binding protein (cbp) |
MX2021014639A (es) | 2019-05-31 | 2022-04-06 | Viracta Subsidiary Inc | Metodos para tratar canceres asociados con virus con inhibidores de la histona deacetilasa. |
US11801243B2 (en) | 2020-09-23 | 2023-10-31 | Forma Therapeutics, Inc. | Bromodomain inhibitors for androgen receptor-driven cancers |
US11795168B2 (en) | 2020-09-23 | 2023-10-24 | Forma Therapeutics, Inc. | Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP) |
CN112812006A (zh) * | 2020-12-30 | 2021-05-18 | 广州城市职业学院 | 一种对羟基苯乙酮半抗原、人工抗原及其合成方法与应用 |
WO2023069529A1 (en) | 2021-10-19 | 2023-04-27 | Akirabio, Inc. | Compositions comprising 2'-deoxycytidine analogs and use thereof for the treatment of sickle cell disease, thalassemia, and cancers |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4704402A (en) * | 1982-06-12 | 1987-11-03 | University Of Pittsburgh | Method of treating sickle cell anemia |
US5025029A (en) * | 1986-10-10 | 1991-06-18 | Children's Hospital Medical Center Of Northern California | Method for augmenting fetal hemoglobin |
GB8912700D0 (en) * | 1989-06-02 | 1989-07-19 | Shell Int Research | Herbicidal compounds |
DE68914197T2 (de) * | 1988-06-20 | 1994-11-10 | Kumiai Chemical Industry Co | Alkansäurederivate und herbizide Mittel. |
SG86966A1 (en) * | 1988-11-29 | 2002-03-19 | Childrens Hosp Medical Center | Medicament for augmenting fetal hemoglobin |
US5569675A (en) * | 1994-03-07 | 1996-10-29 | Bar Ilan University | Methods of using carboxylic acid esters to increase fetal-hemoglobin levels |
US5700640A (en) * | 1994-09-16 | 1997-12-23 | Basf Aktiengesellschaft | Inducers of gamma globin gene expression and screening assays therefor |
US5939456A (en) * | 1996-07-26 | 1999-08-17 | Perrine; Susan P. | Pulsed administration of compositions for the treatment of blood disorders |
US6231880B1 (en) * | 1997-05-30 | 2001-05-15 | Susan P. Perrine | Compositions and administration of compositions for the treatment of blood disorders |
-
2007
- 2007-05-09 AU AU2007249827A patent/AU2007249827A1/en not_active Abandoned
- 2007-05-09 EP EP07794757A patent/EP2023913A2/en not_active Withdrawn
- 2007-05-09 CA CA002652235A patent/CA2652235A1/en not_active Abandoned
- 2007-05-09 JP JP2009509866A patent/JP2009536659A/ja active Pending
- 2007-05-09 US US11/746,543 patent/US20080075692A1/en not_active Abandoned
- 2007-05-09 WO PCT/US2007/011335 patent/WO2007133653A2/en active Application Filing
- 2007-05-09 EA EA200802213A patent/EA200802213A1/ru unknown
- 2007-05-09 CN CNA2007800261090A patent/CN101489544A/zh active Pending
- 2007-05-09 BR BRPI0713096-1A patent/BRPI0713096A2/pt not_active Application Discontinuation
-
2008
- 2008-09-17 US US12/212,000 patent/US8759378B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US8759378B2 (en) | 2014-06-24 |
WO2007133653A2 (en) | 2007-11-22 |
US20090137567A1 (en) | 2009-05-28 |
JP2009536659A (ja) | 2009-10-15 |
CA2652235A1 (en) | 2007-11-22 |
WO2007133653A3 (en) | 2008-01-24 |
CN101489544A (zh) | 2009-07-22 |
US20080075692A1 (en) | 2008-03-27 |
EP2023913A2 (en) | 2009-02-18 |
BRPI0713096A2 (pt) | 2012-10-16 |
AU2007249827A1 (en) | 2007-11-22 |
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