BRPI0515477A - derivados heterocìclicos bicìclicos e o uso dos mesmos como inibidores de estaroil-coa-desaturase (scd) - Google Patents

derivados heterocìclicos bicìclicos e o uso dos mesmos como inibidores de estaroil-coa-desaturase (scd)

Info

Publication number
BRPI0515477A
BRPI0515477A BRPI0515477-4A BRPI0515477A BRPI0515477A BR PI0515477 A BRPI0515477 A BR PI0515477A BR PI0515477 A BRPI0515477 A BR PI0515477A BR PI0515477 A BRPI0515477 A BR PI0515477A
Authority
BR
Brazil
Prior art keywords
scd
inhibitors
stooyl
coa desaturase
bicyclic heterocyclic
Prior art date
Application number
BRPI0515477-4A
Other languages
English (en)
Inventor
Rajender Kamboj
Jian-Min Fu
Vishnumurthy Kodumuru
Shifeng Liu
Kashinath Sadalapure
Nagasree Chakka
Duanjie Hou
Shaoyi Sun
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of BRPI0515477A publication Critical patent/BRPI0515477A/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

DERIVADOS HETEROCìCLICOS BICìCLICOS E O USO DOS MESMOS COMO INIBIDORES DE ESTAROIL-COA-DESATURASE (SCD) Métodos de tratamento de uma doença ou condição mórbida mediada a SCD em um mamífero, de forma preterida ser humano, são descritos, onde os métodos compreendem, por exemplo, administrar a um mamífero em necessidade do mesmo um composto de fórmula (I): onde x, y, k, L, M, W, V, R¬ 2¬, R¬ 3¬, R¬ 4¬, R¬ 5a¬, R¬ 6a¬,R¬ 7a¬, R¬ 8a¬ são definidos aqui. As composições farmacêuticas que compreendem os compostos de fórmula (I) são descritas.
BRPI0515477-4A 2004-09-20 2005-09-20 derivados heterocìclicos bicìclicos e o uso dos mesmos como inibidores de estaroil-coa-desaturase (scd) BRPI0515477A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61164604P 2004-09-20 2004-09-20
PCT/US2005/033738 WO2006034312A1 (en) 2004-09-20 2005-09-20 Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-coa-desaturase (scd)

Publications (1)

Publication Number Publication Date
BRPI0515477A true BRPI0515477A (pt) 2008-07-22

Family

ID=35623357

Family Applications (1)

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BRPI0515477-4A BRPI0515477A (pt) 2004-09-20 2005-09-20 derivados heterocìclicos bicìclicos e o uso dos mesmos como inibidores de estaroil-coa-desaturase (scd)

Country Status (11)

Country Link
US (2) US7547698B2 (pt)
EP (1) EP1804792A1 (pt)
JP (2) JP5080256B2 (pt)
CN (1) CN101083986A (pt)
AR (1) AR051294A1 (pt)
AU (1) AU2005286790A1 (pt)
BR (1) BRPI0515477A (pt)
CA (1) CA2580781A1 (pt)
MX (1) MX2007003329A (pt)
TW (1) TW200626148A (pt)
WO (1) WO2006034312A1 (pt)

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US7547698B2 (en) 2009-06-16
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AU2005286790A1 (en) 2006-03-30
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