MX2012012902A - Analogos heteroarilo biciclicos como moduladores de receptor acoplado a la proteina g gpr119. - Google Patents

Analogos heteroarilo biciclicos como moduladores de receptor acoplado a la proteina g gpr119.

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Publication number
MX2012012902A
MX2012012902A MX2012012902A MX2012012902A MX2012012902A MX 2012012902 A MX2012012902 A MX 2012012902A MX 2012012902 A MX2012012902 A MX 2012012902A MX 2012012902 A MX2012012902 A MX 2012012902A MX 2012012902 A MX2012012902 A MX 2012012902A
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Mexico
Prior art keywords
gpr119
protein
novel compounds
coupled receptor
bicyclic heteroaryl
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Application number
MX2012012902A
Other languages
English (en)
Inventor
Ying Wang
Jeffrey A Robl
Dean A Wacker
Xiang-Yang Ye
Original Assignee
Bristol Myers Squibb Co
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Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2012012902A publication Critical patent/MX2012012902A/es

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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/00—Drugs for disorders of the metabolism
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

La presente invención se refiere a compuestos novedosos de estructura de Fórmula I: (Ver Formula) o un enantiómero, diastereómero, tautómero, profármaco o sal de los mismos, en donde A, D, D1, E, J, L, n, Q, R2 y R4 están definidos en el presente documento, que son moduladores del receptor acoplado a proteína G GPR119. Los moduladores del receptor acoplado a proteína G GPR119 son útiles para tratar, prevenir o ralentizar la progresión de enfermedades que necesitan de terapia moduladora del receptor acoplado a proteína G GPR119. Por tanto, la descripción también se refiere a composiciones que comprenden estos compuestos novedosos y a procedimientos para tratar enfermedades o afecciones relacionadas con la actividad del receptor acoplado a proteína G GPR119 mediante el uso de cualquiera de estos compuestos novedosos o una composición que comprende cualquiera de estos compuestos novedosos.
MX2012012902A 2010-05-06 2011-05-04 Analogos heteroarilo biciclicos como moduladores de receptor acoplado a la proteina g gpr119. MX2012012902A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33186410P 2010-05-06 2010-05-06
PCT/US2011/035086 WO2011140160A1 (en) 2010-05-06 2011-05-04 Bicyclic heteroaryl compounds as gpr119 modulators

Publications (1)

Publication Number Publication Date
MX2012012902A true MX2012012902A (es) 2012-12-17

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Country Status (10)

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US (1) US8940716B2 (es)
EP (1) EP2566860B1 (es)
JP (1) JP2013525489A (es)
CN (1) CN102971311B (es)
BR (1) BR112012028445A2 (es)
CA (1) CA2798610A1 (es)
EA (1) EA201270778A1 (es)
MX (1) MX2012012902A (es)
TW (1) TW201144306A (es)
WO (1) WO2011140160A1 (es)

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CA2798610A1 (en) 2011-11-10
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JP2013525489A (ja) 2013-06-20
EA201270778A1 (ru) 2013-04-30
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US20130053345A1 (en) 2013-02-28
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