MX2015018048A - Compuestos de benzofuranilo y benzoxazolilo sustituídos, y sus usos. - Google Patents

Compuestos de benzofuranilo y benzoxazolilo sustituídos, y sus usos.

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Publication number
MX2015018048A
MX2015018048A MX2015018048A MX2015018048A MX2015018048A MX 2015018048 A MX2015018048 A MX 2015018048A MX 2015018048 A MX2015018048 A MX 2015018048A MX 2015018048 A MX2015018048 A MX 2015018048A MX 2015018048 A MX2015018048 A MX 2015018048A
Authority
MX
Mexico
Prior art keywords
substituted benzofuranyl
benzoxazolyl compounds
substituted
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
MX2015018048A
Other languages
English (en)
Other versions
MX367618B (es
Inventor
Shacham Sharon
Mccauley Dilara
Landesman Yosef
Golan Gali
Kalid Ori
Shechter Sharon
Senapedis William
Baloglu Erkan
Original Assignee
Karyopharm Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karyopharm Therapeutics Inc filed Critical Karyopharm Therapeutics Inc
Publication of MX2015018048A publication Critical patent/MX2015018048A/es
Publication of MX367618B publication Critical patent/MX367618B/es

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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Abstract

La invención se refiere generalmente a compuestos de benzofuranilo sustituido y benzoxazolilo sustituido y más particularmente a un compuesto representado por la Fórmula Estructural A: (ver Fórmula) o una sal farmacéuticamente aceptable de este, donde las variables son las que se definen y describen en la presente. La invención incluye también la síntesis y el uso de un compuesto de la Fórmula Estructural A, o una sal farmacéuticamente aceptable o composición de este, por ejemplo, en el tratamiento del cáncer (por ejemplo, linfoma de células del manto), y otras enfermedades y trastornos.
MX2015018048A 2013-07-03 2014-07-03 Compuestos de benzofuranilo y benzoxazolilo sustituídos, y sus usos. MX367618B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361842856P 2013-07-03 2013-07-03
US201361879070P 2013-09-17 2013-09-17
US201361904843P 2013-11-15 2013-11-15
US201461975171P 2014-04-04 2014-04-04
PCT/US2014/045479 WO2015003166A1 (en) 2013-07-03 2014-07-03 Substituted benzofuranyl and benzoxazolyl compounds and uses thereof

Publications (2)

Publication Number Publication Date
MX2015018048A true MX2015018048A (es) 2016-12-02
MX367618B MX367618B (es) 2019-08-28

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