DE60134995D1 - Verfahren und zusammensetzungen, die eine stearoyl-coa desuturase-hscd5 verwenden - Google Patents

Verfahren und zusammensetzungen, die eine stearoyl-coa desuturase-hscd5 verwenden

Info

Publication number
DE60134995D1
DE60134995D1 DE60134995T DE60134995T DE60134995D1 DE 60134995 D1 DE60134995 D1 DE 60134995D1 DE 60134995 T DE60134995 T DE 60134995T DE 60134995 T DE60134995 T DE 60134995T DE 60134995 D1 DE60134995 D1 DE 60134995D1
Authority
DE
Germany
Prior art keywords
hscd5
coa
desuturase
stearoyl
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60134995T
Other languages
English (en)
Inventor
Alison Brownlie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xenon Pharmaceuticals Inc
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Application granted granted Critical
Publication of DE60134995D1 publication Critical patent/DE60134995D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Seasonings (AREA)
  • Saccharide Compounds (AREA)
DE60134995T 2000-09-26 2001-09-26 Verfahren und zusammensetzungen, die eine stearoyl-coa desuturase-hscd5 verwenden Expired - Fee Related DE60134995D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23564000P 2000-09-26 2000-09-26
PCT/CA2001/001354 WO2002026944A2 (en) 2000-09-26 2001-09-26 METHODS AND COMPOSITIONS EMPLOYING A NOVEL STEAROYL-CoA DESATURASE-hSCD5

Publications (1)

Publication Number Publication Date
DE60134995D1 true DE60134995D1 (de) 2008-09-04

Family

ID=22886344

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60134995T Expired - Fee Related DE60134995D1 (de) 2000-09-26 2001-09-26 Verfahren und zusammensetzungen, die eine stearoyl-coa desuturase-hscd5 verwenden

Country Status (7)

Country Link
US (2) US7232662B2 (de)
EP (1) EP1322767B1 (de)
AT (1) ATE402262T1 (de)
AU (1) AU2001289457A1 (de)
CA (1) CA2430987A1 (de)
DE (1) DE60134995D1 (de)
WO (1) WO2002026944A2 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2430987A1 (en) * 2000-09-26 2002-04-04 Xenon Genetics, Inc. Methods and compositions employing a novel stearoyl-coa desaturase-hscd5
PT2266558T (pt) 2001-06-07 2017-07-21 Analgesic Neuropharmaceuticals Llc Tratamento da dor neuropática com o antagonista dos recetores de n-metil-d-aspartato (nmda) dextrometorfano
US7390813B1 (en) 2001-12-21 2008-06-24 Xenon Pharmaceuticals Inc. Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
WO2003074674A2 (en) 2002-03-01 2003-09-12 Exelixis, Inc. MSRAs AS MODIFIERS OF THE p53 PATHWAY AND METHODS OF USE
ES2375134T3 (es) 2003-07-30 2012-02-27 Xenon Pharmaceuticals Inc. Derivados de piperazina y su uso como agentes terapéuticos.
SG145699A1 (en) 2003-07-30 2008-09-29 Xenon Pharmaceuticals Inc Pyridazine derivatives and their use as therapeutic agents
KR20060037409A (ko) 2003-07-30 2006-05-03 제논 파마슈티칼스 인크. 피페라진 유도체 및 그의 치료제로서의 용도
US7754711B2 (en) 2003-07-30 2010-07-13 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
CA2533900A1 (en) 2003-07-30 2005-02-10 Xenon Pharmaceuticals Inc. Pyridyl derivatives and their use as therapeutic agents
MX2007003321A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como agentes terapeuticos.
US7547698B2 (en) 2004-09-20 2009-06-16 Xenon Pharmaceuticals Inc. Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-coadesaturase (SCD)
DE602005025924D1 (en) 2004-09-20 2011-02-24 Xenon Pharmaceuticals Inc Royl-coa-desaturase
US7829712B2 (en) 2004-09-20 2010-11-09 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase
EP1807085B1 (de) 2004-09-20 2013-08-21 Xenon Pharmaceuticals Inc. Heterozyklische Derivate und ihre Verwendung als Stearoyl-Coa-Desaturase-Inhibitoren
AU2005329423A1 (en) 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
JP5094398B2 (ja) 2004-09-20 2012-12-12 ゼノン・ファーマシューティカルズ・インコーポレイテッド 複素環式誘導体およびステアロイル−ＣｏＡデサチュラーゼのメディエータとしてのそれらの使用
CN101084207A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途
CN101208089A (zh) 2005-06-03 2008-06-25 泽农医药公司 氨基噻唑衍生物作为人硬酯酰-CoA去饱和酶抑制剂
US20060281071A1 (en) * 2005-06-08 2006-12-14 Ntambi James M Stearoyl-CoA desaturase assay
WO2007143597A2 (en) 2006-06-05 2007-12-13 Novartis Ag Organic compounds
CN101506203B (zh) 2006-08-24 2013-10-16 诺瓦提斯公司 治疗代谢病、心血管病和其他病症的作为硬脂酰辅酶a脱饱和酶(scd)抑制剂的2-(吡嗪-2-基)-噻唑和2-(1h-吡唑-3-基)-噻唑衍生物及相关化合物
RU2009111266A (ru) * 2006-08-29 2010-10-10 Коммонвелт Сайентифик энд Индастриал Рисерч Организейшн (AU) Синтез жирных кислот
GB0722077D0 (en) 2007-11-09 2007-12-19 Smithkline Beecham Corp Compounds
NZ588633A (en) 2008-03-20 2012-03-30 Forest Lab Holdings Ltd NOVEL PIPERIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE
JP2011525478A (ja) 2008-03-20 2011-09-22 フォレスト・ラボラトリーズ・ホールディングス・リミテッド ステアロイル−ＣｏＡデサチュラーゼの阻害剤としての新規ピペラジン誘導体
WO2009156484A2 (en) 2008-06-27 2009-12-30 Novartis Ag Organic compounds
CN102317459A (zh) 2008-11-18 2012-01-11 联邦科学技术研究组织 产生ω-3脂肪酸的酶和方法
US8119885B2 (en) * 2009-03-31 2012-02-21 Monsanto Technology Llc Plants and seeds of corn variety CV597869
WO2011039358A1 (en) 2009-10-01 2011-04-07 Novartis Ag Pyrazole derivatives which modulate stearoyl-coa desaturase
NZ631702A (en) 2012-06-15 2017-01-27 Grains Res & Dev Corp Production of long chain polyunsaturated fatty acids in plant cells
US9725399B2 (en) 2013-12-18 2017-08-08 Commonwealth Scientific And Industrial Research Organisation Lipid comprising long chain polyunsaturated fatty acids
KR102527795B1 (ko) 2014-06-27 2023-05-02 커먼웰쓰 사이언티픽 앤 인더스트리알 리서치 오거니제이션 도코사펜타에노산을 포함하는 지질

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ219230A (en) 1986-02-14 1991-06-25 Medeva Plc Method of modifying cell membranes by using c12 - c28 saturated fatty acids
JP3070611B2 (ja) * 1989-03-07 2000-07-31 サントリー株式会社 △▲上５▼―不飽和化酵素阻害剤
GB2237018A (en) 1989-08-18 1991-04-24 Medeva Plc Secondary alcohols and compositions containing fatty acids or esters
AU659087B2 (en) * 1990-05-25 1995-05-11 E.I. Du Pont De Nemours And Company Nucleotide sequence of soybean stearoyl-ACP desaturase gene
US5861485A (en) 1994-08-23 1999-01-19 Millennium Pharmaceuticals, Inc. Polypeptides involved in body weight disorders, including obesity
EP1100511A2 (de) 1998-06-08 2001-05-23 Sambasiva R. Chavali Inhibierung der delta-9-desaturase wirkung mit saponinen
AU5774699A (en) 1998-08-14 2000-03-06 Johnson & Johnson Consumer Companies, Inc. Human stearoyl-coa desaturase-related compositions and methods for treating skin disorders
ATE475718T1 (de) 2000-02-24 2010-08-15 Xenon Pharmaceuticals Inc Stearoyl-coa-desaturase zur identifizierung von triglyceridreduktionstherapeutika
US6686185B1 (en) * 2000-03-07 2004-02-03 Millennium Pharmaceuticals, Inc. 25934, a novel fatty acid desaturase and uses therefor
CA2430987A1 (en) * 2000-09-26 2002-04-04 Xenon Genetics, Inc. Methods and compositions employing a novel stearoyl-coa desaturase-hscd5

Also Published As

Publication number Publication date
EP1322767B1 (de) 2008-07-23
WO2002026944A2 (en) 2002-04-04
AU2001289457A8 (en) 2007-09-20
AU2001289457A1 (en) 2002-04-08
CA2430987A1 (en) 2002-04-04
ATE402262T1 (de) 2008-08-15
US20070238648A1 (en) 2007-10-11
US7232662B2 (en) 2007-06-19
US20040091988A1 (en) 2004-05-13
WO2002026944A3 (en) 2002-10-03
WO2002026944A9 (en) 2007-08-23
US7435559B2 (en) 2008-10-14
EP1322767A2 (de) 2003-07-02

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Legal Events

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8339 Ceased/non-payment of the annual fee