MA27608A1 - Derives d'hydroxyethylamine utilises pour le traitement de la maladie d'alzheimer - Google Patents
Derives d'hydroxyethylamine utilises pour le traitement de la maladie d'alzheimerInfo
- Publication number
- MA27608A1 MA27608A1 MA28368A MA28368A MA27608A1 MA 27608 A1 MA27608 A1 MA 27608A1 MA 28368 A MA28368 A MA 28368A MA 28368 A MA28368 A MA 28368A MA 27608 A1 MA27608 A1 MA 27608A1
- Authority
- MA
- Morocco
- Prior art keywords
- disease
- treatment
- alzheimer
- beta
- hydroxyethylamine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
NOUVEAUX COMPOSES La présente invention concerne de nouveaux composés hydroxyéthylamine possédant une activité inhibitrice de l'Asp2 ((bêta)-sécrétase, BACE1 ou Mémapsine), des procédés pour leur préparation, des compositions les contenant et leur utilisation dans le traitement de maladies caractérisées par des concentrations en ((bêta)-amyloïdes ou dépôts de (bêta)-amyloïdes élevé(e)s, en particulier, la maladie d'Alzheimer.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0228410.7A GB0228410D0 (en) | 2002-12-05 | 2002-12-05 | Novel Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MA27608A1 true MA27608A1 (fr) | 2005-11-01 |
Family
ID=9949141
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA28368A MA27608A1 (fr) | 2002-12-05 | 2005-07-01 | Derives d'hydroxyethylamine utilises pour le traitement de la maladie d'alzheimer |
Country Status (25)
Country | Link |
---|---|
US (1) | US7253198B2 (fr) |
EP (1) | EP1567488B1 (fr) |
JP (1) | JP2006514634A (fr) |
KR (1) | KR20050084143A (fr) |
CN (1) | CN1735592A (fr) |
AT (1) | ATE354565T1 (fr) |
AU (1) | AU2003292198B2 (fr) |
BR (1) | BR0317020A (fr) |
CA (1) | CA2508325A1 (fr) |
DE (1) | DE60312031T2 (fr) |
DK (1) | DK1567488T3 (fr) |
ES (1) | ES2282685T3 (fr) |
GB (1) | GB0228410D0 (fr) |
HK (1) | HK1083624A1 (fr) |
IS (1) | IS7925A (fr) |
MA (1) | MA27608A1 (fr) |
MX (1) | MXPA05006088A (fr) |
NO (1) | NO20053263L (fr) |
NZ (1) | NZ539841A (fr) |
PL (1) | PL377587A1 (fr) |
PT (1) | PT1567488E (fr) |
RU (1) | RU2005121146A (fr) |
SI (1) | SI1567488T1 (fr) |
WO (1) | WO2004050619A1 (fr) |
ZA (1) | ZA200503693B (fr) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0314302D0 (en) * | 2003-06-19 | 2003-07-23 | Glaxo Group Ltd | Novel compounds |
GB0328900D0 (en) * | 2003-12-12 | 2004-01-14 | Glaxo Group Ltd | Novel compounds |
US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
CA2548849A1 (fr) * | 2003-12-19 | 2005-07-21 | Merck & Co., Inc. | Inhibiteurs de phenylamide et de pyridylamide de la beta-secretase, traitant la maladie d'alzheimer |
WO2005087752A2 (fr) * | 2004-03-09 | 2005-09-22 | Elan Pharmaceuticals, Inc. | Aspartyle a base d'hydroxyethylamine inhibiteurs de la protease |
EP1734942A1 (fr) * | 2004-03-09 | 2006-12-27 | Elan Pharmaceuticals, Inc. | Uree et carbamate substitues, phenacyl-2-hydroxy-3-diaminoalcane, et benzamide-2-hydroxy-3-diaminoalcane inhibiteurs d'aspartyl-protease |
CA2558034A1 (fr) | 2004-03-09 | 2005-09-22 | Elan Pharmaceuticals, Inc. | Aspartyle a base d'hydroxyethylamine substitue inhibiteurs de la protease |
EP1734961A2 (fr) * | 2004-03-09 | 2006-12-27 | Elan Pharmaceuticals, Inc. | Procedes de traitement de l'amylose mettant en oeuvre des inhibiteurs de la protease a base d'aspartyle bicyclique |
AU2005236020A1 (en) | 2004-04-20 | 2005-11-03 | Merck & Co., Inc. | 1,3,5-substituted phenyl derivative compounds useful as beta-secretase inhibitors for the treatment of Alzheimer's disease |
CA2563639A1 (fr) | 2004-04-20 | 2005-11-03 | Merck & Co., Inc. | Composes derives de pyridyle substitues aux positions 2, 4, 6 utiles comme inhibiteurs de la beta-secretase dans le traitement de la maladie d'alzheimer |
GB0411404D0 (en) * | 2004-05-21 | 2004-06-23 | Glaxo Group Ltd | Novel compounds |
CA2572775A1 (fr) * | 2004-07-09 | 2006-01-26 | Elan Pharmaceuticals, Inc. | Inhibiteurs d'aspartyl-protease d'hydroxyethylamine derivee des oximes |
CA2573138A1 (fr) | 2004-07-09 | 2006-01-26 | Elan Pharmaceuticals Inc. | Inhibiteurs d'une aspartyl protease de type hydroxyethylamine substituee par un derive d'oxime |
EP1797052A1 (fr) * | 2004-09-17 | 2007-06-20 | Comentis, Inc. | Composes bicycliques inhibant l'activite de la beta-secretase et procedes d'utilisation associes |
JP2008513432A (ja) | 2004-09-21 | 2008-05-01 | ファイザー・プロダクツ・インク | Cns状態の治療に有用なn−メチルヒドロキシエチルアミン |
EP1794115A2 (fr) * | 2004-09-21 | 2007-06-13 | Pfizer Products Incorporated | N-ethyl hydroxyethylamine utile dans le traitement d'affections du systeme nerveux central |
WO2006043710A1 (fr) * | 2004-10-19 | 2006-04-27 | Reverse Proteomics Research Institute Co., Ltd. | Protéine cible et gène cible pour le développement de médicaments et procédé de recherche par criblage |
US8394837B2 (en) | 2004-11-23 | 2013-03-12 | Merck, Sharp & Dohme, Corp. | 2,3,4,6-substituted pyridyl derivative compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease |
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US7662824B2 (en) | 2005-03-18 | 2010-02-16 | Janssen Pharmaceutica Nv | Acylhydrazones as kinase modulators |
CA2604291A1 (fr) | 2005-04-08 | 2006-10-19 | Comentis, Inc. | Composes inhibant l'activite beta-secretase et leurs methodes d'utilisation |
US7476764B2 (en) | 2005-08-04 | 2009-01-13 | Bristol-Myers Squibb Company | Phenylcarboxyamides as beta-secretase inhibitors |
WO2007047305A1 (fr) | 2005-10-12 | 2007-04-26 | Elan Pharmaceuticals, Inc. | Procedes de traitement de l'amyloïdose en utilisant des derives de cyclopropyle inhibiteurs de l'aspartyle-protease |
US7872009B2 (en) * | 2005-11-21 | 2011-01-18 | Amgen Inc. | Beta-Secretase modulators and methods of use |
US7745484B2 (en) * | 2005-11-21 | 2010-06-29 | Amgen Inc. | Beta-secretase modulators and methods of use |
US7838676B2 (en) * | 2005-11-21 | 2010-11-23 | Amgen Inc. | Beta-secretase modulators and methods of use |
CA2629402C (fr) | 2005-11-21 | 2011-07-26 | Amgen Inc. | Modulateurs de beta-secretase et procedes d'utilisation associes |
CA2678577A1 (fr) * | 2007-02-26 | 2008-09-04 | Vitae Pharmaceuticals, Inc. | Inhibiteurs d'uree et de carbamate de 11b-hydroxysteroide deshydrogenase 1 cycliques |
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KR101849680B1 (ko) * | 2009-12-10 | 2018-04-17 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 아밀로이드 결합제 |
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CN110372628B (zh) * | 2019-07-09 | 2021-04-02 | 武汉大学 | 内磺酰胺类化合物及其制备方法 |
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2002
- 2002-12-05 GB GBGB0228410.7A patent/GB0228410D0/en not_active Ceased
-
2003
- 2003-12-03 PT PT03767756T patent/PT1567488E/pt unknown
- 2003-12-03 DK DK03767756T patent/DK1567488T3/da active
- 2003-12-03 CN CNA2003801085153A patent/CN1735592A/zh active Pending
- 2003-12-03 MX MXPA05006088A patent/MXPA05006088A/es active IP Right Grant
- 2003-12-03 US US10/536,303 patent/US7253198B2/en not_active Expired - Fee Related
- 2003-12-03 DE DE60312031T patent/DE60312031T2/de not_active Expired - Fee Related
- 2003-12-03 PL PL377587A patent/PL377587A1/pl not_active Application Discontinuation
- 2003-12-03 AU AU2003292198A patent/AU2003292198B2/en not_active Ceased
- 2003-12-03 BR BR0317020-9A patent/BR0317020A/pt unknown
- 2003-12-03 WO PCT/EP2003/013806 patent/WO2004050619A1/fr active IP Right Grant
- 2003-12-03 ES ES03767756T patent/ES2282685T3/es not_active Expired - Lifetime
- 2003-12-03 JP JP2004556305A patent/JP2006514634A/ja not_active Withdrawn
- 2003-12-03 KR KR1020057010104A patent/KR20050084143A/ko not_active Application Discontinuation
- 2003-12-03 CA CA002508325A patent/CA2508325A1/fr not_active Abandoned
- 2003-12-03 AT AT03767756T patent/ATE354565T1/de not_active IP Right Cessation
- 2003-12-03 RU RU2005121146/04A patent/RU2005121146A/ru not_active Application Discontinuation
- 2003-12-03 EP EP03767756A patent/EP1567488B1/fr not_active Expired - Lifetime
- 2003-12-03 SI SI200330793T patent/SI1567488T1/sl unknown
- 2003-12-03 NZ NZ539841A patent/NZ539841A/xx unknown
-
2005
- 2005-05-09 ZA ZA200503693A patent/ZA200503693B/en unknown
- 2005-06-30 IS IS7925A patent/IS7925A/is unknown
- 2005-07-01 MA MA28368A patent/MA27608A1/fr unknown
- 2005-07-04 NO NO20053263A patent/NO20053263L/no not_active Application Discontinuation
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2006
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Also Published As
Publication number | Publication date |
---|---|
SI1567488T1 (sl) | 2007-08-31 |
EP1567488A1 (fr) | 2005-08-31 |
AU2003292198A1 (en) | 2004-06-23 |
NO20053263D0 (no) | 2005-07-04 |
CA2508325A1 (fr) | 2004-06-17 |
DE60312031D1 (de) | 2007-04-05 |
NO20053263L (no) | 2005-08-31 |
PT1567488E (pt) | 2007-05-31 |
JP2006514634A (ja) | 2006-05-11 |
ATE354565T1 (de) | 2007-03-15 |
CN1735592A (zh) | 2006-02-15 |
PL377587A1 (pl) | 2006-02-06 |
HK1083624A1 (en) | 2006-07-07 |
AU2003292198B2 (en) | 2007-09-06 |
DK1567488T3 (da) | 2007-06-18 |
ZA200503693B (en) | 2008-01-30 |
EP1567488B1 (fr) | 2007-02-21 |
US20060025459A1 (en) | 2006-02-02 |
KR20050084143A (ko) | 2005-08-26 |
IS7925A (is) | 2005-06-30 |
NZ539841A (en) | 2007-11-30 |
RU2005121146A (ru) | 2006-01-20 |
MXPA05006088A (es) | 2005-08-16 |
BR0317020A (pt) | 2005-10-25 |
US7253198B2 (en) | 2007-08-07 |
GB0228410D0 (en) | 2003-01-08 |
DE60312031T2 (de) | 2007-11-22 |
ES2282685T3 (es) | 2007-10-16 |
WO2004050619A1 (fr) | 2004-06-17 |
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