SI1567488T1 - Derivati hidroksietilamina za zdravljenje alzheimerjeve bolezni - Google Patents
Derivati hidroksietilamina za zdravljenje alzheimerjeve bolezniInfo
- Publication number
- SI1567488T1 SI1567488T1 SI200330793T SI200330793T SI1567488T1 SI 1567488 T1 SI1567488 T1 SI 1567488T1 SI 200330793 T SI200330793 T SI 200330793T SI 200330793 T SI200330793 T SI 200330793T SI 1567488 T1 SI1567488 T1 SI 1567488T1
- Authority
- SI
- Slovenia
- Prior art keywords
- disease
- treatment
- alzheimer
- beta
- hydroxyethylamine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0228410.7A GB0228410D0 (en) | 2002-12-05 | 2002-12-05 | Novel Compounds |
PCT/EP2003/013806 WO2004050619A1 (en) | 2002-12-05 | 2003-12-03 | Hydroxyethylamine derivatives for the treatment of alzheimer's disease |
EP03767756A EP1567488B1 (en) | 2002-12-05 | 2003-12-03 | Hydroxyethylamine derivatives for the treatment of alzheimer's disease |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1567488T1 true SI1567488T1 (sl) | 2007-08-31 |
Family
ID=9949141
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200330793T SI1567488T1 (sl) | 2002-12-05 | 2003-12-03 | Derivati hidroksietilamina za zdravljenje alzheimerjeve bolezni |
Country Status (25)
Country | Link |
---|---|
US (1) | US7253198B2 (sl) |
EP (1) | EP1567488B1 (sl) |
JP (1) | JP2006514634A (sl) |
KR (1) | KR20050084143A (sl) |
CN (1) | CN1735592A (sl) |
AT (1) | ATE354565T1 (sl) |
AU (1) | AU2003292198B2 (sl) |
BR (1) | BR0317020A (sl) |
CA (1) | CA2508325A1 (sl) |
DE (1) | DE60312031T2 (sl) |
DK (1) | DK1567488T3 (sl) |
ES (1) | ES2282685T3 (sl) |
GB (1) | GB0228410D0 (sl) |
HK (1) | HK1083624A1 (sl) |
IS (1) | IS7925A (sl) |
MA (1) | MA27608A1 (sl) |
MX (1) | MXPA05006088A (sl) |
NO (1) | NO20053263L (sl) |
NZ (1) | NZ539841A (sl) |
PL (1) | PL377587A1 (sl) |
PT (1) | PT1567488E (sl) |
RU (1) | RU2005121146A (sl) |
SI (1) | SI1567488T1 (sl) |
WO (1) | WO2004050619A1 (sl) |
ZA (1) | ZA200503693B (sl) |
Families Citing this family (83)
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GB0314302D0 (en) * | 2003-06-19 | 2003-07-23 | Glaxo Group Ltd | Novel compounds |
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US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
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JP2007528400A (ja) | 2004-03-09 | 2007-10-11 | エラン ファーマシューティカルズ,インコーポレイテッド | 置換ヒドロキシエチルアミン系のアスパラギン酸プロテアーゼ阻害薬 |
WO2005087714A2 (en) * | 2004-03-09 | 2005-09-22 | Elan Pharmaceuticals, Inc. | Methods of treatment of amyloidosis using bi-cyclic aspartyl protease inhibitors |
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EP1735293A2 (en) * | 2004-03-09 | 2006-12-27 | Elan Pharmaceuticals, Inc. | Substituted hydroxyethylamine aspartyl protease inhibitors |
US7847100B2 (en) | 2004-04-20 | 2010-12-07 | Merck, Sharp & Dohme, Inc. | 1,3,5-substituted phenyl derivative compounds useful as beta-secretase inhibitors for the treatment of Alzheimer's disease |
AU2005236063A1 (en) | 2004-04-20 | 2005-11-03 | Merck & Co., Inc. | 2, 4, 6-substituted pyridyl derivative compounds useful as beta-secretase inhibitors for the treatment of Alzheimer's disease |
GB0411404D0 (en) * | 2004-05-21 | 2004-06-23 | Glaxo Group Ltd | Novel compounds |
EP1773758A1 (en) * | 2004-07-09 | 2007-04-18 | Elan Pharmaceuticals, Inc. | Oxime derivative hydroxyethylamine aspartyl-protease inhibitors |
US7385085B2 (en) | 2004-07-09 | 2008-06-10 | Elan Pharmaceuticals, Inc. | Oxime derivative substituted hydroxyethylamine aspartyl protease inhibitors |
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CA2581023A1 (en) | 2004-09-21 | 2006-03-30 | Pfizer Products Inc. | N-methyl hydroxyethylamine useful in treating cns conditions |
US20070213368A1 (en) * | 2004-09-21 | 2007-09-13 | Kleinman Edward F | N-ethyl hydroxyethylamine useful in treating cns conditions |
JPWO2006043710A1 (ja) * | 2004-10-19 | 2008-05-22 | 株式会社リバース・プロテオミクス研究所 | 創薬標的タンパク質及び標的遺伝子、並びにスクリーニング方法 |
US8394837B2 (en) | 2004-11-23 | 2013-03-12 | Merck, Sharp & Dohme, Corp. | 2,3,4,6-substituted pyridyl derivative compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease |
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DE102011000683A1 (de) | 2011-02-11 | 2012-08-16 | Huf Hülsbeck & Fürst Gmbh & Co. Kg | Montagebaugruppe zur vereinfachten Montage am Fahrzeug |
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CN102336672B (zh) * | 2011-09-21 | 2014-06-18 | 浙江建业化工股份有限公司 | 生产异戊胺的方法 |
WO2013055386A2 (en) | 2011-10-03 | 2013-04-18 | The University Of Utah Research Foundation | Application of 5-ht6 receptor antagonists for the alleviation of cognitive deficits of down syndrome |
CN103508957B (zh) * | 2012-06-25 | 2017-02-08 | 中国科学院上海药物研究所 | 羟乙基吡唑类化合物或氨乙基吡唑类化合物及其制备方法和用途 |
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2002
- 2002-12-05 GB GBGB0228410.7A patent/GB0228410D0/en not_active Ceased
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2003
- 2003-12-03 BR BR0317020-9A patent/BR0317020A/pt unknown
- 2003-12-03 SI SI200330793T patent/SI1567488T1/sl unknown
- 2003-12-03 EP EP03767756A patent/EP1567488B1/en not_active Expired - Lifetime
- 2003-12-03 KR KR1020057010104A patent/KR20050084143A/ko not_active Application Discontinuation
- 2003-12-03 PL PL377587A patent/PL377587A1/pl not_active Application Discontinuation
- 2003-12-03 DK DK03767756T patent/DK1567488T3/da active
- 2003-12-03 CA CA002508325A patent/CA2508325A1/en not_active Abandoned
- 2003-12-03 US US10/536,303 patent/US7253198B2/en not_active Expired - Fee Related
- 2003-12-03 JP JP2004556305A patent/JP2006514634A/ja not_active Withdrawn
- 2003-12-03 WO PCT/EP2003/013806 patent/WO2004050619A1/en active IP Right Grant
- 2003-12-03 AU AU2003292198A patent/AU2003292198B2/en not_active Ceased
- 2003-12-03 CN CNA2003801085153A patent/CN1735592A/zh active Pending
- 2003-12-03 ES ES03767756T patent/ES2282685T3/es not_active Expired - Lifetime
- 2003-12-03 PT PT03767756T patent/PT1567488E/pt unknown
- 2003-12-03 NZ NZ539841A patent/NZ539841A/xx unknown
- 2003-12-03 MX MXPA05006088A patent/MXPA05006088A/es active IP Right Grant
- 2003-12-03 AT AT03767756T patent/ATE354565T1/de not_active IP Right Cessation
- 2003-12-03 RU RU2005121146/04A patent/RU2005121146A/ru not_active Application Discontinuation
- 2003-12-03 DE DE60312031T patent/DE60312031T2/de not_active Expired - Fee Related
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2005
- 2005-05-09 ZA ZA200503693A patent/ZA200503693B/en unknown
- 2005-06-30 IS IS7925A patent/IS7925A/is unknown
- 2005-07-01 MA MA28368A patent/MA27608A1/fr unknown
- 2005-07-04 NO NO20053263A patent/NO20053263L/no not_active Application Discontinuation
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Also Published As
Publication number | Publication date |
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ATE354565T1 (de) | 2007-03-15 |
RU2005121146A (ru) | 2006-01-20 |
US7253198B2 (en) | 2007-08-07 |
NO20053263L (no) | 2005-08-31 |
US20060025459A1 (en) | 2006-02-02 |
KR20050084143A (ko) | 2005-08-26 |
EP1567488A1 (en) | 2005-08-31 |
BR0317020A (pt) | 2005-10-25 |
ZA200503693B (en) | 2008-01-30 |
MA27608A1 (fr) | 2005-11-01 |
MXPA05006088A (es) | 2005-08-16 |
WO2004050619A1 (en) | 2004-06-17 |
DE60312031D1 (de) | 2007-04-05 |
ES2282685T3 (es) | 2007-10-16 |
NO20053263D0 (no) | 2005-07-04 |
PL377587A1 (pl) | 2006-02-06 |
GB0228410D0 (en) | 2003-01-08 |
DE60312031T2 (de) | 2007-11-22 |
CN1735592A (zh) | 2006-02-15 |
JP2006514634A (ja) | 2006-05-11 |
EP1567488B1 (en) | 2007-02-21 |
CA2508325A1 (en) | 2004-06-17 |
AU2003292198A1 (en) | 2004-06-23 |
HK1083624A1 (en) | 2006-07-07 |
IS7925A (is) | 2005-06-30 |
NZ539841A (en) | 2007-11-30 |
AU2003292198B2 (en) | 2007-09-06 |
DK1567488T3 (da) | 2007-06-18 |
PT1567488E (pt) | 2007-05-31 |
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