FR2919285B1 - Derives de 1-oxo-isoindoline-4-carboxamides et de 1-oxo- 1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur preparation et leur application en therapeutique. - Google Patents

Derives de 1-oxo-isoindoline-4-carboxamides et de 1-oxo- 1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur preparation et leur application en therapeutique.

Info

Publication number
FR2919285B1
FR2919285B1 FR0705499A FR0705499A FR2919285B1 FR 2919285 B1 FR2919285 B1 FR 2919285B1 FR 0705499 A FR0705499 A FR 0705499A FR 0705499 A FR0705499 A FR 0705499A FR 2919285 B1 FR2919285 B1 FR 2919285B1
Authority
FR
France
Prior art keywords
oxo
carboxamide
tetrahydroisoquinoleine
isoindoline
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0705499A
Other languages
English (en)
Other versions
FR2919285A1 (fr
Inventor
Bernard Baudoin
Michel Evers
Borella Arielle Genevois
Andreas Karlsson
Jean Luc Malleron
Magali Mathieu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0705499A priority Critical patent/FR2919285B1/fr
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to EP08835551A priority patent/EP2185511A2/fr
Priority to PCT/FR2008/001110 priority patent/WO2009044019A2/fr
Priority to NZ582873A priority patent/NZ582873A/en
Priority to EA201070197A priority patent/EA201070197A1/ru
Priority to CN2008801045290A priority patent/CN101790514B/zh
Priority to JP2010517453A priority patent/JP5412428B2/ja
Priority to MYPI20100428 priority patent/MY150436A/en
Priority to SG2012055539A priority patent/SG183082A1/en
Priority to BRPI0813624A priority patent/BRPI0813624A2/pt
Priority to CA2694322A priority patent/CA2694322A1/fr
Priority to MX2010001079A priority patent/MX2010001079A/es
Priority to AU2008306763A priority patent/AU2008306763B2/en
Priority to KR1020107004339A priority patent/KR20100051830A/ko
Publication of FR2919285A1 publication Critical patent/FR2919285A1/fr
Priority to US12/693,597 priority patent/US8372864B2/en
Priority to CO10007698A priority patent/CO6290678A2/es
Priority to ZA2010/00582A priority patent/ZA201000582B/en
Priority to MA32652A priority patent/MA31635B1/fr
Priority to HK10109764.3A priority patent/HK1143163A1/xx
Publication of FR2919285B1 publication Critical patent/FR2919285B1/fr
Application granted granted Critical
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
FR0705499A 2007-07-27 2007-07-27 Derives de 1-oxo-isoindoline-4-carboxamides et de 1-oxo- 1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur preparation et leur application en therapeutique. Expired - Fee Related FR2919285B1 (fr)

Priority Applications (19)

Application Number Priority Date Filing Date Title
FR0705499A FR2919285B1 (fr) 2007-07-27 2007-07-27 Derives de 1-oxo-isoindoline-4-carboxamides et de 1-oxo- 1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur preparation et leur application en therapeutique.
SG2012055539A SG183082A1 (en) 2007-07-27 2008-07-25 1-oxo-isoindoline-4-carboxamide and 1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide derivatives, preparation and therapeutic use thereof
MX2010001079A MX2010001079A (es) 2007-07-27 2008-07-25 Derivados de 1-oxo-isoindolina-4-carboxamidas y de 1-oxo-1,2,3,4-tetrahidroisoquinoleina-5-carboxamidas, su preparacion y su aplicacion en terapeutica.
EA201070197A EA201070197A1 (ru) 2007-07-27 2008-07-25 Производные 1-оксо-изоиндолин-4-карбоксамидов и 1-оксо-1,2,3,4-тетрагидроизохинолин-5-карбоксамидов, способ их получения и применение в терапии
CN2008801045290A CN101790514B (zh) 2007-07-27 2008-07-25 1-氧代-异二氢吲哚-4-甲酰胺和1-氧代-1,2,3,4-四氢异喹啉-5-甲酰胺衍生物、其制备和治疗用途
JP2010517453A JP5412428B2 (ja) 2007-07-27 2008-07-25 １−オキソ−イソインドリン−４−カルボキサミドおよび１−オキソ−１，２，３，４−テトラヒドロイソキノリン−５−カルボキサミド誘導体、それらの調製および治療上の使用
MYPI20100428 MY150436A (en) 2007-07-27 2008-07-25 1-oxo-isoindoline-4-carboxamide and 1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide derivatives, preparation and therapeutic use thereof
PCT/FR2008/001110 WO2009044019A2 (fr) 2007-07-27 2008-07-25 Dérivés de 1-oxo-isoindoline-4-carboxamides et de 1-oxo-1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur préparation et leur application en thérapeutique
BRPI0813624A BRPI0813624A2 (pt) 2007-07-27 2008-07-25 derivados de 1-oxo-isoindolina-4-carboxamidas e de 1-oxo-1,2,3,4-tetra-hidroisoquinoleína-5-carboxamidas, o respectivo preparo e a respectiva aplicação em terapêutica.
KR1020107004339A KR20100051830A (ko) 2007-07-27 2008-07-25 １-옥소-이소인돌린-４-카르복스아미드 및 １-옥소-１,２,３,４-테트라히드로이소퀴놀린-５-카르복스아미드 유도체, 그의 제조 및 치료적 용도
EP08835551A EP2185511A2 (fr) 2007-07-27 2008-07-25 Dérivés de 1-oxo-isoindoline-4-carboxamides et de 1-oxo-1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur préparation et leur application en thérapeutique
NZ582873A NZ582873A (en) 2007-07-27 2008-07-25 1-oxo-isoindoline-4-carboxamide and 1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide derivatives, preparation and therapeutic use thereof
CA2694322A CA2694322A1 (fr) 2007-07-27 2008-07-25 Derives de 1-oxo-isoindoline-4-carboxamides et de 1-oxo-1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur preparation et leur application en therapeutique
AU2008306763A AU2008306763B2 (en) 2007-07-27 2008-07-25 1-oxo-isoindoline-4-carboxamide and 1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide derivatives, preparation and therapeutic use thereof
ZA2010/00582A ZA201000582B (en) 2007-07-27 2010-01-26 1-oxo-isoindoline-4-carboxamide and 1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide derivatives,preparation and therapeutic use thereof
CO10007698A CO6290678A2 (es) 2007-07-27 2010-01-26 Derivados de 1-oxo-isoindolina-4-carboxamidas y de 1-oxo-1,2,3,4-tetrahidroisoquinoleina-5-carboxamidas su preparacion y su aplicacion en terapeutica
US12/693,597 US8372864B2 (en) 2007-07-27 2010-01-26 1-oxo-isoindoline-4-carboxamide and 1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide derivatives, preparation and therapeutic use thereof
MA32652A MA31635B1 (fr) 2007-07-27 2010-02-24 Dérivés de 1-oxo-isoindoline-4-carboxamides et de 1-oxo-1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur préparation et leur application en thérapeutique
HK10109764.3A HK1143163A1 (fr) 2007-07-27 2010-10-15

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0705499A FR2919285B1 (fr) 2007-07-27 2007-07-27 Derives de 1-oxo-isoindoline-4-carboxamides et de 1-oxo- 1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur preparation et leur application en therapeutique.

Publications (2)

Publication Number Publication Date
FR2919285A1 FR2919285A1 (fr) 2009-01-30
FR2919285B1 true FR2919285B1 (fr) 2012-08-31

Family

ID=39092246

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0705499A Expired - Fee Related FR2919285B1 (fr) 2007-07-27 2007-07-27 Derives de 1-oxo-isoindoline-4-carboxamides et de 1-oxo- 1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur preparation et leur application en therapeutique.

Country Status (19)

Country Link
US (1) US8372864B2 (fr)
EP (1) EP2185511A2 (fr)
JP (1) JP5412428B2 (fr)
KR (1) KR20100051830A (fr)
CN (1) CN101790514B (fr)
AU (1) AU2008306763B2 (fr)
BR (1) BRPI0813624A2 (fr)
CA (1) CA2694322A1 (fr)
CO (1) CO6290678A2 (fr)
EA (1) EA201070197A1 (fr)
FR (1) FR2919285B1 (fr)
HK (1) HK1143163A1 (fr)
MA (1) MA31635B1 (fr)
MX (1) MX2010001079A (fr)
MY (1) MY150436A (fr)
NZ (1) NZ582873A (fr)
SG (1) SG183082A1 (fr)
WO (1) WO2009044019A2 (fr)
ZA (1) ZA201000582B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9173395B2 (en) 2011-07-04 2015-11-03 Bayer Intellectual Property Gmbh Use of substituted isoquinolinones, isoquinolindiones, isoquinolintriones and dihydroisoquinolinones or in each case salts thereof as active agents against abiotic stress in plants
CN105254554B (zh) * 2014-07-14 2018-01-30 南开大学 一种制备异吲哚啉酮类化合物的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6777896A (en) * 1995-08-25 1997-03-19 E.I. Du Pont De Nemours And Company Bicyclic herbicides
DE10018449A1 (de) 2000-04-14 2001-11-22 Top Caredent Ag Zuerich Vorrichtung zum Darbieten von Gerätschaften der Dentalhygiene
CA2466284A1 (fr) * 2001-11-08 2003-05-15 Elan Pharmaceuticals, Inc. Derives 1,3-diamino-2-hydroxypropane n-n'-substitues
GB0228410D0 (en) * 2002-12-05 2003-01-08 Glaxo Group Ltd Novel Compounds
GB0305918D0 (en) * 2003-03-14 2003-04-23 Glaxo Group Ltd Novel compounds
GB0309221D0 (en) 2003-04-23 2003-06-04 Glaxo Group Ltd Novel compounds
GB0328900D0 (en) 2003-12-12 2004-01-14 Glaxo Group Ltd Novel compounds
WO2006099352A1 (fr) 2005-03-10 2006-09-21 Bristol-Myers Squibb Company Nouveaux isophtalates utilises comme inhibiteurs de la beta-secretase
GB0506562D0 (en) 2005-03-31 2005-05-04 Glaxo Group Ltd Novel compounds
EA201070195A1 (ru) * 2007-07-27 2010-10-29 Санофи-Авентис ПРОИЗВОДНЫЕ 1,2,3,4-ТЕТРАГИДРОПИРРОЛО [1,2-А]ПИРАЗИН-6-КАРБОКСАМИДОВ И 2,3,4,5-ТЕТРАГИДРОПИРРОЛО [1,2-a][1,4]-ДИАЗЕПИН-7-КАРБОКСАМИДОВ, ИХ ПОЛУЧЕНИЕ И ИХ ПРИМЕНЕНИЕ В ТЕРАПИИ
FR2919286A1 (fr) * 2007-07-27 2009-01-30 Sanofi Aventis Sa Derives de derives de 1-oxo-1,2-dihydroisoquinoleine-5- carboxamides et de 4-oxo-3,4-dihydroquinazoline-8- carboxamides,leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
CA2694322A1 (fr) 2009-04-09
FR2919285A1 (fr) 2009-01-30
KR20100051830A (ko) 2010-05-18
ZA201000582B (en) 2011-04-28
AU2008306763A1 (en) 2009-04-09
EA201070197A1 (ru) 2010-08-30
US20100197725A1 (en) 2010-08-05
HK1143163A1 (fr) 2010-12-24
JP2010534641A (ja) 2010-11-11
CN101790514A (zh) 2010-07-28
NZ582873A (en) 2012-07-27
CN101790514B (zh) 2012-12-19
WO2009044019A3 (fr) 2009-06-18
MY150436A (en) 2014-01-30
SG183082A1 (en) 2012-08-30
AU2008306763B2 (en) 2013-08-29
MA31635B1 (fr) 2010-08-02
BRPI0813624A2 (pt) 2019-09-24
EP2185511A2 (fr) 2010-05-19
WO2009044019A2 (fr) 2009-04-09
CO6290678A2 (es) 2011-06-20
MX2010001079A (es) 2010-03-24
WO2009044019A9 (fr) 2010-10-14
JP5412428B2 (ja) 2014-02-12
US8372864B2 (en) 2013-02-12

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Effective date: 20160331