ATE402262T1 - Verfahren und zusammensetzungen, die eine stearoyl-coa desuturase-hscd5 verwenden - Google Patents

Verfahren und zusammensetzungen, die eine stearoyl-coa desuturase-hscd5 verwenden

Info

Publication number
ATE402262T1
ATE402262T1 AT01969110T AT01969110T ATE402262T1 AT E402262 T1 ATE402262 T1 AT E402262T1 AT 01969110 T AT01969110 T AT 01969110T AT 01969110 T AT01969110 T AT 01969110T AT E402262 T1 ATE402262 T1 AT E402262T1
Authority
AT
Austria
Prior art keywords
hscd5
coa
methods
desuturase
stearoyl
Prior art date
Application number
AT01969110T
Other languages
English (en)
Inventor
Alison Brownlie
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE402262T1 publication Critical patent/ATE402262T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Seasonings (AREA)
  • Saccharide Compounds (AREA)
AT01969110T 2000-09-26 2001-09-26 Verfahren und zusammensetzungen, die eine stearoyl-coa desuturase-hscd5 verwenden ATE402262T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23564000P 2000-09-26 2000-09-26

Publications (1)

Publication Number Publication Date
ATE402262T1 true ATE402262T1 (de) 2008-08-15

Family

ID=22886344

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01969110T ATE402262T1 (de) 2000-09-26 2001-09-26 Verfahren und zusammensetzungen, die eine stearoyl-coa desuturase-hscd5 verwenden

Country Status (7)

Country Link
US (2) US7232662B2 (de)
EP (1) EP1322767B1 (de)
AT (1) ATE402262T1 (de)
AU (1) AU2001289457A1 (de)
CA (1) CA2430987A1 (de)
DE (1) DE60134995D1 (de)
WO (1) WO2002026944A2 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60134995D1 (de) * 2000-09-26 2008-09-04 Xenon Pharmaceuticals Inc Verfahren und zusammensetzungen, die eine stearoyl-coa desuturase-hscd5 verwenden
EP1395289B1 (de) 2001-06-07 2010-12-15 Christine Dr. Sang Behandlung von neuropathischen schmerzen mittels eines n-methyl-d-aspartate (nmda)-rezeptor-antagonists
US7390813B1 (en) 2001-12-21 2008-06-24 Xenon Pharmaceuticals Inc. Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
WO2003074674A2 (en) 2002-03-01 2003-09-12 Exelixis, Inc. MSRAs AS MODIFIERS OF THE p53 PATHWAY AND METHODS OF USE
ATE532772T1 (de) 2003-07-30 2011-11-15 Xenon Pharmaceuticals Inc Piperazinderivate und deren verwendung als therapeutische mittel
US7754711B2 (en) 2003-07-30 2010-07-13 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
BRPI0412343A (pt) 2003-07-30 2006-09-05 Xenon Pharmaceuticals Inc derivados de piridazina e seu uso como agentes terapêuticos
WO2005011656A2 (en) 2003-07-30 2005-02-10 Xenon Pharmaceuticals Inc. Pyridyl derivatives and their use as therapeutic agents
ES2568769T3 (es) 2003-07-30 2016-05-04 Xenon Pharmaceuticals Inc. Derivados de piperazina y su uso como agentes terapéuticos
US7777036B2 (en) 2004-09-20 2010-08-17 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as therapeutic agents
AU2005286790A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-CoA-desaturase (SCD)
MX2007003325A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores estearoil-coa-desaturasa.
AR051095A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso comoinhibidores de la estearoil-coa desaturasa
AU2005286731A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase
AU2005286728A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
CA2580856A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
EP1804799B1 (de) 2004-09-20 2013-08-21 Xenon Pharmaceuticals Inc. Heterozyklische Derivate und ihre Verwendung als Stearoyl-Coa-Desaturase-Inhibitoren
EP2029138A1 (de) 2005-06-03 2009-03-04 Xenon Pharmaceuticals Inc. Aminothiazolderivate als humane stearoyl-coa desaturasehemmer
US20060281071A1 (en) * 2005-06-08 2006-12-14 Ntambi James M Stearoyl-CoA desaturase assay
KR101124070B1 (ko) 2006-06-05 2012-04-12 제논 파마슈티칼스 인크. 유기 화합물
EP2086970B1 (de) 2006-08-24 2014-02-26 Novartis AG 2-(pyrazin-2-yl)-thiazol und 2-(1h pyrazol-3-yl)-thiazol derivate und verwandte verbindungen als stearoyl-coa desaturase (scd) inhibitoren zur behandlung von stoffwechsel-, herzkreislauf- und anderen erkrankungen
WO2008025068A1 (en) * 2006-08-29 2008-03-06 Commonwealth Scientific And Industrial Research Organisation Synthesis of fatty acids
GB0722077D0 (en) 2007-11-09 2007-12-19 Smithkline Beecham Corp Compounds
AU2009225441B2 (en) 2008-03-20 2012-12-13 Forest Laboratories Holdings Limited Novel piperidine derivatives as inhibitors of stearoyl-CoA desaturase
CA2718993A1 (en) 2008-03-20 2009-09-24 Forest Laboratories Holdings Limited Novel piperazine derivatives as inhibitors of stearoyl-coa desaturase
EA201100049A1 (ru) 2008-06-27 2011-08-30 Новартис Аг Органические соединения
CA2743880C (en) 2008-11-18 2020-08-18 James Robertson Petrie Recombinant cells comprising exogenous a5 elongase and methods for producing docosapentaenoic acid
US8119885B2 (en) * 2009-03-31 2012-02-21 Monsanto Technology Llc Plants and seeds of corn variety CV597869
EP2483264A1 (de) 2009-10-01 2012-08-08 Novartis AG Pyrazolderivate zur modulation von stearoyl-coa-desaturase
MY187101A (en) 2012-06-15 2021-08-31 Commw Scient Ind Res Org Production of long chain polyunsaturated fatty acids in plant cells
UA122768C2 (uk) 2013-12-18 2021-01-06 Коммонвелз Сайнтіфік Енд Індастріал Рисерч Организейшн Екстрагований рослинний ліпід, що містить довголанцюгові поліненасичені жирні кислоти
AU2015281791A1 (en) 2014-06-27 2017-01-12 Commonwealth Scientific And Industrial Research Organisation Lipid comprising docosapentaenoic acid

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ219230A (en) 1986-02-14 1991-06-25 Medeva Plc Method of modifying cell membranes by using c12 - c28 saturated fatty acids
JP3070611B2 (ja) * 1989-03-07 2000-07-31 サントリー株式会社 △▲上５▼―不飽和化酵素阻害剤
GB2237018A (en) 1989-08-18 1991-04-24 Medeva Plc Secondary alcohols and compositions containing fatty acids or esters
CA2083259C (en) * 1990-05-25 2007-05-15 William D. Hitz Nucleotide sequence of soybean stearoyl-acp desaturase gene
US5861485A (en) 1994-08-23 1999-01-19 Millennium Pharmaceuticals, Inc. Polypeptides involved in body weight disorders, including obesity
AU4414999A (en) 1998-06-08 1999-12-30 Sambasiva R. Chavali Inhibition of delta-9-desaturase activity by saponins
AU5774699A (en) * 1998-08-14 2000-03-06 Johnson & Johnson Consumer Companies, Inc. Human stearoyl-coa desaturase-related compositions and methods for treating skin disorders
EP2172560A3 (de) 2000-02-24 2010-09-29 Xenon Pharmaceuticals Inc. Stearoyl-Coa-Desaturase zur Iidentifizierung von Triglyceridreduktionstherapeutika
US6686185B1 (en) * 2000-03-07 2004-02-03 Millennium Pharmaceuticals, Inc. 25934, a novel fatty acid desaturase and uses therefor
DE60134995D1 (de) * 2000-09-26 2008-09-04 Xenon Pharmaceuticals Inc Verfahren und zusammensetzungen, die eine stearoyl-coa desuturase-hscd5 verwenden

Also Published As

Publication number Publication date
US20070238648A1 (en) 2007-10-11
US7435559B2 (en) 2008-10-14
US20040091988A1 (en) 2004-05-13
CA2430987A1 (en) 2002-04-04
EP1322767B1 (de) 2008-07-23
DE60134995D1 (de) 2008-09-04
WO2002026944A9 (en) 2007-08-23
US7232662B2 (en) 2007-06-19
WO2002026944A2 (en) 2002-04-04
AU2001289457A8 (en) 2007-09-20
WO2002026944A3 (en) 2002-10-03
EP1322767A2 (de) 2003-07-02
AU2001289457A1 (en) 2002-04-08

Similar Documents

Publication Publication Date Title
ATE402262T1 (de) Verfahren und zusammensetzungen, die eine stearoyl-coa desuturase-hscd5 verwenden
TNSN02022A1 (fr) Triazolopyridines anti-inflammatoires nouvelles, et compositions les contenant
DE60312031D1 (de) Hydroxyethylamin-derivate für die behandlung von alzheimer
DE60143292D1 (de) Varianten des menschlichen Koagulationsfaktors VII
WO2001083782A3 (en) Novel proteases
NO20031129D0 (no) Varianter av human koagulasjonsfaktor VII
MXPA02011656A (es) Moleculas de acido nucleico nrg-2, polipeptidos, y metodos de diagnostico y terapeuticos.
TNSN02021A1 (fr) Derives de benzimidazole nouveaux, et compositions les contenant
TNSN02008A1 (fr) Derives d'acides isophtalique nouveaux inhibiteurs de mmp, et compositions les contenant
WO2008063382A3 (en) Antagonists of pcsk9
WO2008057457A3 (en) Antagonists of pcsk9
WO2008133647A3 (en) Antagonists of pcsk9
FR2882751B1 (fr) Hydrazinocarbonyl-thieno[2,3-c]pyrazoles, procede de preparation, compositions les contenant et utilisation
WO2003010336A3 (de) Molekulare marker beim hepatozellulären karzinom
BR0213072A (pt) Sabonete em barra
ATE541583T1 (de) Enzym-enthaltendes präparat, verfahren zur herstellung und verwendung
GB0328900D0 (en) Novel compounds
HK1059439A1 (en) Compounds having activity as inhibitors of cytochrome p450rai
ATE361993T1 (de) Diagnose und behandlung von prostatakrebs
ATE229481T1 (de) Mittel zur wasserbehandlung
ATE330610T1 (de) Neues eisenchelat als hemmungsmittel von durch eisen vermittelte oxydation
ATE386525T1 (de) 3-substituierte 6,7- dihydroxytetrahydroisochinolin-derivate zur verwendung als antibkaterielle mittel
WO2002059327A3 (en) Sulfatases and methods of use thereof
MXPA03000979A (es) Moleculas tipo receptor de complemento c3b/c4b y usos de las mismas.
IL144199A0 (en) Novel bretylium compositions and kits, and their use in preventing and treating cardiovascular conditions

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties