ATE402262T1 - Verfahren und zusammensetzungen, die eine stearoyl-coa desuturase-hscd5 verwenden - Google Patents

Verfahren und zusammensetzungen, die eine stearoyl-coa desuturase-hscd5 verwenden

Info

Publication number
ATE402262T1
ATE402262T1 AT01969110T AT01969110T ATE402262T1 AT E402262 T1 ATE402262 T1 AT E402262T1 AT 01969110 T AT01969110 T AT 01969110T AT 01969110 T AT01969110 T AT 01969110T AT E402262 T1 ATE402262 T1 AT E402262T1
Authority
AT
Austria
Prior art keywords
hscd5
coa
methods
desuturase
stearoyl
Prior art date
Application number
AT01969110T
Other languages
English (en)
Inventor
Alison Brownlie
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE402262T1 publication Critical patent/ATE402262T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Seasonings (AREA)
  • Saccharide Compounds (AREA)
AT01969110T 2000-09-26 2001-09-26 Verfahren und zusammensetzungen, die eine stearoyl-coa desuturase-hscd5 verwenden ATE402262T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23564000P 2000-09-26 2000-09-26

Publications (1)

Publication Number Publication Date
ATE402262T1 true ATE402262T1 (de) 2008-08-15

Family

ID=22886344

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01969110T ATE402262T1 (de) 2000-09-26 2001-09-26 Verfahren und zusammensetzungen, die eine stearoyl-coa desuturase-hscd5 verwenden

Country Status (7)

Country Link
US (2) US7232662B2 (de)
EP (1) EP1322767B1 (de)
AT (1) ATE402262T1 (de)
AU (1) AU2001289457A1 (de)
CA (1) CA2430987A1 (de)
DE (1) DE60134995D1 (de)
WO (1) WO2002026944A2 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1322767B1 (de) * 2000-09-26 2008-07-23 Xenon Pharmaceuticals Inc. Verfahren und zusammensetzungen, die eine stearoyl-coa desuturase-hscd5 verwenden
DK2266558T3 (en) 2001-06-07 2017-07-31 Analgesic Neuropharmaceuticals Llc TREATMENT OF NEUROPATHIC PAIN WITH RECEPTOR ANTAGONIST: N-METHYL-D-ASPARTATE (NMDA)
US7390813B1 (en) 2001-12-21 2008-06-24 Xenon Pharmaceuticals Inc. Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
WO2003073823A2 (en) 2002-03-01 2003-09-12 Exelixis, Inc. PDPK1s AS MODIFIERS OF THE p53 PATHWAY AND METHODS OF USE
CN101712653A (zh) 2003-07-30 2010-05-26 泽农医药公司 哒嗪衍生物和它们作为治疗剂的用途
AU2004261267B9 (en) 2003-07-30 2009-04-09 Xenon Pharmaceuticals Inc. Pyridyl derivatives and their use as therapeutic agents
BRPI0412348A (pt) 2003-07-30 2006-09-05 Xenon Pharmaceuticals Inc derivados de piperazina e seu uso como agentes terapêuticos
JP4808616B2 (ja) 2003-07-30 2011-11-02 ゼノン・ファーマシューティカルズ・インコーポレイテッド ピリダジン誘導体および治療剤としてのその用途
US7754711B2 (en) 2003-07-30 2010-07-13 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
BRPI0515477A (pt) 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos bicìclicos e o uso dos mesmos como inibidores de estaroil-coa-desaturase (scd)
CN101083994A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其用作硬脂酰CoA去饱和酶抑制剂的用途
BRPI0515482A (pt) 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos e seus usos como agentes terapêuticos
BRPI0515488A (pt) 2004-09-20 2008-07-29 Xenon Pharmaceuticals Inc derivados de heterocìclicos e seu uso como agentes terapêuticos
WO2006034338A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase
US7829712B2 (en) 2004-09-20 2010-11-09 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase
TW200624427A (en) 2004-09-20 2006-07-16 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
EP1827438B2 (de) 2004-09-20 2014-12-10 Xenon Pharmaceuticals Inc. Piperazine derivate zur hemmung der menschlichen stearoyl-coa-desaturase
BRPI0611187A2 (pt) 2005-06-03 2010-08-24 Xenon Pharmaceuticals Inc derivados aminotiazàis como inibidores da estearoil-coa desaturase humana
US20060281071A1 (en) * 2005-06-08 2006-12-14 Ntambi James M Stearoyl-CoA desaturase assay
WO2007143597A2 (en) 2006-06-05 2007-12-13 Novartis Ag Organic compounds
CN101506203B (zh) 2006-08-24 2013-10-16 诺瓦提斯公司 治疗代谢病、心血管病和其他病症的作为硬脂酰辅酶a脱饱和酶(scd)抑制剂的2-(吡嗪-2-基)-噻唑和2-(1h-吡唑-3-基)-噻唑衍生物及相关化合物
WO2008025068A1 (en) * 2006-08-29 2008-03-06 Commonwealth Scientific And Industrial Research Organisation Synthesis of fatty acids
GB0722077D0 (en) 2007-11-09 2007-12-19 Smithkline Beecham Corp Compounds
AU2009225441B2 (en) 2008-03-20 2012-12-13 Forest Laboratories Holdings Limited Novel piperidine derivatives as inhibitors of stearoyl-CoA desaturase
CN102036666A (zh) 2008-03-20 2011-04-27 森林实验室控股有限公司 作为硬脂酰-辅酶a去饱和酶的抑制剂的新型哌嗪衍生物
NZ589962A (en) 2008-06-27 2012-12-21 Novartis Ag Inhibitors of stearoyl-CoA desaturase and uses thereof
BR122021003835B1 (pt) 2008-11-18 2022-02-08 Grains Research And Development Corporation Polinucleotídeo isolado e/ou exógeno que não ocorre de forma natural, vetor compreendendo o referido polinucleotídeo e método de produção de óleo contendo ácidos graxos insaturados
US8119885B2 (en) * 2009-03-31 2012-02-21 Monsanto Technology Llc Plants and seeds of corn variety CV597869
US20130011361A1 (en) 2009-10-01 2013-01-10 Xenon Pharmaceuticals Inc. Pyrazole derivatives which modulate stearoyl-coa desaturase
SG11201408362SA (en) 2012-06-15 2015-01-29 Commw Scient Ind Res Org Production of long chain polyunsaturated fatty acids in plant cells
WO2015196250A1 (en) 2014-06-27 2015-12-30 Commonwealth Scientific And Industrial Research Organisation Lipid comprising docosapentaenoic acid
CN111154724B (zh) 2013-12-18 2024-02-06 联邦科学技术研究组织 包含二十二碳六烯酸的提取的植物脂质

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN164555B (de) 1986-02-14 1989-04-08 Adly Habib Nagy
JP3070611B2 (ja) 1989-03-07 2000-07-31 サントリー株式会社 △▲上５▼―不飽和化酵素阻害剤
GB2237018A (en) 1989-08-18 1991-04-24 Medeva Plc Secondary alcohols and compositions containing fatty acids or esters
EP0537178B2 (de) 1990-05-25 2007-06-13 E.I. Du Pont De Nemours And Company Nukleotidsequenz des gens für stearoyl-acp-desaturase aus soja
US5861485A (en) 1994-08-23 1999-01-19 Millennium Pharmaceuticals, Inc. Polypeptides involved in body weight disorders, including obesity
AU4414999A (en) 1998-06-08 1999-12-30 Sambasiva R. Chavali Inhibition of delta-9-desaturase activity by saponins
AU5774699A (en) 1998-08-14 2000-03-06 Johnson & Johnson Consumer Companies, Inc. Human stearoyl-coa desaturase-related compositions and methods for treating skin disorders
EP1315831B8 (de) * 2000-02-24 2010-09-01 Xenon Pharmaceuticals Inc. Stearoyl-coa-desaturase zur identifizierung von triglyceridreduktionstherapeutika
US6686185B1 (en) * 2000-03-07 2004-02-03 Millennium Pharmaceuticals, Inc. 25934, a novel fatty acid desaturase and uses therefor
EP1322767B1 (de) * 2000-09-26 2008-07-23 Xenon Pharmaceuticals Inc. Verfahren und zusammensetzungen, die eine stearoyl-coa desuturase-hscd5 verwenden

Also Published As

Publication number Publication date
EP1322767A2 (de) 2003-07-02
EP1322767B1 (de) 2008-07-23
WO2002026944A3 (en) 2002-10-03
AU2001289457A1 (en) 2002-04-08
US7435559B2 (en) 2008-10-14
WO2002026944A2 (en) 2002-04-04
AU2001289457A8 (en) 2007-09-20
US7232662B2 (en) 2007-06-19
CA2430987A1 (en) 2002-04-04
US20070238648A1 (en) 2007-10-11
WO2002026944A9 (en) 2007-08-23
DE60134995D1 (de) 2008-09-04
US20040091988A1 (en) 2004-05-13

Similar Documents

Publication Publication Date Title
ATE402262T1 (de) Verfahren und zusammensetzungen, die eine stearoyl-coa desuturase-hscd5 verwenden
MA27608A1 (fr) Derives d'hydroxyethylamine utilises pour le traitement de la maladie d'alzheimer
TNSN02022A1 (fr) Triazolopyridines anti-inflammatoires nouvelles, et compositions les contenant
ATE485371T1 (de) Varianten des menschlichen koagulationsfaktors vii
WO2001083782A3 (en) Novel proteases
NO20031129D0 (no) Varianter av human koagulasjonsfaktor VII
MXPA02011656A (es) Moleculas de acido nucleico nrg-2, polipeptidos, y metodos de diagnostico y terapeuticos.
TNSN02021A1 (fr) Derives de benzimidazole nouveaux, et compositions les contenant
TNSN02008A1 (fr) Derives d'acides isophtalique nouveaux inhibiteurs de mmp, et compositions les contenant
WO2008057459A3 (en) Antagonists of pcsk9
WO2008057457A3 (en) Antagonists of pcsk9
WO2008133647A3 (en) Antagonists of pcsk9
HUP0301246A2 (hu) Humán véralvadási faktor VII változatai
WO2003010336A3 (de) Molekulare marker beim hepatozellulären karzinom
BR0213072A (pt) Sabonete em barra
GB0328900D0 (en) Novel compounds
AU8647101A (en) Compounds having activity as inhibitors of cytochrome p450rai
DE60128368D1 (de) Diagnose und behandlung von prostatakrebs
ATE541583T1 (de) Enzym-enthaltendes präparat, verfahren zur herstellung und verwendung
DE59903778D1 (de) Mittel zur wasserbehandlung
DE69636267D1 (de) Neues eisenchelat als hemmungsmittel von durch eisen vermittelte oxydation
ATE386525T1 (de) 3-substituierte 6,7- dihydroxytetrahydroisochinolin-derivate zur verwendung als antibkaterielle mittel
WO2002059327A3 (en) Sulfatases and methods of use thereof
TR200200278T2 (tr) Kalsilitik bileşimler
DE60044038D1 (de) Xylosyltransferase und isoformen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties