EE04991B1 - Osake, ravimvorm, nende valmistamismeetodid, osakeste kasutamine ning farmatseutiline pakend - Google Patents
Osake, ravimvorm, nende valmistamismeetodid, osakeste kasutamine ning farmatseutiline pakendInfo
- Publication number
- EE04991B1 EE04991B1 EEP200200151A EEP200200151A EE04991B1 EE 04991 B1 EE04991 B1 EE 04991B1 EE P200200151 A EEP200200151 A EE P200200151A EE P200200151 A EEP200200151 A EE P200200151A EE 04991 B1 EE04991 B1 EE 04991B1
- Authority
- EE
- Estonia
- Prior art keywords
- pharmaceutical
- particle
- particles
- preparation
- methods
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99203128 | 1999-09-24 | ||
PCT/EP2000/008522 WO2001022938A1 (en) | 1999-09-24 | 2000-08-31 | Antiviral compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
EE200200151A EE200200151A (et) | 2003-04-15 |
EE04991B1 true EE04991B1 (et) | 2008-04-15 |
Family
ID=8240674
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EEP200200151A EE04991B1 (et) | 1999-09-24 | 2000-08-31 | Osake, ravimvorm, nende valmistamismeetodid, osakeste kasutamine ning farmatseutiline pakend |
Country Status (35)
Country | Link |
---|---|
US (4) | US7241458B1 (et) |
EP (1) | EP1225874B1 (et) |
JP (1) | JP4919566B2 (et) |
KR (2) | KR100785360B1 (et) |
CN (1) | CN1234347C (et) |
AP (1) | AP1639A (et) |
AT (1) | ATE316781T1 (et) |
AU (2) | AU775360B2 (et) |
BG (1) | BG65754B1 (et) |
BR (1) | BRPI0014271B1 (et) |
CA (1) | CA2384188C (et) |
CY (1) | CY1105268T1 (et) |
CZ (1) | CZ300712B6 (et) |
DE (1) | DE60025837T2 (et) |
DK (1) | DK1225874T3 (et) |
EA (1) | EA005423B1 (et) |
EE (1) | EE04991B1 (et) |
ES (1) | ES2258018T3 (et) |
HK (1) | HK1048768B (et) |
HR (1) | HRP20020247B1 (et) |
HU (1) | HU228449B1 (et) |
IL (1) | IL148801A0 (et) |
IS (1) | IS2567B (et) |
MX (1) | MXPA02003182A (et) |
NO (1) | NO333358B1 (et) |
NZ (1) | NZ517025A (et) |
OA (1) | OA12029A (et) |
PL (1) | PL207590B1 (et) |
PT (1) | PT1225874E (et) |
SI (1) | SI1225874T1 (et) |
SK (1) | SK285240B6 (et) |
TR (1) | TR200200763T2 (et) |
UA (1) | UA74797C2 (et) |
WO (1) | WO2001022938A1 (et) |
ZA (1) | ZA200202289B (et) |
Families Citing this family (106)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1218360B1 (en) | 1999-10-07 | 2008-05-28 | Amgen Inc., | Triazine kinase inhibitors |
JP5767429B2 (ja) | 1999-11-12 | 2015-08-19 | アッヴィ・インコーポレイテッド | 固体分散剤中の結晶化阻害剤 |
CA2400447C (en) | 2000-02-17 | 2008-04-22 | Amgen Inc. | Kinase inhibitors |
DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
WO2002068398A1 (en) | 2001-02-27 | 2002-09-06 | Teva Pharmaceutical Industries Ltd. | New crystal forms of lamotrigine and processes for their preparations |
CA2450957A1 (en) | 2001-06-22 | 2003-01-03 | Pfizer Products Inc. | Pharmaceutical compositions of dispersions of drugs and neutral polymers |
US7638522B2 (en) | 2001-08-13 | 2009-12-29 | Janssen Pharmaceutica N.V. | Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile |
JO3429B1 (ar) | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
US8101629B2 (en) | 2001-08-13 | 2012-01-24 | Janssen Pharmaceutica N.V. | Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile |
US6939874B2 (en) | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
US7115617B2 (en) | 2001-08-22 | 2006-10-03 | Amgen Inc. | Amino-substituted pyrimidinyl derivatives and methods of use |
EP2332924A1 (de) | 2001-10-17 | 2011-06-15 | Boehringer Ingelheim Pharma GmbH & Co. KG | Pyrimidinderivate, Arzneimittel enthaltend diese Verbindungen, deren Verwendung und Verfahren zu ihrer Herstellung |
SE0104140D0 (sv) | 2001-12-07 | 2001-12-07 | Astrazeneca Ab | Novel Compounds |
TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
PT1479397E (pt) | 2002-02-05 | 2011-09-01 | Astellas Pharma Inc | Derivados de 2,4,6-triamino-1,3,5-triazina |
CA2483103A1 (en) * | 2002-04-23 | 2003-11-06 | Teva Pharmaceutical Industries Ltd. | Pharmaceutical composition containing lamotrigine particles of defined morphology |
AR039540A1 (es) * | 2002-05-13 | 2005-02-23 | Tibotec Pharm Ltd | Compuestos microbicidas con contenido de pirimidina o triazina |
AU2003249369A1 (en) | 2002-06-21 | 2004-01-06 | Cellular Genomics, Inc. | Certain amino-substituted monocycles as kinase modulators |
NZ537752A (en) | 2002-07-29 | 2006-12-22 | Rigel Pharmaceuticals Inc | Use of 2,4-pyrimidinediamine compounds in the preparation of medicaments for treating autoimmune diseases |
KR101140785B1 (ko) | 2002-08-09 | 2012-05-03 | 얀센 파마슈티카 엔.브이. | 4-〔〔4-〔〔4-(2-시아노에테닐)-2,6-디메틸페닐〕아미노〕-2-피리미디닐〕아미노〕벤조니트릴의 제조방법 |
WO2004026283A1 (en) * | 2002-09-20 | 2004-04-01 | Alpharma, Inc. | Sequestering subunit and related compositions and metohds |
RS20050363A (en) * | 2002-11-28 | 2007-11-15 | Schering Aktiengesellschaft, | Chk-,pdk-and akt-inhibitory pyrimidines,their production an use as pharmaceutical agents |
WO2004050068A1 (en) | 2002-11-29 | 2004-06-17 | Janssen Pharmaceutica N.V. | Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base |
US8293751B2 (en) | 2003-01-14 | 2012-10-23 | Arena Pharmaceuticals, Inc. | 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia |
PL227577B1 (pl) | 2003-02-07 | 2017-12-29 | Janssen Pharmaceutica Nv | Zastosowanie pochodnych pirymidyny do wytwarzania leku do zapobiegania zakażeniu wirusem HIV oraz kompozycja farmaceutyczna |
CL2004000303A1 (es) * | 2003-02-20 | 2005-04-08 | Tibotec Pharm Ltd | Compuestos derivados de pirimidinas y triazinas; proceso de preparacion; composicion farmaceutica; y su uso para inhibir la replicacion del vih. |
EP1648467B1 (en) | 2003-07-17 | 2018-03-21 | Janssen Sciences Ireland UC | Process for preparing particles containing an antiviral |
ES2421139T3 (es) | 2003-07-30 | 2013-08-29 | Rigel Pharmaceuticals, Inc. | Compuestos de 2,4-pirimidindiamina para su uso en el tratamiento o la prevención de enfermedades autoinmunitarias |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
US7579349B2 (en) | 2003-10-17 | 2009-08-25 | Astrazeneca Ab | 4-(pyrazol-3-ylamino) pyrimidine derivatives for use in the treatment of cancer |
EP2343282B1 (en) | 2004-03-05 | 2015-07-22 | F. Hoffmann-La Roche AG | Diaminopyrimidines as P2X3 and P2X2/3 antagonists |
BRPI0515505A (pt) | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e sua utilização como inibidores da estearoil-coa desaturase |
AR051090A1 (es) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
US8071603B2 (en) | 2004-09-20 | 2011-12-06 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
EP1814551A2 (en) | 2004-09-20 | 2007-08-08 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
CA2580844A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase |
AR051026A1 (es) | 2004-09-20 | 2006-12-13 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
US7592343B2 (en) | 2004-09-20 | 2009-09-22 | Xenon Pharmaceuticals Inc. | Pyridazine-piperazine compounds and their use as stearoyl-CoA desaturase inhibitors |
US7557207B2 (en) | 2004-11-24 | 2009-07-07 | Rigel Pharmaceuticals, Inc. | Spiro 2,4-pyrimidinediamine compounds and their uses |
ES2337496T3 (es) | 2005-01-19 | 2010-04-26 | Rigel Pharmaceuticals, Inc. | Profarmacos de compuestos de 2,4-pirimidindiamina y sus usos. |
SI1853588T1 (sl) | 2005-02-16 | 2008-10-31 | Astrazeneca Ab | Kemične spojine |
MX2007010051A (es) * | 2005-02-18 | 2007-09-21 | Tibotec Pharm Ltd | Derivados de oxido de 2-(4-cianofenilamino)pirimidina que inhiben el virus de inmunodeficiencia humana. |
ATE473212T1 (de) * | 2005-03-04 | 2010-07-15 | Tibotec Pharm Ltd | Hiv-inhibierende 2-(4-cyanophenyl)-6- hydroxylaminopyrimidine |
TW200710091A (en) | 2005-04-11 | 2007-03-16 | Tibotec Pharm Ltd | (1,10B-dihydro-2-(aminoalkyl-phenyl)-5H-pyrazolo [1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as HIV viral replication inhibitors |
JP2008540622A (ja) | 2005-05-16 | 2008-11-20 | アストラゼネカ アクチボラグ | 化合物 |
PT1888537E (pt) * | 2005-05-26 | 2013-11-26 | Janssen R & D Ireland | Processo para preparar 4-[(1,6-dihidro-6-oxo-2-pirimidinil)amino benzonitrilo |
AU2006343359A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
EP1924565B1 (en) | 2005-09-01 | 2016-09-14 | F.Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p3x2/3 modulators |
CA2619919C (en) | 2005-09-01 | 2014-04-01 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
JP4850913B2 (ja) | 2005-09-01 | 2012-01-11 | エフ.ホフマン−ラ ロシュ アーゲー | P2x3及びp2x2/3調節因子としてのジアミノピリジン |
WO2007049041A1 (en) | 2005-10-28 | 2007-05-03 | Astrazeneca Ab | 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer |
JP2009514884A (ja) * | 2005-11-04 | 2009-04-09 | イーストマン ケミカル カンパニー | 難溶性医薬活性剤の投与のためのカルボキシアルキルセルロースエステル |
ATE522202T1 (de) | 2006-06-06 | 2011-09-15 | Tibotec Pharm Ltd | Verfahren zur herstellung von sprühgetrockneten formulierungen von tmc125 |
PL2526932T3 (pl) | 2006-06-19 | 2017-12-29 | Alpharma Pharmaceuticals Llc | Kompozycja farmaceutyczna |
CA2665726C (en) * | 2006-10-11 | 2016-04-19 | Alpharma, Inc. | Pharmaceutical compositions |
WO2008068299A2 (en) * | 2006-12-06 | 2008-06-12 | Tibotec Pharmaceuticals Ltd. | Hydrobromide salt of an anti-hiv compound |
TWI494133B (zh) * | 2007-03-14 | 2015-08-01 | Tibotec Pharm Ltd | 重組用粉末 |
UA99459C2 (en) | 2007-05-04 | 2012-08-27 | Астразенека Аб | 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer |
WO2008154234A2 (en) * | 2007-06-08 | 2008-12-18 | Boehringer Ingelheim International Gmbh | Extended release formulation of nevirapine |
CA2689330A1 (en) * | 2007-06-25 | 2008-12-31 | Tibotec Pharmaceuticals | Combination formulations |
US8410124B2 (en) * | 2007-10-18 | 2013-04-02 | Concert Pharmaceuticals Inc. | Deuterated etravirine |
JP5600063B2 (ja) | 2007-10-19 | 2014-10-01 | セルジーン アビロミクス リサーチ, インコーポレイテッド | ヘテロアリール化合物およびその使用 |
US7989465B2 (en) * | 2007-10-19 | 2011-08-02 | Avila Therapeutics, Inc. | 4,6-disubstituted pyrimidines useful as kinase inhibitors |
US20090196890A1 (en) * | 2007-12-17 | 2009-08-06 | Alpharma Pharmaceuticals, Llc | Pharmaceutical compositions |
US8623418B2 (en) | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
CA2734489C (en) * | 2008-08-20 | 2016-11-08 | Southern Research Institute | Ethenyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
TW201020245A (en) * | 2008-08-20 | 2010-06-01 | Schering Corp | Ethynyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
US20110195912A1 (en) * | 2008-09-17 | 2011-08-11 | Nektar Therapeutics | Oligomer-Protease Inhibitor Conjugates |
CN101744823B (zh) * | 2008-12-17 | 2013-06-19 | 广东东阳光药业有限公司 | 一种二氢嘧啶类化合物的固体分散体及其药用制剂 |
CA2757228C (en) | 2009-03-30 | 2018-01-02 | Tibotec Pharmaceuticals | Co-crystal of etravirine and nicotinamide |
JP2012529512A (ja) * | 2009-06-08 | 2012-11-22 | アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー | トリアジン誘導体類及びそれらの治療応用 |
EP2342186B1 (en) * | 2009-06-22 | 2014-09-17 | Emcure Pharmaceuticals Limited | Process for synthesis of etravirine |
JP5713367B2 (ja) | 2010-06-04 | 2015-05-07 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Lrrk2モジュレーターとしてのアミノピリミジン誘導体 |
CA2812061A1 (en) | 2010-09-22 | 2012-03-29 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
BR112013011600B1 (pt) | 2010-11-10 | 2022-01-11 | Genentech, Inc | Derivados de pirazol aminopirimidina, seu uso e composição que os compreende |
WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
PT2836559T (pt) * | 2012-04-11 | 2016-08-31 | Dow Global Technologies Llc | Composição que compreende um diluente orgânico e um éter de celulose. |
BR112014020719B1 (pt) * | 2012-04-11 | 2020-03-03 | Dow Global Technologies Llc | Forma de dosagem de liberação constante, método para preparar uma forma de dosagem de liberação constante e uso de um éter de celulose |
BR112014020718B1 (pt) | 2012-04-11 | 2020-11-17 | Dow Global Technologies Llc | composição polimérica extrusada sob fusão, processo para produzir uma composição polimérica extrusada sob fusão e uso de pelo menos um éter de celulose |
IL289834B1 (en) | 2012-06-13 | 2024-03-01 | Incyte Holdings Corp | Conversion of tricyclic compounds as FGFR inhibitors |
EP2872492B1 (en) * | 2012-07-12 | 2018-01-31 | Hetero Research Foundation | Process for the preparation of rilpivirine using a novel intermediate |
US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
SG10201708520YA (en) | 2013-04-19 | 2017-12-28 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
MX2021011472A (es) | 2015-01-06 | 2022-08-17 | Arena Pharm Inc | Metodos de condiciones de tratamiento relacionadas con el receptor s1p1. |
MX2017010673A (es) | 2015-02-20 | 2018-03-21 | Incyte Corp | Heterociclos biciclicos como inhibidores de receptores del factor de crecimiento fibroblastico (fgfr). |
MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
AR100459A1 (es) * | 2015-05-15 | 2016-10-05 | Química Luar S R L | Una composición farmacéutica antiviral de uso tópico |
MA42807A (fr) | 2015-06-22 | 2018-07-25 | Arena Pharm Inc | Sel l-arginine cristallin d'acide (r)-2-(7-(4-cyclopentyl-3-(trifluorométhyl)benzyloxy)-1,2,3,4-tétrahydrocyclo-penta[b]indol-3-yl)acétique (composé 1) pour une utilisation dans des troubles associés au récepteur de s1p1 |
MX2019009841A (es) | 2017-02-16 | 2020-01-30 | Arena Pharm Inc | Compuestos y metodos para el tratamiento de la colangitis biliar primaria. |
WO2018187652A1 (en) | 2017-04-06 | 2018-10-11 | Janssen Pharmaceutica Nv | 2,4-diaminopyrimidine derivatives as histamine h4 modulators |
AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
CR20200590A (es) | 2018-05-04 | 2021-04-26 | Incyte Corp | Formas sólidas de un inhibidor de fgfr y procesos para prepararlas |
US11174257B2 (en) | 2018-05-04 | 2021-11-16 | Incyte Corporation | Salts of an FGFR inhibitor |
US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
JP2022552324A (ja) | 2019-10-14 | 2022-12-15 | インサイト・コーポレイション | Fgfr阻害剤としての二環式複素環 |
WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
WO2021104487A1 (en) | 2019-11-29 | 2021-06-03 | Aptorum Therapeutics Limited | Composition including rilpivirine and use thereof for treating tumors or cancer |
US11897891B2 (en) | 2019-12-04 | 2024-02-13 | Incyte Corporation | Tricyclic heterocycles as FGFR inhibitors |
BR112022010664A2 (pt) | 2019-12-04 | 2022-08-16 | Incyte Corp | Derivados de um inibidor de fgfr |
KR102145925B1 (ko) | 2020-03-03 | 2020-08-19 | 협동조합 바이오융합기술 | 사포닌 성분이 함유된 항 바이러스용 조성물의 제조방법 |
CN111875548A (zh) * | 2020-07-16 | 2020-11-03 | 山东大学 | 一种5位芳环取代的二芳基嘧啶类衍生物及其制备方法与应用 |
US11939331B2 (en) | 2021-06-09 | 2024-03-26 | Incyte Corporation | Tricyclic heterocycles as FGFR inhibitors |
Family Cites Families (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US230963A (en) | 1880-08-10 | John kobeetson | ||
US2742466A (en) | 1956-04-17 | Chx n nhx c c | ||
US2671810A (en) | 1952-05-24 | 1954-03-09 | Du Pont | Long-chain diketones |
US2748124A (en) | 1954-05-06 | 1956-05-29 | Searle & Co | 1-(4-anilino-2-pyrimidino)-3-alkylureas |
SU143808A1 (ru) | 1961-02-14 | 1961-11-30 | Н.В. Козлова | Способ получени 2-хлор-4,6-ди и 2,4,6-три-(2,4-дихлоранилин)-симм. триазинов |
GB1010998A (en) | 1962-10-09 | 1965-11-24 | British Petroleum Co | Pyrimidine derivatives |
US3478030A (en) | 1966-06-27 | 1969-11-11 | Abbott Lab | Benzamide substituted anilino aminopyrimidines |
BE754242A (fr) | 1970-07-15 | 1971-02-01 | Geigy Ag J R | Diamino-s-triazines et dinitro-s-triazines |
DE2038182C3 (de) | 1970-07-31 | 1980-10-09 | Ciba-Geigy Ag, Basel (Schweiz) | 2-Substituierte 4,6-Diamino-stri azine |
GB1483271A (en) | 1975-03-22 | 1977-08-17 | Ciba Geigy Ag | Pigment complexes |
GB1477349A (en) | 1975-09-24 | 1977-06-22 | Ciba Geigy Ag | Azo pigments |
US4096206A (en) | 1976-02-09 | 1978-06-20 | Borg-Warner Corporation | Flame-retardant triazines |
FR2400535A1 (fr) | 1977-01-27 | 1979-03-16 | Borg Warner | Composition de polymere contenant des tris(haloarylamino)triazines ou des tris(haloarylthio)triazines fournissant une aptitude au retardement d'inflammation |
FR2398740A1 (fr) | 1978-11-06 | 1979-02-23 | Borg Warner | Compose fournissant une aptitude au retardement d'inflammation dans un polymere |
JPS57203072A (en) | 1981-06-05 | 1982-12-13 | Sankyo Co Ltd | 4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient |
US4659363A (en) | 1983-07-25 | 1987-04-21 | Ciba-Geigy Corporation | N-(2-nitrophenyl)-2-aminopyrimidine derivatives, the preparation and use thereof |
US4652645A (en) | 1983-11-16 | 1987-03-24 | Ciba-Geigy Corporation | Cationic compounds |
ATE60591T1 (de) | 1984-06-25 | 1991-02-15 | Ciba Geigy Ag | Pyrimidinderivate wirksam als schaedlingsbekaempfungsmittel. |
JPH0784445B2 (ja) * | 1986-12-03 | 1995-09-13 | クミアイ化学工業株式会社 | ピリミジン誘導体および農園芸用殺菌剤 |
ES2013664A6 (es) | 1988-03-31 | 1990-05-16 | Mitsubishi Chem Ind | Un procedimiento para preparar derivados de nucleosidos de aciclopiramidina sustituidos en la posicion 6. |
JPH0252360A (ja) | 1988-08-15 | 1990-02-21 | Fujitsu Ltd | 電子写真感光体 |
US4980371A (en) | 1988-12-21 | 1990-12-25 | Merrell Dow Pharmaceuticals | Antiretroviral furan ketones |
DE59010042D1 (de) | 1989-03-22 | 1996-02-22 | Ciba Geigy Ag | Schädlingsbekämpfungsmittel |
IE63502B1 (en) | 1989-04-21 | 1995-05-03 | Zeneca Ltd | Aminopyrimidine derivatives useful for treating cardiovascular disorders |
JPH02300264A (ja) | 1989-05-16 | 1990-12-12 | Fuji Photo Film Co Ltd | アミノピリミジンアゾメチン色素とその製造方法 |
JPH02308248A (ja) | 1989-05-24 | 1990-12-21 | Fuji Photo Film Co Ltd | アミノピリミジン系色素形成カプラーおよび該カプラーを含有するハロゲン化銀カラー写真感光材料 |
US5064963A (en) | 1990-04-25 | 1991-11-12 | American Cyanamid Company | Process for the synthesis of n-(3-(1h-imidazol-1-yl)phenyl-4-(substituted)-2-pyrimidinamines |
GB9012592D0 (en) | 1990-06-06 | 1990-07-25 | Smithkline Beecham Intercredit | Compounds |
IE75693B1 (en) | 1990-07-10 | 1997-09-10 | Janssen Pharmaceutica Nv | HIV-inhibiting benzeneacetamide derivatives |
JPH04159381A (ja) | 1990-10-23 | 1992-06-02 | Arakawa Chem Ind Co Ltd | ロジンエステルの製造方法 |
EP0541966A3 (en) | 1991-11-15 | 1994-09-07 | American Cyanamid Co | Process for preparing amide derivatives from halomines and acid halides |
US5283274A (en) | 1992-06-19 | 1994-02-01 | Uniroyal Chemical Company, Inc. | Substituted pyrimidines and substituted triazines as rubber-to-metal adhesion promoters |
TW234077B (et) | 1992-07-17 | 1994-11-11 | Shell Internat Res Schappej B V | |
US5516775A (en) | 1992-08-31 | 1996-05-14 | Ciba-Geigy Corporation | Further use of pyrimidine derivatives |
SG49651A1 (en) | 1993-02-22 | 1998-06-15 | Janssen Pharmaceutica Nv | Method of reversing resistance of hiv-1 strains to zidovudine |
HUT74464A (en) | 1993-10-12 | 1996-12-30 | Du Pont Merck Pharma | 1n-alkyl-n-arylpyrimidinamines and derivatives thereof, and pharmaceutical compositions containing them |
CN1142817A (zh) | 1993-10-12 | 1997-02-12 | 杜邦麦克制药有限公司 | 1n-烷基-n-芳基嘧啶胺及其衍生物 |
GB9325217D0 (en) | 1993-12-09 | 1994-02-09 | Zeneca Ltd | Pyrimidine derivatives |
DE19509807A1 (de) * | 1995-03-21 | 1996-09-26 | Basf Ag | Verfahren zur Herstellung von Wirkstoffzubereitungen in Form einer festen Lösung des Wirkstoffs in einer Polymermatrix sowie mit diesem Verfahren hergestellte Wirkstoffzubereitungen |
TW530047B (en) | 1994-06-08 | 2003-05-01 | Pfizer | Corticotropin releasing factor antagonists |
IL114208A0 (en) | 1994-06-27 | 1995-10-31 | Merck & Co Inc | Combinations of compounds pharmaceutical compositions containing them and their use as hiv protease inhibitors |
TW401303B (en) | 1994-07-01 | 2000-08-11 | Janssen Pharmaceutica Nv | Anti-HIV triple combination |
US5574040A (en) | 1995-01-06 | 1996-11-12 | Picower Institute For Medical Research | Pyrimidine compounds and methods of use to derivatize neighboring lysine residues in proteins under physiologic conditions |
JP3691101B2 (ja) | 1995-01-24 | 2005-08-31 | 三洋電機株式会社 | 有機エレクトロルミネッセンス素子 |
DE19504832A1 (de) * | 1995-02-14 | 1996-08-22 | Basf Ag | Feste Wirkstoff-Zubereitungen |
US5691364A (en) | 1995-03-10 | 1997-11-25 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
JPH09101590A (ja) | 1995-07-28 | 1997-04-15 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料およびその包装体 |
US5837436A (en) | 1995-07-28 | 1998-11-17 | Fuji Photo Film Co., Ltd. | Silver halide color photographic material and package thereof |
JPH0968784A (ja) | 1995-08-31 | 1997-03-11 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料 |
JPH0980676A (ja) | 1995-09-13 | 1997-03-28 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料およびその包装体 |
GB9519197D0 (en) | 1995-09-20 | 1995-11-22 | Affinity Chromatography Ltd | Novel affinity ligands and their use |
GB9523675D0 (en) | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
CN1163401A (zh) | 1996-02-13 | 1997-10-29 | 李占元 | 全自动血球计数仪试剂及配制方法 |
GB9619284D0 (en) | 1996-09-16 | 1996-10-30 | Celltech Therapeutics Ltd | Chemical compounds |
NO311614B1 (no) * | 1996-10-01 | 2001-12-17 | Janssen Pharmaceutica Nv | Substituerte diamino-1,3,5-triazinderivater |
GB9705361D0 (en) | 1997-03-14 | 1997-04-30 | Celltech Therapeutics Ltd | Chemical compounds |
EP0872233A1 (en) | 1997-04-14 | 1998-10-21 | Janssen Pharmaceutica N.V. | Antiretroviral compositions with improved bioavailability |
JPH11116555A (ja) | 1997-10-14 | 1999-04-27 | Ube Ind Ltd | 4−アニリノピリミジン誘導体及びそれを有効成分とする農園芸用の殺虫・殺ダニ・殺菌剤 |
AU748087B2 (en) | 1998-02-17 | 2002-05-30 | Tularik Inc. | Anti-viral pyrimidine derivatives |
DE69905306T2 (de) | 1998-03-27 | 2003-11-27 | Janssen Pharmaceutica Nv | HIV hemmende Pyrimidin Derivate |
DE69943247D1 (de) * | 1998-03-27 | 2011-04-14 | Janssen Pharmaceutica Nv | HIV hemmende Pyrimidin Derivate |
EP0945442A1 (en) | 1998-03-27 | 1999-09-29 | Janssen Pharmaceutica N.V. | Trisubstituted pyrimidine derivatives |
EP0945447A1 (en) | 1998-03-27 | 1999-09-29 | Janssen Pharmaceutica N.V. | Trisubstituted 1,3,5-triazine derivatives for treatment of HIV infections |
JP2000111191A (ja) | 1998-08-04 | 2000-04-18 | Tokyo Gas Co Ltd | 吸収冷温水機 |
NZ511116A (en) | 1998-11-10 | 2003-08-29 | Janssen Pharmaceutica Nv | HIV replication inhibiting pyrimidines |
US6876717B1 (en) * | 2004-08-19 | 2005-04-05 | Intel Corporation | Multi-stage programmable Johnson counter |
-
2000
- 2000-08-31 MX MXPA02003182A patent/MXPA02003182A/es active IP Right Grant
- 2000-08-31 AP APAP/P/2002/002482A patent/AP1639A/en active
- 2000-08-31 TR TR2002/00763T patent/TR200200763T2/xx unknown
- 2000-08-31 AT AT00964080T patent/ATE316781T1/de active
- 2000-08-31 JP JP2001526150A patent/JP4919566B2/ja not_active Expired - Lifetime
- 2000-08-31 SK SK376-2002A patent/SK285240B6/sk not_active IP Right Cessation
- 2000-08-31 PT PT00964080T patent/PT1225874E/pt unknown
- 2000-08-31 SI SI200030842T patent/SI1225874T1/sl unknown
- 2000-08-31 CA CA002384188A patent/CA2384188C/en not_active Expired - Lifetime
- 2000-08-31 DK DK00964080T patent/DK1225874T3/da active
- 2000-08-31 IL IL14880100A patent/IL148801A0/xx active IP Right Grant
- 2000-08-31 CN CNB008133212A patent/CN1234347C/zh not_active Expired - Lifetime
- 2000-08-31 ES ES00964080T patent/ES2258018T3/es not_active Expired - Lifetime
- 2000-08-31 EA EA200200401A patent/EA005423B1/ru not_active IP Right Cessation
- 2000-08-31 DE DE60025837T patent/DE60025837T2/de not_active Expired - Lifetime
- 2000-08-31 OA OA1200200085A patent/OA12029A/en unknown
- 2000-08-31 KR KR1020027002218A patent/KR100785360B1/ko active IP Right Grant
- 2000-08-31 AU AU75127/00A patent/AU775360B2/en not_active Revoked
- 2000-08-31 KR KR1020077006306A patent/KR100820605B1/ko active IP Right Grant
- 2000-08-31 PL PL354026A patent/PL207590B1/pl unknown
- 2000-08-31 EP EP00964080A patent/EP1225874B1/en not_active Expired - Lifetime
- 2000-08-31 BR BRPI0014271-9A patent/BRPI0014271B1/pt not_active IP Right Cessation
- 2000-08-31 US US10/088,805 patent/US7241458B1/en not_active Expired - Lifetime
- 2000-08-31 NZ NZ517025A patent/NZ517025A/en not_active IP Right Cessation
- 2000-08-31 EE EEP200200151A patent/EE04991B1/et unknown
- 2000-08-31 CZ CZ20020907A patent/CZ300712B6/cs not_active IP Right Cessation
- 2000-08-31 WO PCT/EP2000/008522 patent/WO2001022938A1/en active IP Right Grant
- 2000-08-31 UA UA2002043289A patent/UA74797C2/uk unknown
- 2000-08-31 HU HU0203568A patent/HU228449B1/hu unknown
-
2002
- 2002-01-31 IS IS6256A patent/IS2567B/is unknown
- 2002-03-14 BG BG106521A patent/BG65754B1/bg unknown
- 2002-03-20 ZA ZA200202289A patent/ZA200202289B/en unknown
- 2002-03-22 NO NO20021443A patent/NO333358B1/no not_active IP Right Cessation
- 2002-03-22 HR HR20020247A patent/HRP20020247B1/xx not_active IP Right Cessation
-
2003
- 2003-02-11 HK HK03100992.5A patent/HK1048768B/zh not_active IP Right Cessation
-
2004
- 2004-10-29 AU AU2004224973A patent/AU2004224973C1/en not_active Expired
-
2006
- 2006-02-03 US US11/347,071 patent/US7887845B2/en not_active Expired - Lifetime
- 2006-04-28 CY CY20061100557T patent/CY1105268T1/el unknown
-
2007
- 2007-04-10 US US11/733,507 patent/US20070196478A1/en not_active Abandoned
-
2010
- 2010-03-16 US US12/724,566 patent/US20100172970A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EE200200151A (et) | Osake, ravimvorm, nende valmistamismeetodid, osakeste kasutamine ning farmatseutiline pakend | |
EE9800304A (et) | Osakesed, nende valmistamismeetod ja kasutamine, farmatseutiline doseerimisvorm ja selle valmistamismeetod, tahke dispersioon ning farmatseutiline pakend | |
AU5936400A (en) | Formulations comprising dehydrated particles of pharmaceutical agents and process for preparing the same | |
HUP0300593A3 (en) | Pharmaceutical formulations for dry powder inhalers in the form of hard-pellets | |
HUP0301046A3 (en) | Quinazoline derivatives for the treatment of tumours, process for their preparation and pharmaceutical compositions containing them | |
EE04996B1 (et) | Reguleeritud vabanemisega galantamiinipreparaat, meetod selle valmistamiseks, seda sisaldav doseerimisvorm ning farmatseutiline pakend | |
NO20014835L (no) | Fremgangsmate for fremstilling av monodisperse polymerpartikler | |
HUP0200309A2 (en) | Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression, process for their preparation and pharmaceutical compositions containing them | |
EE9800383A (et) | Meetod bioloogiliselt sobivate biodegradeeruvate mikroosakeste valmistamiseks, mikroosakesed ja nendest koosnev materjal, farmatseutiline kompositsioon ning mikroosakeste kasutamine | |
HK1164133A1 (en) | Nasal pharmaceutical formulations and methods of using the same | |
IL150539A0 (en) | Novel 1,3-dihydro-2h-indol-2-one derivatives, preparation method and pharmaceutical compositions containing them | |
EP1242112A4 (en) | PRODUCTS CONTAINING MEDICINANT SUBSTANCE PARTICLES AND PROCESS FOR PREPARING THE SAME | |
PL361833A1 (en) | Modified inorganic particles, method of their manufakturing and use thereof | |
IL162185A0 (en) | Phenylpropionate derivatives, methods for the preparation thereof and pharmaceutical compositions containing the same | |
HUP0104687A3 (en) | Methods for preparing coated drug particles and pharmaceutical formulations thereof | |
AU1080901A (en) | Catalyst compositions employing sol particles and methods of using the same | |
HUP0202781A3 (en) | Betha-carboline particulate form, pharmaceutical compositions containing it, their preparations and their use | |
FR2807038B1 (fr) | Nouveaux derives d'indolin-2-one, leur preparation et les compositions pharmaceutiques les contenant | |
HK1091727A1 (en) | Nasal pharmaceutical formulations and methods of using the same | |
DE60131760D1 (de) | Vorrichtung zur verabreichung von physiologisch aktiven wirkstoffen in pulverform | |
IL158297A0 (en) | Pharmaceutical compositions containing immune globulin and methods for the preparation thereof | |
IL151912A0 (en) | Pyrolidine derivatives, their preparation and pharmaceutical compositions containing them | |
IL159006A0 (en) | Phenoxy-phenyl derivatives and pharmaceutical compositions containing the same | |
EP1476174A4 (en) | PHARMACEUTICAL PREPARATION WITH PROPHYLACTIC EFFECTS ON LAMIVUDINE-RELATED REACTIONS AND PHARMACORESISTANCE, AND METHODS OF USING THE SAME | |
IL156532A0 (en) | Lipid microparticles, their preparation and pharmaceutical compositions containing them |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB4A | Valid patent at the end of a year |
Effective date: 20081231 |
|
KB4A | Valid patent at the end of a year |
Effective date: 20101231 |