AR037247A1 - Compuestos inhibidores de dipeptidil peptidasa iv (dp-iv), sus composiciones farmaceuticas y usos, y metodos de tratamiento de enfermedades de humanos tales como tolerancia alterada a la glucosa, diabetes tipo 2 e hiperglucemia - Google Patents
Compuestos inhibidores de dipeptidil peptidasa iv (dp-iv), sus composiciones farmaceuticas y usos, y metodos de tratamiento de enfermedades de humanos tales como tolerancia alterada a la glucosa, diabetes tipo 2 e hiperglucemiaInfo
- Publication number
- AR037247A1 AR037247A1 ARP020103995A ARP020103995A AR037247A1 AR 037247 A1 AR037247 A1 AR 037247A1 AR P020103995 A ARP020103995 A AR P020103995A AR P020103995 A ARP020103995 A AR P020103995A AR 037247 A1 AR037247 A1 AR 037247A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- optionally substituted
- treatment
- compounds
- diabetes
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Profármacos inhibidoresde la DP-IV con propiedades mejoradas. Los compuestos pueden usarse para el tratamiento de una cantidad de enfermedades humanas de tolerancia alterada a la glucosa y diabetes tipo II. Los compuestos de la presente se describen a través de la fórmula general (1), donde R1 es H ó CN; R2 se selecciona entre CH2R5, CH2CH2R5 y C(R3)(R4)-X2-(CH2)aR5; R3 y R4 se seleccionan cada uno independientemente entre H y Me; R5 se selecciona entre CON(R6)(R7), N(R8)C(=O)R8, N(R8)C(=S)R9, N(R8)SO2R11 y N(R8)R10; R6 y R7 son cada uno independientemente R11(CH2)b ó juntos son -(CH2)2-Z-(CH2)2- ó -CH2-o-C8H4-Z-CH2-; R8 es H ó Me; R9 se selecciona entre R11(CH2)b, R11(CH2)bO y N(R6)(R7); R10 es R11(CH2)b; R11 se selecciona entre H, alquilo, arilo opcionalmente sustituido, aroilo opcionalmente sustituido, arilsulfonilo opcionalmente sustituido y heteroarilo opcionalmente sustituido; R12 se selecciona entre H2NCH(R11)CO, H2NCH(R14)CONHCH(R15)CO, C(R16)=C(R17)COR18 y R19OCO; R13, R14 y R15 se seleccionan entre las cadenas laterales de aminoácidos proteináceos; R16 se seleccionan entre H, alquilo inferior C1-6 y fenilo; R17 se selecciona entre H y alquilo inferior C1-6; R18 se selecciona entre H, alquilo inferior C1-6, OH, O-(alquilo inferior C1-6) y fenilo; R19 se selecciona entre alquilo inferior C1-6, fenilo opcionalmente sustituido y R20C(=O)OC(R21)(R22); R20 y R22 se seleccionan cada uno independientemente entre H y alquilo inferior C1-6; Z se selecciona entre un enlace covalente, -(CH2)e-, -O-, -SOd- y -N(R10)-; X1 es S ó CH2; X2 es O, S ó CH2, a es 1, 2 ó 3; b es 0 - 3; c es 1 ó 2 y d es 0, 1 ó 2. Composiciones farmacéuticas que incluyen dichos compuestos de fórmula (1) y usos de dichos compuestos en la preparación de medicamentos. Método de tratamiento de hiperglucemia que comprende la administración un individuo en necesidad de tal tratamiento de una cantidad efectiva de dicho compuesto de fórmula (1).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0125446.5A GB0125446D0 (en) | 2001-10-23 | 2001-10-23 | Novel anti-diabetic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
AR037247A1 true AR037247A1 (es) | 2004-11-03 |
Family
ID=9924376
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020103995A AR037247A1 (es) | 2001-10-23 | 2002-10-22 | Compuestos inhibidores de dipeptidil peptidasa iv (dp-iv), sus composiciones farmaceuticas y usos, y metodos de tratamiento de enfermedades de humanos tales como tolerancia alterada a la glucosa, diabetes tipo 2 e hiperglucemia |
Country Status (18)
Country | Link |
---|---|
US (1) | US7144886B2 (es) |
EP (1) | EP1450794A1 (es) |
JP (1) | JP2005510499A (es) |
KR (1) | KR20040049321A (es) |
CN (1) | CN1329375C (es) |
AR (1) | AR037247A1 (es) |
CA (1) | CA2464256A1 (es) |
GB (1) | GB0125446D0 (es) |
HU (1) | HUP0402403A3 (es) |
IL (1) | IL161192A0 (es) |
MX (1) | MXPA04003828A (es) |
NO (1) | NO20042114L (es) |
NZ (1) | NZ532044A (es) |
PL (1) | PL370149A1 (es) |
RU (1) | RU2004110055A (es) |
UY (1) | UY27511A1 (es) |
WO (1) | WO2003035067A1 (es) |
ZA (1) | ZA200402500B (es) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
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US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
KR20040015298A (ko) | 2001-06-27 | 2004-02-18 | 스미스클라인 비참 코포레이션 | 디펩티딜 펩티다제 억제제로서의 플루오로피롤리딘 |
US7183290B2 (en) | 2001-06-27 | 2007-02-27 | Smithkline Beecham Corporation | Fluoropyrrolidines as dipeptidyl peptidase inhibitors |
JP4300108B2 (ja) | 2001-06-27 | 2009-07-22 | スミスクライン ビーチャム コーポレーション | ジペプチジルペプチダーゼ阻害剤としてのピロリジン類 |
EP1620091B1 (en) | 2003-05-05 | 2010-03-31 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
WO2004099134A2 (en) * | 2003-05-05 | 2004-11-18 | Prosidion Ltd. | Glutaminyl based dp iv-inhibitors |
DE10348023A1 (de) * | 2003-10-15 | 2005-05-19 | Imtm Gmbh | Neue Alanyl-Aminopeptidasen-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
DE10348044A1 (de) | 2003-10-15 | 2005-05-19 | Imtm Gmbh | Duale Alanyl-Aminopeptidase- und Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
DK1675578T3 (da) | 2003-10-15 | 2013-08-26 | Probiodrug Ag | Inhibitorer af glutaminyl- og glutamatcyclaser til behandling af de neurodegenerative sygdomme FBD og FDD |
DE10348022A1 (de) * | 2003-10-15 | 2005-05-25 | Imtm Gmbh | Neue Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
NZ546887A (en) | 2003-11-03 | 2009-04-30 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
MXPA06005518A (es) | 2003-11-17 | 2006-08-17 | Novartis Ag | Uso de inhibidores de la dipeptidil peptidasa iv. |
ES2684325T5 (es) | 2004-01-20 | 2024-06-10 | Novartis Ag | Formulación y proceso de compresión directa |
JP4996926B2 (ja) | 2004-02-05 | 2012-08-08 | プロビオドルグ エージー | グルタミニルシクラーゼの新規の阻害剤 |
DOP2006000008A (es) * | 2005-01-10 | 2006-08-31 | Arena Pharm Inc | Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1 |
WO2006116157A2 (en) * | 2005-04-22 | 2006-11-02 | Alantos Pharmaceuticals Holding, Inc. | Dipeptidyl peptidase-iv inhibitors |
MY152185A (en) | 2005-06-10 | 2014-08-29 | Novartis Ag | Modified release 1-[(3-hydroxy-adamant-1-ylamino)-acetyl]-pyrrolidine-2(s)-carbonitrile formulation |
JP2009504599A (ja) * | 2005-08-11 | 2009-02-05 | エフ.ホフマン−ラ ロシュ アーゲー | Dpp−iv阻害剤を含有する医薬組成物 |
ZA200802857B (en) | 2005-09-14 | 2009-09-30 | Takeda Pharmaceutical | Dipeptidyl peptidase inhibitors for treating diabetes |
KR101368988B1 (ko) | 2005-09-16 | 2014-02-28 | 다케다 야쿠힌 고교 가부시키가이샤 | 디펩티딜 펩티다제 억제제 |
GB0526291D0 (en) | 2005-12-23 | 2006-02-01 | Prosidion Ltd | Therapeutic method |
PE20071221A1 (es) | 2006-04-11 | 2007-12-14 | Arena Pharm Inc | Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas |
PL1971862T3 (pl) * | 2006-04-11 | 2011-04-29 | Arena Pharm Inc | Sposoby stosowania receptora GPR119 w celu identyfikacji związków przydatnych w zwiększeniu masy kostnej osobnika |
WO2007116092A1 (en) | 2006-04-12 | 2007-10-18 | Probiodrug Ag | Enzyme inhibitors |
EP2089383B1 (en) | 2006-11-09 | 2015-09-16 | Probiodrug AG | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
WO2008128985A1 (en) | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Thiourea derivatives as glutaminyl cyclase inhibitors |
EP2146210A1 (en) | 2008-04-07 | 2010-01-20 | Arena Pharmaceuticals, Inc. | Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY |
AR077642A1 (es) | 2009-07-09 | 2011-09-14 | Arena Pharm Inc | Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo |
KR101755737B1 (ko) | 2009-09-11 | 2017-07-07 | 프로비오드룩 아게 | 글루타미닐 사이클라제의 억제제로서 헤테로사이클릭 유도체 |
US9181233B2 (en) | 2010-03-03 | 2015-11-10 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
CA2789440C (en) | 2010-03-10 | 2020-03-24 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
MX2012011631A (es) | 2010-04-06 | 2013-01-18 | Arena Pharm Inc | Moduladores del receptor gpr119 y el tratamiento de trastornos relacionados con el mismo. |
JP5945532B2 (ja) | 2010-04-21 | 2016-07-05 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体 |
CA2812061A1 (en) | 2010-09-22 | 2012-03-29 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
ES2570167T3 (es) | 2011-03-16 | 2016-05-17 | Probiodrug Ag | Derivados de benzimidazol como inhibidores de glutaminil ciclasa |
WO2012135570A1 (en) | 2011-04-01 | 2012-10-04 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
US20140066369A1 (en) | 2011-04-19 | 2014-03-06 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
US20140038889A1 (en) | 2011-04-22 | 2014-02-06 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
WO2012145604A1 (en) | 2011-04-22 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
WO2012170702A1 (en) | 2011-06-08 | 2012-12-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
WO2013055910A1 (en) | 2011-10-12 | 2013-04-18 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
TWI500613B (zh) | 2012-10-17 | 2015-09-21 | Cadila Healthcare Ltd | 新穎之雜環化合物 |
WO2014074668A1 (en) | 2012-11-08 | 2014-05-15 | Arena Pharmaceuticals, Inc. | Modulators of gpr119 and the treatment of disorders related thereto |
GB201415598D0 (en) | 2014-09-03 | 2014-10-15 | Univ Birmingham | Elavated Itercranial Pressure Treatment |
EA201791982A1 (ru) | 2015-03-09 | 2020-02-17 | Интекрин Терапьютикс, Инк. | Способы лечения неалкогольной жировой болезни печени и/или липодистрофии |
WO2018162722A1 (en) | 2017-03-09 | 2018-09-13 | Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke | Dpp-4 inhibitors for use in treating bone fractures |
EP3606527A1 (en) | 2017-04-03 | 2020-02-12 | Coherus Biosciences, Inc. | Ppar-gamma agonist for treatment of progressive supranuclear palsy |
ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
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US3959248A (en) * | 1974-04-03 | 1976-05-25 | Merck & Co., Inc. | Analogs of thyrotropin-releasing hormone |
IL111785A0 (en) * | 1993-12-03 | 1995-01-24 | Ferring Bv | Dp-iv inhibitors and pharmaceutical compositions containing them |
DE19823831A1 (de) * | 1998-05-28 | 1999-12-02 | Probiodrug Ges Fuer Arzneim | Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen |
GB9928330D0 (en) * | 1999-11-30 | 2000-01-26 | Ferring Bv | Novel antidiabetic agents |
GB0010183D0 (en) | 2000-04-26 | 2000-06-14 | Ferring Bv | Inhibitors of dipeptidyl peptidase IV |
GB0010188D0 (en) | 2000-04-26 | 2000-06-14 | Ferring Bv | Inhibitors of dipeptidyl peptidase IV |
-
2001
- 2001-10-23 GB GBGB0125446.5A patent/GB0125446D0/en not_active Ceased
-
2002
- 2002-10-22 AR ARP020103995A patent/AR037247A1/es unknown
- 2002-10-22 UY UY27511A patent/UY27511A1/es not_active Application Discontinuation
- 2002-10-23 CA CA002464256A patent/CA2464256A1/en not_active Abandoned
- 2002-10-23 EP EP02801961A patent/EP1450794A1/en not_active Withdrawn
- 2002-10-23 MX MXPA04003828A patent/MXPA04003828A/es active IP Right Grant
- 2002-10-23 PL PL02370149A patent/PL370149A1/xx not_active Application Discontinuation
- 2002-10-23 IL IL16119202A patent/IL161192A0/xx unknown
- 2002-10-23 CN CNB028208544A patent/CN1329375C/zh not_active Expired - Fee Related
- 2002-10-23 US US10/491,288 patent/US7144886B2/en not_active Expired - Fee Related
- 2002-10-23 WO PCT/GB2002/004787 patent/WO2003035067A1/en not_active Application Discontinuation
- 2002-10-23 KR KR10-2004-7005917A patent/KR20040049321A/ko not_active Application Discontinuation
- 2002-10-23 RU RU2004110055/04A patent/RU2004110055A/ru not_active Application Discontinuation
- 2002-10-23 HU HU0402403A patent/HUP0402403A3/hu unknown
- 2002-10-23 NZ NZ532044A patent/NZ532044A/en unknown
- 2002-10-23 JP JP2003537634A patent/JP2005510499A/ja not_active Withdrawn
-
2004
- 2004-03-30 ZA ZA200402500A patent/ZA200402500B/xx unknown
- 2004-05-19 NO NO20042114A patent/NO20042114L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1575171A (zh) | 2005-02-02 |
MXPA04003828A (es) | 2004-07-16 |
CN1329375C (zh) | 2007-08-01 |
WO2003035067A1 (en) | 2003-05-01 |
RU2004110055A (ru) | 2005-10-20 |
NO20042114L (no) | 2004-07-21 |
US7144886B2 (en) | 2006-12-05 |
KR20040049321A (ko) | 2004-06-11 |
GB0125446D0 (en) | 2001-12-12 |
ZA200402500B (en) | 2005-01-24 |
EP1450794A1 (en) | 2004-09-01 |
HUP0402403A2 (hu) | 2005-04-28 |
PL370149A1 (en) | 2005-05-16 |
UY27511A1 (es) | 2003-04-30 |
HUP0402403A3 (en) | 2009-05-28 |
IL161192A0 (en) | 2004-08-31 |
CA2464256A1 (en) | 2003-05-01 |
US20050004205A1 (en) | 2005-01-06 |
NZ532044A (en) | 2005-03-24 |
JP2005510499A (ja) | 2005-04-21 |
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