EA201791982A1 - Способы лечения неалкогольной жировой болезни печени и/или липодистрофии - Google Patents

Способы лечения неалкогольной жировой болезни печени и/или липодистрофии

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Publication number
EA201791982A1
EA201791982A1 EA201791982A EA201791982A EA201791982A1 EA 201791982 A1 EA201791982 A1 EA 201791982A1 EA 201791982 A EA201791982 A EA 201791982A EA 201791982 A EA201791982 A EA 201791982A EA 201791982 A1 EA201791982 A1 EA 201791982A1
Authority
EA
Eurasian Patent Office
Prior art keywords
lipodystrophy
methods
treating
nafld
compositions
Prior art date
Application number
EA201791982A
Other languages
English (en)
Inventor
Кристос Мантзорос
Original Assignee
Интекрин Терапьютикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Интекрин Терапьютикс, Инк. filed Critical Интекрин Терапьютикс, Инк.
Publication of EA201791982A1 publication Critical patent/EA201791982A1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration

Abstract

Настоящее изобретение относится к способам лечения заболевания, связанного с резистентностью к инсулину, выбранного из неалкогольной жировой болезни печени (НАЖБП) и ее осложнений, липодистрофического синдрома или их комбинации, селективным агонистом PPARγ, INT131 и необязательно витамином E или их композициями. НАЖБП, которые могут подвергаться лечению способами и композициями по настоящему изобретению, включают, но не ограничиваются ими, простую неалкогольную жировую печень и неалкогольный стеатогепатит (NASH). Липодистрофические синдромы, которые могут подвергаться лечению способами и композициями по настоящему изобретению, включают, но не ограничиваются ими, генерализованную липодистрофию, включая врожденную генерализованную липодистрофию и приобретенную генерализованную липодистрофию и/или частичную липодистрофию, включая врожденную частичную липодистрофию и приобретенную частичную липодистрофию, каждая из которых может включать или может не включать гиперплексию и/или гипергликемию и может включать или может не включать НАЖБП.
EA201791982A 2015-03-09 2016-03-07 Способы лечения неалкогольной жировой болезни печени и/или липодистрофии EA201791982A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562130488P 2015-03-09 2015-03-09
PCT/US2016/021162 WO2016144862A1 (en) 2015-03-09 2016-03-07 Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy

Publications (1)

Publication Number Publication Date
EA201791982A1 true EA201791982A1 (ru) 2020-02-17

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201791982A EA201791982A1 (ru) 2015-03-09 2016-03-07 Способы лечения неалкогольной жировой болезни печени и/или липодистрофии

Country Status (16)

Country Link
US (3) US10555929B2 (ru)
EP (1) EP3267994A4 (ru)
JP (2) JP2018507914A (ru)
KR (2) KR20180006881A (ru)
CN (1) CN107683135A (ru)
AU (2) AU2016229982B2 (ru)
BR (1) BR112017019170A2 (ru)
CA (1) CA2979033A1 (ru)
EA (1) EA201791982A1 (ru)
HK (1) HK1249847A1 (ru)
IL (1) IL254282A0 (ru)
MA (1) MA42450A (ru)
MX (2) MX2017011586A (ru)
SG (2) SG11201707276PA (ru)
TW (1) TWI769976B (ru)
WO (1) WO2016144862A1 (ru)

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US20220175758A1 (en) * 2019-04-04 2022-06-09 Coherus Biosciences, Inc. Compositions and methods to treat non-alcoholic fatty liver diseases (nafld)
WO2020205025A1 (en) * 2019-04-04 2020-10-08 Coherus Biosciences, Inc. Compositions and methods to treat non-alcoholic fatty liver diseases (nafld)
EP3946337A1 (en) * 2019-04-04 2022-02-09 Coherus Biosciences, Inc. Compositions and methods to treat non-alcoholic fatty liver diseases (nafld)
WO2020205024A1 (en) * 2019-04-04 2020-10-08 Coherus Biosciences, Inc. Compositions and methods to treat non-alcoholic fatty liver diseases (nafld)
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