HUP0200849A2 - N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra - Google Patents
N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukraInfo
- Publication number
- HUP0200849A2 HUP0200849A2 HU0200849A HUP0200849A HUP0200849A2 HU P0200849 A2 HUP0200849 A2 HU P0200849A2 HU 0200849 A HU0200849 A HU 0200849A HU P0200849 A HUP0200849 A HU P0200849A HU P0200849 A2 HUP0200849 A2 HU P0200849A2
- Authority
- HU
- Hungary
- Prior art keywords
- aminoacetyl
- pyrrolidine
- producing
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 abstract 1
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- -1 p-toluenesulfonyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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- C—CHEMISTRY; METALLURGY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07—ORGANIC CHEMISTRY
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
Abstract
A találmány tárgyát az új (I) általános képletű 1-szubsztituált-acetil-2-ciano-4,4'-difluoro-pirrolidinek és analógjaik képezik,melyek a dipeptidil peptidáz IV enzim aktivitását erősen gátolják. Az(I) általános képletben R1 nitrogénatomot tartalmazó egy- vagy kéttagúaromás gyűrű; tienil- vagy furilcsoport; p- toluolszulfonilcsoportvagy R1a-CO-csoport R2 hidrogén vagy fluoratom; R3 fluoratom; Bjelentése (1), (2), (3), (4) vagy (5) általános képletű csoport. Ó
Priority Applications (32)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0200849A HUP0200849A2 (hu) | 2002-03-06 | 2002-03-06 | N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra |
BR0307960-0A BR0307960A (pt) | 2002-03-06 | 2003-03-04 | N-aminoacetil-pirrolidina-2-carbonitrilas e seu uso como inibidores de ddp-iv |
US10/507,005 US7348327B2 (en) | 2002-03-06 | 2003-03-04 | Compounds |
PL03371099A PL371099A1 (en) | 2002-03-06 | 2003-03-04 | New compounds |
CNA038052636A CN1639159A (zh) | 2002-03-06 | 2003-03-04 | N-氨基乙酰基-吡咯烷-2-腈和它们作为ddp-iv抑制剂的用途 |
PCT/HU2003/000017 WO2003074500A2 (en) | 2002-03-06 | 2003-03-04 | N-aminoacetyl-pyrrolidine-2-carbonitriles and their use as ddp-iv inhibitors |
AU2003209514A AU2003209514B2 (en) | 2002-03-06 | 2003-03-04 | N-aminoacetyl-pyrrolidine-2-carbonitriles and their use as DDP-IV inhibitors |
MXPA04008613A MXPA04008613A (es) | 2002-03-06 | 2003-03-04 | N-aminoacetil-pirrolidina-2-carbonitrilos y su uso como inhibidores de ddp-iv. |
DE60329282T DE60329282D1 (de) | 2002-03-06 | 2003-03-04 | Cyano-pyrrolidine als DPP-IV Inhibitoren |
EP03743452A EP1487807B1 (en) | 2002-03-06 | 2003-03-04 | Cyano-pyrrolidines as DPP-IV inhibitors |
YU79004A RS79004A (en) | 2002-03-06 | 2003-03-04 | New compounds |
AT03743452T ATE443054T1 (de) | 2002-03-06 | 2003-03-04 | Cyano-pyrrolidine als dpp-iv inhibitoren |
CNA2006101640208A CN1990486A (zh) | 2002-03-06 | 2003-03-04 | N-氨基乙酰基-吡咯烷-2-腈和它们作为ddp-iv抑制剂的用途 |
CA2475312A CA2475312C (en) | 2002-03-06 | 2003-03-04 | N-aminoacetyl-pyrrolidine-2-carbonitriles and their use as ddp-iv inhibitors |
KR1020047013870A KR100977898B1 (ko) | 2002-03-06 | 2003-03-04 | 화합물 |
EA200401157A EA007410B1 (ru) | 2002-03-06 | 2003-03-04 | N-аминоацетилпирролидин-2-карбонитрилы и их применение в качестве ингибиторов ddp-iv |
NZ535662A NZ535662A (en) | 2002-03-06 | 2003-03-04 | N-aminoacetyl-pyrrolidine-2-carbonitriles and their use as DDP-IV inhibitors |
JP2003572969A JP4559737B2 (ja) | 2002-03-06 | 2003-03-04 | N−アミノアセチル−ピロリジン−2−カルボニトリルおよびddp−iv阻害剤としてのその使用 |
ARP030100723A AR038868A1 (es) | 2002-03-06 | 2003-03-05 | Derivados de 1-(2-aminoacetil)2-pirrolidincarbonitrilo, su uso para la preparacion de una formulacion farmaceutica, las formulaciones farmaceuticas que los contienen, un procedimiento para la preparacion de estos derivados, y los intermediarios y su uso en dicho procedimiento de preparacion |
TW092104743A TWI250978B (en) | 2002-03-06 | 2003-03-06 | New compounds |
UA20041008080A UA78291C2 (en) | 2002-03-06 | 2003-04-03 | N-aminoacetylpyrrolidine-2-carbonitrils, method for production thereof, pharmaceutical composition, application thereof, and intermediate products for production process |
IL163286A IL163286A (en) | 2002-03-06 | 2004-07-29 | 1-(substituted glycyl)pyrrolidine-2-carbonitriles, their preparation and pharmaceutical compositions containing them |
TNP2004000141A TNSN04141A1 (en) | 2002-03-06 | 2004-07-29 | NEW COMPOUNDS - DDP - IV difluor |
MA27806A MA27105A1 (fr) | 2002-03-06 | 2004-07-29 | Nouveaux composes |
ZA200406467A ZA200406467B (en) | 2002-03-06 | 2004-08-13 | N-aminoacetyl-pyrrolidine-2-carbonitriles and their use as DDP-IV inhibitors. |
IS7434A IS7434A (is) | 2002-03-06 | 2004-09-02 | N-amínóasetýl-pýrrólídín-2-karbónítríl og notkun þeirra sem DDP-IV tálma |
EC2004005274A ECSP045274A (es) | 2002-03-06 | 2004-09-03 | N-aminoacetil-pirrolidina-2-carbonitrilosy su uso como inhibidores ddp-iv |
HR20040910A HRP20040910A2 (en) | 2002-03-06 | 2004-10-04 | New compounds |
NO20044221A NO20044221L (no) | 2002-03-06 | 2004-10-05 | Nye forbindelser |
IL177933A IL177933A0 (en) | 2002-03-06 | 2006-09-07 | New compounds |
US12/042,595 US7655663B2 (en) | 2002-03-06 | 2008-03-05 | Fluoropyrrolidines having dipeptidyl peptidase enzyme inhibitory activity |
US12/697,762 US8063045B2 (en) | 2002-03-06 | 2010-02-01 | Fluoropyrrolidines having dipeptidyl peptidase enzyme inhibitory activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0200849A HUP0200849A2 (hu) | 2002-03-06 | 2002-03-06 | N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0200849D0 HUP0200849D0 (hu) | 2002-05-29 |
HUP0200849A2 true HUP0200849A2 (hu) | 2004-08-30 |
Family
ID=90001540
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0200849A HUP0200849A2 (hu) | 2002-03-06 | 2002-03-06 | N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra |
Country Status (28)
Country | Link |
---|---|
US (3) | US7348327B2 (hu) |
EP (1) | EP1487807B1 (hu) |
JP (1) | JP4559737B2 (hu) |
KR (1) | KR100977898B1 (hu) |
CN (2) | CN1639159A (hu) |
AR (1) | AR038868A1 (hu) |
AT (1) | ATE443054T1 (hu) |
AU (1) | AU2003209514B2 (hu) |
BR (1) | BR0307960A (hu) |
CA (1) | CA2475312C (hu) |
DE (1) | DE60329282D1 (hu) |
EA (1) | EA007410B1 (hu) |
EC (1) | ECSP045274A (hu) |
HR (1) | HRP20040910A2 (hu) |
HU (1) | HUP0200849A2 (hu) |
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