CO4970731A1 - Tetrahidro prostaglandinas c16-c29 sustituidas utiles como agonistas fp - Google Patents

Tetrahidro prostaglandinas c16-c29 sustituidas utiles como agonistas fp

Info

Publication number
CO4970731A1
CO4970731A1 CO98051818A CO98051818A CO4970731A1 CO 4970731 A1 CO4970731 A1 CO 4970731A1 CO 98051818 A CO98051818 A CO 98051818A CO 98051818 A CO98051818 A CO 98051818A CO 4970731 A1 CO4970731 A1 CO 4970731A1
Authority
CO
Colombia
Prior art keywords
ring
alkyl
aliphatic ring
heteroaromatic
heteroalkyl
Prior art date
Application number
CO98051818A
Other languages
English (en)
Inventor
John August Wos
Mitchell Anthony Delong
S Amburgey Jack Jr
De Biswanath
Dai George Haiyan
Wang Yili
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of CO4970731A1 publication Critical patent/CO4970731A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se relaciona con un compuesto quetiene la extructura:donde (a) R1 es CO2 H, C(O)NHOH, CO2 R5 , CH2 OH, S(O)2 R5 , C(O)NHR5 , C(O)NHS(O)2 R5 o tetrazol; donde R5 es alquilo, heteroalquilo, anillo alifático carbocíclico, anillo alifático heterocíclico, anillo aromático o anillo heteroaromático;(b) R2 es H o alquilo inferior;(c) X es NR6 R7 , OR8 , SR9 , S(O)R9 , ó S(O)2 R9 ; donde R6 , R7 y R8 son independientemente seleccionados del grupo consistente de H, acilo, alquilo, heteroalquilo, anillo alifático carbocíclico, anillo alifático heterocíclico, anillo aromático o anillo heteroaromático; y donde R9 es alquilo, eteroalquilo, anillo alifático carbocíclico, anillo alifático heterocíclico, anillo aromático o anillo heteroaromático;(d) R3 y R4 son independientemente seleccionados del grupo consistente de H, CH3 y C2 H5 ;(e) Y es NR10 , S, S(O) ó S(O)2 ; donde R10 es H, acilo, alquilo, heteroalquilo, anillo alifático heterocíclico, anillo aromático o anillo eteroaromático.(f) Z es anillo alifático heterocíclico, anillo aromático o anillo heteroaromático; ycualquier isómero óptico, diestereómero, enantiómero de la extructura anterior o una sal farmacéuticamente aceptable o amida biohidrolizable, éster o imida de ellos.
CO98051818A 1997-09-09 1998-09-09 Tetrahidro prostaglandinas c16-c29 sustituidas utiles como agonistas fp CO4970731A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5821797P 1997-09-09 1997-09-09

Publications (1)

Publication Number Publication Date
CO4970731A1 true CO4970731A1 (es) 2000-11-07

Family

ID=22015427

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98051818A CO4970731A1 (es) 1997-09-09 1998-09-09 Tetrahidro prostaglandinas c16-c29 sustituidas utiles como agonistas fp

Country Status (24)

Country Link
US (1) US5977173A (es)
EP (1) EP1012136B1 (es)
JP (1) JP2001515882A (es)
KR (1) KR20010023839A (es)
CN (1) CN1269786A (es)
AR (1) AR013477A1 (es)
AT (1) ATE270660T1 (es)
AU (1) AU731153B2 (es)
BR (1) BR9811774A (es)
CA (1) CA2303764C (es)
CO (1) CO4970731A1 (es)
DE (1) DE69824966T2 (es)
ES (1) ES2223141T3 (es)
HU (1) HUP0100638A3 (es)
ID (1) ID23971A (es)
IL (1) IL134839A0 (es)
NO (1) NO20001141L (es)
NZ (1) NZ503735A (es)
PE (1) PE115499A1 (es)
PL (1) PL339212A1 (es)
SK (1) SK3372000A3 (es)
TR (1) TR200000671T2 (es)
WO (1) WO1999012895A1 (es)
ZA (1) ZA988230B (es)

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US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020037914A1 (en) * 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
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US9216183B2 (en) 2002-02-04 2015-12-22 Allergan, Inc. Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists
US7351404B2 (en) 2002-02-04 2008-04-01 Allergan, Inc. Method of enhancing hair growth
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US20070254920A1 (en) * 2006-04-26 2007-11-01 Aerie Pharmaceuticals, Inc. Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
RU2010121880A (ru) * 2007-10-31 2011-12-10 Памела ЛИПКИН (US) Композиции аналогов простагландина и способы лечения состояний, затрагивающих эпителий
US20100074857A1 (en) * 2008-09-23 2010-03-25 Pamela Lipkin Compositions and methods to treat epithelial-related conditions
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
EP2349242B1 (en) 2008-10-29 2018-12-05 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8623918B2 (en) 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
WO2010077101A2 (ko) 2008-12-30 2010-07-08 조선대학교산학협력단 신규한 티아졸리딘디온 유도체 및 그의 용도
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
US8394826B2 (en) 2009-05-01 2013-03-12 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
US9149484B2 (en) 2009-11-09 2015-10-06 Allergan, Inc. Compositions and methods for stimulating hair growth
NZ628266A (en) 2009-11-09 2016-02-26 Allergan Inc Compositions and methods for stimulating hair growth
US8859616B2 (en) 2011-01-21 2014-10-14 Allergan, Inc. Compounds and methods for enhancing hair growth
EP3811943B1 (en) 2013-03-15 2023-02-22 Aerie Pharmaceuticals, Inc. Compound for use in the treatment of ocular disorders
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
BR112019003945A2 (pt) 2016-08-31 2019-05-21 Aerie Pharmaceuticals, Inc. composições oftálmicas
CN110506037A (zh) 2017-03-31 2019-11-26 爱瑞制药公司 芳基环丙基-氨基-异喹啉酰胺化合物
WO2020056345A1 (en) 2018-09-14 2020-03-19 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds

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Also Published As

Publication number Publication date
TR200000671T2 (tr) 2000-07-21
HUP0100638A3 (en) 2002-12-28
EP1012136B1 (en) 2004-07-07
NO20001141D0 (no) 2000-03-06
JP2001515882A (ja) 2001-09-25
PL339212A1 (en) 2000-12-04
IL134839A0 (en) 2001-05-20
CA2303764A1 (en) 1999-03-18
ES2223141T3 (es) 2005-02-16
EP1012136A1 (en) 2000-06-28
ID23971A (id) 2000-06-14
NZ503735A (en) 2001-05-25
SK3372000A3 (en) 2000-10-09
CN1269786A (zh) 2000-10-11
NO20001141L (no) 2000-05-04
DE69824966D1 (de) 2004-08-12
HUP0100638A2 (hu) 2001-07-30
US5977173A (en) 1999-11-02
AU731153B2 (en) 2001-03-22
ZA988230B (en) 1999-03-09
DE69824966T2 (de) 2005-04-07
WO1999012895A1 (en) 1999-03-18
AU9219398A (en) 1999-03-29
KR20010023839A (ko) 2001-03-26
BR9811774A (pt) 2000-08-29
ATE270660T1 (de) 2004-07-15
CA2303764C (en) 2005-02-15
AR013477A1 (es) 2000-12-27
PE115499A1 (es) 2000-02-03

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