AR008920A1 - Proceso para la preparacion de los derivados de 2-amino-2-imidaxolina, guanidina, y 2-amino-3,4,5,6-tetrahidropiridimina - Google Patents
Proceso para la preparacion de los derivados de 2-amino-2-imidaxolina, guanidina, y 2-amino-3,4,5,6-tetrahidropiridiminaInfo
- Publication number
- AR008920A1 AR008920A1 ARP970105531A ARP970105531A AR008920A1 AR 008920 A1 AR008920 A1 AR 008920A1 AR P970105531 A ARP970105531 A AR P970105531A AR P970105531 A ARP970105531 A AR P970105531A AR 008920 A1 AR008920 A1 AR 008920A1
- Authority
- AR
- Argentina
- Prior art keywords
- methylene group
- methyl
- group connected
- membered ring
- ethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
Abstract
Un proceso para preparar un compuesto de la siguiente estructura de formula (I) o los teutomeros que de allí se obtienen, donde: (a) R1 es metil, etil, ungrupo metileno conectado a R2 mediante un enlace simple de forma tal que R1 y R2, forman un anillo de cinco miembros, o un grupo de metileno conectado a R2 através de otro grupo metileno de forma que R1 y R2, forman un anillo de seis miembros. (b) R2 es metil, etil un grupo metileno conectado a R2 mediante unenlace simple de forma tal queR1 y R2 forman un anillo de cinco miembros, o un grupo de metileno conectado a R1 a través de otro grupo metileno de forma queR1 y R2 forman un anillo de seis miembros; (c) Z es un carbociclo o heterociclo saturado, sin saturar o aromático, monocíclico o policíclico, que contiene unoo más heteroátomos de O, N o S y (d) R4 es uno o más sustituyentes del anillo Z que contienen independientemente hidrogeno, alcoxi, alquiltio, alquil, alquenilamino, ciano, halogeno, hidroxi, nitro y tiol; (e) o unaforma protegida, sal sal farmacéuticamente aceptable, ester biohidrolizable o un solvato que seobtiene de ellos. Está compuesto por las siguientes etapas (1) preparacion de un compuesto intermedio cuya estructura general sea formula (II) donde: (a)R seselecciona del grupo compuesto por metil, etil y bencil; (b) R1 es metil, etil, un grupo metileno conectado a R2 mediante un enlace simple de forma tal que R1y R2 forman un anillo de cinco miembros, o un grupo de metileno conectado a R1 a través de otro grupo metileno de forma que R1 y R2 forman un anillo de seismiembros; R2 es metil, etil, un grupo metileno conectado a R1 mediante un enlace simple de forma tal que R1 y R2 forman un anillo de 5 miembros o ungrupo metileno conectadoa R1 a traves de otro grupo metileno de forma que R1 y R2 formen un anillo de 6 miembros; (d) R3 es -O-R5 o -R6, (e) R5 es metilo,
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3431896P | 1996-11-25 | 1996-11-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR008920A1 true AR008920A1 (es) | 2000-02-23 |
Family
ID=21875679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970105531A AR008920A1 (es) | 1996-11-25 | 1997-11-25 | Proceso para la preparacion de los derivados de 2-amino-2-imidaxolina, guanidina, y 2-amino-3,4,5,6-tetrahidropiridimina |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0944603B1 (es) |
| JP (1) | JP2001506605A (es) |
| KR (1) | KR20000069132A (es) |
| AR (1) | AR008920A1 (es) |
| AT (1) | ATE232851T1 (es) |
| AU (1) | AU732056B2 (es) |
| BR (1) | BR9713296A (es) |
| CA (1) | CA2272690C (es) |
| CO (1) | CO4910165A1 (es) |
| CZ (1) | CZ183599A3 (es) |
| DE (1) | DE69719210T2 (es) |
| DK (1) | DK0944603T3 (es) |
| ID (1) | ID22896A (es) |
| IL (1) | IL130095A0 (es) |
| NO (1) | NO312721B1 (es) |
| PE (1) | PE28099A1 (es) |
| SK (1) | SK69899A3 (es) |
| TR (1) | TR199901484T2 (es) |
| TW (1) | TW472043B (es) |
| WO (1) | WO1998023595A1 (es) |
| ZA (1) | ZA9710581B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996004270A1 (en) | 1994-08-04 | 1996-02-15 | Synaptic Pharmaceutical Corporation | Novel benzimidazole derivatives |
| US6495583B1 (en) | 1997-03-25 | 2002-12-17 | Synaptic Pharmaceutical Corporation | Benzimidazole derivatives |
| US20040167194A1 (en) | 2003-02-20 | 2004-08-26 | Randall Jared Lynn | Methods of making 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile and its preferred salt form |
| US11077053B2 (en) | 2018-08-21 | 2021-08-03 | Allergan, Inc. | Alpha-2-adrenergic receptor agonists for treatment of presbyopia, visual glare, visual starbursts, visual halos and night myopia |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1670807A1 (de) * | 1967-02-17 | 1971-03-11 | Bayer Ag | Verfahren zur Herstellung von cyclischen Guanidinen |
| DE2854659A1 (de) * | 1978-12-18 | 1980-07-10 | Boehringer Sohn Ingelheim | Neue 3,4-disubstituierte 2-phenylimino-imidazolidine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung |
-
1997
- 1997-11-25 ZA ZA9710581A patent/ZA9710581B/xx unknown
- 1997-11-25 AU AU74021/98A patent/AU732056B2/en not_active Ceased
- 1997-11-25 CA CA002272690A patent/CA2272690C/en not_active Expired - Fee Related
- 1997-11-25 WO PCT/US1997/021646 patent/WO1998023595A1/en active IP Right Grant
- 1997-11-25 DK DK97949622T patent/DK0944603T3/da active
- 1997-11-25 CZ CZ991835A patent/CZ183599A3/cs unknown
- 1997-11-25 AT AT97949622T patent/ATE232851T1/de not_active IP Right Cessation
- 1997-11-25 EP EP97949622A patent/EP0944603B1/en not_active Expired - Lifetime
- 1997-11-25 CO CO97068899A patent/CO4910165A1/es unknown
- 1997-11-25 TR TR1999/01484T patent/TR199901484T2/xx unknown
- 1997-11-25 IL IL13009597A patent/IL130095A0/xx unknown
- 1997-11-25 PE PE1997001068A patent/PE28099A1/es not_active Application Discontinuation
- 1997-11-25 SK SK698-99A patent/SK69899A3/sk unknown
- 1997-11-25 AR ARP970105531A patent/AR008920A1/es not_active Application Discontinuation
- 1997-11-25 JP JP52482898A patent/JP2001506605A/ja active Pending
- 1997-11-25 KR KR1019997004620A patent/KR20000069132A/ko not_active Application Discontinuation
- 1997-11-25 BR BR9713296-9A patent/BR9713296A/pt unknown
- 1997-11-25 ID IDW990413A patent/ID22896A/id unknown
- 1997-11-25 DE DE69719210T patent/DE69719210T2/de not_active Expired - Lifetime
-
1998
- 1998-03-07 TW TW087103342A patent/TW472043B/zh active
-
1999
- 1999-05-25 NO NO19992501A patent/NO312721B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ID22896A (id) | 1999-12-16 |
| NO992501D0 (no) | 1999-05-25 |
| DK0944603T3 (da) | 2003-06-16 |
| SK69899A3 (en) | 2000-01-18 |
| TW472043B (en) | 2002-01-11 |
| CO4910165A1 (es) | 2000-04-24 |
| CA2272690A1 (en) | 1998-06-04 |
| NO312721B1 (no) | 2002-06-24 |
| BR9713296A (pt) | 1999-10-26 |
| IL130095A0 (en) | 2000-02-29 |
| ATE232851T1 (de) | 2003-03-15 |
| CZ183599A3 (cs) | 1999-10-13 |
| CA2272690C (en) | 2004-07-13 |
| WO1998023595A1 (en) | 1998-06-04 |
| ZA9710581B (en) | 1998-06-12 |
| JP2001506605A (ja) | 2001-05-22 |
| EP0944603B1 (en) | 2003-02-19 |
| NO992501L (no) | 1999-07-22 |
| EP0944603A1 (en) | 1999-09-29 |
| KR20000069132A (ko) | 2000-11-25 |
| AU7402198A (en) | 1998-06-22 |
| PE28099A1 (es) | 1999-03-31 |
| AU732056B2 (en) | 2001-04-12 |
| DE69719210T2 (de) | 2004-02-12 |
| DE69719210D1 (de) | 2003-03-27 |
| TR199901484T2 (xx) | 1999-09-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |