PE28099A1 - Proceso para hacer derivados de 2-amino-2-imidazolina, guanidina y 2-amino-3,4,5,6-tetrahidropirimidina - Google Patents
Proceso para hacer derivados de 2-amino-2-imidazolina, guanidina y 2-amino-3,4,5,6-tetrahidropirimidinaInfo
- Publication number
- PE28099A1 PE28099A1 PE1997001068A PE00106897A PE28099A1 PE 28099 A1 PE28099 A1 PE 28099A1 PE 1997001068 A PE1997001068 A PE 1997001068A PE 00106897 A PE00106897 A PE 00106897A PE 28099 A1 PE28099 A1 PE 28099A1
- Authority
- PE
- Peru
- Prior art keywords
- amino
- procedure
- preparing
- compounds
- tetrahydropyrimidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE AL PROCEDIMIENTO DE PREPARACION DE LOS COMPUESTOS (I), QUE COMPRENDE: (I) PREPARAR R-S-C(=NR1)-NR2-CO-R3 EN UN PROCEDIMIENTO DE DOS PASOS, EN UN MISMO RECIPIENTE, QUE CONSISTE EN (a) ALQUILAR R1-NH-CS-NH-R2 USANDO UN AGENTE ALQUILANTE TAL COMO: CH3I, CH3Br, CH3Cl, (CH3)2SO4, C2H5I, C2H5Br, C2H5Cl, (C2H5)2SO4 Y C6H5-CH2Br; (b) ACILAR LO OBTENIDO EN (a) CON UN AGENTE ACILANTE TAL COMO: DICARBONATO DE DITERT-BUTILO, DIETILPIROCARBONATO, DIMETILPIROCARBONATO, ClCOOCH3, ClCOOC2H5, CH3COCl, C2H5COCl, (CH3CO)20, (C2H5CO)2O, C(CH3)3COCl, (C(CH3)3CO)2O Y CLORURO DE BENZOILO, EN PRESENCIA DE UNA BASE TAL COMO: N(C2H5)3, N(CH3)3, 4-DIMETILAMINOPIRIDINA, PIRIDINA, K2CO3, Na2CO3, KHCO3 Y NaHCO3; (ii) ACOPLANDO EL COMPUESTO INTERMEDIO DE (i) CON R4-Z-NH2, EN PRESENCIA DE UN ACIDO ORGANICO TAL COMO CH3COOH, C2H5COOH, CH2ClCOOH, ENTRE OTROS, A UNA TEMPERATURA QUE VA DE LA TEMPERATURA AMBIENTE A 150�C; EN DONDE: R1 Y R2 SON METILO, ETILO o AMBOS SE UNEN FORMANDO UN ANILLO DE 5 o 6 MIEMBROS; "Z" ES UN CARBOCICLO o HETEROCICLO; R4 ES H, ALCOXI, ALQUILTIO, ENTRE OTROS. ESTE PROCEDIMIENTO MEJORA EL RENDIMIENTO, LA PUREZA DEL PRODUCTO Y PROPORCIONA UNA FLEXIBILIDAD SINTETICA PARA LA PREPARACION DE DICHOS COMPUESTOS QUE ACTUAN COMO AGONISTAS DE ALFA-2-ADRENORECEPTOR, SIENDO UTILES EN EL TRATAMIENTO DE LA HIPERTENSION, MIGRANA, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3431896P | 1996-11-25 | 1996-11-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE28099A1 true PE28099A1 (es) | 1999-03-31 |
Family
ID=21875679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1997001068A PE28099A1 (es) | 1996-11-25 | 1997-11-25 | Proceso para hacer derivados de 2-amino-2-imidazolina, guanidina y 2-amino-3,4,5,6-tetrahidropirimidina |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0944603B1 (es) |
| JP (1) | JP2001506605A (es) |
| KR (1) | KR20000069132A (es) |
| AR (1) | AR008920A1 (es) |
| AT (1) | ATE232851T1 (es) |
| AU (1) | AU732056B2 (es) |
| BR (1) | BR9713296A (es) |
| CA (1) | CA2272690C (es) |
| CO (1) | CO4910165A1 (es) |
| CZ (1) | CZ183599A3 (es) |
| DE (1) | DE69719210T2 (es) |
| DK (1) | DK0944603T3 (es) |
| ID (1) | ID22896A (es) |
| IL (1) | IL130095A0 (es) |
| NO (1) | NO312721B1 (es) |
| PE (1) | PE28099A1 (es) |
| SK (1) | SK69899A3 (es) |
| TR (1) | TR199901484T2 (es) |
| TW (1) | TW472043B (es) |
| WO (1) | WO1998023595A1 (es) |
| ZA (1) | ZA9710581B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU704972B2 (en) | 1994-08-04 | 1999-05-13 | H. Lundbeck A/S | Novel benzimidazole derivatives |
| US6495583B1 (en) | 1997-03-25 | 2002-12-17 | Synaptic Pharmaceutical Corporation | Benzimidazole derivatives |
| US20040167194A1 (en) | 2003-02-20 | 2004-08-26 | Randall Jared Lynn | Methods of making 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile and its preferred salt form |
| US11077053B2 (en) | 2018-08-21 | 2021-08-03 | Allergan, Inc. | Alpha-2-adrenergic receptor agonists for treatment of presbyopia, visual glare, visual starbursts, visual halos and night myopia |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1670807A1 (de) * | 1967-02-17 | 1971-03-11 | Bayer Ag | Verfahren zur Herstellung von cyclischen Guanidinen |
| DE2854659A1 (de) * | 1978-12-18 | 1980-07-10 | Boehringer Sohn Ingelheim | Neue 3,4-disubstituierte 2-phenylimino-imidazolidine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung |
-
1997
- 1997-11-25 ZA ZA9710581A patent/ZA9710581B/xx unknown
- 1997-11-25 JP JP52482898A patent/JP2001506605A/ja active Pending
- 1997-11-25 ID IDW990413A patent/ID22896A/id unknown
- 1997-11-25 CO CO97068899A patent/CO4910165A1/es unknown
- 1997-11-25 WO PCT/US1997/021646 patent/WO1998023595A1/en active IP Right Grant
- 1997-11-25 CA CA002272690A patent/CA2272690C/en not_active Expired - Fee Related
- 1997-11-25 AT AT97949622T patent/ATE232851T1/de not_active IP Right Cessation
- 1997-11-25 AU AU74021/98A patent/AU732056B2/en not_active Ceased
- 1997-11-25 TR TR1999/01484T patent/TR199901484T2/xx unknown
- 1997-11-25 KR KR1019997004620A patent/KR20000069132A/ko not_active Application Discontinuation
- 1997-11-25 SK SK698-99A patent/SK69899A3/sk unknown
- 1997-11-25 DE DE69719210T patent/DE69719210T2/de not_active Expired - Lifetime
- 1997-11-25 DK DK97949622T patent/DK0944603T3/da active
- 1997-11-25 IL IL13009597A patent/IL130095A0/xx unknown
- 1997-11-25 BR BR9713296-9A patent/BR9713296A/pt unknown
- 1997-11-25 CZ CZ991835A patent/CZ183599A3/cs unknown
- 1997-11-25 PE PE1997001068A patent/PE28099A1/es not_active Application Discontinuation
- 1997-11-25 EP EP97949622A patent/EP0944603B1/en not_active Expired - Lifetime
- 1997-11-25 AR ARP970105531A patent/AR008920A1/es not_active Application Discontinuation
-
1998
- 1998-03-07 TW TW087103342A patent/TW472043B/zh active
-
1999
- 1999-05-25 NO NO19992501A patent/NO312721B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK0944603T3 (da) | 2003-06-16 |
| ID22896A (id) | 1999-12-16 |
| NO312721B1 (no) | 2002-06-24 |
| CO4910165A1 (es) | 2000-04-24 |
| AU7402198A (en) | 1998-06-22 |
| TR199901484T2 (xx) | 1999-09-21 |
| AR008920A1 (es) | 2000-02-23 |
| NO992501L (no) | 1999-07-22 |
| NO992501D0 (no) | 1999-05-25 |
| BR9713296A (pt) | 1999-10-26 |
| JP2001506605A (ja) | 2001-05-22 |
| ATE232851T1 (de) | 2003-03-15 |
| DE69719210T2 (de) | 2004-02-12 |
| AU732056B2 (en) | 2001-04-12 |
| IL130095A0 (en) | 2000-02-29 |
| CA2272690C (en) | 2004-07-13 |
| WO1998023595A1 (en) | 1998-06-04 |
| CA2272690A1 (en) | 1998-06-04 |
| EP0944603A1 (en) | 1999-09-29 |
| ZA9710581B (en) | 1998-06-12 |
| EP0944603B1 (en) | 2003-02-19 |
| KR20000069132A (ko) | 2000-11-25 |
| SK69899A3 (en) | 2000-01-18 |
| CZ183599A3 (cs) | 1999-10-13 |
| TW472043B (en) | 2002-01-11 |
| DE69719210D1 (de) | 2003-03-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FX | Voluntary withdrawal |