KR960703936A - 4"-데옥시-4"-에피-메틸아미노 에버멕틴 B1a/B1b 벤조산 염의 열역학적으로 안정한 결정체형 및 이의 제조방법(Thermodynamically stable crystal form of 4"-deoxy-4"-epi-methylamino avermectin B1a/B1b benzoic acid salt and process for its preparation) - Google Patents

4"-데옥시-4"-에피-메틸아미노 에버멕틴 B1a/B1b 벤조산 염의 열역학적으로 안정한 결정체형 및 이의 제조방법(Thermodynamically stable crystal form of 4"-deoxy-4"-epi-methylamino avermectin B1a/B1b benzoic acid salt and process for its preparation) Download PDF

Info

Publication number
KR960703936A
KR960703936A KR1019960700754A KR19960700754A KR960703936A KR 960703936 A KR960703936 A KR 960703936A KR 1019960700754 A KR1019960700754 A KR 1019960700754A KR 19960700754 A KR19960700754 A KR 19960700754A KR 960703936 A KR960703936 A KR 960703936A
Authority
KR
South Korea
Prior art keywords
benzoic acid
acid salt
epi
deoxy
preparation
Prior art date
Application number
KR1019960700754A
Other languages
English (en)
Other versions
KR100370697B1 (ko
Inventor
크베토비치 레이몬드
뎀차크 리차드
에이. 맥컬리 제임스
제이. 바르살로나 리차드
Original Assignee
도나 엘. 폴락
머크 앤드 캄파니, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 도나 엘. 폴락, 머크 앤드 캄파니, 인코포레이티드 filed Critical 도나 엘. 폴락
Publication of KR960703936A publication Critical patent/KR960703936A/ko
Application granted granted Critical
Publication of KR100370697B1 publication Critical patent/KR100370697B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

반수화물로서의 4″-데옥시-4″에피-메틸아미노 에버멕틴 B1a/B1b 벤조산 염의 열역학적으로 안정한 결정체 형태는 조절된 양의 물을 함유하는 유기 용매로부터 결정화함으로써 수득한다.

Description

4″-데옥시-4″에피-메틸아미노 에버멕틴 B1a/B1b 벤조산 염의 열역학적으로 안정한 결정체형 및 이의 제조방법(Thermodynamically stable crystal form of 4″-deoxy-4″-epi-methylamino avermectin B1a/B1b benz-oic acid salt and process for its preparation)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 실질적으로 순수한 형태인 결정 화합물 4″-데옥시-4″에피-메틸아미노 에버멕틴 B1a/B1b 벤조산염, 반수화물.
  2. 결정 화합물 4″-데옥시-4″에피-메틸아미노 에버멕틴 B1a/B1b 벤조산 염, 반수화물(B형)의 다른 형태 또는 혼합물 형태를 50 내지 60℃온도에서 약 0.1 내지 4%(w/w)으 LANF을 가하고 수성 유기 용매에 용해시키고; 약 45 내지 35℃로 냉각시키고; 결정체 B형을 시딩하고; 결정화가 본질적으로 완결될때까지 유지시키고; 15 내지 30℃에서 약 2 내지 4시간 동안 냉각시키고 유지시킨 다음, 1 내지 2시간에 걸쳐 약 5℃로 냉각시킨 후 고체를 수거하여 건조시킴으로써 수성 유기 용매로부터 상기 개시 물질을 재결정화함을 포함하는, 실질적으로 순수한 형태인 결정 화합물 4″-데옥시-4″에피-메틸아미노 에버멕틴 B1a/B1b 벤조산 염, 반수화물(B형)의 제조방법.
  3. 제 2항에 있어서, 수성 유기 용매가 2 내지 4중량(w/w)의 물을 함유하는 아세토니트릴; 0.5 내지 0.8%(w/w)의 물을 함유하는 메틸 3급-부틸 에테르; 도는 0.1 내지 0.3%(w/w)으 LANF을 함유하는 이소프로판올인 방법.
  4. 제 3항에 있어서, 수성 유기 용매가 2 내지 4%(w/w)의 물을 함유하는 아세토니트릴인 방법.
  5. 제 1항의 안정한 염의 유효량을 농작물 해충이 만연하는 지역에 적용함을 포함하는 농작물 해충의 박멸 방법.
  6. 불활성 담체 및 제 1항의 안정한 염의 유효량을 포함하는, 식물 또는 이의 생산물에 만연하는 곤충을 처리하는데 유용한 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960700754A 1993-08-19 1994-08-15 4'-데옥시-4'-에피-메틸아미노에버멕틴B1a/B1b벤조산염의순수한결정성반수화물형태B,이의제조방법및이를함유하는해충방제용조성물 KR100370697B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10918993A 1993-08-19 1993-08-19
US08/109189 1993-08-19
US08/109,189 1993-08-19
PCT/US1994/009207 WO1995005390A1 (en) 1993-08-19 1994-08-15 THERMODYNAMICALLY STABLE CRYSTAL FORM OF 4'-DEOXY-4'-EPI-METHYLAMINO AVERMECTIN B1a/B1b BENZOIC ACID SALT AND PROCESSES FOR ITS PREPARATION

Publications (2)

Publication Number Publication Date
KR960703936A true KR960703936A (ko) 1996-08-31
KR100370697B1 KR100370697B1 (ko) 2003-06-11

Family

ID=22326282

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960700754A KR100370697B1 (ko) 1993-08-19 1994-08-15 4'-데옥시-4'-에피-메틸아미노에버멕틴B1a/B1b벤조산염의순수한결정성반수화물형태B,이의제조방법및이를함유하는해충방제용조성물

Country Status (25)

Country Link
EP (1) EP0714400B1 (ko)
JP (3) JP3954093B2 (ko)
KR (1) KR100370697B1 (ko)
CN (1) CN1041523C (ko)
AT (1) ATE187735T1 (ko)
AU (1) AU684828B2 (ko)
BR (1) BR9407300A (ko)
CA (1) CA2168843C (ko)
CY (1) CY2181B1 (ko)
CZ (1) CZ287929B6 (ko)
DE (1) DE69422182T2 (ko)
DK (1) DK0714400T3 (ko)
ES (1) ES2139753T3 (ko)
FI (2) FI110783B (ko)
GR (1) GR3032164T3 (ko)
HU (1) HU217769B (ko)
LV (1) LV12571B (ko)
NO (1) NO305658B1 (ko)
NZ (1) NZ273129A (ko)
PL (1) PL176300B1 (ko)
PT (1) PT714400E (ko)
RU (1) RU2133753C1 (ko)
SK (1) SK281684B6 (ko)
WO (1) WO1995005390A1 (ko)
ZA (1) ZA946203B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6486195B1 (en) * 1993-08-19 2002-11-26 Merck & Co., Inc. Thermodynamically stable crystal form of 4″-deoxy-4″-epi-methylamino avermectin B1a/B1b benzoic acid salt and processes for its preparation
CR6574A (es) 2001-02-27 2004-10-28 Syngenta Participations Ag Sales de avermectinas substituidas en la posicion 4 con propiedades plaguicidas
ES2523758T3 (es) * 2010-02-23 2014-12-01 Nippon Kayaku Co., Ltd. Forma cristalina estable de carbonato de 2-etil-3,7-dimetil-6-(4-(trifluorometoxi)fenoxi)quinolin-4-il-metilo, método de producción de la misma, y composición química agrícola que contiene cristales de la misma
CN106995476B (zh) * 2017-05-16 2018-03-13 河北美荷药业有限公司 一种甲氨基阿维菌素b2苯甲酸盐的制备方法
CN108840893A (zh) * 2018-07-01 2018-11-20 李万强 一种甲氨基阿维菌素苯甲酸盐的新晶型及其制备方法
CN109912671B (zh) * 2019-04-12 2022-04-26 宁夏泰益欣生物科技有限公司 一种利用阿维菌素结晶母液提取阿维菌素B2a的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57212200A (en) * 1981-06-23 1982-12-27 Takeda Chem Ind Ltd Preparation of echinoside a
GB8518422D0 (en) * 1985-07-22 1985-08-29 Beecham Group Plc Compounds
IT1216059B (it) * 1988-03-11 1990-02-22 Crc Ricerca Chim Procedimento per la separazione di diastereomeri macrociclici.
JPH0631302B2 (ja) * 1988-11-16 1994-04-27 日本化薬株式会社 エトポシド−２−ジメチルアミノ体塩酸二水和結晶及びその製造法
JPH0615557B2 (ja) * 1990-02-19 1994-03-02 ヤマサ醤油株式会社 ２’―デオキシ―２’―メチリデンシチジンの２水和物結晶
JPH0446192A (ja) * 1990-06-12 1992-02-17 Nippon Kayaku Co Ltd オキセタノシンｇ無水物結晶及びその製造法
IL98599A (en) * 1990-06-28 1995-06-29 Merck & Co Inc Stable salts of "4-deoxy-" 4-epi-methylamino abramectin and insecticides containing them
JP2652272B2 (ja) * 1990-12-31 1997-09-10 住化ファインケム株式会社 １−（４−アミノ−６，７−ジメトキシ−２−キナゾリニル）−４−（２−テトラヒドロフロイル）ピペラジン塩酸塩の新規な結晶体および該結晶体の製造方法
RU2057132C1 (ru) * 1991-05-15 1996-03-27 Яманоути Фармасьютикал Ко., Лтд. Моногидрат (-)-(s)-2,8-диметил-3-метилен-1-окса-8-азаспиро[4,5]-декана l-тартрата и способ его получения
JP2848721B2 (ja) * 1991-08-09 1999-01-20 森永乳業株式会社 結晶ラクチュロース三水和物とその製造法

Also Published As

Publication number Publication date
JP2007176946A (ja) 2007-07-12
ATE187735T1 (de) 2000-01-15
FI111165B (fi) 2003-06-13
KR100370697B1 (ko) 2003-06-11
WO1995005390A1 (en) 1995-02-23
ES2139753T3 (es) 2000-02-16
LV12571B (en) 2001-04-20
CZ287929B6 (cs) 2001-03-14
NZ273129A (en) 1996-08-27
SK281684B6 (sk) 2001-06-11
PL176300B1 (pl) 1999-05-31
FI960725A0 (fi) 1996-02-16
DK0714400T3 (da) 2000-04-10
JP2011207899A (ja) 2011-10-20
BR9407300A (pt) 1996-10-08
JPH09502169A (ja) 1997-03-04
PT714400E (pt) 2000-05-31
SK20996A3 (en) 1996-06-05
LV12571A (en) 2000-11-20
NO305658B1 (no) 1999-07-05
DE69422182D1 (de) 2000-01-20
CN1041523C (zh) 1999-01-06
AU684828B2 (en) 1998-01-08
HUT73552A (en) 1996-08-28
HU217769B (hu) 2000-04-28
CA2168843C (en) 2004-10-19
CN1129453A (zh) 1996-08-21
AU7631994A (en) 1995-03-14
CY2181B1 (en) 2002-08-23
CA2168843A1 (en) 1995-02-23
PL313043A1 (en) 1996-05-27
HU9600345D0 (en) 1996-04-29
FI20021120A (fi) 2002-06-11
NO960618D0 (no) 1996-02-16
JP3954093B2 (ja) 2007-08-08
NO960618L (no) 1996-02-16
ZA946203B (en) 1995-03-31
EP0714400A1 (en) 1996-06-05
GR3032164T3 (en) 2000-04-27
EP0714400B1 (en) 1999-12-15
CZ45996A3 (en) 1996-05-15
RU2133753C1 (ru) 1999-07-27
DE69422182T2 (de) 2000-06-21
FI110783B (fi) 2003-03-31
FI960725A (fi) 1996-02-16

Similar Documents

Publication Publication Date Title
SU1715187A3 (ru) Способ борьбы с сорн ками в посевах сорго
KR870001088B1 (ko) 2-[1-(옥시아미노)-알킬리덴]사이클로핵산-1,3-디온 유도체의 제조방법
KR960703936A (ko) 4"-데옥시-4"-에피-메틸아미노 에버멕틴 B1a/B1b 벤조산 염의 열역학적으로 안정한 결정체형 및 이의 제조방법(Thermodynamically stable crystal form of 4"-deoxy-4"-epi-methylamino avermectin B1a/B1b benzoic acid salt and process for its preparation)
US6486195B1 (en) Thermodynamically stable crystal form of 4″-deoxy-4″-epi-methylamino avermectin B1a/B1b benzoic acid salt and processes for its preparation
US4849438A (en) 1,2-benzoisothiazol-3(2H)-one 1,1-dioxide, ion(1-),2-hydroxy-N,N,N-trimethyl-ethanaminium which is plant protection agent for control of fungi and bacteria
RU95104884A (ru) 13-замещенные производные милбемицинов, антигельминтная акарицидная и инсектицидная композиция, способ защиты растений
RU96107041A (ru) Термодинамически стабильная кристаллическая форма соли бензойной кислоты 4''-деокси-4''-эпи-метиламиноавермектина bia/bib и способ ее получения
NO170881B (no) Salicylsyreamider og deres anvendelse, i kosmetiske sammensetninger
KR950014078A (ko) 결정형태 b의(4-시클로프로필-6-메틸-피리미딘-2-일)-페닐-아민
IL41709A (en) N-aminomethylene thiolphosphoric acid ester amides,their manufacture and their use as insecticides and acaricides
US2913370A (en) Method of inhibiting growth of plant viruses
JPH07196411A (ja) 菌・カビ類の防除法
US3086059A (en) 4-halo-2-butynyl sulfides and use for controlling nematodes
US3262843A (en) Nematocides
KR800000745B1 (ko) N-메틸카바닐산-[3-(에톡시카보닐아미노)-페닐]-에스텔의 제조방법
KR930011487B1 (ko) 제초력이 있는 신규 이소옥사졸린 디페닐에테르 유도체
JPS5455546A (en) Preparation of optically active alpha-cyano-3-phenoxy-benzyl 2-(4-chlorophenyl)-isovalerate
JPS5589254A (en) Substituted isovaleric acid derivative
SU1823537A1 (ru) Способ получения монокристаллов мочевины
JPH01249706A (ja) 除草用組成物および雑草防除方法
TH9338B (th) สารฆ่าวัชพืช [[1, 3, 5-ไทรอะซิน-2-อิล) อะมิโนคาร์บอนิล]อะมิโนซัลโนิล] เบนโซอิค เอสเทอร์, การเตรียม และการใช้สารเหล่านั้น
MXPA99006009A (en) Aminobutyric acid fungicides
TH6452B (th) สารประกอบแมคโครไลต์
TH8463A (th) สารฆ่าวัชพืช [[1, 3, 5-ไทรอะซิน-2-อิล) อะมิโนคาร์บอนิล]อะมิโนซัลโนิล] เบนโซอิค เอสเทอร์, การเตรียม และการใช้สารเหล่านั้น

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20121227

Year of fee payment: 11

FPAY Annual fee payment

Payment date: 20131227

Year of fee payment: 12

EXPY Expiration of term