KR950014078A - 결정형태 b의(4-시클로프로필-6-메틸-피리미딘-2-일)-페닐-아민 - Google Patents

결정형태 b의(4-시클로프로필-6-메틸-피리미딘-2-일)-페닐-아민 Download PDF

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KR950014078A
KR950014078A KR1019940029519A KR19940029519A KR950014078A KR 950014078 A KR950014078 A KR 950014078A KR 1019940029519 A KR1019940029519 A KR 1019940029519A KR 19940029519 A KR19940029519 A KR 19940029519A KR 950014078 A KR950014078 A KR 950014078A
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weak
medium
cyclopropyl
pyrimidin
phenyl
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KR1019940029519A
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KR100349994B1 (ko
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바티그 윌리
게오르그 한라이히 라인하드
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베르너 발데크
시바-가이기 아게
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

공지된 결정형태 A의 (4-시클로프로필-6-메틸-피리미딘-2-일)-페닐-아민과는 달리, 73℃내지 75℃의 융점을 갖고 식물보호 조성물에서 살진균 활성성분 유용한 높은 공융 순도(적어도 98 %)의 결정형태 8의 (4-시클로프로필-6-메틸-피리미딘-2-일)-페닐-아민은 결정성장 경향을 나타내지 않는다. 이러한 조성물은 고도의 저장 안정성을 갖고 또 양호한 현탁성과 분사성을 보유한다.

Description

결정형태 B의 (4-시클로프로필-6-메틸-피리미딘-2-일)-페닐-아민
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (18)

  1. 73℃이상, 바람직하게는 73℃내지 75℃의 융점을 갖고 3200내지 3300cm-1에서 특징적인 NH 밴드를 갖는 IR스펙트럼과 하기 데이타를 갖는 X-선 분말 다이아그램을 갖는 높은 공융 순도(적어도 98%함량)의 결정형태 B의 (4-시클로프로필-6-메틸-피리미딘-2-일)-페닐-아민 :
    d-값(Å) 밀도 d-값(Å) 밀도
    12.9 중간 3.97 약함
    8.7 강함 3.86 중간
    6.8 강함 3.80 매우 강함
    6.1 약함 3.78 중간
    5.93 매우약함 3.67 중간
    5.66 강함 3.56 중간
    5.39 약함 3.54 매우 약함
    5.19 매우약함 3.42 중간
    4.96 약함 3.38 약함
    4.81 중간 3.30 중간
    4.75 중간 3.25 매우 약함
    4.55 매우 강함 3.16 약함
    4.47 중간 3.09 약함
    4.36 약함 3.04 매우 약함
  2. 결정화가 26℃이상의 온도에서 실시되는 제1항에 따른 결정형태 B의 (4-시클로프로필-6-메틸-피리미딘-2-일)-페닐-아민의 제조방법.
  3. 제2항에 있어서, 결정화가 용해제 존재하에서 실시되는 방법.
  4. 제3항에 있어서, 유기 용매가 용해제로서 사용되는 방법.
  5. 제4항에 있어서, 톨루엔, 이소프로판올 또는 메틸시클로헥산이 용해제로서 사용되는 방법.
  6. 용융-결정화에 의한 제1항에 따른 결정형태 B의 (4-시클로프로필-6-메틸-피리미딘-2-일) 페닐 -아민의 제조방법.
  7. 제6항에 있어서, 제조반응이 스크레이퍼 반웅기 내에서 실시되는 방법.
  8. 제6항에 있어서, 상기 형성된 결정을 냉각된 반응기 벽으로 부터 긁어내는 방법.
  9. 제8항에 있어서, 반응기 벽의 온도가 40℃ 내지 60℃인 방법.
  10. 제9항에 있어서, 상기 온도가 50℃인 방법.
  11. 제6항에 있어서, 용융-결정화에 있어서 제일 먼저 종자 결정을 함유하는 용융물이 제조되는 방법.
  12. 제6항에 있어서, 결정화 공정을 완료하기 위해 용융물이 냉각되는 방법.
  13. 활성성분으로 73℃ 이상의 융점을 갖는 결정형태 B의 (4-시클로프로필-6-메틸-피리미딘-2일)-페닐-아민 살진균 유효량과 함께 적합한 담체를 포함하는 살진균 조성물.
  14. 73℃이상의 융점을 갖는 결정형태 B의 (4-시클로프로필-6-메틸-피리미딘-2-일)-페닐-아민과 함께 적합한 고체 또는 액체 보조제 및/또는 계면활성제를 긴밀하게 혼합하는 것을 포함하는 제13항에 따른 조성물의 제조방법.
  15. 제14항에 있어서, 적합한 분배 기구를 이용하여 73℃이상의 융점을 갖는 결정형태 B의 (4-시클로프로필-6-메틸-피리미딘-2-일)-페닐-아민의 종자 결정을 함유하는 용융물을 냉각 표면을 통과시켜 결정화된 활성성분을 특정 용도에 적합한 제형 기구.
  16. 73℃이상의 융점을 갖는 결정형태 B의 (4-시클로프로필-6-메틸-피리미딘-2-일)-페닐-아민의 진균 감염 방제에서의 용도.
  17. 활성성분인 73℃이상의 융점을 갖는 결정형태 B의 (4-시클로프로필-6-메틸-피리미딘-2-일)-페닐-아민을 식물, 식물의 부위 또는 식물의 재배지에 투여하는 것을 포함하는 재배 식물에서 진균 감염을 방제 또는 예방하기 위한 방법.
  18. 제17항에 있어서, 식물의 부위가 종자인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940029519A 1993-11-09 1994-11-08 결정형태b의(4-시클로프로필-6-메틸-피리미딘-2-일)-페닐-아민 KR100349994B1 (ko)

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Application Number Priority Date Filing Date Title
CH93-1/3368 1993-11-09
CH336893 1993-11-09
CH94-2/2393 1994-07-28
CH239394 1994-07-28

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KR950014078A true KR950014078A (ko) 1995-06-15
KR100349994B1 KR100349994B1 (ko) 2002-12-16

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US (1) US5830899A (ko)
EP (1) EP0655441B1 (ko)
JP (1) JP3617015B2 (ko)
KR (1) KR100349994B1 (ko)
CN (1) CN1053897C (ko)
AT (1) ATE212337T1 (ko)
AU (1) AU689805B2 (ko)
BR (1) BR9404388A (ko)
CA (1) CA2135251C (ko)
CZ (1) CZ291977B6 (ko)
DE (1) DE59410036D1 (ko)
DK (1) DK0655441T3 (ko)
ES (1) ES2171443T3 (ko)
FI (1) FI112215B (ko)
HK (1) HK1008961A1 (ko)
HU (1) HU213946B (ko)
IL (1) IL111537A (ko)
NO (1) NO306551B1 (ko)
PL (1) PL179802B1 (ko)
PT (1) PT655441E (ko)
RU (1) RU2145601C1 (ko)
SK (1) SK282969B6 (ko)
UA (1) UA39175C2 (ko)

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GB0706044D0 (en) * 2007-03-28 2007-05-09 Syngenta Ltd C0-Crystals
CN101311170B (zh) 2007-05-25 2010-09-15 中国中化股份有限公司 取代嘧啶醚类化合物及其应用
GB0817976D0 (en) * 2008-10-01 2008-11-05 Syngenta Ltd Co-crystals
CN101906075B (zh) 2009-06-05 2012-11-07 中国中化股份有限公司 含取代苯胺基嘧啶基团的e-型苯基丙烯酸酯类化合物及其应用
GB201006326D0 (en) * 2010-04-15 2010-06-02 Syngenta Ltd Formulation
FR2965563B1 (fr) 2010-09-30 2015-05-15 Roquette Freres Pastilles de dianhydrohexitols de grande fluidite et non mottantes
KR102116254B1 (ko) 2019-01-28 2020-05-28 서진영 프리사이즈 절단가능한 스폰지 재단장치

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DE3881320D1 (de) * 1987-09-28 1993-07-01 Ciba Geigy Ag Schaedlingsbekaempfungsmittel.
US5153200A (en) * 1987-09-28 1992-10-06 Ciba-Geigy Corporation Pesticides

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FI945231A0 (fi) 1994-11-07
HU213946B (en) 1997-11-28
CA2135251A1 (en) 1995-05-10
AU7768894A (en) 1995-05-18
FI945231A (fi) 1995-05-10
FI112215B (fi) 2003-11-14
HUT68779A (en) 1995-07-28
NO944253L (no) 1995-05-10
PT655441E (pt) 2002-06-28
ATE212337T1 (de) 2002-02-15
HU9403214D0 (en) 1995-01-30
JPH07188183A (ja) 1995-07-25
CN1053897C (zh) 2000-06-28
JP3617015B2 (ja) 2005-02-02
EP0655441B1 (de) 2002-01-23
HK1008961A1 (en) 1999-05-21
CZ273094A3 (en) 1995-05-17
UA39175C2 (uk) 2001-06-15
EP0655441A1 (de) 1995-05-31
NO944253D0 (no) 1994-11-08
US5830899A (en) 1998-11-03
NO306551B1 (no) 1999-11-22
CA2135251C (en) 2005-12-20
PL305740A1 (en) 1995-05-15
KR100349994B1 (ko) 2002-12-16
PL179802B1 (pl) 2000-10-31
ES2171443T3 (es) 2002-09-16
BR9404388A (pt) 1995-07-04
AU689805B2 (en) 1998-04-09
CN1105995A (zh) 1995-08-02
SK133094A3 (en) 1995-06-07
SK282969B6 (sk) 2003-01-09
RU94040724A (ru) 1996-10-10
RU2145601C1 (ru) 2000-02-20
IL111537A0 (en) 1995-01-24
IL111537A (en) 2001-06-14
DK0655441T3 (da) 2002-05-06
DE59410036D1 (de) 2002-03-14
CZ291977B6 (cs) 2003-06-18

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