JP2007176946A - 熱力学的に安定な結晶形の4″−デオキシ−4″−エピ−メチルアミノアベルメクチンB1a/B1bの安息香酸塩及びその製造法 - Google Patents
熱力学的に安定な結晶形の4″−デオキシ−4″−エピ−メチルアミノアベルメクチンB1a/B1bの安息香酸塩及びその製造法 Download PDFInfo
- Publication number
- JP2007176946A JP2007176946A JP2007030096A JP2007030096A JP2007176946A JP 2007176946 A JP2007176946 A JP 2007176946A JP 2007030096 A JP2007030096 A JP 2007030096A JP 2007030096 A JP2007030096 A JP 2007030096A JP 2007176946 A JP2007176946 A JP 2007176946A
- Authority
- JP
- Japan
- Prior art keywords
- crystal form
- epi
- deoxy
- production method
- benzoate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
【解決手段】結晶形A、C又はDの化合物を約50〜60℃の有機溶媒に溶解し、必要量の水で処理し、タイプBの結晶を接種し、約15〜30℃に冷却し、該温度で約2〜4時間熟成させ、さらに約1〜2時間かけて約5℃に冷却する。結晶性物質を濾過して回収し、真空下に乾燥する。
【選択図】なし
Description
本発明は、公知の農業用殺虫剤である、4″−デオキシ−4″−エピ−メチルアミノアベルメクチンB1a/B1b安息香酸塩の4種の結晶形のうちで、最も安定な形態及びその製造法に関する。
タイプB結晶の形成を確実にするためには、結晶化の開始及び進行の大部分を>35℃でしなければならない。
Claims (3)
- 実質的に純粋な形態の半水和物(タイプB)である、結晶性化合物4”−デオキシ−4”−エピ−メチルアミノアベルメクチンB1a/B1bの安息香酸塩。
- 農業昆虫の防除法であって、そのような農業昆虫に感染した領域に有効量の請求項1に記載の安定な塩を適用することを含む方法。
- 不活性担体及び有効量の請求項1に記載の安定な塩を含む植物又は植物製品の昆虫による感染を処置するのに有用な組成物。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10918993A | 1993-08-19 | 1993-08-19 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50713095A Division JP3954093B2 (ja) | 1993-08-19 | 1994-08-15 | 熱力学的に安定な結晶形の4″−デオキシ−4″−エピ−メチルアミノアベルメクチンB1a/B1bの安息香酸塩及びその製造法 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011117141A Division JP2011207899A (ja) | 1993-08-19 | 2011-05-25 | 熱力学的に安定な結晶形の4″−デオキシ−4″−エピ−メチルアミノアベルメクチンB1a/B1bの安息香酸塩及びその製造法 |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2007176946A true JP2007176946A (ja) | 2007-07-12 |
Family
ID=22326282
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50713095A Expired - Lifetime JP3954093B2 (ja) | 1993-08-19 | 1994-08-15 | 熱力学的に安定な結晶形の4″−デオキシ−4″−エピ−メチルアミノアベルメクチンB1a/B1bの安息香酸塩及びその製造法 |
JP2007030096A Withdrawn JP2007176946A (ja) | 1993-08-19 | 2007-02-09 | 熱力学的に安定な結晶形の4″−デオキシ−4″−エピ−メチルアミノアベルメクチンB1a/B1bの安息香酸塩及びその製造法 |
JP2011117141A Pending JP2011207899A (ja) | 1993-08-19 | 2011-05-25 | 熱力学的に安定な結晶形の4″−デオキシ−4″−エピ−メチルアミノアベルメクチンB1a/B1bの安息香酸塩及びその製造法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50713095A Expired - Lifetime JP3954093B2 (ja) | 1993-08-19 | 1994-08-15 | 熱力学的に安定な結晶形の4″−デオキシ−4″−エピ−メチルアミノアベルメクチンB1a/B1bの安息香酸塩及びその製造法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011117141A Pending JP2011207899A (ja) | 1993-08-19 | 2011-05-25 | 熱力学的に安定な結晶形の4″−デオキシ−4″−エピ−メチルアミノアベルメクチンB1a/B1bの安息香酸塩及びその製造法 |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP0714400B1 (ja) |
JP (3) | JP3954093B2 (ja) |
KR (1) | KR100370697B1 (ja) |
CN (1) | CN1041523C (ja) |
AT (1) | ATE187735T1 (ja) |
AU (1) | AU684828B2 (ja) |
BR (1) | BR9407300A (ja) |
CA (1) | CA2168843C (ja) |
CY (1) | CY2181B1 (ja) |
CZ (1) | CZ287929B6 (ja) |
DE (1) | DE69422182T2 (ja) |
DK (1) | DK0714400T3 (ja) |
ES (1) | ES2139753T3 (ja) |
FI (2) | FI110783B (ja) |
GR (1) | GR3032164T3 (ja) |
HU (1) | HU217769B (ja) |
LV (1) | LV12571B (ja) |
NO (1) | NO305658B1 (ja) |
NZ (1) | NZ273129A (ja) |
PL (1) | PL176300B1 (ja) |
PT (1) | PT714400E (ja) |
RU (1) | RU2133753C1 (ja) |
SK (1) | SK281684B6 (ja) |
WO (1) | WO1995005390A1 (ja) |
ZA (1) | ZA946203B (ja) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6486195B1 (en) * | 1993-08-19 | 2002-11-26 | Merck & Co., Inc. | Thermodynamically stable crystal form of 4″-deoxy-4″-epi-methylamino avermectin B1a/B1b benzoic acid salt and processes for its preparation |
CR6574A (es) | 2001-02-27 | 2004-10-28 | Syngenta Participations Ag | Sales de avermectinas substituidas en la posicion 4 con propiedades plaguicidas |
ES2523758T3 (es) * | 2010-02-23 | 2014-12-01 | Nippon Kayaku Co., Ltd. | Forma cristalina estable de carbonato de 2-etil-3,7-dimetil-6-(4-(trifluorometoxi)fenoxi)quinolin-4-il-metilo, método de producción de la misma, y composición química agrícola que contiene cristales de la misma |
CN106995476B (zh) * | 2017-05-16 | 2018-03-13 | 河北美荷药业有限公司 | 一种甲氨基阿维菌素b2苯甲酸盐的制备方法 |
CN108840893A (zh) * | 2018-07-01 | 2018-11-20 | 李万强 | 一种甲氨基阿维菌素苯甲酸盐的新晶型及其制备方法 |
CN109912671B (zh) * | 2019-04-12 | 2022-04-26 | 宁夏泰益欣生物科技有限公司 | 一种利用阿维菌素结晶母液提取阿维菌素B2a的方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2045864A1 (en) * | 1990-06-28 | 1991-12-29 | Raymond Cvetovich | Stable salts of 4"-deoxy-4" epi-methylamino avermectin bla/blb |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57212200A (en) * | 1981-06-23 | 1982-12-27 | Takeda Chem Ind Ltd | Preparation of echinoside a |
GB8518422D0 (en) * | 1985-07-22 | 1985-08-29 | Beecham Group Plc | Compounds |
IT1216059B (it) * | 1988-03-11 | 1990-02-22 | Crc Ricerca Chim | Procedimento per la separazione di diastereomeri macrociclici. |
JPH0631302B2 (ja) * | 1988-11-16 | 1994-04-27 | 日本化薬株式会社 | エトポシド−2−ジメチルアミノ体塩酸二水和結晶及びその製造法 |
JPH0615557B2 (ja) * | 1990-02-19 | 1994-03-02 | ヤマサ醤油株式会社 | 2’―デオキシ―2’―メチリデンシチジンの2水和物結晶 |
JPH0446192A (ja) * | 1990-06-12 | 1992-02-17 | Nippon Kayaku Co Ltd | オキセタノシンg無水物結晶及びその製造法 |
JP2652272B2 (ja) * | 1990-12-31 | 1997-09-10 | 住化ファインケム株式会社 | 1−(4−アミノ−6,7−ジメトキシ−2−キナゾリニル)−4−(2−テトラヒドロフロイル)ピペラジン塩酸塩の新規な結晶体および該結晶体の製造方法 |
RU2057132C1 (ru) * | 1991-05-15 | 1996-03-27 | Яманоути Фармасьютикал Ко., Лтд. | Моногидрат (-)-(s)-2,8-диметил-3-метилен-1-окса-8-азаспиро[4,5]-декана l-тартрата и способ его получения |
JP2848721B2 (ja) * | 1991-08-09 | 1999-01-20 | 森永乳業株式会社 | 結晶ラクチュロース三水和物とその製造法 |
-
1994
- 1994-08-15 AT AT94926502T patent/ATE187735T1/de active
- 1994-08-15 NZ NZ273129A patent/NZ273129A/en not_active IP Right Cessation
- 1994-08-15 BR BR9407300A patent/BR9407300A/pt not_active IP Right Cessation
- 1994-08-15 SK SK209-96A patent/SK281684B6/sk not_active IP Right Cessation
- 1994-08-15 EP EP94926502A patent/EP0714400B1/en not_active Expired - Lifetime
- 1994-08-15 WO PCT/US1994/009207 patent/WO1995005390A1/en active IP Right Grant
- 1994-08-15 DE DE69422182T patent/DE69422182T2/de not_active Expired - Lifetime
- 1994-08-15 AU AU76319/94A patent/AU684828B2/en not_active Expired
- 1994-08-15 PT PT94926502T patent/PT714400E/pt unknown
- 1994-08-15 CZ CZ1996459A patent/CZ287929B6/cs not_active IP Right Cessation
- 1994-08-15 PL PL94313043A patent/PL176300B1/pl unknown
- 1994-08-15 CA CA002168843A patent/CA2168843C/en not_active Expired - Lifetime
- 1994-08-15 ES ES94926502T patent/ES2139753T3/es not_active Expired - Lifetime
- 1994-08-15 RU RU96107041A patent/RU2133753C1/ru active
- 1994-08-15 DK DK94926502T patent/DK0714400T3/da active
- 1994-08-15 KR KR1019960700754A patent/KR100370697B1/ko not_active IP Right Cessation
- 1994-08-15 HU HU9600345A patent/HU217769B/hu unknown
- 1994-08-15 JP JP50713095A patent/JP3954093B2/ja not_active Expired - Lifetime
- 1994-08-15 CN CN94193136A patent/CN1041523C/zh not_active Expired - Lifetime
- 1994-08-17 ZA ZA946203A patent/ZA946203B/xx unknown
-
1996
- 1996-02-16 FI FI960725A patent/FI110783B/fi not_active IP Right Cessation
- 1996-02-16 NO NO960618A patent/NO305658B1/no not_active IP Right Cessation
-
1999
- 1999-12-16 GR GR990403202T patent/GR3032164T3/el unknown
-
2000
- 2000-08-10 CY CY0000041A patent/CY2181B1/xx unknown
- 2000-09-07 LV LVP-00-120A patent/LV12571B/en unknown
-
2002
- 2002-06-11 FI FI20021120A patent/FI111165B/fi not_active IP Right Cessation
-
2007
- 2007-02-09 JP JP2007030096A patent/JP2007176946A/ja not_active Withdrawn
-
2011
- 2011-05-25 JP JP2011117141A patent/JP2011207899A/ja active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2045864A1 (en) * | 1990-06-28 | 1991-12-29 | Raymond Cvetovich | Stable salts of 4"-deoxy-4" epi-methylamino avermectin bla/blb |
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