ES2139753T3 - Forma cristalina termodinamicamente estable de la sal del acido benzoico de la 4''-desoxi-4''-epi-metilamino avermectina b1a/b1b y procedimiento para su preparacion. - Google Patents
Forma cristalina termodinamicamente estable de la sal del acido benzoico de la 4''-desoxi-4''-epi-metilamino avermectina b1a/b1b y procedimiento para su preparacion.Info
- Publication number
- ES2139753T3 ES2139753T3 ES94926502T ES94926502T ES2139753T3 ES 2139753 T3 ES2139753 T3 ES 2139753T3 ES 94926502 T ES94926502 T ES 94926502T ES 94926502 T ES94926502 T ES 94926502T ES 2139753 T3 ES2139753 T3 ES 2139753T3
- Authority
- ES
- Spain
- Prior art keywords
- epi
- benzoic acid
- crystalline form
- avermectin
- desoxi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
LA FORMA CRISTALINA MAS TERMODINAMICAMENTE ESTABLE DE LA SAL DEL ACIDO BENZOICO DE LA AVERMECTINA B1A/B1B DE 4"-DEOXI-4"-EPIMETILAMINO COMO HEMIHIDRATO SE OBTIENE MEDIANTE CRISTALIZACION A PARTIR DE SOLVENTES ORGANICOS QUE CONTENGAN UNA CANTIDAD CONTROLADA DE AGUA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10918993A | 1993-08-19 | 1993-08-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2139753T3 true ES2139753T3 (es) | 2000-02-16 |
Family
ID=22326282
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94926502T Expired - Lifetime ES2139753T3 (es) | 1993-08-19 | 1994-08-15 | Forma cristalina termodinamicamente estable de la sal del acido benzoico de la 4''-desoxi-4''-epi-metilamino avermectina b1a/b1b y procedimiento para su preparacion. |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP0714400B1 (es) |
JP (3) | JP3954093B2 (es) |
KR (1) | KR100370697B1 (es) |
CN (1) | CN1041523C (es) |
AT (1) | ATE187735T1 (es) |
AU (1) | AU684828B2 (es) |
BR (1) | BR9407300A (es) |
CA (1) | CA2168843C (es) |
CY (1) | CY2181B1 (es) |
CZ (1) | CZ287929B6 (es) |
DE (1) | DE69422182T2 (es) |
DK (1) | DK0714400T3 (es) |
ES (1) | ES2139753T3 (es) |
FI (2) | FI110783B (es) |
GR (1) | GR3032164T3 (es) |
HU (1) | HU217769B (es) |
LV (1) | LV12571B (es) |
NO (1) | NO305658B1 (es) |
NZ (1) | NZ273129A (es) |
PL (1) | PL176300B1 (es) |
PT (1) | PT714400E (es) |
RU (1) | RU2133753C1 (es) |
SK (1) | SK281684B6 (es) |
WO (1) | WO1995005390A1 (es) |
ZA (1) | ZA946203B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6486195B1 (en) * | 1993-08-19 | 2002-11-26 | Merck & Co., Inc. | Thermodynamically stable crystal form of 4″-deoxy-4″-epi-methylamino avermectin B1a/B1b benzoic acid salt and processes for its preparation |
CR6574A (es) | 2001-02-27 | 2004-10-28 | Syngenta Participations Ag | Sales de avermectinas substituidas en la posicion 4 con propiedades plaguicidas |
US8648195B2 (en) * | 2010-02-23 | 2014-02-11 | Nippon Kayaku Co., Ltd. | Stabilized crystal of 2-ethyl-3,7-dimethyl-6-(4-(trifluoromethoxy)phenoxy)quinoline-4-yl methyl carbonate, process for producing the crystal, and agricultural chemical composition comprising the crystal |
CN106995476B (zh) * | 2017-05-16 | 2018-03-13 | 河北美荷药业有限公司 | 一种甲氨基阿维菌素b2苯甲酸盐的制备方法 |
CN108840893A (zh) * | 2018-07-01 | 2018-11-20 | 李万强 | 一种甲氨基阿维菌素苯甲酸盐的新晶型及其制备方法 |
CN109912671B (zh) * | 2019-04-12 | 2022-04-26 | 宁夏泰益欣生物科技有限公司 | 一种利用阿维菌素结晶母液提取阿维菌素B2a的方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57212200A (en) * | 1981-06-23 | 1982-12-27 | Takeda Chem Ind Ltd | Preparation of echinoside a |
GB8518422D0 (en) * | 1985-07-22 | 1985-08-29 | Beecham Group Plc | Compounds |
IT1216059B (it) * | 1988-03-11 | 1990-02-22 | Crc Ricerca Chim | Procedimento per la separazione di diastereomeri macrociclici. |
JPH0631302B2 (ja) * | 1988-11-16 | 1994-04-27 | 日本化薬株式会社 | エトポシド−2−ジメチルアミノ体塩酸二水和結晶及びその製造法 |
JPH0615557B2 (ja) * | 1990-02-19 | 1994-03-02 | ヤマサ醤油株式会社 | 2’―デオキシ―2’―メチリデンシチジンの2水和物結晶 |
JPH0446192A (ja) * | 1990-06-12 | 1992-02-17 | Nippon Kayaku Co Ltd | オキセタノシンg無水物結晶及びその製造法 |
IL98599A (en) * | 1990-06-28 | 1995-06-29 | Merck & Co Inc | Stable salts of "4-deoxy-" 4-epi-methylamino abramectin and insecticides containing them |
JP2652272B2 (ja) * | 1990-12-31 | 1997-09-10 | 住化ファインケム株式会社 | 1−(4−アミノ−6,7−ジメトキシ−2−キナゾリニル)−4−(2−テトラヒドロフロイル)ピペラジン塩酸塩の新規な結晶体および該結晶体の製造方法 |
DK0590150T3 (da) * | 1991-05-15 | 1999-04-19 | Yamanouchi Pharma Co Ltd | (-)-(S)-2,8-dimethyl-3-methylen-1-oxa-8-azaspiro[4,5]decan-L-tartrat |
JP2848721B2 (ja) * | 1991-08-09 | 1999-01-20 | 森永乳業株式会社 | 結晶ラクチュロース三水和物とその製造法 |
-
1994
- 1994-08-15 AT AT94926502T patent/ATE187735T1/de active
- 1994-08-15 EP EP94926502A patent/EP0714400B1/en not_active Expired - Lifetime
- 1994-08-15 KR KR1019960700754A patent/KR100370697B1/ko not_active IP Right Cessation
- 1994-08-15 PL PL94313043A patent/PL176300B1/pl unknown
- 1994-08-15 JP JP50713095A patent/JP3954093B2/ja not_active Expired - Lifetime
- 1994-08-15 PT PT94926502T patent/PT714400E/pt unknown
- 1994-08-15 DK DK94926502T patent/DK0714400T3/da active
- 1994-08-15 BR BR9407300A patent/BR9407300A/pt not_active IP Right Cessation
- 1994-08-15 HU HU9600345A patent/HU217769B/hu unknown
- 1994-08-15 CA CA002168843A patent/CA2168843C/en not_active Expired - Lifetime
- 1994-08-15 WO PCT/US1994/009207 patent/WO1995005390A1/en active IP Right Grant
- 1994-08-15 AU AU76319/94A patent/AU684828B2/en not_active Expired
- 1994-08-15 CZ CZ1996459A patent/CZ287929B6/cs not_active IP Right Cessation
- 1994-08-15 SK SK209-96A patent/SK281684B6/sk not_active IP Right Cessation
- 1994-08-15 NZ NZ273129A patent/NZ273129A/en not_active IP Right Cessation
- 1994-08-15 ES ES94926502T patent/ES2139753T3/es not_active Expired - Lifetime
- 1994-08-15 DE DE69422182T patent/DE69422182T2/de not_active Expired - Lifetime
- 1994-08-15 RU RU96107041A patent/RU2133753C1/ru active
- 1994-08-15 CN CN94193136A patent/CN1041523C/zh not_active Expired - Lifetime
- 1994-08-17 ZA ZA946203A patent/ZA946203B/xx unknown
-
1996
- 1996-02-16 FI FI960725A patent/FI110783B/fi not_active IP Right Cessation
- 1996-02-16 NO NO960618A patent/NO305658B1/no not_active IP Right Cessation
-
1999
- 1999-12-16 GR GR990403202T patent/GR3032164T3/el unknown
-
2000
- 2000-08-10 CY CY0000041A patent/CY2181B1/xx unknown
- 2000-09-07 LV LVP-00-120A patent/LV12571B/en unknown
-
2002
- 2002-06-11 FI FI20021120A patent/FI111165B/fi not_active IP Right Cessation
-
2007
- 2007-02-09 JP JP2007030096A patent/JP2007176946A/ja not_active Withdrawn
-
2011
- 2011-05-25 JP JP2011117141A patent/JP2011207899A/ja active Pending
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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