CO4930262A1 - Producto farmaceutico cristalino, su preparacion y uso como sustancia terapeutica - Google Patents

Producto farmaceutico cristalino, su preparacion y uso como sustancia terapeutica

Info

Publication number
CO4930262A1
CO4930262A1 CO97050462A CO97050462A CO4930262A1 CO 4930262 A1 CO4930262 A1 CO 4930262A1 CO 97050462 A CO97050462 A CO 97050462A CO 97050462 A CO97050462 A CO 97050462A CO 4930262 A1 CO4930262 A1 CO 4930262A1
Authority
CO
Colombia
Prior art keywords
preparation
pharmaceutical product
therapeutic substance
crystalline pharmaceutical
hydrochloride
Prior art date
Application number
CO97050462A
Other languages
English (en)
Inventor
Ross Stephem Torey
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of CO4930262A1 publication Critical patent/CO4930262A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Ácido (S)-7-[(4,4´- bipiperidin-1-il)carbonil]-2,3,4,5-tetrahidro-4-metil-3-oxo-1H-1,4-benzodiazepina-2-acético, hidrocloruro. Un procedimiento de preparación del compuesto según la reivindicación 1, que comprende formar una solución del ácido (S)-7-[(4,4- bipiperidin-1-il)carbonil]-2,3,4,5-tetrahidro-4-metil-3-oxo-1H-1-4-benzodiazepina-2-acético, hidrocloruro, y cristalizar dicha sal hidrocloruro por precipitación o recristalización.
CO97050462A 1996-09-03 1997-09-01 Producto farmaceutico cristalino, su preparacion y uso como sustancia terapeutica CO4930262A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2536996P 1996-09-03 1996-09-03

Publications (1)

Publication Number Publication Date
CO4930262A1 true CO4930262A1 (es) 2000-06-27

Family

ID=21825633

Family Applications (1)

Application Number Title Priority Date Filing Date
CO97050462A CO4930262A1 (es) 1996-09-03 1997-09-01 Producto farmaceutico cristalino, su preparacion y uso como sustancia terapeutica

Country Status (32)

Country Link
US (1) US6335330B1 (es)
EP (1) EP0964684B1 (es)
JP (1) JP2000517342A (es)
CN (1) CN1102391C (es)
AP (1) AP9901472A0 (es)
AR (1) AR008154A1 (es)
AT (1) ATE245984T1 (es)
AU (1) AU731173B2 (es)
BG (1) BG103196A (es)
BR (1) BR9711981A (es)
CA (1) CA2264607A1 (es)
CO (1) CO4930262A1 (es)
CZ (1) CZ71999A3 (es)
DE (1) DE69723873T2 (es)
DZ (1) DZ2302A1 (es)
EA (1) EA001363B1 (es)
ES (1) ES2205254T3 (es)
HU (1) HUP9904077A3 (es)
ID (1) ID18156A (es)
IL (1) IL128782A0 (es)
MA (1) MA24309A1 (es)
MY (1) MY118175A (es)
NO (1) NO991013L (es)
NZ (1) NZ334438A (es)
OA (1) OA10986A (es)
PE (1) PE107198A1 (es)
PL (1) PL332006A1 (es)
SK (1) SK27699A3 (es)
TR (1) TR199900480T2 (es)
UY (1) UY24690A1 (es)
WO (1) WO1998009629A1 (es)
ZA (1) ZA977870B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19902529A1 (de) * 1999-01-22 2000-08-03 Goldwell Gmbh Haarbehandlungsmittel
FR2797400A1 (fr) * 1999-08-11 2001-02-16 Sanofi Synthelabo Associations a activite anti-thrombotique constituees de l'hydrogenosulfate de clopidogrel et d'un antagoniste des recepteurs gpiib/iiia et les compositions pharmaceutiques les contenant
CN100560131C (zh) 2001-10-22 2009-11-18 斯克里普斯研究学院 抗体靶向化合物
US20050202151A1 (en) * 2004-03-15 2005-09-15 Land O'lakes, Inc. Method of preparing egg nuggets
KR101046977B1 (ko) * 2004-11-15 2011-07-07 삼성에스디아이 주식회사 카본나노튜브, 이를 포함한 전자 방출원 및 이를 구비한전자 방출 소자
WO2007048127A2 (en) * 2005-10-20 2007-04-26 The Scripps Research Institute Fc labeling for immunostaining and immunotargeting
US8518927B2 (en) 2009-02-10 2013-08-27 The Scripps Research Institute Chemically programmed vaccination

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD138319A1 (de) * 1978-08-08 1979-10-24 Helmut Roehnert Verfahren zur herstellung einer stabilen,kristallwasser-und kristalloesungsmittelfreien kristallform des 7-chlor-2-methylamino-5-phenyl-3h-1,4-benzodiazepin-4-oxid-hydrochlorids
US5939412A (en) 1992-06-26 1999-08-17 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
AU666318B2 (en) 1991-06-28 1996-02-08 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
DE69332860T2 (de) 1992-12-21 2004-03-11 Smithkline Beecham Corp. Bicyklische fibrinogen antagoniste
MA23420A1 (fr) 1994-01-07 1995-10-01 Smithkline Beecham Corp Antagonistes bicycliques de fibrinogene.

Also Published As

Publication number Publication date
DZ2302A1 (fr) 2002-12-28
EP0964684B1 (en) 2003-07-30
PE107198A1 (es) 1999-03-21
US6335330B1 (en) 2002-01-01
NO991013D0 (no) 1999-03-02
AU731173B2 (en) 2001-03-22
EA199900260A1 (ru) 1999-08-26
EP0964684A4 (en) 2002-05-29
CZ71999A3 (cs) 1999-08-11
MY118175A (en) 2004-09-30
ZA977870B (en) 1998-03-03
NO991013L (no) 1999-03-02
AU4242597A (en) 1998-03-26
PL332006A1 (en) 1999-08-16
ES2205254T3 (es) 2004-05-01
BR9711981A (pt) 1999-08-24
SK27699A3 (en) 2000-02-14
CN1102391C (zh) 2003-03-05
AR008154A1 (es) 1999-12-09
EP0964684A1 (en) 1999-12-22
WO1998009629A1 (en) 1998-03-12
DE69723873T2 (de) 2004-04-22
TR199900480T2 (xx) 1999-06-21
HUP9904077A3 (en) 2002-03-28
JP2000517342A (ja) 2000-12-26
BG103196A (en) 1999-09-30
EA001363B1 (ru) 2001-02-26
MA24309A1 (fr) 1998-04-01
AP9901472A0 (en) 1999-03-31
NZ334438A (en) 2000-10-27
CN1234739A (zh) 1999-11-10
DE69723873D1 (de) 2003-09-04
ID18156A (id) 1998-03-05
OA10986A (en) 2003-03-04
ATE245984T1 (de) 2003-08-15
CA2264607A1 (en) 1998-03-12
IL128782A0 (en) 2000-01-31
UY24690A1 (es) 1998-02-27
HUP9904077A2 (hu) 2000-05-28

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