UY24690A1 - Procedimiento para preparar un producto farmaceutico cristalino - Google Patents
Procedimiento para preparar un producto farmaceutico cristalinoInfo
- Publication number
- UY24690A1 UY24690A1 UY24690A UY24690A UY24690A1 UY 24690 A1 UY24690 A1 UY 24690A1 UY 24690 A UY24690 A UY 24690A UY 24690 A UY24690 A UY 24690A UY 24690 A1 UY24690 A1 UY 24690A1
- Authority
- UY
- Uruguay
- Prior art keywords
- water
- bipiperidin
- benzodiazepine
- tetrahydro
- oxo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un procedimiento para la preparación de una sal hidroclórica del ácido (S)-7-[(4,4'-bipiperidin-1-il)]-2,3,4,5-tetrahidro-4-metil-3-oxo-1H-1,4-benzodiacepina-2-acético, caracterizada por ser térmicamente estable, tener muy baja higroscopicidad, una estructura microcristalina y ser aproximadamente diez veces más soluble en agua que el zwitterion, donde el procedimiento comprende: a- formar una suspensión del ácdio (S)-7-[(4,4'-bipiperidin-1-il)carbonil]-2,3,4,5-tetrahidro-4-metil-3-oxo-1H-1,4-benzodiacepina-2-acético en agua; b- agregar gota a gota ácido clorhídrico, controlando el pH hasta lograr una solución amarillenta transparente; c- evaporar el agua a presión reducida, obteniendo una mesa vítrea; d- agitar y triturar dicha masa vítrea con etanol absoluto hasta obtener un sólido cristalino; e- filtrar y secar al aire. Esta invención comprende un método de antagonización del receptor de fibrinógeno para prevenir o tratar enfermedades en las que la agregación plaquetaria o la unión de ligando al receptor de fibrinógeno es un factor.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2536996P | 1996-09-03 | 1996-09-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY24690A1 true UY24690A1 (es) | 1998-02-27 |
Family
ID=21825633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY24690A UY24690A1 (es) | 1996-09-03 | 1997-09-01 | Procedimiento para preparar un producto farmaceutico cristalino |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6335330B1 (es) |
| EP (1) | EP0964684B1 (es) |
| JP (1) | JP2000517342A (es) |
| CN (1) | CN1102391C (es) |
| AP (1) | AP9901472A0 (es) |
| AR (1) | AR008154A1 (es) |
| AT (1) | ATE245984T1 (es) |
| AU (1) | AU731173B2 (es) |
| BG (1) | BG103196A (es) |
| BR (1) | BR9711981A (es) |
| CA (1) | CA2264607A1 (es) |
| CO (1) | CO4930262A1 (es) |
| CZ (1) | CZ71999A3 (es) |
| DE (1) | DE69723873T2 (es) |
| DZ (1) | DZ2302A1 (es) |
| EA (1) | EA001363B1 (es) |
| ES (1) | ES2205254T3 (es) |
| HU (1) | HUP9904077A3 (es) |
| ID (1) | ID18156A (es) |
| IL (1) | IL128782A0 (es) |
| MA (1) | MA24309A1 (es) |
| MY (1) | MY118175A (es) |
| NO (1) | NO991013D0 (es) |
| NZ (1) | NZ334438A (es) |
| OA (1) | OA10986A (es) |
| PE (1) | PE107198A1 (es) |
| PL (1) | PL332006A1 (es) |
| SK (1) | SK27699A3 (es) |
| TR (1) | TR199900480T2 (es) |
| UY (1) | UY24690A1 (es) |
| WO (1) | WO1998009629A1 (es) |
| ZA (1) | ZA977870B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19902529A1 (de) * | 1999-01-22 | 2000-08-03 | Goldwell Gmbh | Haarbehandlungsmittel |
| FR2797400A1 (fr) * | 1999-08-11 | 2001-02-16 | Sanofi Synthelabo | Associations a activite anti-thrombotique constituees de l'hydrogenosulfate de clopidogrel et d'un antagoniste des recepteurs gpiib/iiia et les compositions pharmaceutiques les contenant |
| CN100560131C (zh) | 2001-10-22 | 2009-11-18 | 斯克里普斯研究学院 | 抗体靶向化合物 |
| US20050202151A1 (en) * | 2004-03-15 | 2005-09-15 | Land O'lakes, Inc. | Method of preparing egg nuggets |
| KR101046977B1 (ko) * | 2004-11-15 | 2011-07-07 | 삼성에스디아이 주식회사 | 카본나노튜브, 이를 포함한 전자 방출원 및 이를 구비한전자 방출 소자 |
| US20070122408A1 (en) * | 2005-10-20 | 2007-05-31 | The Scripps Research Institute | Fc Labeling for Immunostaining and Immunotargeting |
| US8518927B2 (en) | 2009-02-10 | 2013-08-27 | The Scripps Research Institute | Chemically programmed vaccination |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD138319A1 (de) * | 1978-08-08 | 1979-10-24 | Helmut Roehnert | Verfahren zur herstellung einer stabilen,kristallwasser-und kristalloesungsmittelfreien kristallform des 7-chlor-2-methylamino-5-phenyl-3h-1,4-benzodiazepin-4-oxid-hydrochlorids |
| ES2190428T3 (es) | 1991-06-28 | 2003-08-01 | Smithkline Beecham Corp | Antagonistas biciclicos de fibrinogeno. |
| US5939412A (en) | 1992-06-26 | 1999-08-17 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
| DE69332860T2 (de) | 1992-12-21 | 2004-03-11 | Smithkline Beecham Corp. | Bicyklische fibrinogen antagoniste |
| MA23420A1 (fr) * | 1994-01-07 | 1995-10-01 | Smithkline Beecham Corp | Antagonistes bicycliques de fibrinogene. |
-
1997
- 1997-08-29 AT AT97940707T patent/ATE245984T1/de not_active IP Right Cessation
- 1997-08-29 NZ NZ334438A patent/NZ334438A/xx unknown
- 1997-08-29 AR ARP970103966A patent/AR008154A1/es not_active Application Discontinuation
- 1997-08-29 MA MA24781A patent/MA24309A1/fr unknown
- 1997-08-29 JP JP10512762A patent/JP2000517342A/ja active Pending
- 1997-08-29 EP EP97940707A patent/EP0964684B1/en not_active Expired - Lifetime
- 1997-08-29 PL PL97332006A patent/PL332006A1/xx unknown
- 1997-08-29 ES ES97940707T patent/ES2205254T3/es not_active Expired - Lifetime
- 1997-08-29 AP APAP/P/1999/001472A patent/AP9901472A0/en unknown
- 1997-08-29 IL IL12878297A patent/IL128782A0/xx unknown
- 1997-08-29 WO PCT/US1997/015292 patent/WO1998009629A1/en not_active Application Discontinuation
- 1997-08-29 CZ CZ99719A patent/CZ71999A3/cs unknown
- 1997-08-29 BR BR9711981A patent/BR9711981A/pt not_active Application Discontinuation
- 1997-08-29 HU HU9904077A patent/HUP9904077A3/hu unknown
- 1997-08-29 SK SK276-99A patent/SK27699A3/sk unknown
- 1997-08-29 EA EA199900260A patent/EA001363B1/ru not_active IP Right Cessation
- 1997-08-29 AU AU42425/97A patent/AU731173B2/en not_active Ceased
- 1997-08-29 US US09/254,305 patent/US6335330B1/en not_active Expired - Fee Related
- 1997-08-29 DE DE69723873T patent/DE69723873T2/de not_active Expired - Lifetime
- 1997-08-29 TR TR1999/00480T patent/TR199900480T2/xx unknown
- 1997-08-29 CN CN97199135A patent/CN1102391C/zh not_active Expired - Fee Related
- 1997-08-29 CA CA002264607A patent/CA2264607A1/en not_active Abandoned
- 1997-09-01 UY UY24690A patent/UY24690A1/es not_active IP Right Cessation
- 1997-09-01 CO CO97050462A patent/CO4930262A1/es unknown
- 1997-09-02 MY MYPI97004043A patent/MY118175A/en unknown
- 1997-09-02 ID IDP973061A patent/ID18156A/id unknown
- 1997-09-02 DZ DZ970152A patent/DZ2302A1/fr active
- 1997-09-02 ZA ZA9707870A patent/ZA977870B/xx unknown
- 1997-09-03 PE PE1997000779A patent/PE107198A1/es not_active Application Discontinuation
-
1999
- 1999-02-22 BG BG103196A patent/BG103196A/xx unknown
- 1999-03-02 NO NO991013A patent/NO991013D0/no not_active Application Discontinuation
- 1999-03-03 OA OA9900047A patent/OA10986A/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL158589A (en) | Carboxylic acid substituted oxazole derivatives, process for their manufacture, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments for the treatment and prophylaxis of diseases which are modulated by ppar-alpha and -gamma activators | |
| DK1227806T3 (da) | Farmaceutisk præparat indeholdende tolterodin og dets anvendelse | |
| MY124853A (en) | 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives. | |
| EA013973B1 (ru) | Способы лечения кожной волчанки при помощи аминоизоиндолиновых соединений | |
| ATE304528T1 (de) | Verbindungen mit wachstumshormon-freisetzenden eigenschaften | |
| AR056468A1 (es) | Formulaciones de ibandronato mejoradas | |
| NO166448C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive tiazolidindioner. | |
| TNSN06226A1 (en) | Pyrazolo[1,5-a]pyrimidin-7-yl-amine derivatives for use in the treatment of protein kinase dependent diseases | |
| ES2084579T3 (es) | Uso de buspirona en la preparacion de una composicion farmaceutica para el tratamiento del abuso del alcohol. | |
| AU3261799A (en) | Inorganic nitrite and organic acid in combination as topical antiviral composition | |
| BR9916361A (pt) | Forma de dosagem de tabletes de liberação controlada, formulação de tablete de liberação controlada, composição granular para prensagem em uma forma de dosagem de tablete de liberação controlada, e, métodos para preparar uma composição granular, para preparar uma forma de dosagem de tabletes de liberação controlada de divalproex sódio e para tratar epilepsia | |
| IL75536A0 (en) | Pseudomonic acid salt,its preparation and pharmaceutical and veterinary compositions comprising it | |
| CA2392050A1 (en) | Pharmaceutical formulations containing zolmitriptan | |
| UY24690A1 (es) | Procedimiento para preparar un producto farmaceutico cristalino | |
| EP1001759B1 (en) | Viral inhibition by long-chain alcohols, alkanes, fatty acids and amides | |
| US6174541B1 (en) | Skin aging and wound treatment using cell migration agents | |
| DE69217511T2 (de) | Pyridazindionderivate, ihre Herstellung und Verwendung als Arzneimittel | |
| EG19302A (en) | Compound with gastric acid inhibitory effect and process for its preparation | |
| ATE116849T1 (de) | Pharmazeutische verwendung von fettsäuren. | |
| ES2052000T3 (es) | Procedimiento para preparar composiciones farmaceuticas que contienen pentamidina. | |
| Zhang et al. | Effects of prostaglandin E1 on human keratinocytes and dermal fibroblasts: a possible mechanism for the healing of skin ulcers | |
| CA2544432A1 (en) | Stable pharmaceutical composition comprising granulocyte-colony stimulating factor | |
| PE20040916A1 (es) | Diamidas de acido pirimidin-4,6-dicarboxilico como inhibidores selectivos de mmp-13 | |
| DE60226225D1 (de) | Phtalazine derivate mit angiogenesis inhibierender wirkung | |
| DE60008293D1 (de) | Pharmazeutische zusammensetzung die einen no donor enthält und dessen therapeutische anwendung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| VENC | Patent expired |
Effective date: 20170901 |