PE20040916A1 - Diamidas de acido pirimidin-4,6-dicarboxilico como inhibidores selectivos de mmp-13 - Google Patents
Diamidas de acido pirimidin-4,6-dicarboxilico como inhibidores selectivos de mmp-13Info
- Publication number
- PE20040916A1 PE20040916A1 PE2003001280A PE2003001280A PE20040916A1 PE 20040916 A1 PE20040916 A1 PE 20040916A1 PE 2003001280 A PE2003001280 A PE 2003001280A PE 2003001280 A PE2003001280 A PE 2003001280A PE 20040916 A1 PE20040916 A1 PE 20040916A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- pyrimidin
- halogen
- substituted
- mmp
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
SE REFIERE A DIAMIDAS DE ACIDO PIRIMIDIN-4,6-DICARBOXILICO DE FORMULA I DONDE R1 ES H O ALQUILO C1-C6; R2 ES ALQUILO C1-C6 SUSTITUIDO UNA A TRES VECES POR C(O)-O-R8, ALQUIL(C1-C6)-O-R8, ENTRE OTROS; R3, R4, R5, R6 y R7 SON H, HALOGENO, ALQUILO C1-C6 NO SUSTITUIDO O SUSTITUIDO HASTA TRES VECES POR HALOGENO, O-ALQUILO C1-C6 NO SUSTITUIDO O SUSTITUIDO HASTA TRES VECES POR HALOGENO, S-ALQUILO C1-C6; R8 ES H O ALQUILO C1-C6. SON COMPUESTOS PREFERIDOS: [4-({[6-(4-FLUORO-3-METILBENCILCARBAMOIL)-PIRIMIDIN-4-CARBONIL]AMINO}METIL)FENOXI] ACETATO DE TERC-BUTILO; ACIDO [4-({[6-(4-FLUORO-3-METILBENCILCARBAMOIL)-PIRIMIDIN-4-CARBONIL]AMINO}METIL)FENOXI] ACETICO, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA PREPARAR ESTOS COMPUESTOS Y UN PRODUCTO FARMACEUTICO. ESTOS COMPUESTOS SON UTILES PARA LA PROFILAXIS Y LA TERAPIA DE ENFERMEDADES CUYO CURSO IMPLICA UNA ACTIVIDAD INCREMENTADA DE METALOPROTEINASA DE MATRIZ 13 COMO SON ENFERMEDADES DEGENERATIVAS DE LAS ARTICULACIONES, ENFERMEDADES DEL TEJIDO CONECTIVO, ENFERMEDADES CANCEROSAS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10300017A DE10300017A1 (de) | 2003-01-03 | 2003-01-03 | Selektive MMP 13 Inhibitoren |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20040916A1 true PE20040916A1 (es) | 2005-01-25 |
Family
ID=32519591
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2003001280A PE20040916A1 (es) | 2003-01-03 | 2003-12-12 | Diamidas de acido pirimidin-4,6-dicarboxilico como inhibidores selectivos de mmp-13 |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP1587803A1 (es) |
JP (1) | JP2006515595A (es) |
AR (1) | AR042687A1 (es) |
AU (1) | AU2003293951A1 (es) |
BR (1) | BR0317834A (es) |
CA (1) | CA2512183A1 (es) |
DE (1) | DE10300017A1 (es) |
MX (1) | MXPA05006401A (es) |
PE (1) | PE20040916A1 (es) |
TW (1) | TW200505906A (es) |
WO (1) | WO2004060883A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060173183A1 (en) * | 2004-12-31 | 2006-08-03 | Alantos Pharmaceuticals, Inc., | Multicyclic bis-amide MMP inhibitors |
US20070155737A1 (en) * | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
US20070155738A1 (en) * | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
JP2009522295A (ja) * | 2005-12-30 | 2009-06-11 | アラントス・フアーマシユーテイカルズ・ホールデイング・インコーポレイテツド | 置換ビス−アミドメタロプロテアーゼ阻害剤 |
US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
EP2094707A1 (en) * | 2006-11-20 | 2009-09-02 | Alantos Pharmaceuticals Holding, Inc. | Heterobicyclic matrix metalloprotease inhibitors |
US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
SG10201505700QA (en) | 2010-04-22 | 2015-08-28 | Vertex Pharma | Process of producing cycloalkylcarboxamido-indole compounds |
SI3131582T1 (sl) | 2014-04-15 | 2018-09-28 | Vertex Pharmaceuticals Incorporated | Farmacevtski sestavki za zdravljenje bolezni, pri katerih posreduje regulator transmembranske prevodnosti |
GB201908453D0 (en) * | 2019-06-12 | 2019-07-24 | Enterprise Therapeutics Ltd | Compounds for treating respiratory disease |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3931432A1 (de) * | 1989-09-21 | 1991-04-04 | Hoechst Ag | Pyrimidin-4,6-dicarbonsaeurediamide, verfahren zu deren herstellung sowie verwendung derselben sowie arzneimittel auf basis dieser verbindungen |
DE60236851D1 (en) * | 2001-02-14 | 2010-08-12 | Warner Lambert Co | Pyrimidinmatrixmetalloproteinaseinhibitoren |
DE10160357A1 (de) * | 2001-12-08 | 2003-06-18 | Aventis Pharma Gmbh | Verwendung von Pyridin-2,4-dicarbonsäurediamiden und Pyrimidin-4,6-dicarbonsäurediamiden zur selektiven Inhibierung von Kollagenasen |
-
2003
- 2003-01-03 DE DE10300017A patent/DE10300017A1/de not_active Withdrawn
- 2003-12-12 PE PE2003001280A patent/PE20040916A1/es not_active Application Discontinuation
- 2003-12-19 CA CA002512183A patent/CA2512183A1/en not_active Abandoned
- 2003-12-19 MX MXPA05006401A patent/MXPA05006401A/es unknown
- 2003-12-19 BR BR0317834-0A patent/BR0317834A/pt not_active IP Right Cessation
- 2003-12-19 EP EP03789359A patent/EP1587803A1/de not_active Withdrawn
- 2003-12-19 JP JP2004564206A patent/JP2006515595A/ja not_active Abandoned
- 2003-12-19 AU AU2003293951A patent/AU2003293951A1/en not_active Abandoned
- 2003-12-19 WO PCT/EP2003/014612 patent/WO2004060883A1/de not_active Application Discontinuation
- 2003-12-30 AR ARP030104874A patent/AR042687A1/es unknown
- 2003-12-31 TW TW092137550A patent/TW200505906A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
TW200505906A (en) | 2005-02-16 |
WO2004060883A1 (de) | 2004-07-22 |
MXPA05006401A (es) | 2005-08-19 |
AU2003293951A1 (en) | 2004-07-29 |
DE10300017A1 (de) | 2004-07-15 |
EP1587803A1 (de) | 2005-10-26 |
BR0317834A (pt) | 2005-11-29 |
JP2006515595A (ja) | 2006-06-01 |
CA2512183A1 (en) | 2004-07-22 |
AR042687A1 (es) | 2005-06-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ME01310B (me) | Derivati oksazola koji su supstituisani karboksilnom kiselinom za primenu kao ppar-alfa-1-gama aktivatori u lečenju dijabetesa | |
SE0200979D0 (sv) | New compounds | |
NO20071577L (no) | Bifenyloksyiddiksyrederivater for behandling av luftveissykdommer | |
SE9903760D0 (sv) | New compounds | |
BRPI0414867A (pt) | pirazolopiridinas e seus análogos | |
AP1822A (en) | Substituted pyridinones as modulators of P38 MAP kinase. | |
IL159843A0 (en) | Amino-phthalazinone derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them | |
TW200517109A (en) | Substituted pyridinones | |
RS20070076A (en) | Novel sulphonamide derivatives as glucocorticoid receptor modulators for the treatment of inflammatory diseases | |
EA200501332A1 (ru) | Производные пиримидин-4-она и их применение в качестве модуляторов киназы p38 | |
EA200970611A1 (ru) | Замещенные пиразолохиназолиновые производные, способ их получения и их применение в качестве ингибиторов киназы | |
HRP20050967B1 (hr) | Derivati pirazolo-kinazolina, postupak njihovog dobivanja i njihova uporaba kao inhibitora kinaze | |
NO20012158L (no) | Substituerte 2-fenylbenzimidazoler, fremgangsmåte til fremstilling og anvendelse derav | |
NO20093464L (no) | Nye medikamentblandinger basert pa anti-cholinergisk effektive forbindelser og beta-mimetika | |
WO2005016867A3 (en) | Anthranilic acid derivatives and their use as activators of the hm74a receptor | |
NO990433L (no) | Nye forbindelser og blandinger for behandling av sykdommer i forbindelse med tryptase-aktivitet | |
CY1109376T1 (el) | Παραγωγα υδαντοϊνης χρησιμα ως αναστολεις μεταλλοπρωτεϊνασης | |
PE20040916A1 (es) | Diamidas de acido pirimidin-4,6-dicarboxilico como inhibidores selectivos de mmp-13 | |
WO2003063791A3 (en) | Non-steroidal analogs of 2-methoxyestradiol | |
BRPI0413438A (pt) | derivados de pirimidilpirrol ativos como inibidores de cinase | |
UY29823A1 (es) | Derivados sustituidos de 7-cloro-3h-imidazol-(4,5-b) piridina, composiciones farmacéuticas que los contienen, procesos para la preparación de los mismos y aplicaciones | |
EE200200504A (et) | Farmatseutilised preparaadid | |
ATE444069T1 (de) | Chinolin-derivate zur behandlung von mglur5- rezeptor-vermittelten erkrankungen | |
EA200401319A1 (ru) | Новые гетероциклические соединения, способы их получения и фармацевтические композиции, содержащие эти соединения, и их использование в медицине | |
DK1228758T3 (da) | Anvendelse af sulfodehydroabietinsyre til behandling af inflammatorisk tarmsygdom |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |