DE60226225D1 - Phtalazine derivate mit angiogenesis inhibierender wirkung - Google Patents
Phtalazine derivate mit angiogenesis inhibierender wirkungInfo
- Publication number
- DE60226225D1 DE60226225D1 DE60226225T DE60226225T DE60226225D1 DE 60226225 D1 DE60226225 D1 DE 60226225D1 DE 60226225 T DE60226225 T DE 60226225T DE 60226225 T DE60226225 T DE 60226225T DE 60226225 D1 DE60226225 D1 DE 60226225D1
- Authority
- DE
- Germany
- Prior art keywords
- treatment
- derivatives
- inhibiving
- phtalazine
- angiogenesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000033115 angiogenesis Effects 0.000 title 1
- 150000003020 phtalazines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 108091008605 VEGF receptors Proteins 0.000 abstract 1
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- LFSXCDWNBUNEEM-UHFFFAOYSA-N phthalazine Chemical class C1=NN=CC2=CC=CC=C21 LFSXCDWNBUNEEM-UHFFFAOYSA-N 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 230000000552 rheumatic effect Effects 0.000 abstract 1
- 201000003068 rheumatic fever Diseases 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0111078.2A GB0111078D0 (en) | 2001-05-04 | 2001-05-04 | Organic compounds |
| GB0111078 | 2001-05-04 | ||
| PCT/EP2002/004892 WO2002090346A1 (en) | 2001-05-04 | 2002-05-03 | Phthalazine derivatives with angiogenesis inhibiting activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60226225D1 true DE60226225D1 (de) | 2008-06-05 |
| DE60226225T2 DE60226225T2 (de) | 2009-09-10 |
Family
ID=9914117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60226225T Expired - Lifetime DE60226225T2 (de) | 2001-05-04 | 2002-05-03 | Phtalazine derivate mit angiogenesis inhibierender wirkung |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7399761B2 (de) |
| EP (1) | EP1387836B1 (de) |
| JP (1) | JP4365586B2 (de) |
| CN (1) | CN1314681C (de) |
| AT (1) | ATE393152T1 (de) |
| BR (1) | BR0209332A (de) |
| CA (1) | CA2446051A1 (de) |
| DE (1) | DE60226225T2 (de) |
| ES (1) | ES2301648T3 (de) |
| GB (1) | GB0111078D0 (de) |
| PT (1) | PT1387836E (de) |
| WO (1) | WO2002090346A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1712234B1 (de) * | 2001-09-12 | 2009-01-28 | Novartis AG | Die Verwendung von 4-Pyridylmethylphthalazinen zur Behandlung von Nierentumoren |
| CN100355423C (zh) | 2002-06-28 | 2007-12-19 | 诺瓦提斯公司 | 用于治疗肿瘤的包含血管抑制化合物和烷化剂的组合 |
| AU2003292888A1 (en) * | 2002-12-27 | 2004-07-22 | Schering Aktiengesellschaft | Pharmaceutical combinations of phthalazine vegf inhibitors and benzamide hdac inhibitors |
| UA89035C2 (ru) | 2003-12-03 | 2009-12-25 | Лео Фарма А/С | Эфиры гидроксамовых кислот и их фармацевтическое применение |
| JP2009506123A (ja) * | 2005-08-29 | 2009-02-12 | バーテックス ファーマシューティカルズ インコーポレイテッド | 非受容体型チロシンキナーゼのｔｅｃファミリーの阻害剤として有用な３，５−二置換ピリド−２−オン |
| DK2346827T3 (da) | 2008-08-27 | 2014-02-03 | Leo Pharma As | Pyridinderivater som VEGFR-2 receptor og proteintyrosinkinasehæmmere |
| CA2890671A1 (en) * | 2012-11-16 | 2014-05-22 | F. Hoffmann-La Roche Ag | Inhibitors of bruton's tyrosine kinase |
| RU2668073C2 (ru) | 2013-03-14 | 2018-09-26 | Дарт Нейросайенс (Кайман) Лтд. | Замещенные пиридиновые и пиразиновые соединения в качестве ингибиторов pde4 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE567431A (de) | 1957-05-07 | |||
| GB1293565A (en) * | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
| US4665181A (en) * | 1984-05-17 | 1987-05-12 | Pennwalt Corporation | Anti-inflammatory phthalazinones |
| JPH03106875A (ja) | 1989-09-20 | 1991-05-07 | Morishita Pharmaceut Co Ltd | １―（３―ピリジルメチル）フタラジン誘導体 |
| EP0600831A1 (de) | 1992-11-27 | 1994-06-08 | Ciba-Geigy Ag | Phthalazinonderivate |
| ES2224130T3 (es) * | 1994-08-09 | 2005-03-01 | Eisai Co., Ltd. | Compuesto de piridazina condensada. |
| NZ326354A (en) | 1996-01-15 | 1999-05-28 | Janssen Pharmaceutica Nv | 3-(substituted-1-piperazinyl)-6-(substituted-1,2,4-thiadiazol-5 -yl)-pyridazine derivatives and medicaments |
| CO4950519A1 (es) | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| EP1165085B1 (de) * | 1999-03-30 | 2006-06-14 | Novartis AG | Phthalazinderivate zur behandlung von entzündlicher erkrankungen |
| AR025068A1 (es) * | 1999-08-10 | 2002-11-06 | Bayer Corp | Pirazinas sustituidas y piridazinas fusionadas, composicion farmaceutica que las comprenden, uso de dichos compuestos para la manufactura de un medicamentocon actividad inhibidora de angiogenesis |
-
2001
- 2001-05-04 GB GBGB0111078.2A patent/GB0111078D0/en not_active Ceased
-
2002
- 2002-05-03 WO PCT/EP2002/004892 patent/WO2002090346A1/en active IP Right Grant
- 2002-05-03 AT AT02738031T patent/ATE393152T1/de active
- 2002-05-03 US US10/475,419 patent/US7399761B2/en not_active Expired - Fee Related
- 2002-05-03 ES ES02738031T patent/ES2301648T3/es not_active Expired - Lifetime
- 2002-05-03 CN CNB028092937A patent/CN1314681C/zh not_active Expired - Fee Related
- 2002-05-03 PT PT02738031T patent/PT1387836E/pt unknown
- 2002-05-03 CA CA002446051A patent/CA2446051A1/en not_active Abandoned
- 2002-05-03 DE DE60226225T patent/DE60226225T2/de not_active Expired - Lifetime
- 2002-05-03 BR BR0209332-4A patent/BR0209332A/pt not_active IP Right Cessation
- 2002-05-03 EP EP02738031A patent/EP1387836B1/de not_active Expired - Lifetime
- 2002-05-03 JP JP2002587426A patent/JP4365586B2/ja not_active Expired - Fee Related
-
2008
- 2008-06-18 US US12/141,179 patent/US20090076003A1/en not_active Abandoned
-
2010
- 2010-11-24 US US12/953,837 patent/US8034814B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| GB0111078D0 (en) | 2001-06-27 |
| US7399761B2 (en) | 2008-07-15 |
| CN1314681C (zh) | 2007-05-09 |
| US20110130399A1 (en) | 2011-06-02 |
| ES2301648T3 (es) | 2008-07-01 |
| US8034814B2 (en) | 2011-10-11 |
| EP1387836B1 (de) | 2008-04-23 |
| DE60226225T2 (de) | 2009-09-10 |
| PT1387836E (pt) | 2008-06-27 |
| EP1387836A1 (de) | 2004-02-11 |
| CN1507444A (zh) | 2004-06-23 |
| WO2002090346A1 (en) | 2002-11-14 |
| BR0209332A (pt) | 2004-07-20 |
| US20040180899A1 (en) | 2004-09-16 |
| US20090076003A1 (en) | 2009-03-19 |
| JP2004532241A (ja) | 2004-10-21 |
| ATE393152T1 (de) | 2008-05-15 |
| JP4365586B2 (ja) | 2009-11-18 |
| CA2446051A1 (en) | 2002-11-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |
|
| 8328 | Change in the person/name/address of the agent |
Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN |