PE107198A1 - Forma cristalina del acido(s)-7-[4,4`-bipiperidin-1-il)carbonil]-2,3,4,5-tetrahidro -4-metil-3-oxo-1h-1,4-benzodiazepina-2-acetico, hidrocloruro - Google Patents
Forma cristalina del acido(s)-7-[4,4`-bipiperidin-1-il)carbonil]-2,3,4,5-tetrahidro -4-metil-3-oxo-1h-1,4-benzodiazepina-2-acetico, hidrocloruroInfo
- Publication number
- PE107198A1 PE107198A1 PE1997000779A PE00077997A PE107198A1 PE 107198 A1 PE107198 A1 PE 107198A1 PE 1997000779 A PE1997000779 A PE 1997000779A PE 00077997 A PE00077997 A PE 00077997A PE 107198 A1 PE107198 A1 PE 107198A1
- Authority
- PE
- Peru
- Prior art keywords
- hydrochloride
- bipiperidin
- benzodiazepine
- tetrahydro
- oxo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
CARACTERIZADA POR UN PUNTO DE FUSION DE 291�C Y UNA ROTACION ESPECIFICA NEGATIVA DE 175; TAMBIEN SE REFIERE AL PROCEDIMIENTO DE PREPARACION DEL PRODUCTO CRISTALINO, QUE CRISTALIZA CON UNA MOLECULA DE HCl Y PARECE QUE EXISTE EN UNA FORMA ANHIDRA, PRESENTANDO UNA DISOLUCION Y SOLUBILIDAD EN AGUA MEJORADAS, ADEMAS DE FACILITAR SU MANIPULACION A GRANEL. ESTA FORMA DE SAL HIDROCLORURO ACTUA INHIBIENDO EL RECEPTOR FIBRINOGENO POR LO QUE ES UN INHIBIDOR DE LA AGREGACION PLAQUETARIA, UTIL EN EL TRATAMIENTO DEL INFARTO DEL MIOCARDIO, LA TROMBOSIS, LA EMBOLIA, EL ATAQUE APOPLETICO Y LAS ENFERMEDADES RELACIONADAS CON EL INFARTO O LAS RESTENOSIS QUE SIGUEN A LA ANGIOPLASTIA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2536996P | 1996-09-03 | 1996-09-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE107198A1 true PE107198A1 (es) | 1999-03-21 |
Family
ID=21825633
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1997000779A PE107198A1 (es) | 1996-09-03 | 1997-09-03 | Forma cristalina del acido(s)-7-[4,4`-bipiperidin-1-il)carbonil]-2,3,4,5-tetrahidro -4-metil-3-oxo-1h-1,4-benzodiazepina-2-acetico, hidrocloruro |
Country Status (32)
Country | Link |
---|---|
US (1) | US6335330B1 (es) |
EP (1) | EP0964684B1 (es) |
JP (1) | JP2000517342A (es) |
CN (1) | CN1102391C (es) |
AP (1) | AP9901472A0 (es) |
AR (1) | AR008154A1 (es) |
AT (1) | ATE245984T1 (es) |
AU (1) | AU731173B2 (es) |
BG (1) | BG103196A (es) |
BR (1) | BR9711981A (es) |
CA (1) | CA2264607A1 (es) |
CO (1) | CO4930262A1 (es) |
CZ (1) | CZ71999A3 (es) |
DE (1) | DE69723873T2 (es) |
DZ (1) | DZ2302A1 (es) |
EA (1) | EA001363B1 (es) |
ES (1) | ES2205254T3 (es) |
HU (1) | HUP9904077A3 (es) |
ID (1) | ID18156A (es) |
IL (1) | IL128782A0 (es) |
MA (1) | MA24309A1 (es) |
MY (1) | MY118175A (es) |
NO (1) | NO991013D0 (es) |
NZ (1) | NZ334438A (es) |
OA (1) | OA10986A (es) |
PE (1) | PE107198A1 (es) |
PL (1) | PL332006A1 (es) |
SK (1) | SK27699A3 (es) |
TR (1) | TR199900480T2 (es) |
UY (1) | UY24690A1 (es) |
WO (1) | WO1998009629A1 (es) |
ZA (1) | ZA977870B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19902529A1 (de) * | 1999-01-22 | 2000-08-03 | Goldwell Gmbh | Haarbehandlungsmittel |
FR2797400A1 (fr) * | 1999-08-11 | 2001-02-16 | Sanofi Synthelabo | Associations a activite anti-thrombotique constituees de l'hydrogenosulfate de clopidogrel et d'un antagoniste des recepteurs gpiib/iiia et les compositions pharmaceutiques les contenant |
KR20040058229A (ko) | 2001-10-22 | 2004-07-03 | 더 스크립스 리서치 인스티튜트 | 항체 표적화 화합물 |
US20050202151A1 (en) * | 2004-03-15 | 2005-09-15 | Land O'lakes, Inc. | Method of preparing egg nuggets |
KR101046977B1 (ko) * | 2004-11-15 | 2011-07-07 | 삼성에스디아이 주식회사 | 카본나노튜브, 이를 포함한 전자 방출원 및 이를 구비한전자 방출 소자 |
JP2009512443A (ja) * | 2005-10-20 | 2009-03-26 | ザ スクリップス リサーチ インスチチュート | 免疫染色及び免疫標的化のためのFc標識化 |
JP2012517447A (ja) | 2009-02-10 | 2012-08-02 | ザ スクリプス リサーチ インスティチュート | 化学的にプログラムされたワクチン接種法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD138319A1 (de) * | 1978-08-08 | 1979-10-24 | Helmut Roehnert | Verfahren zur herstellung einer stabilen,kristallwasser-und kristalloesungsmittelfreien kristallform des 7-chlor-2-methylamino-5-phenyl-3h-1,4-benzodiazepin-4-oxid-hydrochlorids |
US5939412A (en) | 1992-06-26 | 1999-08-17 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
AU666318B2 (en) | 1991-06-28 | 1996-02-08 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
AU689762B2 (en) | 1992-12-21 | 1998-04-09 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
MA23420A1 (fr) * | 1994-01-07 | 1995-10-01 | Smithkline Beecham Corp | Antagonistes bicycliques de fibrinogene. |
-
1997
- 1997-08-29 AP APAP/P/1999/001472A patent/AP9901472A0/en unknown
- 1997-08-29 EA EA199900260A patent/EA001363B1/ru not_active IP Right Cessation
- 1997-08-29 CN CN97199135A patent/CN1102391C/zh not_active Expired - Fee Related
- 1997-08-29 HU HU9904077A patent/HUP9904077A3/hu unknown
- 1997-08-29 ES ES97940707T patent/ES2205254T3/es not_active Expired - Lifetime
- 1997-08-29 AU AU42425/97A patent/AU731173B2/en not_active Ceased
- 1997-08-29 TR TR1999/00480T patent/TR199900480T2/xx unknown
- 1997-08-29 IL IL12878297A patent/IL128782A0/xx unknown
- 1997-08-29 CA CA002264607A patent/CA2264607A1/en not_active Abandoned
- 1997-08-29 NZ NZ334438A patent/NZ334438A/xx unknown
- 1997-08-29 DE DE69723873T patent/DE69723873T2/de not_active Expired - Lifetime
- 1997-08-29 PL PL97332006A patent/PL332006A1/xx unknown
- 1997-08-29 JP JP10512762A patent/JP2000517342A/ja active Pending
- 1997-08-29 WO PCT/US1997/015292 patent/WO1998009629A1/en not_active Application Discontinuation
- 1997-08-29 US US09/254,305 patent/US6335330B1/en not_active Expired - Fee Related
- 1997-08-29 CZ CZ99719A patent/CZ71999A3/cs unknown
- 1997-08-29 EP EP97940707A patent/EP0964684B1/en not_active Expired - Lifetime
- 1997-08-29 AR ARP970103966A patent/AR008154A1/es not_active Application Discontinuation
- 1997-08-29 AT AT97940707T patent/ATE245984T1/de not_active IP Right Cessation
- 1997-08-29 SK SK276-99A patent/SK27699A3/sk unknown
- 1997-08-29 BR BR9711981A patent/BR9711981A/pt not_active Application Discontinuation
- 1997-08-29 MA MA24781A patent/MA24309A1/fr unknown
- 1997-09-01 UY UY24690A patent/UY24690A1/es not_active IP Right Cessation
- 1997-09-01 CO CO97050462A patent/CO4930262A1/es unknown
- 1997-09-02 ID IDP973061A patent/ID18156A/id unknown
- 1997-09-02 DZ DZ970152A patent/DZ2302A1/fr active
- 1997-09-02 MY MYPI97004043A patent/MY118175A/en unknown
- 1997-09-02 ZA ZA9707870A patent/ZA977870B/xx unknown
- 1997-09-03 PE PE1997000779A patent/PE107198A1/es not_active Application Discontinuation
-
1999
- 1999-02-22 BG BG103196A patent/BG103196A/xx unknown
- 1999-03-02 NO NO991013A patent/NO991013D0/no not_active Application Discontinuation
- 1999-03-03 OA OA9900047A patent/OA10986A/en unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |